Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Actazin® green kiwifruit powder consumption at 600 mg per day for 28 days improves stool form and relieves occasional constipation in healthy individuals: A randomized controlled trial","authors":"Emma Graham ,&nbsp;Starin McKeen ,&nbsp;Erin D. Lewis ,&nbsp;Malkanthi Evans ,&nbsp;Zhaoping Li ,&nbsp;Susanne M. Henning ,&nbsp;Neville Jopson ,&nbsp;Jennifer Gu ,&nbsp;Doug Rosendale","doi":"10.1016/j.bcdf.2024.100436","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100436","url":null,"abstract":"<div><p>Constipation is a global issue which impacts quality of life. Kiwifruit promote laxation without the urgency induced by therapeutic laxatives. Actazin® is a skinless, seedless, cold-processed green kiwifruit powder previously shown to improve laxation at 2400 mg daily dosages. Here we investigated the laxation support provided by a 600 mg daily dosage of Actazin.</p><p>A randomized, double-blinded, placebo-controlled parallel study for 28 days across four North American sites (NCT03462199) enrolled 85 participants with non-pathological constipation who had ≤3 complete spontaneous bowel movements (CSBM) per week. Participants consuming Actazin reported improved Bristol stool form scores (BSFS) over placebo (p &lt; 0.05), improving the normality of stool form. Both Actazin and placebo showed improvements of &gt;1 CSBM per week over baseline (p &lt; 0.05). Actazin was safe and well tolerated by participants and resulted in changes (p &lt; 0.05) in the relative abundance of fecal bacterial taxa consistent with consumption of kiwifruit cell wall components.</p><p>This study demonstrated that once daily supplementation of 600 mg Actazin green kiwifruit powder resulted in clinically significant improvements in stool form and improved participant bowel habits in healthy individuals with occasional constipation. To the best of our knowledge this is the first recorded observation of this BSFS improvement over placebo by a kiwifruit product.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100436"},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141583008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches to pectin processing: Enhancing techno-functional properties for applications in food and beyond","authors":"Gurjeet Kaur ,&nbsp;Zakir Showat Khan ,&nbsp;Ömer Said Toker ,&nbsp;Mohmad Sayeed Bhat ,&nbsp;Bulent Basyigit ,&nbsp;Abdullah Kurt ,&nbsp;Sarvesh Rustagi ,&nbsp;Shweta Suri ,&nbsp;Samaneh Hatami ,&nbsp;Shemilah Fayaz ,&nbsp;Thameed Aijaz","doi":"10.1016/j.bcdf.2024.100437","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100437","url":null,"abstract":"<div><p>Pectin, a natural polysaccharide, has a great scope in food industries due to its valuable techno-functional characteristics including stabilization, gelation, and thickening and emulsification. To widen the applicability and address specific challenges associated with food formulations, there is a need to explore some promising techniques to further enhance its techno-functional properties. This review provides an overview of some novel approaches as well their combinations with other techniques to process pectin. Non-thermal techniques such as high-intensity ultrasound (HIU), high hydrostatic pressure processing (HHPP), pulsed electric field (PEF) are the commonly adopted which lead to pectin modification, promotion of enzymatic reactions and hence, improve weight distribution, gelation, emulsifying and rheological properties. Furthermore, use of combined HIU and Enzyme Systemhas emerged as a green and sustainable protocol which improves pectin solubilization and its better dispersion in food products. Apart from this, a controlled oxidation reaction known as Fenton system has been investigated for its scope in pectin modification either used individually or coupled with other methods. Thus, a deep insight of these techniques is need of hour to assist food processors in designing pectin based novel food products along with unlocking the primary factors to be considered and their optimization for future food developments.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100437"},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking analysis of Ficus religiosa L. fruit extracts with HMG-COA reductase inhibitors, anti-hyperlipidemic effects of its in Albino wistar rats, triggered by Triton-X 100 and High fat diet","authors":"Shivakumar Inamdar ,&nbsp;Makhmur Ahmad ,&nbsp;B. Tazneem ,&nbsp;Sana Hashmi ,&nbsp;Bhagyalakshmi Kulkarni ,&nbsp;Bander M. Aldhabi ,&nbsp;Ruqaiya Jamal ,&nbsp;Mohamad Taleuzzaman","doi":"10.1016/j.bcdf.2024.100429","DOIUrl":"10.1016/j.bcdf.2024.100429","url":null,"abstract":"<div><p>Hyperlipidemia is the major risk factor for coronary artery disease in various patients suffering with cardiovascular disorders. Literature claims that flavonoids and phenolic compounds are able to reduce hyperlipidemia. Aim of the present study is to establish antihyperlipidemic activity of <em>Ficus religiosa</em> L. fruits extract with molecular docking approach and perform in-vivo study.