{"title":"BLOOD URINE POSITIVITY RATE DIPSTICK METHOD ON THE INCIDENCE OF ANEMIA IN URINARY TRACT INFECTION PATIENTS.","authors":"Siti Zaetun, Lalu Srigede","doi":"10.21010/Ajidv19i2.2","DOIUrl":"10.21010/Ajidv19i2.2","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of anemia in children suffering from urinary tract infections with positive hematuria is very high. UTI is confirmed by a complete urine examination including macroscopic, chemical and microscopic examinations. Chemical examination can be carried out using the dipstick method, while urine microscopy involves looking at the image of the urine sediment. One of the parameters on the dipstick is blood. Examination with a reagent strip (dipstick) function to detect erythrocytes, free hemoglobin and myoglobin. So, the presence of erythrocytes, myoglobin or hemoglobin in the urine will give a positive result on the urine blood dipstick parameters, which means hematuria occurs.</p><p><strong>Materials and methods: </strong>This is a cross-sectional analytical observational method, namely by comparing the results of blood urine examination using the dipstick method, with the results of the erythrocyte index and hemoglobin levels on the incidence of anemia in UTI patients.</p><p><strong>Results: </strong>The results of the blood urine dipstick examination obtained the highest positive value of 3. The average values for Hb, MCV, MCH, MCHC were respectively 10.9 g/dL, 83.3 fL, 28.5 pg, and 34.24%.</p><p><strong>Conclusion: </strong>The results of the Pearson correlation test obtained a degree of relationship of -0.363 which indicates a weak correlation. Blood urine is negatively related to the incidence of anemia (Hb levels), so that the higher the positive blood urine value, the lower the Hb value.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DETERMINANTS AND MAPPING OF LEPTOSPIROSIS IN KEBUMEN, INDONESIA: CASE-CONTROL STUDY.","authors":"Lestari Mugi Rahayu, Nurcandra Fajaria, Buntara Arga, Simanjorang Chandrayani","doi":"10.21010/Ajidv19i2.6","DOIUrl":"10.21010/Ajidv19i2.6","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis is a health concern with a high mortality rate. As of 2022, 9.8% of Indonesians are vulnerable to leptospirosis, and Kebumen Regency has been recognized as an endemic area since 2012. This study aims to identify the determinants and map the incidence of leptospirosis in Kebumen, Indonesia, in 2023.</p><p><strong>Material and methods: </strong>This study used a 1:1 sample of 53 cases and 53 controls in a case-control study design. Each group was sampled using a purposive sampling technique. Cases were defined as individuals seeking care at a health center or hospital and identified as leptospirosis patients in 2023, while controls were individuals living nearest to the cases. Data analysis for this study involved the use of a logistic regression model.</p><p><strong>Results: </strong>Individuals with a history of wounds have 40.20 times higher odds of experiencing leptospirosis. Men have 2.58 times higher odds of experiencing leptospirosis, while poor use of personal protective equipment (PPE) increases the odds by 2.27. Leptospirosis risk is elevated in areas where rats and standing water are prevalent, as these factors are typically found nearby. Furthermore, pets at risk are commonly found in high-risk areas.</p><p><strong>Conclusion: </strong>History of wounds, sex, and use of PPE are factors that can predict the incidence of leptospirosis. Environmental determinant mapping is observed in high-density, geographically proximate locations.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"50-59"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE RELATIONSHIP BETWEEN SCHOOL ENVIRONMENT CONDITION AND DENGUE HEMORRHAGE FEVER INCIDENCE AT PUBLIC ELEMENTARY SCHOOL.","authors":"Selamat Ginting, Hariati Hariati, Friska Ernita Sitorus, Jekson Martiar Siahaan","doi":"10.21010/Ajidv19i2.7","DOIUrl":"10.21010/Ajidv19i2.7","url":null,"abstract":"<p><strong>Background: </strong>Dengue cases in Indonesia remain a significant public health concern, with incidence rates increasing over the years. The school environment, including lighting, humidity, temperature, and ventilation, plays a crucial role in the spread of Dengue Hemorrhagic Fever (DHF). This study aims to analyze the relationship between school environmental conditions and DHF incidence.</p><p><strong>Materials and methods: </strong>This was an analytical observational study with a cross-sectional design. The sample consisted of 157 individuals selected using simple random sampling. Data collection was conducted from August to October 2023 using a validated questionnaire assessing school environmental conditions and DHF incidence. Statistical analysis was performed using chi-square and logistic regression tests with a significance level of p < 0.05.