Clinical and Histopathological Findings of Six Cases of Intravascular Large B-cell Lymphoma Diagnosed from 161 Random Skin Biopsy Cases.

Q3 Medicine

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2026-04-20

Tomomichi Shimizu, Fumikazu Yamazaki, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Shiori Matsumoto, Reiko Saito, Akio Kondoh, Tomotaka Mabuchi

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引用次数: 0

Abstract

Objective: Intravascular large B-cell lymphoma is a rare type of extranodal lymphoma that has an aggressive and sometimes fatal course. Early diagnosis is necessary to improve the prognosis, but very few studies have reported random skin biopsies comparing positive and negative patients.

Methods: A total of 161 patients with malignant lymphoma in the differential diagnosis underwent random skin biopsies. Their clinical presentations included fever, night sweats, and unintentional weight loss. Their laboratory and radiological findings were evaluated.

Results: Six patients were diagnosed with intravascular large B-cell lymphoma, 12 patients were diagnosed with other malignant lymphomas, and the remainder were diagnosed with other diseases. Patients who were diagnosed with intravascular large B-cell lymphoma had a tendency to have B symptoms (p = 0.046), include senile/cherry angioma(s) at the sites of random skin biopsies (p = 0.040), and have thrombocytopenia (p = 0.009).

Conclusions: Patients with intravascular large B-cell lymphoma who have B symptoms and thrombocytopenia tend to be easily diagnosed. In cases with these manifestations, random skin biopsy is recommended, if the patients do not have hemophagocytic lymphohistiocytosis.

本刊更多论文

161例随机皮肤活检中6例血管内大b细胞淋巴瘤的临床和病理分析。

目的：血管内大b细胞淋巴瘤是一种罕见的结外淋巴瘤，具有侵袭性，有时可致死性。早期诊断对于改善预后是必要的，但很少有研究报道随机皮肤活检比较阳性和阴性患者。方法：对161例鉴别诊断为恶性淋巴瘤的患者进行随机皮肤活检。他们的临床表现包括发烧、盗汗和无意中体重减轻。对他们的实验室和放射检查结果进行了评估。结果：6例患者诊断为血管内大b细胞淋巴瘤，12例患者诊断为其他恶性淋巴瘤，其余患者诊断为其他疾病。被诊断为血管内大B细胞淋巴瘤的患者倾向于出现B症状（p = 0.046），包括随机皮肤活检部位的老年性/樱桃血管瘤（p = 0.040）和血小板减少症（p = 0.009）。结论：血管内大B细胞淋巴瘤伴B症状及血小板减少者易确诊。在有这些表现的病例中，如果患者没有噬血细胞性淋巴组织细胞增多症，建议随机进行皮肤活检。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.