Tokai Journal of Experimental and Clinical Medicine最新文献_第5页

Correlation of blood glucose and prostatic-related parameters in patients with prostate enlargement 前列腺肿大患者血糖与前列腺相关参数的相关性

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.19

I. Yatindra, Anak Agung Sagung Mirah Prabandari, P. Tirtayasa, I. Yatindra, A. N. O. Diatmika, Kadek Cindy Merni̇ka

{"title":"Correlation of blood glucose and prostatic-related parameters in patients with prostate enlargement","authors":"I. Yatindra, Anak Agung Sagung Mirah Prabandari, P. Tirtayasa, I. Yatindra, A. N. O. Diatmika, Kadek Cindy Merni̇ka","doi":"10.52142/omujecm.40.1.19","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.19","url":null,"abstract":"Enlarged prostate, either in benign prostatic hyperplasia or prostate cancer is the predominant urological disease affecting older men. Metabolic syndrome including high blood glucose was considered to take part in the development of prostate enlargement, although their association is still unclear. This study aims to investigate the correlation between blood glucose with prostatic-related parameters. A cross-sectional study was conducted involving 91 men with prostate enlargement from Urology Polyclinic, Tabanan Hospital, Bali Province, Indonesia. Prostatic-related parameters collected include patient’s international prostate symptoms score using the questionnaire, prostate-specific antigen and random blood glucose analysis from serum blood sample, and prostate volume determined with transabdominal ultrasonography. Patient’s mean age was 65.4 ± 10 years, mean prostate volume 52.7 ± 26 ml, mean prostate-specific antigen (PSA) 9.2 ± 17 ng/ml, mean international prostatic symptoms score (IPSS) 14.31 ± 7.1, mean random blood glucose 121.1 ± 40.5 mg/dl. This study found weak positive correlation between random blood glucose and prostate volume (r=0.269; p=0.01). PSA and prostate volume showed moderate positive correlation (r=0.365; p<0.001). No correlation between random blood glucose with PSA or IPSS was found in this study. This study found random blood glucose has positive correlation with prostate volume. We recommend enhancing blood glucose control to prevent the progress of prostate enlargement.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77306837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of transvaginal ultrasonography in determining endometrium cancer risk in asymptomatic postmenopausal women with thickened endometrium 经阴道超声在确定无症状的绝经后子宫内膜增厚妇女子宫内膜癌风险中的作用

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.9

Osman Samet Günkaya, A. Tekin, M. Tekelioğlu, Zeynep Gedik Özköse, Ayşegül Bestel, Ü. Kalkan, N. Tuğ

{"title":"Role of transvaginal ultrasonography in determining endometrium cancer risk in asymptomatic postmenopausal women with thickened endometrium","authors":"Osman Samet Günkaya, A. Tekin, M. Tekelioğlu, Zeynep Gedik Özköse, Ayşegül Bestel, Ü. Kalkan, N. Tuğ","doi":"10.52142/omujecm.40.1.9","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.9","url":null,"abstract":"The aim of this study is to determine the cut-off value for the histopathological evaluation of premalignant-malignant endometrial pathologies from benign pathologies in postmenopausal asymptomatic patients with increased endometrial thickness. This cross-sectional study included a population that included asymptomatic 481 postmenopausal women with an endometrial thickness of more than 5mm in TVU who underwent diagnostic/ operative hysteroscopy and full curettage between January 2015 and January 2018. Demographic characteristics TVU, hysteroscopy findings of patients were recorded. As a result, in the histopathological outcome, 154(3%) women were evaluated as having normal endometrium, 189(39.3%) women as having endometrial polyps, 93(19.3%) women as having endometrial atrophy, and 23(4.6%) women as having endometrial simple hyperplasia, 5(1%) women as having endometrial simple hyperplasia, 17(3.5%) women as having endometrial atrophy and only one (0.1%) woman as having fibroids. In the 187 postmenopausal women with normal diagnostic hysteroscopic evaluation, histopathological findings were: 13(7%) endometrial hyperplasia, 2(1.1%) atypical endometrial hyperplasia, 27(14.4%) endometrial polyps, 4 2.1%) endometrial atrophy, and 2(1.1%) endometrial carcinoma. The endometrial thickness was analyzed with the ROC curve for cutoff value differentiating atypical endometrial hypreplasia/endometrial carcinoma from benign lesions and 10.5 mm was found with 90% sensitivity and 63% specificity. In conclusion, hysteroscopy is highly effective for identifying the endometrium and focal intracavitary pathologies such as polyps, myomas and foreign bodies in women with abnormal uterine bleeding. However, for the diagnosis of endometrial hyperplasia and cancer, hysteroscopic-guided biopsy with uterine curettage seems to be the best method.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78148286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between KRAS gene expression and breast tumors in a sample of Iraqi women 伊拉克妇女样本中KRAS基因表达与乳腺肿瘤的关系

