Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis.

Q4 Medicine

Open Rheumatology Journal Pub Date : 2017-01-16 eCollection Date: 2017-01-01 DOI:10.2174/1874312901711010001

Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz

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引用次数: 9

Abstract

Background: Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.

Objective: To study the association between ERAP1, IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.

Methods: rs27044 and rs30187 (ERAP1), rs11209032 (IL23R) and rs10440635 (PTGER4) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of "0" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes (i.e. squaring or erosions) were omitted for clear stratification) regardless of disease duration.

Results: The genotype distributions and allele frequencies of ERAP1 rs27044 and rs30187, IL23R rs11209032 and PTGER4 rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.

Conclusion: In radiographically well-categorized AS patients, ERAP1 rs27044 and rs30187, IL23R rs11209032 and PTGER4 rs10440635 SNPs are not found to be associated with radiographic severity of AS.

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ERAP1, IL23R和PTGER4多态性与强直性脊柱炎放射学严重程度的关系

背景:强直性脊柱炎(AS)的放射学严重程度差异很大，一些患者在整个病程中从未出现综合征，而一些患者则相对较早地出现竹棘。目的:研究AS患者ERAP1、IL23R和PTGER4单核苷酸多态性(snp)与影像学严重程度的关系。方法:对235例符合改良纽约标准的AS患者进行rs27044、rs30187 (ERAP1)、rs11209032 (IL23R)和rs10440635 (PTGER4) snp基因分型。根据改良的Stoke as脊柱评分(mSASSS)将患者分为轻度和重度as。轻度as定义为病程至少10年，mSASSS为“0”。严重as定义为无论病程如何，mSASSS >20(轻度椎体改变(即变方或糜烂)的患者被省略，以明确分层)。结果:ERAP1 rs27044和rs30187、IL23R rs11209032和PTGER4 rs10440635 snp在轻度as (n=171, mSASSS=0, 55.6% HLA-B27阳性)和重度as (n=64, mSASSS=48.5±17.8,73.4% HLA-B27阳性)患者中的基因型分布和等位基因频率相似。通过logistic回归分析调整各组间临床差异(性别、病程、HLA-B27和吸烟状况)后，未发现所调查snp中的等位基因与AS的放射学严重程度相关。结论:在影像学分类良好的AS患者中，未发现ERAP1 rs27044和rs30187、IL23R rs11209032和PTGER4 rs10440635 snp与AS影像学严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

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