Journal of Reproduction and Infertility最新文献

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The Association Between Mature Oocyte Proportion and IVF Success: A Retrospective Analysis of 2,565 ICSI Cycles. 成熟卵母细胞比例与IVF成功率之间的关系:2565例ICSI周期的回顾性分析。
Journal of Reproduction and Infertility Pub Date : 2025-10-01 DOI: 10.18502/jri.v26i4.21090
Oya Korkmaz, Seda Karabulut, Elif Yılmaz, Nuri Delikara
{"title":"The Association Between Mature Oocyte Proportion and IVF Success: A Retrospective Analysis of 2,565 ICSI Cycles.","authors":"Oya Korkmaz, Seda Karabulut, Elif Yılmaz, Nuri Delikara","doi":"10.18502/jri.v26i4.21090","DOIUrl":"10.18502/jri.v26i4.21090","url":null,"abstract":"<p><strong>Background: </strong>IVF/ICSI success depends on the proportion of fertilizable metaphase II (MII) oocytes, yet direct evidence linking mature-oocyte rate to clinical outcomes remains limited. This study aimed to assess the impact of mature oocyte rate on clinical pregnancy outcomes in a large retrospective cohort of women undergoing ICSI.</p><p><strong>Methods: </strong>A total of 2,565 women who underwent ICSI cycles at a single IVF center in Türkiye were retrospectively analyzed. Patients were stratified into three groups according to mature oocyte proportion: Group 1 (0-50%), Group 2 (51-75%), and Group 3 (76-100%). Data were analyzed per initiated ICSI cycle. Embryo transfer was performed on day 3 or day 5 post-fertilization, depending on embryo quality and patient characteristics. Logistic regression analysis was performed to assess the independent effect of mature oocyte rate on pregnancy outcomes. Statistical significance was set at p<0.05.</p><p><strong>Results: </strong>Clinical pregnancy rates were significantly lower in Group 1 (10.23%) compared to Group 2 (28.96%) and Group 3 (29.99%) (p<0.001). Live birth and implantation rates increased in the higher maturity groups (7.5% <i>vs.</i> 21.5% <i>vs</i>. 22.9% and 12.1% <i>vs</i>. 24.3% <i>vs</i>. 26.0%, respectively), whereas miscarriage rates decreased (18.9% <i>vs</i>. 13.4% <i>vs</i>. 12.8%). Logistic regression analysis confirmed that a higher mature oocyte proportion was an independent predictor of clinical pregnancy (Group 2: OR=3.4, 95%CI: 2.5-4.6; Group 3: OR=3.5, 95%CI: 2.6-4.7; p<0.001).</p><p><strong>Conclusion: </strong>This large-scale retrospective cohort analysis demonstrates that mature oocyte proportion is an important prognostic factor of IVF success. Mature oocyte proportion should be considered an essential parameter in clinical practice and patient counseling.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 4","pages":"241-247"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Long-Term and Stimulated Cycle Protocols in Frozen Embryo Transfer Cycles in Women with Polycystic Ovary Syndrome: A Non-Randomized Clinical Trial. 多囊卵巢综合征妇女冷冻胚胎移植周期的长期和刺激周期方案的比较:一项非随机临床试验。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20180
Shamim Pilevari, Mahnaz Yavangi, Zakieh Yarahmadi, Elahe Talebi Ghane
{"title":"Comparison of Long-Term and Stimulated Cycle Protocols in Frozen Embryo Transfer Cycles in Women with Polycystic Ovary Syndrome: A Non-Randomized Clinical Trial.","authors":"Shamim Pilevari, Mahnaz Yavangi, Zakieh Yarahmadi, Elahe Talebi Ghane","doi":"10.18502/jri.v26i3.20180","DOIUrl":"10.18502/jri.v26i3.20180","url":null,"abstract":"<p><strong>Background: </strong>In women with polycystic ovary syndrome (PCOS), the optimal endometrial preparation strategy for frozen embryo transfer (FET) remains unclear. This clinical trial aimed to compare a long-term protocol with a stimulated cycle protocol in FET cycles of PCOS women, with clinical pregnancy rate per embryo transfer as the primary outcome.