Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz
{"title":"ERAP1, IL23R和PTGER4多态性与强直性脊柱炎放射学严重程度的关系","authors":"Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz","doi":"10.2174/1874312901711010001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.</p><p><strong>Objective: </strong>To study the association between <i>ERAP1</i>, <i>IL23R</i> and <i>PTGER4</i> single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.</p><p><strong>Methods: </strong>rs27044 and rs30187 (<i>ERAP1</i>), rs11209032 (<i>IL23R</i>) and rs10440635 (<i>PTGER4</i>) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of \"0\" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes (<i>i.e.</i> squaring or erosions) were omitted for clear stratification) regardless of disease duration.</p><p><strong>Results: </strong>The genotype distributions and allele frequencies of <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.</p><p><strong>Conclusion: </strong>In radiographically well-categorized AS patients, <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs are not found to be associated with radiographic severity of AS.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"1-9"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/c8/TORJ-11-1.PMC5366379.pdf","citationCount":"9","resultStr":"{\"title\":\"Association of <i>ERAP1</i>, <i>IL23R</i> and <i>PTGER4</i> Polymorphisms with Radiographic Severity of Ankylosing Spondylitis.\",\"authors\":\"Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz\",\"doi\":\"10.2174/1874312901711010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.</p><p><strong>Objective: </strong>To study the association between <i>ERAP1</i>, <i>IL23R</i> and <i>PTGER4</i> single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.</p><p><strong>Methods: </strong>rs27044 and rs30187 (<i>ERAP1</i>), rs11209032 (<i>IL23R</i>) and rs10440635 (<i>PTGER4</i>) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of \\\"0\\\" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes (<i>i.e.</i> squaring or erosions) were omitted for clear stratification) regardless of disease duration.</p><p><strong>Results: </strong>The genotype distributions and allele frequencies of <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.</p><p><strong>Conclusion: </strong>In radiographically well-categorized AS patients, <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs are not found to be associated with radiographic severity of AS.</p>\",\"PeriodicalId\":39124,\"journal\":{\"name\":\"Open Rheumatology Journal\",\"volume\":\"11 \",\"pages\":\"1-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/c8/TORJ-11-1.PMC5366379.pdf\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Rheumatology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874312901711010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Rheumatology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874312901711010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis.
Background: Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.
Objective: To study the association between ERAP1, IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.
Methods: rs27044 and rs30187 (ERAP1), rs11209032 (IL23R) and rs10440635 (PTGER4) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of "0" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes (i.e. squaring or erosions) were omitted for clear stratification) regardless of disease duration.
Results: The genotype distributions and allele frequencies of ERAP1 rs27044 and rs30187, IL23R rs11209032 and PTGER4 rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.
Conclusion: In radiographically well-categorized AS patients, ERAP1 rs27044 and rs30187, IL23R rs11209032 and PTGER4 rs10440635 SNPs are not found to be associated with radiographic severity of AS.
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