African Journal of Infectious Diseases最新文献

{"title":"FACTORS CONTRIBUTING TO PULMONARY TB TREATMENT LOST TO FOLLOW-UP IN DEVELOPING COUNTRIES: AN OVERVIEW.","authors":"Opperman Monique,&nbsp;DU Preez Ilse","doi":"10.21010/Ajidv17i1.6","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.6","url":null,"abstract":"<p><strong>Background: </strong>Despite the available treatment options, pulmonary tuberculosis (TB) remains a leading cause of disease-related deaths worldwide. Treatment non-adherence/lost to follow-up (LTFU), particularly in developing countries, is a continuous concern. LTFU prolongs TB infectiousness and contributes to TB treatment failure, relapse, and death. Furthermore, LTFU also delays global TB eradication by promoting TB spread and drug-resistant TB strain development.[1] The purpose of this paper is to give an overview of the commonly observed risk factors associated with TB treatment LTFU in developing countries.</p><p><strong>Materials and methods: </strong>A literature survey was done of studies published in the past decade, which evaluated the risk factors for LTFU in TB patients, specifically in developing countries. Furthermore, some prospective TB treatment adherence initiatives and the feasibility of these initiatives within developing countries were assessed.[3].</p><p><strong>Results: </strong>Several variables, including socio-demographic, patient-related, TB disease and other health-related-factors, healthcare and system determinants, as well as treatment-related factors, were identified to increase the risk of TB treatment LTFU. More recently applied adherence interventions in developing countries, show potential for implementation on a larger scale.</p><p><strong>Conclusion: </strong>Successful TB treatment is contingent on treatment adherence, and by addressing these persisting LTFU risk factors, treatment adherence in developing countries may be improved.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9252887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF BLOOD TYPE AND MORTALITY OF COVID-19: A HOSPITAL-BASED STUDY IN NATIONAL REFERRAL HOSPITAL, INDONESIA.","authors":"Usman Elly,&nbsp;Katar Yusticia","doi":"10.21010/Ajidv17i2.4","DOIUrl":"https://doi.org/10.21010/Ajidv17i2.4","url":null,"abstract":"<p><strong>Background: </strong>The ABO blood type is crucial in a number of illnesses, including cancer, cardiovascular disease, and some communicable and non-communicable illnesses. However, there is currently little clear evidence between COVID-19 with ABO blood types. This study was, therefore, aimed to assess the association between ABO blood type and the mortality of patients infected with COVID-19 in a national referral hospital in Indonesia.</p><p><strong>Materials and methods: </strong>This study used a retrospective cohort design. The research sample was COVID-19 patients who were in Dr. M. Djamil Hospital Padang. The number of samples in this study was 93 subjects. The Chi-square test was used in the data analysis. The data were analyzed using the SPSS version 21.0 program, and p<0.05 was considered significant.</p><p><strong>Results: </strong>The results of this study found the percentage of mortality of COVID-19 patients was higher for blood group O (46.2%), followed by AB (41.7%), B (26.3%), and A (13.9%). There was a relationship between blood type and mortality in hospitalized COVID-19 patients (p <0.05), where blood type O had the highest risk (OR = 5.31, 95% CI 1.57-17.98) followed by blood type AB (OR = 4.43, 95% CI 1.01-19.58).</p><p><strong>Conclusion: </strong>This study confirmed there was a relationship between blood type and mortality in hospitalized COVID-19 patients, where blood type O had the highest risk followed by blood type AB.