Tokai Journal of Experimental and Clinical Medicine最新文献

{"title":"Brain imaging findings of methanol poisoning and detection of chronic stage nervous system damage: A case report","authors":"Fatma Yılmaz Can, M. F. Öztekin","doi":"10.52142/omujecm.40.1.33","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.33","url":null,"abstract":"In this article, we presented the chronic neurological findings of an acute case of methanol intoxication due to the use of homemade alcohol. In the neurological examination performed 6 months after intoxication, bilateral vision loss, tremor, dysarthria, dysphagia, loss of taste sensation, and decrease in the Cognitive State Test score were detected. Peripheral polyneuropathy consistent with axonopathy was detected in the peripheral nerve conduction study, and optical neuropathy was detected in the examination of the pattern visual evoked potential. Brain magnetic resonance imaging revealed findings compatible with bilateral putaminal necrosis.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80688914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of kinesio taping versus extracorporeal shock wave therapy in the short term for the calcaneal spur","authors":"Nurten NAS KIRDAR, Tuba Kanyılmaz","doi":"10.52142/omujecm.40.1.12","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.12","url":null,"abstract":"The calcaneal spur is a common cause of heel pain, and there are various approaches to its treatment. Our aim in this study is to investigate the effectiveness of kinesio taping against Extracorporeal Shock Wave Therapy (ESWT) in the treatment of calcaneal spur. This study was designed as a randomized controlled, prospective and single-center clinical trial. A total of 93 patients with calcaneal spur (18 men, 75 women) were included. Patients were divided into two groups (based on gender, age, BMI, and pain duration) by stratified randomization (kinesio tape group=46, ESWT group=47 patients). 3 sessions of ESWT were applied to the heels of the patients in the 1st group with an interval of 1 week. Kinesio taping was applied to the 2nd group. It was applied once a week, for 3 weeks. Visual Analogue Scale (VAS) and Foot Function Index (FFI) scores of the patients in both groups before the treatment and 1 week after the end of the treatment were recorded. When we evaluated the pre-treatment and post-treatment parameters, we found a significant decrease in VAS, FFI-pain, FFI-disability and FFI-activity restriction scores in both groups (p=0.0001). We also found that kinesio taping was more effective than ESWT in reducing FFI-pain (for after treatment FFI-pain inter group p=0.005, for FFI-pain difference inter group p=0.002) and FFI-disability (for after treatment FFI-disability inter group p=0.023, for FFI-disability difference inter group p=0.0001) scores. To conclude, although both kinesio taping and ESWT treatments reduced patients' pain, disability and activity limitation, kinesio taping was found to be more effective in reducing pain and disability. Studies with longer follow-up are needed to clarify our results.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85527589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anxiety, depression, and quality of life of husbands of women with and without breast cancer","authors":"F. Vizeshfar, F. Dehghanrad, M. Magharei","doi":"10.52142/omujecm.40.1.4","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.4","url":null,"abstract":"The aim of this study was to compare the anxiety, depression, and quality of life of husbands of women with breast cancer referred to the chemotherapy clinic with husbands of non-affected wives. This was a case-control study, with purposive-convenience sampling method. 190 husbands of patients with or without breast cancer participate in this study. Data collection tools included a four-part questionnaire, consisted of demographic characteristics, shortened form of quality of life questionnaire, Beck depression inventory, and Beck anxiety inventory. In the areas of social relations and living environment (QolD3, QolD4), a statistically significant difference was found between the two groups in quality of life (p-value < 0.001). Pearson correlation coefficient showed a statistically significant difference in the case group between the history of chemotherapy and mean anxiety score (p-value < 0.001), and quality of life with number of children (p-value < 0.002). The findings of this study showed that in addition to giving attention to the patients, attention to health needs and quality of life of their spouses is also a priority.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89120456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of complete blood count parameters according to blood type and smoking","authors":"H. İnci","doi":"10.52142/omujecm.40.1.8","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.8","url":null,"abstract":"In this study, it was aimed to investigate the change in the parameters of complete blood count depending on blood type and smoking status. The individuals were grouped according to their blood group type and status of cigarette use, and the statistical differences in their levels of Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), and Mean Platelet Volume/Lymphocyte ratio (MPVLR) were evaluated.3119 individuals participated in the study. 