</p><p><strong>Methods: </strong>This non-randomized, open-label, two-arm clinical trial was conducted at Fatemieh Hamedan Hospital, Iran, involving 340 women with PCOS. Participants were allocated to the long-term or stimulated cycle protocols based on clinical scheduling and physician decision. The long-term protocol included low-dose combined oral contraceptives for 14 days, GnRH agonist downregulation, estradiol valerate (4-6 <i>mg/day</i> for ≥10 days), and progesterone before embryo transfer. The stimulated cycle protocol involved recombinant FSH with ultrasound monitoring, hCG trigger for oocyte maturation, and intramuscular progesterone (50 <i>mg/day</i>) for luteal phase support. For each participant one FET cycle was analyzed.</p><p><strong>Results: </strong>Baseline characteristics were similar between groups (n=170 each). The long-term protocol showed higher clinical pregnancy rates (35.9%) compared to the stimulated cycle (22.9%) (OR=1.92; 95%CI: 1.15-3.19; p=0.011). Chemical pregnancy rates also favored the long-term protocol (34.7% <i>vs</i>. 21.8%) (OR=1.91; 95%CI: 1.17-3.09; p=0.008). Endometrial thickness was significantly greater in the long-term protocol (8.7±0.9 <i>mm vs</i>. 8.4±0.8 <i>mm</i>; p=0.004).</p><p><strong>Conclusion: </strong>Although the long-term protocol showed higher clinical pregnancy rates in unadjusted analyses, after adjusting for confounders, protocol type was not independently associated with clinical pregnancy. Larger randomized trials are needed to confirm these findings, and adverse outcomes should be assessed in future studies.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Analysis of Oxidative Stress and Inflammatory Biomarkers in Different Stages of Endometriosis. 子宫内膜异位症不同阶段氧化应激和炎症生物标志物的比较分析。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20183
Ghazaleh Bigdeli, Maryam Ghobeh, Roya Padmehr, Simin Zafardoust, Zahra Sheikhi, Negin AmirJannati, Mohammad Reza Mahdavi Amiri, Kambiz Gilany
{"title":"A Comparative Analysis of Oxidative Stress and Inflammatory Biomarkers in Different Stages of Endometriosis.","authors":"Ghazaleh Bigdeli, Maryam Ghobeh, Roya Padmehr, Simin Zafardoust, Zahra Sheikhi, Negin AmirJannati, Mohammad Reza Mahdavi Amiri, Kambiz Gilany","doi":"10.18502/jri.v26i3.20183","DOIUrl":"10.18502/jri.v26i3.20183","url":null,"abstract":"<p><strong>Background: </strong>The fundamental mechanisms behind the causes and development of endometriosis are still poorly understood. Therefore, identifying biomarkers that can help with early detection and targeted treatment is crucial for effective management of this disease. This study aimed to compare total antioxidant capacity (TAC), the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and the concentrations of interleukin-6 (IL-6) and phenylalanine (Phe) across different stages of endometriosis.</p><p><strong>Methods: </strong>The plasma samples were collected from women with endometriosis who had undergone laparoscopic surgery. The stages were confirmed by a gynecologist, with 30 plasma samples from stages I-II (mild) and 30 from stages III-IV (severe). The obtained measurement data were first normalized and tested for normality, followed by analysis using the t-test and Mann-Whitney U test. The p-value below 0.05 was considered statistically significant. The sample size was determined based on Cohen's guideline of 30. Biomarker levels were assessed using ELISA and colorimetric techniques.</p><p><strong>Results: </strong>TAC levels, GPx, and SOD activities, as well as Phe concentration significantly differed between endometriosis stages I-II and III-IV (p<0.05). These measured biomarkers were higher in stage I-II. On the other hand, although IL-6 levels were higher in stages III-IV, the differences between stages were not statistically significant.