Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Osteochondroma of the anterior mandible: A rare case report and review of the literature.","authors":"Devendra H Palve, Akshay A Dhobley, Dipak D Ghatage, Ashwini G Kendre","doi":"10.4103/jomfp.jomfp_37_24","DOIUrl":"10.4103/jomfp.jomfp_37_24","url":null,"abstract":"<p><p>Osteochondroma (OC) is the most common benign tumour of the axial skeleton which often occurs from the metaphysis of the long bones but rarely occurs in the craniofacial region (<1% of cases). Literature shows that cases occur more in the mandibular condylar region. To date, only six cases of this incredibly rare OC in the mandibular front region have been documented in the last 30 years. In addition to reviewing the literature on OCs of the mandibular front region, this case report describes a case of OC involving the mandibular symphysis and left para-symphysis in a 67-year-old male patient. Histopathological examination revealed chondroid and osteoid tissue with sparse fibrous tissue patches and columns of chondrocytes with single tiny nuclei within the cartilaginous cap, and all these features were strongly suggestive of OC diagnosis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"672-676"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Enigmatic 'Swiss Cheese' in macroscopic tissue pathology.","authors":"Radhika M Bavle","doi":"10.4103/jomfp.jomfp_333_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_333_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"547-548"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of the burden of lip and oral cavity cancers in the Indian subcontinent.","authors":"Manju Mariam Stephen Mathunny, Ramakrishnan Sivakumar, Sreenivasan Kamalamma Padmakumar","doi":"10.4103/jomfp.jomfp_109_24","DOIUrl":"10.4103/jomfp.jomfp_109_24","url":null,"abstract":"<p><strong>Introduction: </strong>Lip and oral cavity cancers are among the top 10 cancer causes and mortality globally. Some countries in the Indian subcontinent bear a disproportionately higher burden of lip and oral cavity cancers. Detailed analysis of lip and oral cavity cancers in the Indian subcontinent using all available data is important for effective policy planning. This paper aims to summarise the total burden of lip and oral cavity cancer and compare it across countries within the Indian subcontinent.</p><p><strong>Materials and methods: </strong>Data from the Global Cancer Observatory (GCO) and Global Burden of Disease (GBD) Study were extracted to analyse cancer incidence, prevalence, mortality and cancer risk before reaching 74 years. Furthermore, summary estimates of years of life lost (YLL), years lived with disability (YLDs) and disability-adjusted life years (DALYs) attributable to lip and oral cavity cancers were extracted from the GBD database. The data of individual countries within the Indian subcontinent were used for comparison.</p><p><strong>Results: </strong>The estimated number of deaths from lip and oral cavity cancers for 2019 was 90732 in the Indian subcontinent. The Indian subcontinent accounted for 45.3% of the deaths attributable to lip and oral cavity cancers. The incidence of lip and oral cavity cancers in the Indian subcontinent ranged from 3.18 per 100,000 population in Maldives to 12.76 per 100,000 population in Pakistan. The incidence rate of lip and oral cavity cancer in India was 7.54 per 100,000 population. However, due to the population size, India accounted for 104837 incident cases of lip and oral cavity cancers annually. The estimated number of prevalent and incident cases of lip and oral cavity cancers from the Indian subcontinent in 2019 was 0.46 million (30% of overall cases globally) and 0.15 million (39% of incident cases globally), respectively. The Indian subcontinent also accounted for 50% of the DALYs attributable to lip and oral cavity cancers worldwide.</p><p><strong>Discussion and conclusion: </strong>The Indian subcontinent accounts for disproportionately higher cases and deaths due to lip and oral cavity cancers than other regions. It calls for urgent policy action to prevent the disease spread, early diagnosis and optimal management of lip and oral cavity cancers in the Indian subcontinent.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"565-569"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on thyroid autoimmunity of oral lichen planus and oral lichenoid mucositis.","authors":"C Lavanya, K Ranganathan","doi":"10.4103/jomfp.jomfp_85_24","DOIUrl":"10.4103/jomfp.jomfp_85_24","url":null,"abstract":"<p><strong>Context: </strong>Oral lichen planus (OLP) and oral lichenoid mucositis (OLM) are immune-mediated mucosal conditions with multifactorial etiology, with similar clinical and histological characteristics. Diagnosis should be confirmed considering both clinical and histological aspects. Some subsets are associated with immune-mediated thyroid dysfunction due to anti-thyroid peroxidase antibody (TPO) and anti-thyroglobulin antibody (TGA).