Tokai Journal of Experimental and Clinical Medicine最新文献

Relationship Between Lung Sound Power and Factors Related to the Onset of Asthma in Three-year-old Children. 三岁儿童肺声功率与哮喘发病相关因素的关系

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Masanori Ishimaru, Hiroyuki Mochizuki, Takashi Sakama, Fumio Niimura, Hiroyuki Furuya, Masahiko Kato, Yoshiyuki Yamada, Atsushi Uchiyama

{"title":"Relationship Between Lung Sound Power and Factors Related to the Onset of Asthma in Three-year-old Children.","authors":"Masanori Ishimaru, Hiroyuki Mochizuki, Takashi Sakama, Fumio Niimura, Hiroyuki Furuya, Masahiko Kato, Yoshiyuki Yamada, Atsushi Uchiyama","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Childhood asthma can lead to chronic obstructive pulmonary disease in adults, thus necessitating an early diagnosis and timely intervention from early childhood.Methods: A retrospective study was conducted on parameters related to lung sound power in three-year-old healthy children. All cases were surveyed using the ATS-DLD questionnaire, which mainly covered items related to the history of wheezing, diagnosis of asthma/asthmatic bronchitis, and history of allergies, and then lung sounds were measured. From these data, the characteristics of inspiratory and expiratory sound power at this age were examined.Results: There were correlations between the parameters related to lung sound power at the low- and middle-range frequencies. In addition, children with a history of wheezing or diagnosed with asthma/asthmatic bronchitis showed an increase in the power of inspiratory and expiratory sounds and the power ratio of inspiratory and expiratory sounds compared with children without such histories. Furthermore, the parameters of lung sound power correlated with those of the inspiratory sound spectrum.Conclusions: Measurements of the power of inspiratory and expiratory sounds confirmed that three-year-old children with a history of wheezing or diagnosed asthma/asthmatic bronchitis had characteristic lung sounds even when healthy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary Aplastic Anemia During Osimertinib Treatment for Lung Adenocarcinoma: A Case Report. 奥西替尼治疗肺腺癌期间继发性再生障碍性贫血1例报告。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Takahisa Takihara, Ryujiro Hara, Nanami Tsuchiya, Mari Takahashi, Keito Enokida, Kozaburo Sadahiro, Masatoshi Yamada, Koichiro Asano

引用次数: 0

Clinical and Histopathological Findings of Six Cases of Intravascular Large B-cell Lymphoma Diagnosed from 161 Random Skin Biopsy Cases. 161例随机皮肤活检中6例血管内大b细胞淋巴瘤的临床和病理分析。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Tomomichi Shimizu, Fumikazu Yamazaki, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Shiori Matsumoto, Reiko Saito, Akio Kondoh, Tomotaka Mabuchi

{"title":"Clinical and Histopathological Findings of Six Cases of Intravascular Large B-cell Lymphoma Diagnosed from 161 Random Skin Biopsy Cases.","authors":"Tomomichi Shimizu, Fumikazu Yamazaki, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Shiori Matsumoto, Reiko Saito, Akio Kondoh, Tomotaka Mabuchi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Intravascular large B-cell lymphoma is a rare type of extranodal lymphoma that has an aggressive and sometimes fatal course. Early diagnosis is necessary to improve the prognosis, but very few studies have reported random skin biopsies comparing positive and negative patients.Methods: A total of 161 patients with malignant lymphoma in the differential diagnosis underwent random skin biopsies. Their clinical presentations included fever, night sweats, and unintentional weight loss. Their laboratory and radiological findings were evaluated.Results: Six patients were diagnosed with intravascular large B-cell lymphoma, 12 patients were diagnosed with other malignant lymphomas, and the remainder were diagnosed with other diseases. Patients who were diagnosed with intravascular large B-cell lymphoma had a tendency to have B symptoms (p = 0.046), include senile/cherry angioma(s) at the sites of random skin biopsies (p = 0.040), and have thrombocytopenia (p = 0.009).Conclusions: Patients with intravascular large B-cell lymphoma who have B symptoms and thrombocytopenia tend to be easily diagnosed. In cases with these manifestations, random skin biopsy is recommended, if the patients do not have hemophagocytic lymphohistiocytosis.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Squamous Cell Carcinoma Secondary to Chronic Graft-versus-host Disease: Report of Three Cases. 慢性移植物抗宿主病继发口腔鳞状细胞癌3例报告

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Mebae Ichikawa, Takayuki Aoki, Yusuke Kondo, Yasutaka Hoshimoto, Shohei Seta, Masahiro Uchibori, Masashi Sasaki, Yoshihide Ota

