African Journal of Infectious Diseases最新文献

{"title":"PERCEPTION AND WILLINGNESS TO THE UPTAKE OF COVID-19 VACCINE AMONG HOUSEHOLD-HEADS IN A RURAL COMMUNITY OF SOUTH-WESTERN NIGERIA.","authors":"Adewoye Kayode Rasaq,&nbsp;Olalubi Oluwasogo A,&nbsp;Aremu Shuaib Kayode,&nbsp;Alao Taiye Adeyanju,&nbsp;Ekpo David Sylvanus,&nbsp;Ipinnimo Tope Michael,&nbsp;Adeniyi Makinde Adebayo,&nbsp;Ibrahim Azeez Oyemomi,&nbsp;Sanni Taofeek Adedayo,&nbsp;Achebe Chijioke Cosmas,&nbsp;Bakare Adewumi,&nbsp;Orewole Tesleem Olayinka,&nbsp;Abioye Opeyemi Oladipupo","doi":"10.21010/Ajidv17i2.1","DOIUrl":"https://doi.org/10.21010/Ajidv17i2.1","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic and its vaccine have been met with varying perceptions that may have both negative and positive effects on the willingness to uptake the COVID-19 vaccine. The study is set to determine the perception and willingness of the household heads to the uptake of COVID-19 vaccine in a rural community in Southwestern, Nigeria.</p><p><strong>Materials and methods: </strong>A cross-sectional study was carried out among 409 household heads selected through a multistage sampling technique. The instrument of data collection was a semi-structured interviewer-administered questionnaire using the Health Belief model constructs. Data were analyzed with IBM SPSS version 21.0 and Pearson's Chi-square test was used to determine the association between perception and willingness to uptake vaccine. P<0.05 was taken as significant at 95% confidence interval.</p><p><strong>Results: </strong>The majority of the unvaccinated respondents in the study were not willing to take the COVID-19 vaccine (60.1%). There was a poor perception of the susceptibility/severity of unvaccinated respondents to COVID-19 infection and a poor perception of the benefit/barrier to the uptake of the COVID-19 vaccine. Perception of susceptibility and severity of COVID-19 infection were statistically related to the willingness to uptake the COVID-19 vaccine.</p><p><strong>Conclusion: </strong>There should be an increase in awareness campaigns to change the perception of people positively to COVID-19 infection and uptake of the COVID-19 vaccine.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9430228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REACTOGENICITY OF HETEROLOGOUS MRNA-BASED COVID-19 VACCINE BOOSTER IN YOUNG ADULTS IN INDONESIA- A SHORT COMMUNICATION.","authors":"Suryadinata Neneng,&nbsp;Christopher Paulus Mario,&nbsp;Imanuelly Michelle,&nbsp;Wijaya Ratna Sari,&nbsp;Cucunawangsih Cucunawangsih,&nbsp;Lugito Nata Pratama Hardjo","doi":"10.21010/Ajidv17i2.2","DOIUrl":"https://doi.org/10.21010/Ajidv17i2.2","url":null,"abstract":"<p><strong>Background: </strong>Heterologous priming with the inactivated SARS-CoV-2 vaccine (CoronaVac) and boosting with mRNA-based COVID-19 vaccine (Moderna or Pfizer) is currently recommended in Indonesia. The reactogenicity data of these heterologous vaccine regimens are not entirely available, particularly in young adults. The present study, therefore, aimed to evaluate the solicited local and systemic reactions in the first seven days post-vaccination either with Moderna or Pfizer vaccine among previous recipients of two doses of CoronaVac.</p><p><strong>Materials and methods: </strong>An electronic-based cross-sectional study was conducted among medical students at the Pelita Harapan University, Banten, Indonesia, who received mRNA-based COVID-19 vaccine following two doses of CoronaVac. Samples were collected using a cluster sampling technique. Comparison between groups was performed by Fisher's exact test.</p><p><strong>Results: </strong>A total of 72 participants, 23 (32%) of which received the Moderna vaccine and 49 (68%) received the Pfizer vaccine, were included in this study. The median age of participants was 21 (IQR 19-22) years old. The most common local and systemic events for mRNA-based COVID-19 vaccines were injection site pain, fever, headache, fatigue, myalgia, and arthralgia. Solicited local and systemic reactions were reported more frequently in Moderna recipients than Pfizer recipients. Most local and systemic reactions were graded as mild to moderate and did not lead to hospitalization.</p><p><strong>Conclusions: </strong>The reactogenicity of the heterologous prime-boost with CoronaVac and mRNA-based COVID-19 vaccine booster among young adults is reassuring, and no unexpected concerns were identified.