</p><p>Extraction has performed by Soxhlet apparatus with methanol for 72 h. Further, the extract has subjected to phytochemical tests followed by GC-MS analysis. Molecular docking study has been conducted to screening the compounds in extract which have affinity to HMG-COA reductase (PDB ID: 1HWK) receptor with reference to Atorvastatin. Anti-hyperlipidemic activity of the extract has investigated by studying in vivo effects on Triton-X 100 and High fat diet induced animal model. The animals were divided in 5 groups of 6 each. The extract has administered at a dose of 1000 mg/kg (p.o) and 500 mg/kg (p.o) to both models. Atorvastatin was used as standard.</p><p>The GC-MS result of <em>Ficus religiosa</em> L. fruits has demonstrated the presence of phenols, flavonoids. Molecular docking study has been performed to identify the anti-oxidant compounds in the extracts. The extract has shown a significant decrease in the levels of Body weight, serum cholesterol, glucose, triglyceride, LDL, VLDL and significant increase in the level of serum HDL. The result of the research has showed that <em>Ficus religiosa</em> L. fruits possess antihyperlipidemic activity in both groups; the results were statistically significant compared to Atorvastatin.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100429"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharides and atherosclerosis: Focus on the role of key genes of cholesterol metabolism in macrophages","authors":"Alexandra S. Utkina ,&nbsp;Vasily P. Karagodin ,&nbsp;Margarita A. Sazonova ,&nbsp;Shaw-Fang Yet","doi":"10.1016/j.bcdf.2024.100430","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100430","url":null,"abstract":"<div><p>Based on nutrigenomics approaches, the mechanisms of action of glucan on the accumulation and efflux of cholesterol from macrophages derived from the THP-1 cell line were studied. At the first stage, it was established that glucan does not have the ability to inhibit the accumulation of Cholesterol in the macrophages caused by the action of modified low-density lipoproteins (mLDL) on them. However, glucan accelerates the efflux of Cholesterol from the macrophages loaded with it, and this effect is commensurate with the action of verapamil and alpinetin. At the second stage of the work, transcriptomic analysis made it possible to detect differentially expressed genes by observing the effect of glucan on both accumulation and efflux of Cholesterol from the macrophages. In mLDL-induced Cholesterol accumulation, the presence of glucan in the cell model did not change the overall pattern of gene expression, at the same time, monitoring Cholesterol efflux revealed the ability of glucan to increase (LDLR, INSIG1, SCARB1, STARD3, ABCA1) or decrease (FADS1, SR-BI, DSC1) the expression of a set of genes different from the key Cholesterol accumulation genes. Evaluation of the biological activity of genes, associated with accumulation Cholesterol, indicates their role in immune and inflammatory processes, while genes with other functions, including genes known as regulators of Cholesterol metabolism, are involved to a greater extent in Сholesterol efflux under the action of glucan. A conclusion was made that in relation to the pathology of atherosclerosis, it is necessary to consider glucan not so much as a prophylactic, but as a therapeutic agent.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100430"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the functional properties of short-chain xylooligosaccharides obtained from the enzymatic hydrolysis of bamboo culm","authors":"Marcos Fellipe da Silva ,&nbsp;William Gustavo Sganzerla ,&nbsp;Patrícia Félix Ávila ,&nbsp;Tânia Forster Carneiro ,&nbsp;Maria Teresa Pedrosa Silva Clerici ,&nbsp;Rosana Goldbeck","doi":"10.1016/j.bcdf.2024.100431","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100431","url":null,"abstract":"<div><p>Xylooligosaccharides (XOS) are important oligomers of xylose. XOS have received particular interest in recent years from the food and pharmaceutical industries due to their functional properties associated with fighting diseases and maintaining health. Therefore, the objective of this work was to evaluate the in vitro digestibility, prebiotic, and antioxidant effects, as well as the production of short-chain fatty acids from short-chain XOS obtained from enzymatic hydrolysis of the bamboo culm. The xylan extracted from the bamboo culm was subjected to enzymatic hydrolysis at an endoxylanases concentration of 7.5 mg protein/g xylan at 50 °C and pH 5.0 for 24 h. The extract obtained showed a high concentration of XOS, approximately 5 g/L, composed of xylobiose (2.39 g/L), xylotriose (1.31 g/L), xylotetraose (0.567 g/L), xylopentose (0.223 g/L) and xylohexose (0.18 g/L). The in vitro digestibility tests indicated that the XOS presented a high and desirable resistance to digestion, considering that 97.65% of the XOS remained intact in the simulated intestinal phase. The XOs showed an expressive prebiotic effect, promoting the growth of <em>Lactobacillus acidophilus</em> and <em>Bifidobacterium bifidu</em><em>m</em>, fermenting the XOS and producing short-chain fatty acids, highlighting acetate, propionate, and butyrate. These organic acids play important roles in fighting inflammation, protecting brain functions, and inhibiting the development of cancer cells and pathogens. XOS showed a high total antioxidant capacity, eliminating 73.5% of the DPPH free radicals. Finally, the XOS produced from bamboo culm has great prebiotic potential and excellent antioxidant activity and can be applied to food and pharmaceutical products.