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 2","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9430224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA.","authors":"Lumbanraja Sarma,&nbsp;Effendi Iman Helmy,&nbsp;Siahaan Andre M,&nbsp;Bancin Berry E P,&nbsp;Edianto Deri,&nbsp;Asroel Edwin Martin,&nbsp;Sudewo Yudha","doi":"10.21010/Ajidv17i1.4","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.4","url":null,"abstract":"<p><strong>Background: </strong>The pandemic caused by SARS-CoV-2 also caused infection in some pregnant women. Some reports say this viral infection can show symptoms of preeclampsia.</p><p><strong>Material and methods: </strong>We analyzed 25 pregnant women with SARS-CoV-2 infection with 4 patients presenting with symptoms of preeclampsia. we performed routine blood analysis, renal function, liver function, and IHC examination to see the expression of viral proteins in the placenta.</p><p><strong>Results: </strong>we obtained 4 patients with confirmed SARS-CoV-2 infection by RT-PCR. In these 4 cases, none of the cases showed expression of the SARS-CoV-2 viral protein in the placenta, and all 4 mothers were declared dead after treatment, and 2 babies delivered out of these 4 cases died. In one case we had fetal death in pregnancy while in one case prematurity. 2 babies born to mothers with SARS-CoV-2 infection with preeclampsia were born in good condition. There were no babies infected with SARS-CoV-2.</p><p><strong>Conclusion: </strong>We conclude that SAR-CoV-2 infection in pregnant women with comorbidities can lead to a poor prognosis for both mother and baby. We cannot yet conclude whether SARS-CoV-2 infection can cause preeclampsia, but SARS-CoV-2 infection can exacerbate preeclampsia symptoms.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: ANTI-FUNGAL ACTIVITY OF <i>ACALYPHA WILKESIANA</i>: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE.","authors":"Katibi Oludolapo Sherifat,&nbsp;Aboh Mercy Itohan,&nbsp;Salawu Oluwakayinsola Adeola,&nbsp;Kola-Mustapha Adeola,&nbsp;Olatunji Lawrence Aderemi","doi":"10.21010/Ajidv17i1.7","DOIUrl":"https://doi.org/10.21010/Ajidv17i1.7","url":null,"abstract":"<p><p>[This corrects the article on p. 21 in vol. 16.].</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>IN VITRO</i> AND <i>IN SILICO</i> ANTIBACTERIAL ACTIVITIES OF <i>SYZGIUM AROMATICUM</i> ESSENTIAL OIL AGAINST BACTERIA ASSOCIATED WITH <i>OTITIS MEDIA</i> IN CHILDREN.","authors":"Obuotor Tolulope Mobolaji, Adeyanju Folasade Oluwademilade, Kolawole Amos Oyebisi, Idowu Gbohunmi Paul, Oluwamuyiwa Fesobi Andrew, Afolabi Felix Olaide","doi":"10.21010/Ajidv17i1.3","DOIUrl":"10.21010/Ajidv17i1.3","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the efficacy of the essential oil (EO) of <i>Syzgium aromaticum L.</i> (clove) on the bacteria associated with <i>otitis media</i>.</p><p><strong>Materials and methods: </strong>Ear swab samples were collected and bacteria isolated were identified using morphological and biochemical procedures. Essential oil was extracted from the dried flower buds using the hydro-distillation method while physicochemical and phytochemical analysis was done on the oil. Antibiotic susceptibility test and agar well diffusion was used to determine the susceptibility of the isolates to the EO. In - silico analysis was conducted to determine the drugable compound in the EO.</p><p><strong>Results: </strong>Phytochemical analysis of the oil indicated the presence of flavonoids, sterols, phenols, carbohydrates and alkaloids. Physicochemical test of the EO exhibited the presence of eugenol (80.98%) as the most abundant phytocompound. Percentage occurrence of the bacterial isolates are as follows; <i>Proteus mirabilis</i> (31.25%), <i>Staphylococcus aureus</i> (25%), <i>Pseudomonas aeruginosa</i> (18.25%), <i>Proteus vulgaris</i> (3.12%), <i>Moraxella catarrhalis</i> (12.5%), <i>Klebsiella pneumoniae</i> (3.12%) and <i>Staphylococcus epidermidis</i> (6.25%). Zones of inhibition were within the range of 11.5±0.71mm-23.0±2.83mm. In silico studies demonstrated that 16 out of 38 compounds identified passed the ADMET analysis. Various compounds had different binding energies, such as linalool, carvacrol for <i>S. aureus</i> (2NOJ), gamma-eudesmol, eudesmol for <i>Proteus mirabilis</i> (6H2L), eucalyptol, gamma-eudesmol and eudesmol for <i>Proteus vulgaris</i> (4MCX) and <i>Staphylococcus epidermidis</i> (4HBL).