</p><p><strong>Conclusion: </strong>The potential of TAC, SOD, GPx, and Phe as biomarkers for the early diagnosis and treatment of endometriosis underscore the roles of inflammation and oxidative stress in the pathogenesis of the disease, providing insights that may aid in developing more targeted diagnostic and therapeutic strategies.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"180-185"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Reproductive Autonomy in Cystic Fibrosis: The Role of Oocyte Cryopreservation. 囊性纤维化中生殖自主性的优化:卵母细胞冷冻保存的作用。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20185
Saim Mahmood Khan, Rashmeen Khan, Safiyullah Bashir, Mehak Rani, Surraiya RiazMahmood Khan
{"title":"Optimizing Reproductive Autonomy in Cystic Fibrosis: The Role of Oocyte Cryopreservation.","authors":"Saim Mahmood Khan, Rashmeen Khan, Safiyullah Bashir, Mehak Rani, Surraiya RiazMahmood Khan","doi":"10.18502/jri.v26i3.20185","DOIUrl":"10.18502/jri.v26i3.20185","url":null,"abstract":"","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"193-194"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Aspirin Administration on Fetal Cardiovascular Function Between 18 to 24 Weeks of Gestation: A New Perspective on ASA Indication in Obstetrics. 阿司匹林对妊娠18 ~ 24周胎儿心血管功能的影响:ASA在产科指征的新视角
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20181
Behrokh Sahebdel, Mohammad Nasir Hematian, Zohreh Heidary, Fatemeh Golshahi, Nafiseh Saedi, Fatemeh Rahimi-Sharbaf, Mahboobeh Shirazi, Arian Tavasol, Gita Manzari Tavakoli, Mohammad Hossein Golezar, Hamed Ghorani, Elham Feizabad, Soudabeh Rezaei
{"title":"The Effect of Aspirin Administration on Fetal Cardiovascular Function Between 18 to 24 Weeks of Gestation: A New Perspective on ASA Indication in Obstetrics.","authors":"Behrokh Sahebdel, Mohammad Nasir Hematian, Zohreh Heidary, Fatemeh Golshahi, Nafiseh Saedi, Fatemeh Rahimi-Sharbaf, Mahboobeh Shirazi, Arian Tavasol, Gita Manzari Tavakoli, Mohammad Hossein Golezar, Hamed Ghorani, Elham Feizabad, Soudabeh Rezaei","doi":"10.18502/jri.v26i3.20181","DOIUrl":"10.18502/jri.v26i3.20181","url":null,"abstract":"<p><strong>Background: </strong>Low-dose aspirin (ASA) is used in obstetrics for different indications, mainly to prevent preeclampsia. This study investigated the underlying mechanism of ASA's effect on the fetus's cardiovascular functions.</p><p><strong>Methods: </strong>42 pregnant women at 18-24 weeks of gestation, identified as high-risk for preeclampsia, received 160 <i>mg</i> of ASA daily. Fetal Doppler ultrasound was performed before and three weeks after ASA treatment, assessing ductus venosus, middle cerebral, umbilical, and uterine arteries pulsatility indices as well as pulmonary, aorta, and superior vena cava (SVC) diameters in the three-vessel view, including pulmonary/aorta and SVC/aorta ratios. All analyses were performed using SPSS software version 27, with a significance threshold set at p<0.05. A paired t-test was used to assess differences in means. The Chi-square and Fisher's exact test analyzed nominal variables.</p><p><strong>Results: </strong>Post-intervention analysis revealed significant improvements in abnormal uterine artery resistance (p<0.001) and abnormal pulsatility index of the umbilical artery, middle cerebral artery, and ductus venosus (p<0.001 for all). Moreover, 160 <i>mg/day</i> aspirin administration significantly increased mitral E/A (early filling velocity/atrial contraction velocity: 0.397±0.029; p<0.001), diameters of aorta (4.390±0.852; p<0.001), pulmonary artery (4.895±1.087; p<0.001), and SVC (2.511±0.535; p<0.001), while significantly decreasing left ventricular myocardial performance index (p<0.05).