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.5

Roya H. AL-HADDAD, Hameed M. Jasim

引用次数: 0

Epidemiological and clinical characteristics, management, and outcomes of antenatal hydronephrosis: A single-centre experience of 229 cases 流行病学和临床特征，管理和结局产前肾积水:单中心经验229例

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.24

M. Önal, H. G. Önal

{"title":"Epidemiological and clinical characteristics, management, and outcomes of antenatal hydronephrosis: A single-centre experience of 229 cases","authors":"M. Önal, H. G. Önal","doi":"10.52142/omujecm.40.1.24","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.24","url":null,"abstract":"The advances in utilization of USG in antenatal routine follow-up resulted with increased diagnosis of antenatal hydronephrosis (ANH). This study was conducted to elaborate the epidemiological and clinical characteristics, management, outcomes, and possible risk factors of the ANH. A total of 229 cases diagnosed with ANH during the antenatal follow-up at the Obstetrics and Gynecology Department of OndokuzMayis University between 2004 and 2022 were included. The ANH was defined as an USG finding suggesting a hydronephrosis 7 mm. The epidemiological and clinical characteristics, risk factors, treatment and outcomes in the postnatal period were assessed retrospectively. About 75% of the cases were male, 8% were premature births, and the mean gestational week of diagnosis was 22±3 weeks. About 43.7% of mothers had urinary tract infections, and family history of a kidney disease was present in 24.5% of mothers’ and 20.5% of fathers’ family histories.38.7% of cases undergone surgery. At the end of 6-month follow-up, 37.3% had regressed and 38.7% of them had stable hydronephrosis, and 18.9% of them had normal findings in USG. Male gender, increased gestational urinary tract infections, and family histories of parents for a kidney disease were found as possible risk factors for development of ANH. Close follow-up and timely intervention including surgery provides favorable outcomes in these cases.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89515207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period? 绝经后维生素D缺乏对巴氏涂片检查结果有什么影响?

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.15

Asena Ayar Madenli, İnci Öz, Ergul Demircivi

{"title":"What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?","authors":"Asena Ayar Madenli, İnci Öz, Ergul Demircivi","doi":"10.52142/omujecm.40.1.15","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.15","url":null,"abstract":"This study aimed to determine the impact of vitamin D deficiency on Pap smear test results in women in the postmenopausal period. This cross-sectional study included 394 women who applied to İstanbul Medeniyet University, Göztepe Training and Research Hospital gynecology and obstetric clinic for routine Pap smear tests. This study was conducted between May 2019 and December 2020. Cases were divided into severe deficiency (<12 ng/ml), moderate deficiency (12-20 ng/ml), deficiency (21-30 ng/ml), and sufficiency (>30 ng/ml) according to the vitamin D levels measured in the postmenopausal period within the scope of check-up examinations. Pap smear test results compared with vitamin D levels. The mean age of the study group was 48.70±3.46 years. There was a statistically significant association between vitamin D values and Pap smear test results (p<0.05). Vitamin D greater than 20 ng/ml had a significant relationship with the normal cytology results. There was a statistically significant association between vitamin D lower than 20 ng/ml and cervicitis cytology results. The results showed that the serum vitamin D and the Pap smear test results had a significant association. It is recommended that physicians prescribe the use of vitamin D supplements in women in the high-risk group of cervical cancer.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83678676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats 谷氨酰胺对Wistar大鼠抗结核药物肾毒性的保护作用

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.2

Elias Adikwu, Martins Mbonu, Tobechi Brendan Nnanna

{"title":"The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats","authors":"Elias Adikwu, Martins Mbonu, Tobechi Brendan Nnanna","doi":"10.52142/omujecm.40.1.2","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.2","url":null,"abstract":"This study assessed the protective effect of glutamine (GTN) against rifampicin/isoniazid/pyrazinamide/ethambutol (RIPE)-induced nephrotoxicity in rats. Thirty adult Wistar rats (200±20 g) of both sexes were grouped into 6 of 5 rats/group. The rats were treated daily for 30 days as follows: Group 1 (Vehicle control [normal saline 0.2mL]), group 2 (GTN 200 mg/kg), group 3 (RIPE 150, 75, 400 and 275 mg/kg in vehicle), group 4 (GTN 50 mg/kg +RIPE), group 5 (GTN 100 mg/kg +RIPE) and group 6 (GTN 200 mg/kg +RIPE). After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly (p<0.01) decreased body weight and significantly (p<0.01) increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly (p<0.001) increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased (p<0.001) in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mg/kg +RIPE and GTN 200 mg/kg +RIPE-treated rats at p<0.05 and p<0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mg/kg +RIPE, GTN 100 mg/kg +RIPE and GTN 200 mg/kg +RIPE-treated rats at p<0.05, p<0.01 and p<0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86171729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental intervertebral disc degeneration models 实验性椎间盘退变模型