26.67% of them were smokers. According to the ABO blood group system, 44.47% of the participants had type A, 32.48% had type O, 16.09% had type B, and 6.96% had type AB. 88.81% of the participants were Rh(+) and 11.19% of them were Rh(-). The NLR, PLR, and MPVLR of the smokers were higher than those of the non-smokers. The participants’ NLR, PLR, and MPVLR levels showed statistically significant differences depending on ABO and Rh blood groups. This difference was seen to arise from ARh (+) individuals. The NLR, PLR, and MPVLR levels were the highest in ARh (+) individuals and the lowest in the ABRh (-) individuals. The NLR, PLR, and MPVLR values were the highest in the ARh (+) smokers and the lowest in ABRh (-) non-smokers. It was found that there were significant differences in the participants’ blood count parameters depending on blood type and smoking status. This may imply that ARh (+) individuals who smoke have higher parameters than those who have other blood groups and do not smoke, which may be beneficial in predicting the risk of chronic inflammation-related diseases.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72398933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patients admitted to the emergency department after Coronavac (Sinovac) vaccination?","authors":"B. Taşlıdere, Ertan Sönmez, S. Özdemir","doi":"10.52142/omujecm.40.1.17","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.17","url":null,"abstract":"To evaluate the symptoms and laboratory parameters of patients admitted to the emergency department after CoronaVac (Sinovac) vaccination. Complaints, demographic characteristics, laboratory tests, interventions, and outcomes of patients admitted to the emergency department within seven days of receiving the CoronaVac (Sinovac) were all evaluated. Pain at the injection site, swelling, redness, and pain in the injected arm were expected side effects of the vaccination. In this study, a total of six people had syncope following the vaccination, one of whom developed an allergic reaction. The most common adverse events in non-geriatrics were fatigue, headache, fever, and abdominal pain, while in geriatric patients’ fatigue, headache, chest pain, and dyspnea were most common, with fever falling in the last place. Rare symptoms following vaccination included syncope and urticaria. It is necessary to be prepared for the side effects that may occur during mass vaccination against COVID-19. In this study, the body’s response to the vaccine in geriatric patients was atypical in vital signs and laboratory values.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"347 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77704030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The investigation of concomitant dermal and oral lichen planus in patients referred to Zahedan University centres","authors":"T. Nosratzehi, A. Payandeh, Atefeh Nosratzehi","doi":"10.52142/omujecm.40.1.11","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.11","url":null,"abstract":"Lichen planus (LP) is a common chronic immunologic inflammatory epidermal and mucocutaneous disorder involving skin, oral mucosa and both sometimes, the main cause of which is still unknown. Due to the importance and its prevalence, this study was carried out in order to assess the association of oral and dermal lesions in patients referring to Dermatology Clinic and Department of Oral and Maxillofacial Diseases, Zahedan Dental School. In this descriptive study, a total of 99 patients with individual involvement of LP in skin or mucosa were selected among 6510 patients referring to Dermatology Clinic and Department of Oral and Maxillofacial Diseases, Zahedan Dental School. The selected cases were subjected to further and exact clinical examination along with interview, while in suspected lesions, the conducted histopatologic tests obtained by biopsy were used for the evaluation. A questionnaire was completed for each patient after taking history and physical examination, including history of systemic diseases, interacting medication, smoking habits, presence of oral and dermal lesions, the onset of mucosal and skin lesions and the treatment period, oral lesions signs and the patients complaint, involvement location, form, manner of distribution, oral lesion history as well as existence of amalgam restorations alongside the lesion chi-square used to assess differences for variables. The study revealed 38 percent association of oral and dermal lesions in the study population, while individual oral lesion was observed in 60.6 percent of patients and individual dermal lesions in 39.3 percent. The most reported symptom of oral lichen planus in the study population was the Oral ulcer, while the buccal mucosa was the most common site of involvement and erosive form was the high prevalent. The most reported symptom of dermal lichen planus in the study population was the Itching, while the Simultaneous hand and foot conflict was the most common site of involvement and Papular form was the high prevalent. High incidence of dermal and oral lichen planus association revealed throughout the study calls the attention for complete systemic examinations of the patients. As this study was carried out in the dermatology clinic, it seems that other studies in dental schools as well as throughout the public will be of necessity and importance to verify the results. According to this study, there was not a significant statistical relationship between LP and other variables.