</p><p><strong>Conclusion: </strong>This study shows the potency of clove EO as an antibacterial agent and its component as potential lead molecules in drug development and design to combat multi - drug resistance.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"27-44"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9252888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MATHEMATICAL MODELLING APPROACH OF THE STUDY OF EBOLA VIRUS DISEASE TRANSMISSION DYNAMICS IN A DEVELOPING COUNTRY.","authors":"Mbah Godwin Christopher E, Onah Ifeanyi Sunday, Ahman Queeneth Ojoma, Collins Obiora C, Asogwa Christopher C, Okoye Chukwudi","doi":"10.21010/Ajidv17i1.2","DOIUrl":"10.21010/Ajidv17i1.2","url":null,"abstract":"<p><strong>Background: </strong>Ebola Virus causes disease both in human and non-human primates especially in developing countries. In 2014 during its outbreak, it led to majority of deaths especially in some impoverished area of West Africa and its effect is still witnessed up till date.</p><p><strong>Materials and methods: </strong>We studied the spread of Ebola virus and obtained a system of equations comprising of eighteen equations which completely described the transmission of Ebola Virus in a population where control measures were incorporated and a major source of contacting the disease which is the traditional washing of dead bodies was also incorporated. We investigated the local stability of the disease-free equilibrium using the Jacobian Matrix approach and the disease- endemic stability using the center manifold theorem. We also investigated the global stability of the equilibrium points using the LaSalle's Invariant principle.</p><p><strong>Results: </strong>The result showed that the disease-free and endemic equilibrium where both local and globally stable and that the system exhibits a forward bifurcation.</p><p><strong>Conclusions: </strong>Numerical simulations were carried out and our graphs show that vaccine and condom use is best for susceptible population, quarantine is best for exposed population, isolation is best for infectious population and proper burial of the diseased dead is the best to avoid further disease spread in the population and have quicker and better recovery.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"17 1","pages":"10-26"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIPLASMODIAL ACTIVITIES OF THE STEM BARK EXTRACT OF <i>ARTOCARPUS ALTILIS</i> FORSBERG.","authors":"Aladesanmi,&nbsp;Adetunji Joseph,&nbsp;Odiba,&nbsp;Ogu Emmanuel,&nbsp;Odediran,&nbsp;Samuel Akintunde,&nbsp;Oriola,&nbsp;Ayodeji Olubunmi","doi":"10.21010/Ajid.v16i2S.5","DOIUrl":"https://doi.org/10.21010/Ajid.v16i2S.5","url":null,"abstract":"<p><strong>Background: </strong>The potential of <i>Artocarpus altilis</i> stem bark as a safe antimalarial agent, and the identification of its antimalarial constituents was explored.</p><p><strong>Materials and methods: </strong>The air-dried stem bark was extracted with 70% ethanol, filtered and concentrated <i>in vacuo</i> to obtain the extract (<b>EE</b>). The extract was successively partitioned to give <i>n</i>-hexane (<b>AAH</b>), dichloromethane (<b>AAD</b>), ethyl acetate (<b>AAE</b>) <i>n</i>-butanol (<b>AAB</b>) and aqueous (<b>AAQ</b>) fractions respectively after determining the acute toxicity using Lorke's method. These were each evaluated for chemosuppressive antimalarial activities (0-200mg/kg) against chloroquine-sensitive <i>Plasmodium berghei-berghei</i>-infected albino mice. Normal saline