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100431"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotic potential of melon (Cucumis melo L.) and watermelon (Citrullus lanatus) shell flours","authors":"Claudia Mariana Pérez-Juárez ,&nbsp;Jesús David García Ortiz ,&nbsp;Adriana Carolina Flores-Gallegos ,&nbsp;Silvia Marina Herrera-Gonzalez ,&nbsp;Marisol Cruz-Requena ,&nbsp;Aidé Sáenz-Galindo ,&nbsp;Raúl Rodríguez-Herrera","doi":"10.1016/j.bcdf.2024.100428","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100428","url":null,"abstract":"<div><p>A potential alternative way of using agricultural waste such as melon and watermelon shells is its use as a prebiotic ingredient, which may improve the production of beneficial metabolites during microbial fermentation in the intestinal section of the host, through probiotic bacteria. The objective of this study wasto evaluate the prebiotic potential of melon and watermelon, which were subjected to an <em>in vitro</em> digestion process and subsequently analyzed by scanning electron microscope. The digest was used as a source of carbohydrates during fermentation by 3 probiotic bacteria (<em>Lactobacillus brevis, L. paracasei, and L. rhamnosus</em>) at 24 and 48 h, evaluating bacterial growth, carbohydrate consumption and the production of short-chain fatty acids (acetic, propionic and butyric acids). Results indicated a degradation of melon and watermelon shells after the digestion process, likewise, the growth of lactic acid bacteria was observed using melon and watermelon shells as a source of carbohydrates.These compounds were significantly reduced at 24 and 48 h. Finally, at 48 h, a higher content of short-chain fatty acids was present with a concentration of 922.31 μmol/L of acetic acid with <em>L. brevis</em> and melon shell, 27.6 μmol/L of propionic acid with <em>L. rhamnosus</em> and melon shell, and 4.96 x10⁻¹³ μmol/L of butyric acid with <em>L. rhamnosus</em> with melon and watermelon shells, which suggests that these types of shells have prebiotic potential.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100428"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalization of psyllium to develop bioactive network hydrogels for sustained drug delivery","authors":"Vikrant Sharma ,&nbsp;Baljit Singh ,&nbsp;Raj Kumar Thakur","doi":"10.1016/j.bcdf.2024.100427","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100427","url":null,"abstract":"<div><p>Recently, bioactive natural fibers have been explored to develop the materials for biomedical applications. Herein this research work, functionalization of psyllium has been carried out to develop hydrogels for sustained drug delivery applications. Copolymeric hydrogels were prepared by copolymerization of poly(methacrylic acid) (MAAc) and polyvinyl alcohol (PVA) with psyllium by grafting reactions. The grafted product was characterized through SEMs, AFM, FTIR, C¹³-NMR, and TGA techniques. Physiochemical and biomedical properties of hydrogels were evaluated. Sustained diffusion of doxycycline in occurred through the non-Fickian diffusion mechanism and release profile of drug was best fitted in the Korsmeyer-Peppas kinetic model. Copolymers have exhibited pH responsive behavior and demonstrated antioxidant, biocompatible and mucoadhesive nature. Overall, findings suggested the suitability of psyllium based hydrogels for drug delivery applications to gastrointestinal tract with enhanced potential.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100427"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of pectin with various degress of esterification by Bacteroides xylanisolvens","authors":"Hedi Xu,&nbsp;Quanyong Wu,&nbsp;Yiru Xuan,&nbsp;Huizi Tan,&nbsp;Shaoping Nie","doi":"10.1016/j.bcdf.2024.100426","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100426","url":null,"abstract":"<div><p>The intricate relationship between the human intestinal microbiota and polysaccharides has a profound and direct impact on health outcomes. Our previous research has shown that pectin possesses beneficial properties that can combat colitis and metabolic disorders, which may be facilitated by the dominant gut commensals such as the <em>Bacteroides</em> genus. This study aims to delve deeper into how pectin with