引用次数: 0

A Case of Pleomorphic Carcinoma of the Lung Complicated by Anti-HMGCR Antibody-Positive Necrotizing Myositis. 多形性肺癌合并抗hmgcr抗体阳性坏死性肌炎1例。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Kozaburo Sadahiro, Katsuyoshi Tomomatsu, Masami Ishimaru, Tomoe Takeuchi, Tomohiro Yoshikawa, Yukihiro Horio, Takahisa Takihara, Naoki Hayama, Yoko Ito, Atsushi Mizuma, Tsuyoshi Oguma, Koichiro Asano

{"title":"A Case of Pleomorphic Carcinoma of the Lung Complicated by Anti-HMGCR Antibody-Positive Necrotizing Myositis.","authors":"Kozaburo Sadahiro, Katsuyoshi Tomomatsu, Masami Ishimaru, Tomoe Takeuchi, Tomohiro Yoshikawa, Yukihiro Horio, Takahisa Takihara, Naoki Hayama, Yoko Ito, Atsushi Mizuma, Tsuyoshi Oguma, Koichiro Asano","doi":"","DOIUrl":"","url":null,"abstract":"A 72-year-old man presented with a four-month history of muscle weakness and pain. Serum creatine kinase level was markedly elevated at 22,720 IU/mL, and magnetic resonance imaging revealed high signal intensity in the thigh and upper arm muscles. The presence of an autoantibody against 3-hydroxy-3-methylglutaryl-coA reductase (HMGCR) in the serum confirmed the diagnosis of immune-mediated necrotizing myositis. Subsequent systemic examination revealed primary lung carcinoma in the right lower lobe. Despite the initial corticosteroid therapy, there was no improvement in muscle symptoms. Surgical resection of the tumor, followed by additional intravenous immunoglobulin therapy, controlled necrotizing myositis. The postoperative pathological diagnosis was pleomorphic carcinoma. Despite adjuvant chemotherapy, lung cancer recurred within six months, leading to the patient's death. This case suggests that while treatment of malignancy can be effective for tumor-associated syndromes, such as anti-HMGCR antibody-positive necrotizing myositis, immunosuppressive therapy used for myositis may be a ssociated with an increased r isk of cancer recurrence.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Home-Visit Nursing for Individuals with Mental Disorders and Physical Complications in Japan: A Focus Group Study. 日本精神障碍和身体并发症患者家访护理的挑战：焦点小组研究。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Natsuko Ogino, Takahiro Kikkawa

{"title":"Challenges in Home-Visit Nursing for Individuals with Mental Disorders and Physical Complications in Japan: A Focus Group Study.","authors":"Natsuko Ogino, Takahiro Kikkawa","doi":"","DOIUrl":"","url":null,"abstract":"Objective: In Japan, many individuals with mental disorders require long-term hospitalization. However, to promote community integration and enable these individuals to live comfortably in their local areas, mental and physical care provided by nurses is essential. Therefore, this study aimed to examine the status of home-visiting health professionals and determine the challenges in providing support to patients with physical and mental health problems.Methods: Focus group interviews with 30 professionals from eight home-visit nursing stations were conducted and analyzed using thematic analysis.Results: The difficulties in providing physical care to patients with mental illness were categorized into three themes: (1) \"fragmentation of healthcare, isolation, and adverse effects of long-term retention,\" arising from non-integrated medical care for individuals with mental disorders; (2) \"background of patients that makes it difficult to participate in physical healthcare,\" stemming from mental symptoms or the patient's own perception; and (3) \"loneliness of the patients concerned and lack of security in medical care\".Conclusion: The results showed that Japanese home-visiting health professionals faced several challenges in providing physical care to individuals with mental disorders. To improve patient care, this study suggests that societal efforts addressing the identified challenges are necessary.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide Online Stress Survey of 100,000 People in Japan. 对日本10万人进行的全国在线压力调查。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Yuki Matsuki, Takashi Haruki, Kei Mizuno, Yasuyoshi Watanabe, Hideki Katano, Hideaki Matsuki

{"title":"Nationwide Online Stress Survey of 100,000 People in Japan.","authors":"Yuki Matsuki, Takashi Haruki, Kei Mizuno, Yasuyoshi Watanabe, Hideki Katano, Hideaki Matsuki","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The purpose of this study was to obtain basic data for stress management by clarifying the current state of stress among the general public and how they cope with stress.Method: An online survey was conducted on 100,000 men and women registered with an online survey company.Results: Respondents with stress test scores of 77 or more were classified as the high-stress group and those with scores below 77 were classified as the non-high-stress group. The proportion of men and women in the high-stress group was 14.8% and 17.7%, respectively. By age, the proportion of men and women in their 20s and 30s was significantly higher than other age groups. For both men and women, the most common ways to deal with stress were \"sleeping\" and \"bathing.\" In the high-stress group, the most common ways to deal with stress were \"receiving chiropractic massage\" for men and \"spending time in the bathroom\" for women. A binomial logistic regression analysis revealed that factors influencing the high-stress group included \"short sleep time,\" \"long working hours,\" and \"low household income.\"Conclusions: The stress factors and coping methods revealed in this study are considered to be important health issues for the entire nation, and we believe that this report will contribute to preventive medicine and public health, which aim to reduce stress among the general public.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial Anomalous Pulmonary Venous Return in Lung Cancer Surgery: Diagnostic Challenges and Surgical Considerations in Two Cases. 肺癌手术中部分肺静脉异常回流：两例诊断挑战和手术考虑。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Hajime Watanabe, Tomoki Nakagawa, Shunsuke Yamada, Ryota Masuda