and chloroquine, 10 mg/kg were negative and positive control respectively.The survival times and percentage survivors of the mice in both experiments were determined after observation for twenty-eight days post-drug administration. The five (5) column chromatographic (<b>CC</b>) fractions, <b>AAH1</b>, <b>AAH2</b>, <b>AAH3</b>, <b>AAH4</b> and <b>AAH5</b> obtained from the most active <b>AAH,</b> were also evaluated for antimalarial activities (0-50mg/kg). Further column purification and repeated <b>PTLC</b> of <b>AAH5</b> yielded three bands, which were finally subjected to GC-MS analysis.</p><p><strong>Results: </strong><b>EE</b> gave ED₅₀ and LD₅₀ values of 227.17and >5000 mg/kg while its partitioned fractions gave ED₅₀ values as follows: <b>AAH,</b> 79.14; <b>AAD</b>, 215.59; A<b>AE,</b> 160.46, <b>AAB,</b> .42; and <b>AAQ</b>, 90.85 mg/kg respectively. The primary <b>CC</b> fractions also gave <b>ED</b> ₅₀ values as follows: <b>AAH1</b> 21.95; <b>AAH2,</b> 26.96; <b>AAH3,</b> 21.30; <b>AAH4,</b> 20.92 and <b>AAH5,</b> 20.75 mg/kg respectively to identify <b>AAH5</b> as the putative fraction. GC-MS analysis revealed eleven major compounds (<b>1-11</b>) in the three <b>PTLC</b> bands as the antiplasmodial constituents of the plant.</p><p><strong>Conclusion: </strong>The stem bark of <i>A. altilis</i> is a potential agent in malaria control which is safe for oral use.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"16 2 Suppl","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40370785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOFILM: FORMATION AND NATURAL PRODUCTS’ APPROACH TO CONTROL – A REVIEW.","authors":"M. Osungunna","doi":"10.21010/ajidv16i2s.7","DOIUrl":"https://doi.org/10.21010/ajidv16i2s.7","url":null,"abstract":"Biofilm formation, especially on indwelling medical devices such as catheters, can result in infections and substantially affect patients' quality of life. Biofilm-associated infections have led to increased morbidity and mortality, increased cost of treatment, and length of hospital stay. However, all of the identified consequences of the biofilm-associated infections had been attributed to the reduced susceptibility of biofilm to conventional antimicrobial agents which has necessitated the development of a new strategy for biofilm infections control, thereby making a search for more effective antimicrobial agents from plant source inevitable. So far, some antimicrobial agents (crude or isolated compounds) from plant sources affect a specific stage of biofilm development while a few of them have been developed into a suitable dosage form for biofilm control. In this review, an attempt is made to look into some definitions of biofilm by \"biofilmologists\", stages in biofilm formation, mechanisms of resistance in biofilm, biofilm control strategies, the use of some natural products in biofilm control and concepts of probiotics as agents of biofilm control.","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44085789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROSPECTS OF LASSA FEVER CANDIDATE VACCINES.","authors":"Ademusire Babatunde Isaac,&nbsp;Wieczorek Karolina,&nbsp;Alonge Aishat Temitope,&nbsp;Rajen Anuska,&nbsp;Egbe Joanne,&nbsp;Adebambo Deborah,&nbsp;Offorbuike Chiamaka Bianca,&nbsp;Trojan Filip,&nbsp;Przypaśniak Zofia,&nbsp;Oduguwa Ifeoluwa Oluwasegun,&nbsp;Omitoyin Oluwaferanmi,&nbsp;Balogun Toluwalogo Grace","doi":"10.21010/Ajid.v16i2S.6","DOIUrl":"https://doi.org/10.21010/Ajid.v16i2S.6","url":null,"abstract":"Background: Lassa fever is an acute viral haemorrhagic disease caused by the Lassa virus (LASV). It is endemic in West Africa and infects about 300,000 people each year, leading to approximately 5000 deaths annually. The development of the LASV vaccine has been listed as a priority by the World Health Organization since 2018. Considering the accelerated development and availability of