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 2","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9485154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FACTORS CONTRIBUTING TO PULMONARY TB TREATMENT LOST TO FOLLOW-UP IN DEVELOPING COUNTRIES: AN OVERVIEW.","authors":"Opperman Monique,&nbsp;DU Preez Ilse","doi":"10.21010/Ajidv17i1.6","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.6","url":null,"abstract":"<p><strong>Background: </strong>Despite the available treatment options, pulmonary tuberculosis (TB) remains a leading cause of disease-related deaths worldwide. Treatment non-adherence/lost to follow-up (LTFU), particularly in developing countries, is a continuous concern. LTFU prolongs TB infectiousness and contributes to TB treatment failure, relapse, and death. Furthermore, LTFU also delays global TB eradication by promoting TB spread and drug-resistant TB strain development.[1] The purpose of this paper is to give an overview of the commonly observed risk factors associated with TB treatment LTFU in developing countries.</p><p><strong>Materials and methods: </strong>A literature survey was done of studies published in the past decade, which evaluated the risk factors for LTFU in TB patients, specifically in developing countries. Furthermore, some prospective TB treatment adherence initiatives and the feasibility of these initiatives within developing countries were assessed.[3].</p><p><strong>Results: </strong>Several variables, including socio-demographic, patient-related, TB disease and other health-related-factors, healthcare and system determinants, as well as treatment-related factors, were identified to increase the risk of TB treatment LTFU. More recently applied adherence interventions in developing countries, show potential for implementation on a larger scale.</p><p><strong>Conclusion: </strong>Successful TB treatment is contingent on treatment adherence, and by addressing these persisting LTFU risk factors, treatment adherence in developing countries may be improved.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9252887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF BLOOD TYPE AND MORTALITY OF COVID-19: A HOSPITAL-BASED STUDY IN NATIONAL REFERRAL HOSPITAL, INDONESIA.","authors":"Usman Elly,&nbsp;Katar Yusticia","doi":"10.21010/Ajidv17i2.4","DOIUrl":"https://doi.org/10.21010/Ajidv17i2.4","url":null,"abstract":"<p><strong>Background: </strong>The ABO blood type is crucial in a number of illnesses, including cancer, cardiovascular disease, and some communicable and non-communicable illnesses. However, there is currently little clear evidence between COVID-19 with ABO blood types. This study was, therefore, aimed to assess the association between ABO blood type and the mortality of patients infected with COVID-19 in a national referral hospital in Indonesia.</p><p><strong>Materials and methods: </strong>This study used a retrospective cohort design. The research sample was COVID-19 patients who were in Dr. M. Djamil Hospital Padang. The number of samples in this study was 93 subjects. The Chi-square test was used in the data analysis. The data were analyzed using the SPSS version 21.0 program, and p<0.05 was considered significant.</p><p><strong>Results: </strong>The results of this study found the percentage of mortality of COVID-19 patients was higher for blood group O (46.2%), followed by AB (41.7%), B (26.3%), and A (13.9%). There was a relationship between blood type and mortality in hospitalized COVID-19 patients (p <0.05), where blood type O had the highest risk (OR = 5.31, 95% CI 1.57-17.98) followed by blood type AB (OR = 4.43, 95% CI 1.01-19.58).</p><p><strong>Conclusion: </strong>This study confirmed there was a relationship between blood type and mortality in hospitalized COVID-19 patients, where blood type O had the highest risk followed by blood type AB.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 2","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9430224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA.","authors":"Lumbanraja Sarma,&nbsp;Effendi Iman Helmy,&nbsp;Siahaan Andre M,&nbsp;Bancin Berry E P,&nbsp;Edianto Deri,&nbsp;Asroel Edwin Martin,&nbsp;Sudewo Yudha","doi":"10.21010/Ajidv17i1.4","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.4","url":null,"abstract":"<p><strong>Background: </strong>The pandemic caused by SARS-CoV-2 also caused infection in some pregnant women. Some reports say this viral infection can show symptoms of preeclampsia.</p><p><strong>Material and methods: </strong>We analyzed 25 pregnant women with SARS-CoV-2 infection with 4 patients presenting with symptoms of preeclampsia. we performed routine blood analysis, renal function, liver function, and IHC examination to see the expression of viral proteins in the placenta.</p><p><strong>Results: </strong>we obtained 4 patients with confirmed SARS-CoV-2 infection by RT-PCR. In these 4 cases, none of the cases showed expression of the SARS-CoV-2 viral protein in the placenta, and all 4 mothers were declared dead after treatment, and 2 babies delivered out of these 4 cases died. In one case we had fetal death in pregnancy while in one case prematurity. 