</p><p><strong>Aims: </strong>To ascertain the presence of thyroid autoantibodies in a cohort of patients with OLP and OLM from a South Indian population.</p><p><strong>Methods and materials: </strong>This observational study comprised 21 patients with 7 cases of OLP (Group I) and 14 cases of OLM (Group II) who reported from 2021-2023 for 2 years. Serum anti-thyroid antibodies including TPO and TGA was estimated using chemiluminescence immunoassay technique along with clinical and histological aspects. Altered levels of serological parameters were compared with respect to these auto-immune conditions.</p><p><strong>Results: </strong>Increased level of thyroid autoantibodies was observed in three (42%) of the seven cases of OLP. Two cases had elevated TPO (3-4 folds) and TGA (6-38 folds) and the subjects were above 50 years. Seven (50%) of the 14 OLM cases exhibited increased thyroid autoantibody levels and were above 50 years, predominantly females. TPO levels were increased in the range of 12 to 178 and TGA from 2 to 136 folds. Duration of these lesions were more than a year.</p><p><strong>Conclusions: </strong>Increased thyroid autoantibodies observed in both OLP and OLM represent an underlying autoimmune response. Long-term monitoring will enable the clinicians to correlate the antibody levels with the management of these lesions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"549-554"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid-based cytology in the diagnosis of oral pre-cancer, cancer, and other oral lesions - A narrative review.","authors":"Usha Hegde, Sreeshyla H Sheshanna, H P Jaishankar, R Shashidara","doi":"10.4103/jomfp.jomfp_332_24","DOIUrl":"10.4103/jomfp.jomfp_332_24","url":null,"abstract":"<p><p>Though cytology is one of the most simple and economical diagnostic techniques, several disadvantages set it back as a good diagnostic tool. Liquid-based cytology (LBC) is an advanced diagnostic cytological technique that is being technically modified from conventional cytology to produce better sample preparation to aid in improved diagnosis. It produces a more representative sample of the specimen, with reduced obscuring background material which allows for faster and more reliable screening. Instead of being spread onto a glass slide and fixed, the samples are suspended in a vial of liquid preservative, processed to break the clot and remove the debris. The cell pellet is then placed onto the glass slide to obtain a thin monolayer of cells with a clean background. LBC is found to have several advantages against the conventional techniques. LBC has been researched in cervical cytology and has shown good sensitivity, specificity, improved sampling, and quality of smears. It has been adopted to study several oral lesions and has been found to be a reliable substitute for conventional smear. This article reviews LBC technique and its applications to oral diseases, in specific to oral cancer and pre-cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"535-543"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant fibrous histiocytoma of the mandible: A rare case report with diagnostic challenge and treatment approach.","authors":"Preethi N Sharma, Minal S Chaudhary, Alka H Hande, Swati K Patil","doi":"10.4103/jomfp.jomfp_98_24","DOIUrl":"10.4103/jomfp.jomfp_98_24","url":null,"abstract":"<p><p>Malignant fibrous histiocytoma (MFH), now termed undifferentiated pleomorphic sarcoma (UPS), is a high-grade tumour, mostly affecting the extremities and retroperitoneum. It is a rare entity in the mandible. After a literature search in the PubMed database, only 15 cases have been reported, indicating how uncommon it is in the mandible. In this instance, we document an unusual occurrence of MFH, affecting the mandible in a 37-year-old male patient. Histopathology of the biopsy specimen along with the strong positivity to immunohistochemical markers such as Vimentin and CD68 confirmed the diagnosis of MFH. It is a rare entity presenting diagnostic and therapeutic challenges requiring a multidisciplinary approach for optimal management and treatment.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"705-707"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The concept of dysplasia in the lining of odontogenic keratocyst: A case report and review of the literature.","authors":"Deepak Pandiar, Reshma Poothakulath Krishnan","doi":"10.4103/jomfp.jomfp_145_24","DOIUrl":"10.4103/jomfp.jomfp_145_24","url":null,"abstract":"<p><p>Odontogenic keratocyst (OKC) is an uncommon developmental cyst with a high recurrence rate. Epithelial dysplasia is a rarely recognized phenomenon in OKCs, with only a few acceptable cases reported in the literature. The exact pathogenesis of dysplastic changes in epithelial lining is difficult to explain, in the absence of molecular analyses. Here, we report a rare case of maxillary OKC with multiple cystic compartments displaying epithelial dysplasia in a 62-year-old man with immunohistochemical analyses and a comprehensive review of the literature. It may be prudent to believe that the aggressive behaviour in the epithelial lining of OKC is an inherent property of all OKCs, which is only dictated by the epithelium but is also determined by the stromal cells of the cyst wall; the dysplastic changes, however, could be resultant to chronic inflammatory reaction and inflammation-mediated carcinogenesis mechanism. It is recommended that the dysplastic features in the epithelial lining of all odontogenic cysts must be addressed in all pathology reports along with close clinical follow-up.