</p><p><strong>Conclusion: </strong>Daily administration of 160 <i>mg</i> of aspirin enhances fetal vascular and cardiac function. Evaluating fetal cardiovascular parameters beyond routine uterine artery Doppler, especially in high-risk pregnancies, and initiating ASA therapy in cases of insidious abnormalities, may help delay or prevent fetal complications such as intrauterine growth restriction (IUGR) by improving cardiovascular function.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"165-171"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Brain Midline Structure Measurements: Cavum Septi Pellucidi and Corpus Callosum Indices in Multiple Views at Late Gestation. 妊娠后期胎儿脑中线结构测量:透明中隔腔和胼胝体指数的多角度观察。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20182
Sedigheh Borna, Azadeh Shabani, Seyedeh Noushin Ghalandarpoor-Attar, Seyedeh Mojgan Ghalandarpoor-Attar, Asghar Ghorbani
{"title":"Fetal Brain Midline Structure Measurements: Cavum Septi Pellucidi and Corpus Callosum Indices in Multiple Views at Late Gestation.","authors":"Sedigheh Borna, Azadeh Shabani, Seyedeh Noushin Ghalandarpoor-Attar, Seyedeh Mojgan Ghalandarpoor-Attar, Asghar Ghorbani","doi":"10.18502/jri.v26i3.20182","DOIUrl":"10.18502/jri.v26i3.20182","url":null,"abstract":"<p><strong>Background: </strong>Few studies evaluated cavum septum pellucidum (CSP) and corpus callosum (CC) indices in late gestation. This study assessed CSP and CC indices, along with frontal lobe measurements, and examined correlations among parameters.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Imam Khomeini Hospital Complex on 150 fetuses at ≥36 weeks' gestation. Transabdominal ultrasound was used to measure CSP length, width, trace length, and area in the axial view; frontal lobe thickness from anterior and posterior CSP margins in horizontal and vertical directions; and CC lengths and thicknesses. CSP trace length and area were also obtained in the midsagittal view. Data were analyzed using SPSS 23.</p><p><strong>Results: </strong>Mean gestational age, biparietal diameter (BPD), head circumference (HC), and estimated fetal weight (EFW) were 37.56±1.08 weeks, 90.73±3.20 <i>mm</i>, 326.58±10.59 <i>mm</i>, and 2987.82±333.68 <i>gr</i>. In the trans-thalamic view, median CSP length, width, trace length, and area were 8.92 <i>mm</i>, 6.05 <i>mm</i>, 2.81 <i>mm</i>, and 0.49 <i>mm</i> <sup>2</sup>. Median CSP height in the coronal view was 5.85 <i>mm</i>. In the midsagittal view, mean CC outer-to-outer length, inner-to-inner length, CSP trace length, and CSP area were 41.31±4.81 <i>mm</i>, 29.73±4.17 <i>mm</i>, 2.56±0.63 <i>mm</i>, and 0.36±0.19 <i>mm</i> <sup>2</sup>. All CC and CSP indices correlated significantly with HC (p<0.05). Frontal bone-to-CSP anterior and posterior distances in axial and near-field views also correlated with HC (p=0.0001).</p><p><strong>Conclusion: </strong>This study provides normative measurements for CC, CSP, and frontal lobe indices at ≥36 weeks' gestation. These values support late-gestation brain assessment and early identification of newborns potentially at risk for neurodevelopmental concerns.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"172-179"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive Oxygen Species in Follicular Fluid as a Potential Biomarker of Oocyte Developmental Competence. 卵泡液中活性氧作为卵母细胞发育能力的潜在生物标志物。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20178
Sara Borjian-Boroujeni, Naser Shams-Esfandabadi, Abolfazl Shirazi, Ebrahim Ahmadi, Kambiz Gilany