2 babies born to mothers with SARS-CoV-2 infection with preeclampsia were born in good condition. There were no babies infected with SARS-CoV-2.</p><p><strong>Conclusion: </strong>We conclude that SAR-CoV-2 infection in pregnant women with comorbidities can lead to a poor prognosis for both mother and baby. We cannot yet conclude whether SARS-CoV-2 infection can cause preeclampsia, but SARS-CoV-2 infection can exacerbate preeclampsia symptoms.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: ANTI-FUNGAL ACTIVITY OF <i>ACALYPHA WILKESIANA</i>: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE.","authors":"Katibi Oludolapo Sherifat,&nbsp;Aboh Mercy Itohan,&nbsp;Salawu Oluwakayinsola Adeola,&nbsp;Kola-Mustapha Adeola,&nbsp;Olatunji Lawrence Aderemi","doi":"10.21010/Ajidv17i1.7","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.7","url":null,"abstract":"<p><p>[This corrects the article on p. 21 in vol. 16.].</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>IN VITRO</i> AND <i>IN SILICO</i> ANTIBACTERIAL ACTIVITIES OF <i>SYZGIUM AROMATICUM</i> ESSENTIAL OIL AGAINST BACTERIA ASSOCIATED WITH <i>OTITIS MEDIA</i> IN CHILDREN.","authors":"Obuotor Tolulope Mobolaji, Adeyanju Folasade Oluwademilade, Kolawole Amos Oyebisi, Idowu Gbohunmi Paul, Oluwamuyiwa Fesobi Andrew, Afolabi Felix Olaide","doi":"10.21010/Ajidv17i1.3","DOIUrl":"10.21010/Ajidv17i1.3","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the efficacy of the essential oil (EO) of <i>Syzgium aromaticum L.</i> (clove) on the bacteria associated with <i>otitis media</i>.</p><p><strong>Materials and methods: </strong>Ear swab samples were collected and bacteria isolated were identified using morphological and biochemical procedures. Essential oil was extracted from the dried flower buds using the hydro-distillation method while physicochemical and phytochemical analysis was done on the oil. Antibiotic susceptibility test and agar well diffusion was used to determine the susceptibility of the isolates to the EO. In - silico analysis was conducted to determine the drugable compound in the EO.</p><p><strong>Results: </strong>Phytochemical analysis of the oil indicated the presence of flavonoids, sterols, phenols, carbohydrates and alkaloids. Physicochemical test of the EO exhibited the presence of eugenol (80.98%) as the most abundant phytocompound. Percentage occurrence of the bacterial isolates are as follows; <i>Proteus mirabilis</i> (31.25%), <i>Staphylococcus aureus</i> (25%), <i>Pseudomonas aeruginosa</i> (18.25%), <i>Proteus vulgaris</i> (3.12%), <i>Moraxella catarrhalis</i> (12.5%), <i>Klebsiella pneumoniae</i> (3.12%) and <i>Staphylococcus epidermidis</i> (6.25%). Zones of inhibition were within the range of 11.5±0.71mm-23.0±2.83mm. In silico studies demonstrated that 16 out of 38 compounds identified passed the ADMET analysis. Various compounds had different binding energies, such as linalool, carvacrol for <i>S. aureus</i> (2NOJ), gamma-eudesmol, eudesmol for <i>Proteus mirabilis</i> (6H2L), eucalyptol, gamma-eudesmol and eudesmol for <i>Proteus vulgaris</i> (4MCX) and <i>Staphylococcus epidermidis</i> (4HBL).</p><p><strong>Conclusion: </strong>This study shows the potency of clove EO as an antibacterial agent and its component as potential lead molecules in drug development and design to combat multi - drug resistance.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"27-44"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9252888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MATHEMATICAL MODELLING APPROACH OF THE STUDY OF EBOLA VIRUS DISEASE TRANSMISSION DYNAMICS IN A DEVELOPING COUNTRY.","authors":"Mbah Godwin Christopher E, Onah Ifeanyi Sunday, Ahman Queeneth Ojoma, Collins Obiora C, Asogwa Christopher C, Okoye Chukwudi","doi":"10.21010/Ajidv17i1.2","DOIUrl":"10.21010/Ajidv17i1.2","url":null,"abstract":"<p><strong>Background: </strong>Ebola Virus causes disease both in human and non-human primates especially in developing countries. In 2014 during its outbreak, it led to majority of deaths especially in some impoverished area of West Africa and its effect is still witnessed up till date.</p><p><strong>Materials and methods: </strong>We studied the spread of Ebola virus and obtained a system of equations comprising of eighteen equations which completely described the transmission of Ebola Virus in a population where control measures were incorporated and a major source of contacting the disease which is the traditional washing of dead bodies was also incorporated. We investigated the local stability of the disease-free equilibrium using the Jacobian Matrix approach and the disease- endemic stability using the center manifold theorem. We also investigated the global stability of the equilibrium points using the LaSalle's Invariant principle.