The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma

Abstract

The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.