{"title":"Reactive Oxygen Species in Follicular Fluid as a Potential Biomarker of Oocyte Developmental Competence.","authors":"Sara Borjian-Boroujeni, Naser Shams-Esfandabadi, Abolfazl Shirazi, Ebrahim Ahmadi, Kambiz Gilany","doi":"10.18502/jri.v26i3.20178","DOIUrl":"10.18502/jri.v26i3.20178","url":null,"abstract":"<p><strong>Background: </strong>Reactive oxygen species (ROS) are critical factors for oocyte maturation and early embryogenesis; however, excessive ROS can induce oxidative stress, impairing mitochondrial function, DNA integrity, and embryo competence. The role of oxidative status in buffalo follicular fluid (FF) remains underexplored. This study assessed the relationship between total oxidant status (TOS) in buffalo FF and the developmental competence of oocytes retrieved by ovum pick-up (OPU) for subsequent in vitro fertilization (OPU-IVF).</p><p><strong>Methods: </strong>Follicular fluid and cumulus-oocyte complexes (COCs) were collected from 62 healthy buffaloes. Oocytes were matured and fertilized <i>in vitro</i>, and the animals were classified based on blastocyst yield: G1 (no blastocysts), G2 (≥2 blastocysts), and G3 (>3 blastocysts). TOS was measured spectrophotometrically. The relationship between TOS and oocyte competence was analyzed by ROC (G1 <i>vs</i>. G3) and Spearman correlation (G1 <i>vs</i>. G2), with p<0.05 considered statistically significant.</p><p><strong>Results: </strong>G2 group with >2 blastocyst exhibited lower TOS levels (1.10±0.51 <i>μmol</i> H<sub>2</sub>O<sub>2</sub> Eq/L) than G1 (2.15±0.92; p=0.004), with higher follicle counts, oocyte yield, cleavage rate, and blastocyst production (p<0.05). ROC analysis identified a TOS threshold of 1.12 <i>μmol</i> H<sub>2</sub>O<sub>2</sub> Eq/L (area under the curve [AUC]=0.851), and TOS inversely correlated with the proportion of high-quality blastocysts (r=-0.553, p= 0.021).</p><p><strong>Conclusion: </strong>Elevated oxidative stress in FF compromises oocyte developmental competence and embryo quality. TOS may serve as a predictive biomarker, supporting antioxidant-based optimization of assisted reproductive technology (ART) in buffalo.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"144-151"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of hCG Supplementation on Embryo Quality after Rescue In Vitro Maturation (r-IVM). 补充hCG对体外抢救成熟(r-IVM)后胚胎质量的影响。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20179
Novita Prasetiawati, Ayu Mulia Sundari, Agus Supriyadi, Hadi Sjarbaini, Tarigan Sudirmanto, Gde Suardana, Mohammad Haekal, Gangsar Pariyanti, Deana Rosaria Indah, Mulyoto Pangestu, Anom Bowolaksono
{"title":"The Effect of hCG Supplementation on Embryo Quality after Rescue <i>In Vitro</i> Maturation (r-IVM).","authors":"Novita Prasetiawati, Ayu Mulia Sundari, Agus Supriyadi, Hadi Sjarbaini, Tarigan Sudirmanto, Gde Suardana, Mohammad Haekal, Gangsar Pariyanti, Deana Rosaria Indah, Mulyoto Pangestu, Anom Bowolaksono","doi":"10.18502/jri.v26i3.20179","DOIUrl":"10.18502/jri.v26i3.20179","url":null,"abstract":"<p><strong>Background: </strong>The supplementation of human chorionic gonadotropin (hCG) into culture medium in rescue <i>in vitro</i> maturation (r-IVM) has been reported to improve the maturation rates of immature oocytes derived from stimulated cycles. However, the impact of this enrichment on embryo quality is yet to be understood. The purpose of the current study was to investigate the effect of hCG on the embryo quality following r-IVM.