</p><p><strong>Results: </strong>The result showed that the disease-free and endemic equilibrium where both local and globally stable and that the system exhibits a forward bifurcation.</p><p><strong>Conclusions: </strong>Numerical simulations were carried out and our graphs show that vaccine and condom use is best for susceptible population, quarantine is best for exposed population, isolation is best for infectious population and proper burial of the diseased dead is the best to avoid further disease spread in the population and have quicker and better recovery.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"10-26"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIPLASMODIAL ACTIVITIES OF THE STEM BARK EXTRACT OF <i>ARTOCARPUS ALTILIS</i> FORSBERG.","authors":"Aladesanmi,&nbsp;Adetunji Joseph,&nbsp;Odiba,&nbsp;Ogu Emmanuel,&nbsp;Odediran,&nbsp;Samuel Akintunde,&nbsp;Oriola,&nbsp;Ayodeji Olubunmi","doi":"10.21010/Ajid.v16i2S.5","DOIUrl":"https://doi.org/10.21010/Ajid.v16i2S.5","url":null,"abstract":"<p><strong>Background: </strong>The potential of <i>Artocarpus altilis</i> stem bark as a safe antimalarial agent, and the identification of its antimalarial constituents was explored.</p><p><strong>Materials and methods: </strong>The air-dried stem bark was extracted with 70% ethanol, filtered and concentrated <i>in vacuo</i> to obtain the extract (<b>EE</b>). The extract was successively partitioned to give <i>n</i>-hexane (<b>AAH</b>), dichloromethane (<b>AAD</b>), ethyl acetate (<b>AAE</b>) <i>n</i>-butanol (<b>AAB</b>) and aqueous (<b>AAQ</b>) fractions respectively after determining the acute toxicity using Lorke's method. These were each evaluated for chemosuppressive antimalarial activities (0-200mg/kg) against chloroquine-sensitive <i>Plasmodium berghei-berghei</i>-infected albino mice. Normal saline and chloroquine, 10 mg/kg were negative and positive control respectively.The survival times and percentage survivors of the mice in both experiments were determined after observation for twenty-eight days post-drug administration. The five (5) column chromatographic (<b>CC</b>) fractions, <b>AAH1</b>, <b>AAH2</b>, <b>AAH3</b>, <b>AAH4</b> and <b>AAH5</b> obtained from the most active <b>AAH,</b> were also evaluated for antimalarial activities (0-50mg/kg). Further column purification and repeated <b>PTLC</b> of <b>AAH5</b> yielded three bands, which were finally subjected to GC-MS analysis.</p><p><strong>Results: </strong><b>EE</b> gave ED₅₀ and LD₅₀ values of 227.17and >5000 mg/kg while its partitioned fractions gave ED₅₀ values as follows: <b>AAH,</b> 79.14; <b>AAD</b>, 215.59; A<b>AE,</b> 160.46, <b>AAB,</b> .42; and <b>AAQ</b>, 90.85 mg/kg respectively. The primary <b>CC</b> fractions also gave <b>ED</b> ₅₀ values as follows: <b>AAH1</b> 21.95; <b>AAH2,</b> 26.96; <b>AAH3,</b> 21.30; <b>AAH4,</b> 20.92 and <b>AAH5,</b> 20.75 mg/kg respectively to identify <b>AAH5</b> as the putative fraction. GC-MS analysis revealed eleven major compounds (<b>1-11</b>) in the three <b>PTLC</b> bands as the antiplasmodial constituents of the plant.</p><p><strong>Conclusion: </strong>The stem bark of <i>A. altilis</i> is a potential agent in malaria control which is safe for oral use.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"16 2 Suppl","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40370785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOFILM: FORMATION AND NATURAL PRODUCTS’ APPROACH TO CONTROL – A REVIEW.","authors":"M. Osungunna","doi":"10.21010/ajidv16i2s.7","DOIUrl":"https://doi.org/10.21010/ajidv16i2s.7","url":null,"abstract":"Biofilm formation, especially on indwelling medical devices such as catheters, can result in infections and substantially affect patients' quality of life. Biofilm-associated infections have led to increased morbidity and mortality, increased cost of treatment, and length of hospital stay. However, all of the identified consequences of the biofilm-associated infections had been attributed to the reduced susceptibility of biofilm to conventional antimicrobial agents which has necessitated the development of a new strategy for biofilm infections control, thereby making a search for more effective antimicrobial agents from plant source inevitable. So far, some antimicrobial agents (crude or isolated compounds) from plant sources affect a specific stage of biofilm development while a few of them have been developed into a suitable dosage form for biofilm control. In this review, an attempt is made to look into some definitions of biofilm by \"biofilmologists\", stages in biofilm formation, mechanisms of resistance in biofilm, biofilm control strategies, the use of some natural products in biofilm control and concepts of probiotics as agents of biofilm control.","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44085789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}