</p><p><strong>Results: </strong>School environmental factors significantly associated with DHF incidence included lighting (p = 0.008, PR = 1.82), humidity (p = 0.008, PR = 1.75), temperature (p = 0.045, PR = 1.498), and screen ventilation (p = 0.000, PR = 2.26). Logistic regression analysis identified humidity (OR = 7.16; 95% CI, 2.09-38.37) and ventilation (OR = 18.12; 95% CI, 3.36-56.70) as the most influential factors.</p><p><strong>Conclusion: </strong>The incidence of DHF is closely related to school environmental conditions. Preventive measures focusing on environmental cleanliness and improved ventilation could significantly reduce the risk of dengue transmission among school children.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geni Lenggo, Widodo Lovendo Ilham, Swestikaputri Chrecentia Hanna, Syahrurachman Agus, Dewi Beti Ernawati
{"title":"THE REPLICATION EFFICIENCY OF DENGUE VIRUS SEROTYPE 1 ISOLATED FROM PATIENTS WITH DENGUE FEVER IN HUMAN HEPATOCYTE CELL LINES.","authors":"Geni Lenggo, Widodo Lovendo Ilham, Swestikaputri Chrecentia Hanna, Syahrurachman Agus, Dewi Beti Ernawati","doi":"10.21010/Ajidv19i2.4","DOIUrl":"10.21010/Ajidv19i2.4","url":null,"abstract":"<p><strong>Background: </strong>The Efficiency of viral replication in cells depends on the capability of supporting virus replication by the cells. We characterized the effectiveness of Dengue Virus Serotype 1 (DENV-1) replication in various cell lines and various multiplicity of infection (MOI) starting from 2 FFU/cell up to 0,3125 FFU/cell.</p><p><strong>Materials and method: </strong>We used HepG2 and Huh-7 human hepatocyte cell lines and in addition, we also used non-human kidney cells (Vero cells). DENV-1 strain IDS 11/2010 was isolated from DF patients and previously propagated in Huh7 and Vero cells as DENV-1-adapted Huh-7 and DENV-1-adapted Vero cells, respectively. Huh7 cells, Hep G2 cells, and Vero cells were infected with DENV-1 at various MOI and incubated for 48 hours at 37<sup>0</sup>C with 5% CO<sub>2</sub>. DENV-infected cells were determined by indirect immuno-peroxidase staining using 3,3'-Diaminobenzidine (DAB). DENV-1 infected cells as foci were counted under inverted light microscopy and were used to determine the virus titer.</p><p><strong>Results: </strong>The virus was adapted to Huh-7 and Vero cells, with results showing that Vero cells exhibited the highest replication efficiency, evidenced by significant viral titers. Among human hepatocyte cell lines, DENV-1 demonstrated greater replication in Huh-7 cells than in HepG2 cells. Notably, no foci formation was observed in HepG2 cells after 48 hours of infection.</p><p><strong>Conclusion: </strong>These findings underscore the suitability of Vero and Huh-7 cells as optimal environments for DENV-1 replication, offering valuable insights for enhancing laboratory diagnostics and advancing antiviral strategies and vaccine development against DENV-1.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nindrea Ricvan Dana, Ming Long Chiau, Agustian Dede Rahman
{"title":"FAMILY SUPPORT, MOTIVATION, AND PATIENT ADHERENCE TO TUBERCULOSIS TREATMENT: INSIGHTS FROM INDONESIA.","authors":"Nindrea Ricvan Dana, Ming Long Chiau, Agustian Dede Rahman","doi":"10.21010/Ajidv19i2.5","DOIUrl":"10.21010/Ajidv19i2.5","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) remains a significant public health issue globally, with patient adherence to treatment being critical for successful outcomes.This study aimed to investigate the roles of family support and motivation in influencing adherence to TB treatment in Indonesia.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among patients at four health centers in Padang Municipality, Indonesia, between January and November 2024. A total of 125 respondents diagnosed with drug-sensitive TB and in the second stage of treatment participated. Data were collected through structured interviews using validated questionnaires, assessing family support, motivation, and treatment adherence. Structural Equation Modeling (SEM) was used to analyze the relationships between variables.</p><p><strong>Results: </strong>The findings revealed significant relationships between family support and motivation (β = 0.931, t-value = 47.016, P<0.001), family support and adherence to TB treatment (β = 0.229, t-value = 2.743, P=0.006), and motivation and adherence to TB treatment (β = 0.775, t-value = 9.334, P<0.001).</p><p><strong>Conclusion: </strong>Family support and motivation play crucial roles in enhancing patient adherence to TB treatment. Strategies to strengthen family involvement and patient motivation should be integrated into TB control programs to improve treatment outcomes. Further research is recommended to explore additional factors influencing adherence in different contexts.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Utomo Budi, Fatmaningrum Widati, Sulistiawati Sulistiawati, Khuen Chan Chow, Fauziyah Shifa, Adnyana I Made Dwi Mertha, Eljatin Dwinka Syafira, Sucipto Teguh Hari
