2002 IEEE Nuclear Science Symposium Conference Record最新文献_第3页

CoALA-SPECT: a coded aperture laboratory animal SPECT system for pre clinical imaging CoALA-SPECT:用于临床前成像的编码孔径实验动物SPECT系统

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239505

S. Meikle, R. Wojcik, A. Weisenberger, M. Smith, S. Majewski, P. Kench, S. Eberl, R. Fulton, M. Lerch, A. Rosenfeld

{"title":"CoALA-SPECT: a coded aperture laboratory animal SPECT system for pre clinical imaging","authors":"S. Meikle, R. Wojcik, A. Weisenberger, M. Smith, S. Majewski, P. Kench, S. Eberl, R. Fulton, M. Lerch, A. Rosenfeld","doi":"10.1109/NSSMIC.2002.1239505","DOIUrl":"https://doi.org/10.1109/NSSMIC.2002.1239505","url":null,"abstract":"We have previously demonstrated the potential of multi-pinhole coded apertures when used in conjunction with compact pixelated detectors for high resolution, high sensitivity small animal SPECT. We are now constructing a prototype SPECT system with three such detectors mounted on a rotating gantry. Each detector comprises a 12 cm diameter circular array of NaI(Tl) crystals, each 1/spl times/1/spl times/5 mm/sup 3/ on a 1.25 mm pitch. Each crystal array is coupled to a Hamamatsu R3292 12.7 cm diameter PS-PMT. Signals from the three detectors are read out by a custom subtractive resistive circuit and multiplexed. Data are acquired by a National Instruments PCI-6110E board running on a Macintosh dual processor G4 computer under Kmax software control. Images are reconstructed using a 3D iterative MAP-EM algorithm based on a multi-pinhole forward and back projector. The trade-off between contrast and variance was studied by simulation for a number of multi-pinhole configurations. We also performed initial planar imaging studies on one of the detectors. Our results indicate that spatial resolution approaching 1 mm full width at half maximum (FWHM) can be achieved with a single pinhole aperture, while improved contrast and variance may result from using optimized multi-pinhole apertures.","PeriodicalId":385259,"journal":{"name":"2002 IEEE Nuclear Science Symposium Conference Record","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116461541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Transmission imaging and attenuation correction for the microPET/spl reg/ P4 tomograph 微pet /spl reg/ P4层析成像的透射成像和衰减校正

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239557

P. Chow, B. Bai, S. Siegel, R. Leahy, A. Chatziioannou

{"title":"Transmission imaging and attenuation correction for the microPET/spl reg/ P4 tomograph","authors":"P. Chow, B. Bai, S. Siegel, R. Leahy, A. Chatziioannou","doi":"10.1109/NSSMIC.2002.1239557","DOIUrl":"https://doi.org/10.1109/NSSMIC.2002.1239557","url":null,"abstract":"Imaging with Positron Emission Tomography (PET) requires compensation for attenuation of the annihilation photons in subject tissues. Although the magnitude of this correction for small subjects is significantly smaller than for humans, it Is important for a quantitatively accurate representation of the tracer distribution. Attenuation correction (AC) has been implemented on the Concorde microPET/spl reg/ P4 scanner using a Ge-68 point source (PS) that spirals through the field of view under computer control. Transmission (TX) scans of a rat-sized phantom were acquired with this PS and this tomograph by varying acquisition parameters including: acquisition mode (coincidence vs. singles), energy window, coincidence timing window, PS radius, PS activity, and acquisition time. We also evaluated the quality of post-injection TX images. Transmission data were processed by reconstruction of the log of the attenuation sinograms with 3D filtered backprojection. The attenuation coefficient images were subsequently analyzed with regions of interest in the uniform region of the phantom. Despite a significant amount of scatter contribution, singles data acquisition was found to have the best signal-to-noise ratio (SNR). We found that using higher PS activity or smaller PS radius resulted in a dramatic improvement in the SNR. A combination of both could lead to short acquisition times appropriate for TX imaging in a high throughput imaging facility. Attenuation correction sinograms were created by forward projecting through a smoothed TX image, in which the water-equivalent tissues were scaled to the appropriate /spl mu/-values. Noise levels in the corrected and uncorrected emission images indicate that no significant noise was introduced from the correction. A rat was imaged postinjection in the heart region. Singles TX images were used to create AC sinograms after emission contamination subtraction using a mock scan. The results are encouraging and demonstrate the feasibility of using PET TX images in AC.","PeriodicalId":385259,"journal":{"name":"2002 IEEE Nuclear Science Symposium Conference Record","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122340714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Transmission imaging with a compact gamma camera: initial results for mammotomography 用紧凑型伽马照相机透射成像:乳房x线摄影的初步结果

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239628

M. Tornai, Caryl N. Archer, J. Bowsher, R. L. McKinley, R. Jaszczak

引用次数: 4

Effect of Mg, Zr, Ta - doping on scintillation properties of Gd/sub 2/SiO/sub 5/:Ce crystal Mg、Zr、Ta掺杂对Gd/sub 2/SiO/sub 5/:Ce晶体闪烁性能的影响

