伊拉克妇女样本中KRAS基因表达与乳腺肿瘤的关系

Q3 Medicine

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-18 DOI:10.52142/omujecm.40.1.5

Roya H. AL-HADDAD, Hameed M. Jasim

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引用次数: 0

摘要

在伊拉克，乳腺癌被认为是造成妇女死亡的最普遍的癌症类型之一，原因是控制细胞生长和增殖的基因发生了变化。KRAS基因在30%的人类癌症中起作用。本研究旨在评估KRAS基因的表达及其在女性乳腺肿瘤中的作用。共有120名妇女(60名患有乳腺肿瘤的妇女和60名来自表面健康妇女的样本)参加了这项研究，以确定KRAS基因的表达。RT-qPCR用于此目的。纤维腺瘤(FA)是最常见的肿瘤，占53%，其次是纤维囊性变(26%)。其他良性肿瘤占20%;然而，IDC是最常见的浸润性乳腺癌类型，占所有乳腺癌的70%。此外，患有乳腺肿瘤(良性和恶性)的妇女的KRAS基因表达与正常健康妇女没有显著差异。

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The association between KRAS gene expression and breast tumors in a sample of Iraqi women

In Iraq, breast cancer is considered one of the most widespread cancer types causing death in women due to changes in the genes that control cell growth and proliferation. KRAS gene plays a role in 30% of human cancers. This study aims to evaluate the expression of the KRAS gene and its role in women with breast tumours. A total of 120 women (60 women with breast tumours and 60 samples from apparently healthy women) were enrolled in this study to determine the expression of the KRAS gene. The RT-qPCR was used for this purpose. Fibroadenoma (FA) was the most common tumours, accounting for 53% of cases, followed by fibrocystic change (26%). Other benign tumours accounted for 20% of the cases; however, IDC is the most common type of invasive breast cancer, accounting for 70% of all breast cancers. Moreover, KRAS gene expression in women with breast tumours (benign and malignant) was not- significantly different from that seen in normal healthy women.

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.