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.29

O. Sönmez, Ayşe İkinci Keleş

引用次数: 0

Lumbosacral transitional vertebrae: An overlooked cause of back pain on MRI 腰骶过渡椎:MRI上被忽视的背痛原因

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.13

Gamze Türk, M. Bilgili, A. Açan, A. Koç

{"title":"Lumbosacral transitional vertebrae: An overlooked cause of back pain on MRI","authors":"Gamze Türk, M. Bilgili, A. Açan, A. Koç","doi":"10.52142/omujecm.40.1.13","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.13","url":null,"abstract":"To evaluate the frequency of lumbosacral transitional vertebrae (LSTV) on MRI in patients with backpain and clinically suspected of sacroiliitis. Sacroiliac MRI of patients who had backpain and were clinically suspicious for sacroiliitis between November 2021-March 2022 were retrospectively analyzed from the hospital database by two different radiologists. LSTV cases were identified and subgrouped according to Castellvi classification. Presence of sacroiliitis, degeneration and /or herniation of cranial segment intervertebral disc, facet joint hypertrophy, coxarthrosis and psoas atrophy were recorded. In cases where radiologists were in conflict, consensus was made. Between November 2021-March 2022, 614 sacroiliac MRIs were obtained and 81 (13%) had LSTV. Fifty-nine patients were female (72.8%). Mean age was 43.4. The most common identified LSTV was type 1a (n=30, 10 right-sided, 20 left-sided). Sacroiliitis was significantly more common in younger patients (p=0.04) and in males (p=0.009). Disc degeneration, disc herniation, facet joint hypertrophy and psoas atrophy increased significantly with age (p=0.007, p=0.001, p=0.002 and p=0.013 respectively). No correlation was found between gender or presence of sacroiliitis and any type of LSTV.LSTV may present with backpain and should be considered in patients where sacroiliitis is clinically suspected. MRI is a useful tool to identify other accompanying pathologies in these cases.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curative breast cancer surgery with local anesthesia 局部麻醉治疗乳腺癌手术

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.36

Yasin Dalda, Özlem Dalda, D. Baskiran, F. Gönültaş

引用次数: 0

Relationship between psychiatric symptoms, childhood traumas, and types of crime of convicts in Elazig closed prisons 埃拉兹格封闭式监狱罪犯精神症状、童年创伤与犯罪类型的关系

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.20

Şüheda Kaya, Gulay Tasci, Nulufer Kilic, Bahadır Demir, Filiz Özsoy

{"title":"Relationship between psychiatric symptoms, childhood traumas, and types of crime of convicts in Elazig closed prisons","authors":"Şüheda Kaya, Gulay Tasci, Nulufer Kilic, Bahadır Demir, Filiz Özsoy","doi":"10.52142/omujecm.40.1.20","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.20","url":null,"abstract":"Our study aimed to examine the childhood traumas and psychiatric symptoms of prisoners and their relationship with crime types. Persons convicted in Elazig Penitentiary Institutions were included in the study. The Demographic and Clinical Evaluation Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Childhood Trauma Questionnaire (CTQ) and Symptom Checklist (SCL-90) were administered to all participants. A total of 370 people were included in the study. For prisoners who have been imprisoned before, CTQ-physical abuse, BAI, SCL-90-somatization, anxiety, and hostility subscale scores were higher than those who entered the prison for the first time (p values: 0.020, 0.003, 0.016, 0.017, 0.047, respectively). Prisoners with a family history of prison entry had higher SCL-90 test all subscale scores, total scores and CTQ physical abuse subscale scores than the group without a family history of prison entry. Those exposed to violence in childhood and those who had attempted suicide before had higher scores on all scales. Those with a history of alcohol and substance use had higher total scores on the CTQ-emotional abuse and sexual abuse scale. According to the type of crime committed, only the CTQ-sexual abuse subscale scores differed. These subscale scores of the prisoners involved in more than one crime were higher than those involved in a single crime (p=0.030). The CTQ-sexual abuse subscale scores of those who were involved in the crime of willful homicide were calculated to be high (p=0.030). It was thought that preventing abuse, violence, and traumas in childhood may be necessary in reducing the tendency to crimes.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83743429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0