</p><p><strong>Methods: </strong>A total of 152 immature oocytes consisting of germinal vesicles (GV) and metaphase I (MI) were collected and classified into 1) control group (n=73; GV=22, MI=51) cultured in culture medium only, and 2) experimental group (n=79; GV= 23, MI=56) cultured in culture medium supplemented with 0.5 <i>IU</i> hCG. Study parameters were analyzed using Student's T-test or Kruskal Wallis and chi-square at a 95% confidence level.</p><p><strong>Results: </strong>After 24 <i>hr</i>, the maturation rate of the control and experimental groups was comparable (57% <i>vs</i>. 70%, p=0.58). Following intracytoplasmic sperm injection (ICSI), the fertilization rate was significantly higher in the experimental group than in the control group (49% <i>vs</i>. 36%; p=0.03). However, the number of good-quality embryos was similar in the groups (16% <i>vs</i>. 6%).</p><p><strong>Conclusion: </strong>Our study suggests that hCG supplementation into the culture medium during r-IVM does not affect embryo quality but improves the fertilization rate. Further research is needed to scrutinize the role of hCG in fertilization.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends of Multiple Births in Iran from 2014 to 2023. 2014 - 2023年伊朗多胞胎趋势
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20184
Milad Ahmadi Gohari, Maryam Chegeni, Firoozeh Mirzaee, Yunes Jahani
{"title":"Trends of Multiple Births in Iran from 2014 to 2023.","authors":"Milad Ahmadi Gohari, Maryam Chegeni, Firoozeh Mirzaee, Yunes Jahani","doi":"10.18502/jri.v26i3.20184","DOIUrl":"10.18502/jri.v26i3.20184","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to analyze the trends of multiple births at both national and provincial levels in Iran from 2014 to 2023.</p><p><strong>Methods: </strong>Data on the number of live births and multiple births from 2014 to 2023 at national and provincial levels were obtained from the Iran's Bureau of Vital Statistics. The multiple birth rate (MBR), defined as the number of live births from multiple births per 1,000 live births, was calculated annually. To examine temporal trends and detect significant changes in MBR over the study period, joinpoint regression analysis was performed. Annual percent change (APC) and average annual percent change (AAPC) were calculated for the entire period.</p><p><strong>Result: </strong>The national AAPC in the MBR was estimated at 2.38% (95%CI: 1.95 to 2.76) over the entire study period. A significant shift in trend was identified in 2020. Specifically, the APC from 2014 to 2020 was 0.24%. However, from 2020 to 2023, the APC markedly increased to 6.8%, reflecting a substantial rise in MBR during this latter period. Furthermore, the study findings demonstrated that nearly all provinces across the country have exhibited an upward trend in MBR in recent years.</p><p><strong>Conclusion: </strong>The increasing trend of multiple births in Iran aligns with global patterns. Several factors may have contributed to this rise, including increased maternal age at childbirth, higher prevalence of infertility, expanded use of assisted reproductive technologies (ARTs), and shifts in population policies.</p>","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"186-192"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertility in Fevered Planet, Hidden Costs of Global Warming. 全球变暖的隐性成本,炽热星球的生育能力。
Journal of Reproduction and Infertility Pub Date : 2025-07-01 DOI: 10.18502/jri.v26i3.20177
Mohammad Reza Sadeghi
{"title":"Fertility in Fevered Planet, Hidden Costs of Global Warming.","authors":"Mohammad Reza Sadeghi","doi":"10.18502/jri.v26i3.20177","DOIUrl":"10.18502/jri.v26i3.20177","url":null,"abstract":"","PeriodicalId":38826,"journal":{"name":"Journal of Reproduction and Infertility","volume":"26 3","pages":"142-143"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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