SCUBE-1作为一种新的血栓栓塞事件预测因子

Q3 Medicine

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI:10.52142/omujecm.40.1.40

H. Akça

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引用次数: 0

摘要

SCUBE-1是一种新发现的分泌细胞表面蛋白，在胚胎发生早期确定。该蛋白由n端信号肽序列后的级联egf样重复序列、间隔区、富含半胱氨酸的重复基序和c端CUB结构域组成。这些分子储存在失活血小板中的α颗粒中，被凝血酶激活后转运到血小板表面，以可溶性小片段的形式分泌，并并入血栓。

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SCUBE-1 as a novel predictor of thromboembolic event

SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.