vaccines against COVID-19, we set out to assess the prospects of LASV vaccines and the progress made so far. Materials and Methods: We reviewed the progress made on twenty-six vaccine candidates listed by Salami et al. (2019) and searched for new vaccine candidates through Google Scholar, PubMed, and DOAJ from June to July 2021. We searched the articles published in English using keywords that included “vaccine” AND “Lassa fever” OR “Lassa virus” in the title/abstract. Results: Thirty-four candidate vaccines were identified – 26 already listed in the review by Salami et al. and an additional 8, which were developed over the last seven years. 30 vaccines are still in the pre-clinical stage while 4 of them are currently undergoing clinical trials. The most promising candidates in 2019 were vesicular stomatitis virus-vectored vaccine and live-attenuated MV/LASV vaccine; both had progressed to clinical trials. Conclusions: Despite the focus on COVID-19 vaccines since 2020, LASV vaccine is under development and continues to make impressive progress, hence more emphasis should be put into exploring further clinical studies related to the most promising types of vaccines identified.","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"16 2 Suppl","pages":"46-58"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40370784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CROSS-SECTIONAL ASSESSMENT OF PHARMACISTS' KNOWLEDGE, ATTITUDE AND PRACTICE OF PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HIV IN TWO NIGERIAN TEACHING HOSPITALS.","authors":"Isah Abdulmuminu, Abubakar Mustapha Muhammed, Igboeli Nneka Uchenna, Ibezim Isaac Chijioke, Ibenekwu Chisom Sandra","doi":"10.21010/Ajid.v16i2S.3","DOIUrl":"10.21010/Ajid.v16i2S.3","url":null,"abstract":"<p><strong>Background: </strong>The pharmacological component of prevention of mother-to-child transmission (PMTCT) services involves the provision of antiretroviral agents (ARVs) to the mothers and/or their babies at any stage of pregnancy. This study assessed the knowledge, attitude and practice (KAP) of Pharmacists about PMTCT.</p><p><strong>Materials and methods: </strong>A questionnaire-based cross-sectional study was conducted among consenting Pharmacists at Ahmadu Bello University Teaching Hospital (ABUTH) and University of Nigeria Teaching Hospital (UNTH). Completed questionnaires were collated and analyzed using SPSS Version-25 with appropriate descriptive and inferential statistics. <i>P</i>-values less than 0.05 were considered to be statistically significant.</p><p><strong>Results: </strong>A total of 77 Pharmacists participated in the study, with 54(70.13%) being from ABUTH. In ABUTH, 15(33.3%) Pharmacists identified as being females, against 16(69.6%) in UNTH. Majority (40,95.2%) of the Pharmacists in ABUTH had less than 10 years working experience as against 8(34.8%) in UNTH. Forty-eight (88.9%) respondents knew the correct meaning of PMTCT. The Pharmacists in ABUTH and UNTH had mean knowledge scores of 58.70±2.88% and 52.17±6.19%, respectively; <i>t</i>(75)=1.094, <i>p</i>=0.760. In ABUTH and UNTH, 16(69.6%) and 22(42.3%) Pharmacists, respectively, strongly agreed that PMTCT can prevent future infections in the infants. Their mean attitude scores were 69.65±1.22% (ABUTH) and 74.09±1.68% (UNTH); <i>t</i>(73)=-2.063, <i>p</i>=0.487. For practice, 4(5.33%) Pharmacists in both hospitals very often dispensed PMTCT drugs, while 37(70.83%) counseled PMTCT treatment-naïve patients.</p><p><strong>Conclusion: </strong>The Pharmacists assessed in both hospitals had a fair knowledge of PMTCT services. Their attitudes to PMTCT was very good, although only a few of them had experience in providing care for PMTCT patients.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"16 2 Suppl","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40370786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}