Tokai Journal of Experimental and Clinical Medicine最新文献_第6页

The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma 晚期喉癌全喉切除术患者术前炎性指标的价值

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.22

M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür

{"title":"The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma","authors":"M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür","doi":"10.52142/omujecm.40.1.22","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.22","url":null,"abstract":"The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89604013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From laboratory studies to clinical applications mesenchymal stem cells in cancer treatment: Translational oncology 从实验室研究到临床应用间充质干细胞在癌症治疗:转化肿瘤学

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.32

M. Yüce

引用次数: 0

Impact of an HPV diagnosis on the psychosexual sphere HPV诊断对性心理领域的影响

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.18

E. Keleş, U. Öztürk, C. Alınca, Damla Yücel, M. Api, K. N. Baydili

{"title":"Impact of an HPV diagnosis on the psychosexual sphere","authors":"E. Keleş, U. Öztürk, C. Alınca, Damla Yücel, M. Api, K. N. Baydili","doi":"10.52142/omujecm.40.1.18","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.18","url":null,"abstract":"We aimed to evaluate the psychosexual impact of being diagnosed with human papillomavirus (HPV). A cross-sectional study was conducted to assess the anxiety and depression levels and sexual functions in women with and without HPV between March and May 2021. Beck anxiety inventory (BAI), the Beck depression inventory (BDI), and the Libido scoring system scales (LSSS) were used as scales. A total of 575 respondents were included; 292 (50.2%) HPV-negative, and 283 (49.8%) HPV-positive, of whom 170 (60,1%) had high risk HPV genotypes 16/18 and 113 (39,9%) had non-16/18 high risk HPV-positive patients. There was no significant association between HPV-negative and HPV-positive patients in terms of sociodemographic characteristics. While 21.6% of the HPV-positive group experienced masturbation, it was 15.1% in the HPV-negative group (p=0.044). While severe depression was 4.9% in HPV-positive women, this rate was 1.4% in HPV-negative women (p=0.002). The present study showed that being diagnosed with HPV made a significant difference in sexual function, except for sexual interest, but increased anxiety and depression scores. Sexual dysfunction following an HPV diagnosis cannot be explained solely by depression and anxiety.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76678126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries 谷胱甘肽对大鼠卵巢缺血再灌注损伤的保护作用

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.1

Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar

{"title":"Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries","authors":"Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar","doi":"10.52142/omujecm.40.1.1","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.1","url":null,"abstract":"We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83817923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of chamomile on nausea and vomiting after laparoscopic cholecystectomy: A triple-blind randomized clinical trial 甘菊对腹腔镜胆囊切除术后恶心呕吐的影响:一项三盲随机临床试验

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.7

Soheila BAKHTIARI, Gholamreza KHALILI, Razieh Salimi ZADAK

{"title":"The effect of chamomile on nausea and vomiting after laparoscopic cholecystectomy: A triple-blind randomized clinical trial","authors":"Soheila BAKHTIARI, Gholamreza KHALILI, Razieh Salimi ZADAK","doi":"10.52142/omujecm.40.1.7","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.7","url":null,"abstract":"The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergencies in movement disorders 运动障碍的紧急情况

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.30

D. Aygün, Murat Polat

引用次数: 0

SCUBE-1 as a novel predictor of thromboembolic event SCUBE-1作为一种新的血栓栓塞事件预测因子

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.40

H. Akça

引用次数: 0

Comparison of depression and anxiety in inflammatory bowel patients treated with anti-TNF or immune modulators 抗肿瘤坏死因子或免疫调节剂治疗炎性肠患者抑郁和焦虑的比较

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.10

Esra Çataltepe, Nergiz Ekmen, M. Cindoruk

{"title":"Comparison of depression and anxiety in inflammatory bowel patients treated with anti-TNF or immune modulators","authors":"Esra Çataltepe, Nergiz Ekmen, M. Cindoruk","doi":"10.52142/omujecm.40.1.10","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.10","url":null,"abstract":"The aim of this study was to investigate patients diagnosed with inflammatory bowel disease (IBD), the effects of drug groups used in the treatment of inflammatory bowel disease on depression and anxiety. This study was a single-center prospective study involving 94 patients with inflammatory bowel disease, 51 of whom had ulcerative colitis (UC) and 43 had Crohn's disease (CD). Harvey-Bradshaw activity scores for CD and Mayo Clinic activation scores for UC were calculated. Depression and anxiety data were collected with the Beck Depression Inventory and Beck Anxiety Inventory. The mean age for UC and CD were 40.25 ± 14 and 38.9 ± 13.8 years, respectively. There was a positive correlation between disease activation and depression and anxiety levels in both IBD subgroups (p<0.05). All patients included in the study were compared in terms of depression and anxiety levels before and after treatment, and a statistically significant improvement was found with the remission of both ulcerative colitis and Crohn's disease (p<0.001). There was a significant difference in depression and anxiety levels before and after treatment according to treatment options (p<0.001). There is a positive relationship between the disease activation score and the level of depression and anxiety in IBD. Immunosuppressive and immunomodulatory drugs used in the treatment of IBD may also improve the parameters of depression and anxiety in this disease.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76172582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post arrest bispectral index monitoring 逮捕后双谱指数监测

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.35

S. Özdemir, Oktay Öcal, Hasan Demi̇r, Yasin Metiner, Tuba Ci̇mi̇lli̇, Aysel Hünük, Özge Ecmel Onur

引用次数: 0

Overview of hematopoietic stem cell transplantation 造血干细胞移植综述

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI: 10.52142/omujecm.40.1.27

Neslihan Meriç

引用次数: 0