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88532177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas9 system in hematopoietic stem cells: Basic research and clinical applications","authors":"Esra Albayrak","doi":"10.52142/omujecm.40.1.31","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.31","url":null,"abstract":"Clustered regularly interspaced short palindromic repeats (CRISPR) approach adapted from the prokaryotic adaptive immune system against to pathogen attack is so valuable and promising tool for treatment of human malignant and non-malignant hematological disease and disorders through genome editing in hematopoietic stem cells (HSCs). Moreover, CRISPR/Cas9 approach is not only useful for therapeutic purposes; it is considerably preferred for the generation of in vitro and in vivo animal disease models. CRISPR/Cas9 approach has been developed for highly efficient on-target cleavage, and low off-target effect via delivery systems and manipulation of CRISPR components including single guide RNA (sgRNA) and Cas enzymes. In this review, we focused on the CRISPR/Cas9 system applications on hematopoietic stem cells in basic research and clinical area with basic research and clinical perspectives.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73670521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of NO2 levels on mortality in four key cities of Türkiye between 2017-2019","authors":"Elif Nur Yıldırım Öztürk, Mustafa Öztürk","doi":"10.52142/omujecm.40.1.14","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.14","url":null,"abstract":"In this study, it was aimed to evaluate the NO2 levels in four key cities of Turkey (Istanbul, Ankara, Izmir and Bursa) over a three-year period and to examine the effect of NO2 on mortality. The research is of descriptive-ecological type. In the research, air quality (NO2), population and death data were needed for each city to cover the dates 01.01.2017-31.12-2019. In the research, 20 μg/m3 was accepted as the annual NO2 limit value. Numbers, percentages, mean, standard deviation, minimum and maximum values were used in summarizing data. Calculations related to mortality attributed to NO2-induced air pollution were made using the AirQ+ software’s own methodology. In 2019, 33 stations in Istanbul, 4 stations in Ankara, 5 stations in Izmir and 5 stations in Bursa were measuring NO2. In 2019, the weighted NO2 mean was 40.61 μg/m3 in Istanbul, 32.94 μg/m3 in Ankara, 7.87 μg/m3 in Izmir and 31.68 μg/m3 in Bursa. The estimated percentage of deaths attributed to NO2 in 2019 was 7.95 in Istanbul, 5.07 in Ankara and 4.58 in Bursa. Calculations for 2018 in Ankara and 2017, 2018 and 2019 in Izmir were not made because the NO2 levels in these cities were less than 20 μg/m3 in these years. As a result of the research, it was determined that the NO2 levels were higher than the limit value in three of the four key cities in Turkey and the mortality rates attributed to NO2 were found to be higher compared to similar studies in the literature.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88144976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical management during the pandemic period","authors":"E. Pala","doi":"10.52142/omujecm.40.1.38","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.38","url":null,"abstract":"We read with great interest the article titled \"Diagnostic Accuracy of Clinical Gestalt of Doctors with Different Experiences in COVID-19 Suspected Patients\" prepared by Özkan and published in the third issue of your journal in 2022. Thanks to the author and editorial board for this interesting and informative article. In addition, we would like to briefly touch on the parameters used in the perception of triage and patient management during the pandemic process.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87658785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemiplegia and oral health","authors":"Manolya Ilhanli, I. Ilhanli, P. Celenk","doi":"10.52142/omujecm.40.1.25","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.25","url":null,"abstract":"Oral health problems are often neglected due to other problems that are thought to be more vital in stroke patients. However, oral health is a significant quality of life determinant and needs to be protected in stroke patients as well as general population. Moreover, problems such as hemiparesis, hemiplegia, dysphagia, balance and coordination disorder and cognitive dysfunction due to strokes have a very negative impact on the self -care and/or care support of the caregivers. In this study, we aimed to search a large number of health databases and make a compilation on oral health problems, impact on quality of life and solutions in stroke patients. Keywords ‘oral, dental, health, care, hygiene, dental, prosthesis, denture, tooth brushing, stroke, cerebrovascular and cardiovascular’ and combinations of these words were searched in the literature. Studies involving at least one subject for oral health in stroke patients were included in the review. In the literature, it was seen that the oral health of the stroke patients was discussed more about mastication, swallowing, dysphagia, nutrition, hygiene, prosthesis and quality of life. It was concluded that there are no sufficient assessment and care guides that can be used by stroke patients or caregivers, and the information of dentists, patients and caregivers about special care for stroke patients was not sufficient.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90359059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}