{"title":"Partial Anomalous Pulmonary Venous Return in Lung Cancer Surgery: Diagnostic Challenges and Surgical Considerations in Two Cases.","authors":"Hajime Watanabe, Tomoki Nakagawa, Shunsuke Yamada, Ryota Masuda","doi":"","DOIUrl":"","url":null,"abstract":"Partial anomalous pulmonary venous return (PAPVR) is a rare congenital anomaly in which one or more pulmonary veins drain into the systemic venous system instead of the left atrium, in the absence of associated cardiac defects such as atrial septal defect. When only a single anomalous pulmonary vein is involved, the resulting shunt volume is typically small, allowing asymptomatic progression into advanced age. Consequently, such cases are often incidentally diagnosed or remain undetected. We report herein two cases of PAPVR that required pulmonary resection for primary or metastatic lung cancer. In Patient 1, PAPVR was successfully identified preoperatively using three-dimensional computed tomography in the lobe with cancer, enabling appropriate surgical planning for lobectomy. In Patient 2, segmentectomy was performed to preserve lung function: PAPVR was not recognized preoperatively on conventional two-dimensional computed tomography but only identified postoperatively, in a different lobe to the one with cancer. A deliberate awareness of the possible presence of PAPVR and accurate identification of PAPVR before surgery are essential in patients undergoing pulmonary resection. Segmentectomy may be a viable surgical option in select cases complicated by PAPVR because it potentially minimizes the reduction in pulmonary blood flow while preserving lung function.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment Outcomes of Durvalumab Combination Therapy in Patients with Biliary Tract Cancer. Durvalumab联合治疗胆道癌患者的治疗结果。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Hiroyuki Ito, Seiichiro Kojima, Yousuke Tazawa, Yuji Omura, Toru Yamaguchi, Tsubomi Cho, Shihou Yoshihara, Junko Nagata, Shunji Hirose, Toshihito Ogasawara, Hideki Izumi, Junichi Kaneko, Takayoshi Suzuki

引用次数: 0

Case of a Cesarean Scar Pregnancy Resulting in a Live Birth After in Vitro Fertilization. 剖宫产瘢痕妊娠导致体外受精后活产一例。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Kenji Izumi, Yuki Kuriyama, Rie Nakajima, Masaru Hayashi, Kanako Mitsuzuka, Kenji Sato, Hitoshi Ishimoto

{"title":"Case of a Cesarean Scar Pregnancy Resulting in a Live Birth After in Vitro Fertilization.","authors":"Kenji Izumi, Yuki Kuriyama, Rie Nakajima, Masaru Hayashi, Kanako Mitsuzuka, Kenji Sato, Hitoshi Ishimoto","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cesarean scar pregnancy (CSP) is a rare form of ectopic pregnancy in which a fertilized embryo implants into the cesarean section scar on the anterior uterine wall. CSP occurs more frequently after assisted reproductive technology (ART) than after spontaneous conception; therefore, understanding the relation between ART and CSP is crucial for appropriate pregnancy management. Because CSP may lead to severe complications, termination of pregnancy during the first trimester is often selected. However, when continuation of the pregnancy is desired, management becomes challenging.Case: We report a case of CSP following in vitro fertilization and embryo transfer. The patient chose to continue the pregnancy. Magnetic resonance imaging at 19 weeks and 1 d revealed findings suggestive of placenta accreta (also referred to as placenta creta) at the cesarean scar site. Magnetic resonance imaging at 29 weeks and 1 d showed complete replacement of the anterior myometrium by the placenta. At 32 weeks and 3 d, an elective cesarean section and total hysterectomy with bilateral salpingectomy were performed under multidisciplinary management. The placenta was completely attached to the scar area but did not invade adjacent organs, confirming placenta accreta. Both maternal and neonatal outcomes were favorable.Conclusion: Despite high risks associated with continuing a CSP pregnancy, outcomes can be favorable when management is carefully planned and individualized. Given the increasing prevalence of ART, clinicians should remain aware of the risk of CSP in patients with prior cesarean delivery and focus on early recognition, comprehensive imaging evaluation, and personalized management strategies to ensure optimal maternal and neonatal outcomes.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"51 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0