{"title":"DOES COVID-19 PANDEMIC AFFECT THE ELIMINATION OF TUBERCULOSIS? LESSONS LEARNED FROM INDONESIA.","authors":"Utomo Budi, Fatmaningrum Widati, Sulistiawati Sulistiawati, Khuen Chan Chow, Fauziyah Shifa, Adnyana I Made Dwi Mertha, Eljatin Dwinka Syafira, Sucipto Teguh Hari","doi":"10.21010/Ajidv19i2.1","DOIUrl":"10.21010/Ajidv19i2.1","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis is one of the tropical diseases which still exist in the tropical country specifically Indonesia. This study aims to investigate the recent epidemiology of tuberculosis before and during the pandemic of COVID-19.</p><p><strong>Materials and methods: </strong>Data were collected from East Java Health Profile 2019 and 2020 which was provided by East Java Health Officer. Data were extracted and analyzed by statistical software SPSS and QGIS Application for the geographical map interpretation.</p><p><strong>Results: </strong>This study shows that the total cases of tuberculosis in 2019 was 606,985 cases, while in 2020 was decreased to 384,752 cases. The incidence rate of tuberculosis in 2019 was 224.98 per 100,000 populations, while in 2020 was 134.58 per 100,000 populations. The province with the highest amount of tuberculosis in 2019 was West Java with 143,935 cases, and also in 2020 with 90,905 cases. The province with the lowest number of tuberculosis was North Kalimantan with 2,113 cases, while in 2020 were 985 cases. The highest incidence rate of tuberculosis in 2019 was found in Jakarta which was 443,47 per 100,000 population, while in 2020 was found in Papua which was 279.92 per 100,000 population. The lowest incidence rate in 2019 was found in Bali Province which was 102.72 per 100,000 population, while in 2020 was 67.43 per 100,000 population.</p><p><strong>Conclusion: </strong>There was a decrease in TB cases before the COVID-19 pandemic (2019) compared to during the COVID-19 pandemic (2020).</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SPATIAL MODELING OF RISK FACTORS FOR UNDER-FIVE PNEUMONIA IN ROKAN HILIR DISTRICT, INDONESIA.","authors":"Yusdiana Yusdiana, Sukendi Sukendi, Siregar Yusni Ikhwan, Afandi Dedi","doi":"10.21010/Ajidv19i2.3","DOIUrl":"10.21010/Ajidv19i2.3","url":null,"abstract":"<p><strong>Background: </strong>Under-five pneumonia remains a critical health issue in Indonesia. Identifying risk factors using spatial models is crucial for developing effective disease-prevention strategies. This study aimed to identify risk factors and create a spatial model for under-five pneumonia distribution based on regional vulnerability.</p><p><strong>Materials and methods: </strong>This study used a mixed-method approach that integrated mathematical models and GIS to identify risk factors using generalized Poisson regression (GPR) and developed a GIS-based spatial model with inverse distance weighted (IDW) and natural break methods.</p><p><strong>Results: </strong>The GPR model revealed significant associations between under-five pneumonia and population density (β = 0.004, Z<sub>-score</sub> = 6.118), rainfall (β = 0.002, Z<sub>-score</sub> = 6.031), malnutrition (β = 1.786, Z<sub>-score</sub> = 3.696), and health facilities (β = 0.073, Z<sub>-score</sub> = 13.527). Protective factors included exclusive breastfeeding (β = -0.004, Z<sub>-score</sub> = -2.874), healthy homes (β = -0.021, Z<sub>-score</sub> = -9.532), and under-five health service coverage (β = -0.003, Z<sub>-score</sub> = -2.225). Spatial modeling classified regions into high-risk (5 subdistricts), medium-risk (11 subdistricts), and low-risk (3 subdistricts).</p><p><strong>Conclusion: </strong>This study identified key risk factors and mapped spatial vulnerability for under-five pneumonia. Targeted, integrated interventions in high-risk areas are essential to reduce pneumonia incidence below 12 cases per 1,000 children under five by 2030, aligning with global health goals.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"19 2","pages":"15-32"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: EFFECT OF <i>PENICILLIUM</i> SPECIES ON THE ANTIBIOTIC RESISTANCE PROFILE OF <i>ALCALIGENES FAECALIS</i>.","authors":"Alkhalil S Samia","doi":"10.21010/Ajidv18i2S.6","DOIUrl":"https://doi.org/10.21010/Ajidv18i2S.6","url":null,"abstract":"<p><p>[This corrects the article on p. 8 in vol. 18, PMID: 38606189.].