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239276

S. Shimizu, K. Sumiya, H. Ishibashi, N. Senguttvan, B. Redkin, M. Ishii, M. Kobayashi, K. Susa, H. Murayama

引用次数: 4

Spectroscopy on thick HgI/sub 2/ detectors: a comparison between planar and pixelated electrodes 厚HgI/ sub2 /探测器的光谱学:平面电极和像素电极的比较

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239349

J. Baciak, Zhong He

引用次数: 26

Characteristics of a SrBPO/sub 5/:Eu/sup 2+/ material as a neutron storage phosphor SrBPO/ sub5 /:Eu/sup 2+/材料作为中子存储荧光粉的特性

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239353

K. Sakasai, M. Katagiri, K. Toh, H. Takahashi, M. Nakazawa, Y. Kondo

引用次数: 10

Model-based noninvasive estimation of arterial input function from dynamic H/sub 2//sup 15/O PET images 基于模型的动态H/sub /sup 15/O PET图像动脉输入函数无创估计

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239619

N. Kudomi, H. Watabe, K.M. Kim, T. Hayashi, K. Hayashida, H. Iida

{"title":"Model-based noninvasive estimation of arterial input function from dynamic H/sub 2//sup 15/O PET images","authors":"N. Kudomi, H. Watabe, K.M. Kim, T. Hayashi, K. Hayashida, H. Iida","doi":"10.1109/NSSMIC.2002.1239619","DOIUrl":"https://doi.org/10.1109/NSSMIC.2002.1239619","url":null,"abstract":"For the application of a kinetic model to PET data, it is necessary to obtain the arterial input function. Since arterial blood sampling is invasive and labor intensive, a method to evaluate the input function without arterial blood sampling is important. In case of the [/sup 15/O] water injection study, because of the noise in the time activity curve obtained from the PET reconstructed image round the carotid artery region, a model based evaluation method might be promised. In this study, a model function is composed or combination of blood time activity curve function and tissue time activity curve function which is generated from blood activity curve function. The present method was applied to 15 of dynamic PET scans or /sup 15/O water (10 normal subjects, 10 : Rest, and 5 : Diamox) for normal volunteers. The time activity curve obtained was fitted with the above model function. The shapes or input function obtained was in agreement with that by arterial blood sampling. The accuracy of height of the peak was 14 % and the accuracy of area under the curve was 10 %. This study supposed that present method could be used for direct extraction of the carotid artery input function from the dynamic PET image, and could be used in a quantitative CBF study using /sup 15/O water PET.","PeriodicalId":385259,"journal":{"name":"2002 IEEE Nuclear Science Symposium Conference Record","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122062521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of planar vs. SPECT images for lesion detectability 平面图像与SPECT图像病变可检测性的比较

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239657

E. S. Sørensen, G. L. Zeng, B. Holt, K. Scott, S. Karen, T. Ovard

{"title":"Comparison of planar vs. SPECT images for lesion detectability","authors":"E. S. Sørensen, G. L. Zeng, B. Holt, K. Scott, S. Karen, T. Ovard","doi":"10.1109/NSSMIC.2002.1239657","DOIUrl":"https://doi.org/10.1109/NSSMIC.2002.1239657","url":null,"abstract":"This research used computer simulation along with human observer studies to evaluate SPECT and planar imaging for lesion detection. The research initially focused on a simple computer simulated phantom consisting of a large sphere with a lesion placed inside at various depths. A constant lesion to background ratio of 8 to 1 was maintained throughout the trials. Two noise levels were simulated by varying the mean value of the sphere and lesion. Both planar and SPECT images were generated simulating a clinical scan time of 30 minutes. Results showed SPECT images consistently had higher contrast but also higher noise values than planar images. When the lesion was located near the center of the sphere the contrast-to-noise ratio was consistently higher in SPECT images. Research using a realistic computer model of the human torso along with realistic image acquisition and reconstruction techniques was then carried out. Planar images were generated with modeling attenuation, scatter and geometric point response. SPECT images were projected and then reconstructed with an OSEM algorithm accounting for attenuation, the scatter and the geometric point response of the collimator.","PeriodicalId":385259,"journal":{"name":"2002 IEEE Nuclear Science Symposium Conference Record","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122092848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Solid-state detector design for mobile cargo container inspection system using medium energy X-ray 中能x射线移动集装箱检测系统固态探测器设计

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239358

S. Kwak, K. H. Kim, G. Cho, Insu Kim, Y. Yi, B. Han, S. M. Goh

引用次数: 1

Projection data registration for gated cardiac SPECT reconstruction 门控心脏SPECT重建的投影数据配准

2002 IEEE Nuclear Science Symposium Conference Record Pub Date : 2002-11-10 DOI: 10.1109/NSSMIC.2002.1239609

G. L. Zeng, G. Gullberg, E. Debreuve

引用次数: 1