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"701-704"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are pathologists legally liable?","authors":"Manjunath Rai","doi":"10.4103/jomfp.jomfp_323_24","DOIUrl":"10.4103/jomfp.jomfp_323_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"544-546"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of varying tobacco habits on salivary flow rate, pH and taste perception.","authors":"Pearl Gupta, Aparna Dave, Pulin Saluja, Manpreet Arora","doi":"10.4103/jomfp.jomfp_523_23","DOIUrl":"10.4103/jomfp.jomfp_523_23","url":null,"abstract":"<p><strong>Background: </strong>Smoking and smokeless form of tobacco consumption is highly prevalent among the adult population worldwide. Tobacco use has an adverse effect on oral health. It may contribute to an impaired salivary flow rate and influence salivary pH and taste perception.</p><p><strong>Aim: </strong>To evaluate the effects of tobacco on salivary flow rate, salivary pH and taste perception.</p><p><strong>Objective: </strong>To evaluate salivary flow rate, pH and taste perception in tobacco chewers and tobacco smokers.</p><p><strong>Materials and method: </strong>Sixty subjects were selected from the patients attending Dental OPD. Group A included 20 subjects who has the habit of chewing tobacco for a minimum period of 5 years. Group B included 20 subjects who has the habit of smoking tobacco for at least a period of 5 years. Group C included 20 healthy individuals who did not have habit of chewing or smoking tobacco, and they formed the control group.</p><p><strong>Results: </strong>On comparing salivary pH between tobacco chewers (Group A) and control group (Group C), it was observed that there was not much difference in salivary pH between the groups. The mean value of Group A (tobacco chewers) of salivary pH was calculated as 7.59 with 0.70 SD. For the control group (Group C), the mean value was obtained as 7.42 with 0.96 standard deviation. The independent <i>t</i>-test was applied, and the result was nonsignificant. Similarly, when SFR was evaluated, it was observed that the mean value for SFR of Group A was 1.75 with 0.71 SD, and for the control group, it was 1.51. There was no significant difference in pH between Group A and Group B. A significant reduction in taste perception was observed in smokers as compared to nonsmokers (<i>P</i> < 0.05). Smokers rated the intensity of all taste solutions lower than the nonsmokers.</p><p><strong>Conclusion: </strong>Frequent tobacco use impacts oral health, often unknown to the users. This study found altered perception of bitter taste in tobacco users. However, salivary pH and SFR showed minimal variation.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"560-564"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid peripheral nerve sheath tumours - A Review.","authors":"Himani T Chaturvedi, Chandrashekher Chaturvedi","doi":"10.4103/jomfp.jomfp_126_24","DOIUrl":"10.4103/jomfp.jomfp_126_24","url":null,"abstract":"<p><p>Hybrid peripheral nerve sheath tumours (PNSTs) are mainly benign, which represent combined areas of neurofibroma, schwannoma, and perineurioma in various combinations and pose challenges to the surgeon and the pathologist. They are relatively new in pathology and were first published in the fourth edition of World Health Organization Classification of Tumors of Soft tissue and Bone in 2013. They are mainly dermal or subcutaneous, and the most common variant of hybrid nerve sheath tumour is perineurioma-schwannoma. The combination of neurofibroma/schwannoma usually has an increased frequency with neurofibromatosis (NF) type 1 or 2 and schwannomatosis. In contrast, neurofibroma/perineurioma, mainly associated with NF1, are rare. Diagnosis is established by histopathology and immunohistochemistry. Hence, they embark diagnostic challenge and demand extreme vigilance and caution. However, the molecular pathogenesis, recurrence rates, and risk of malignant transformation of hybrid PNST remain poorly understood. A novel <i>CHD7-VGLL3</i> fusion gene in a hybrid schwannoma-perineurioma and recurrent <i>ERBB2</i> mutations in a subset of hybrid neurofibroma/schwannomas were identified. We have tried, via this article, to represent a brief update on hybrid nerve sheath tumours.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"651-656"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}