</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"18 2 Suppl","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SOCIAL MEDIA USE, KNOWLEDGE, AND ATTITUDES TOWARDS PEOPLE LIVING WITH HIV/AIDS AMONG HIGH SCHOOL STUDENTS IN AN INDONESIAN TOURISM REGION.","authors":"Nindrea Ricvan Dana, Darma Ika Yulia, Sukma Muthia, Mardiah Ainil, Agustian Dede Rahman, Sholihati Mursyidah","doi":"10.21010/Ajidv18i2S.4","DOIUrl":"10.21010/Ajidv18i2S.4","url":null,"abstract":"<p><strong>Background: </strong>Social media has become an integral part of adolescent life in Indonesia, particularly in tourism regions. It serves as a platform for disseminating information, including about HIV/AIDS. However, it also has the potential to spread misinformation and harmful content, which can increase stigma and discrimination against people living with HIV/AIDS (PLWHA).</p><p><strong>Aim: </strong>The aim of this study was to determine the relationships between social media use, knowledge, and attitudes towards PLWHA among high school students in an Indonesian tourism region.</p><p><strong>Methods: </strong>This research utilized a school-based cross-sectional study design in several high schools located in Bukittinggi City, a renowned tourist destination in West Sumatra Province, Indonesia. The study sample comprised high school students aged 15-18 years, with a total of 118 respondents selected. The sample was chosen using a multistage stratified clustered sampling method. The variables measured in this study included social media usage, HIV/AIDS knowledge, and attitudes towards PLWHA. To test the research hypotheses, data analysis was conducted using structural equation modeling techniques. P<0.05 is considered significant.</p><p><strong>Results: </strong>There were relationships between social media use and knowledge of HIV/AIDS (β=0.614, t-value=9.327, p-value=<0.001), knowledge of HIV/AIDS and attitudes towards PLWHA (β=0.601, t-value=8.344, p-value=0.014) and social media use and attitudes towards PLWHA (β=0.218, t-value=2.469, p-value=<0.001).</p><p><strong>Conclusion: </strong>This study confirmed significant relationships were found between social media use, knowledge, and attitudes towards PLWHA. The results highlight the necessity for comprehensive interventions and ongoing support to promote the well-being of students amid the dynamic changes in global tourism.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"18 2 Suppl","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kabambi Kasandji Freddy, Joseph Sibi Sebastian, Panicker Mahesh Kumar, Ndlovu Nomagugu, Ekpebegh Chukwuma
{"title":"CLINICAL PROFILES AND OUTCOMES OF ADMISSIONS FOLLOWING COVID-19 ADMISSIONS DURING THREE WAVES OF THE PANDEMIC: EXPERIENCE OF A TERTIARY HOSPITAL IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA.","authors":"Kabambi Kasandji Freddy, Joseph Sibi Sebastian, Panicker Mahesh Kumar, Ndlovu Nomagugu, Ekpebegh Chukwuma","doi":"10.21010/Ajidv18i2S.3","DOIUrl":"10.21010/Ajidv18i2S.3","url":null,"abstract":"<p><strong>Background: </strong>South Africa was the country worst affected by the Covid-19 pandemic in Africa. There is a paucity of data on the clinical characteristics and mortality of Covid-19 from the Eastern Cape province of South Africa. We report on the demographic and clinical characteristics as well as the mortality of patients admitted to the Covid-19 ward of Nelson Mandela Academic Hospital (NMAH), Mthatha, during three waves of the Covid-19 pandemic in South Africa.</p><p><strong>Materials and methods: </strong>We conducted a single centre retrospective observational study of patients admitted for Covid-19 in a tertiary hospital in the rural Eastern Cape of South Africa. Data were collected from patient files, electronic databases and the National Health Laboratory Services (NHLS) database. The outcomes were duration of admission and in-hospital mortality.</p><p><strong>Results: </strong>There were 371 patients admitted across all three waves with a mean age of 52.2 ± 16.3 years. The proportion of females across the three waves is 61.2%. The commonly associated comorbidities, irrespective of the wave, were hypertension, diabetes and HIV infection. The median duration of admission was six days, with an overall mortality of 31%. The mortality for first, second and third wave were 29.3%, 31.5% and 37.9% respectively.</p><p><strong>Conclusion: </strong>Admissions for Covid-19 were predominantly in females and middle-aged. One third of the admitted patients died. Diabetes, hypertension and HIV infection were the most commonly associated comorbidities.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"18 2 Suppl","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}