varying esterification degrees is utilized by ten distinct <em>Bacteroides</em> strains. Among the tested strains, <em>Bacteroides xylanisolvens</em> Bt-17 demonstrated a remarkable capacity for efficiently utilizing pectin L102, as indicated by its growth rate, sugar consumption, pH changes, and production of short-chain fatty acids. The fermentation of pectin L102 by B<em>. xylanisolvens</em> Bt-17 potentially led to the production of novel substrates, which in turn promoted the growth of <em>Bacteroides stercoris</em> Bt-8. Furthermore, we observed significant regulatory changes in multiple genes encoding glycoside hydrolases and glycosyltransferases in <em>B. xylanisolvens</em> Bt-17 during the degradation of pectin L102. These insights deepen our understanding of the interplay between pectin polysaccharides and the gut microbiota, and they may offer evidence for a gut microbiota-targeted mechanism underlying pectin's functional benefits.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100426"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fibre profiling of various edible parts of winged bean (Psophocarpus tetragonolobus L.): Pods, whole seeds, endosperms, seed coats, and cooked seeds","authors":"Surya Aulia H ,&nbsp;Fransiska Rungkat Zakaria ,&nbsp;Hanifah Nuryani Lioe ,&nbsp;Erniati ,&nbsp;Rizki Dwi Setiawan","doi":"10.1016/j.bcdf.2024.100425","DOIUrl":"10.1016/j.bcdf.2024.100425","url":null,"abstract":"<div><p>This study aimed to identify the dietary fibre profiles of various winged bean components (green pods, whole seeds, endosperms, seed coats, and canned whole seeds). Soluble dietary fibre (SDF), insoluble dietary fibre (IDF) (hemicellulose, cellulose, and lignin), total dietary fibre (TDF), and oligosaccharide components (raffinose, stachyose, and verbascose), were analyzed. The various winged bean components had a higher IDF content than SDF content (21.12–50.11% and 0.83–1.25%, respectively), with the highest TDF content observed in the seed coat (51.81%). Raffinose was the most dominant oligosaccharide component in green pods (2.7 mg/g), while verbascose was the most dominant component in all seed form samples, including seed coats (1.41–3.65 mg/g). The IDF in all samples was dominated by cellulose (5.07–39.34%), followed by hemicellulose (1.5–27.19%), and lignin (0.09–0.98%). Seed dehusking led to significant decreases in all types of dietary fibre analyzed, except for stachyose. Soaking and sterilization processes resulted in an increase in SDF, but decreased IDF, stachyose, verbascose, and hemicellulose compared to raw whole seeds. Principal component analysis (PCA) revealed that raw whole seeds still exhibit similarities in dietary fibre composition with canned seeds, but differ from green pods, endosperms, and seed coats. These findings imply that all edible parts of winged beans offer a large quantity of dietary fibre, especially whole seeds, which have potential benefits as prebiotic sources to improve health.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100425"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Jerusalem artichoke tuber as a prebiotic on the nutrient utilization, weaning stress indicators and immunocompetence of crossbred calves during the pre- and post-weaning phases","authors":"Yancy Mary Issac ,&nbsp;Ashok Kumar Pattanaik ,&nbsp;Asmita Singh ,&nbsp;Mokshata Gupta ,&nbsp;Sunil Ekanath Jadhav ,&nbsp;Gyanendra Kumar Gaur ,&nbsp;Anju Kala","doi":"10.1016/j.bcdf.2024.100423","DOIUrl":"https://doi.org/10.1016/j.bcdf.2024.100423","url":null,"abstract":"<div><p>This study explored the potential prebiotic properties of pulverized Jerusalem artichoke tuber (JAP) in pre- and post-weaned calves. Accordingly, 24 fifteen-day-old calves were randomly assigned to four groups (n = 6). The groups received JAP supplementation at levels of 0 (CON), 1 (JAP1), 2 (JAP2), and 3 (JAP3) percent of dry matter intake (DMI) during the first 60 days of the 120-day experiment. Two 6-days digestion trials were conducted: one during the 4th week of the experiment (pre-wean), and the second during the tenth week (post-wean). Additionally, serum concentrations of cortisol and epinephrine were measured in both the pre- and post-weaning phases to assess the stress levels. Immunocompetence of the calves during both the stages was evaluated through lymphocyte proliferation response. In the pre-weaning phase, the calves supplemented with JAP had better (P &lt; 0.05) protein intake and digestion compared to the control group. In the post-weaning phase, the JAP supplemented groups exhibited significantly (P &lt; 0.05) improved digestibility coefficients for dry matter, organic matter, crude protein, ether extract, and neutral detergent fibre. Although cortisol levels didn't show significant differences (P &gt; 0.05) between the groups during both pre-weaning and post-weaning stages, the post-weaning stage did reveal a significant reduction (P &lt; 0.05) in epinephrine levels in JAP1 compared to the other groups. Additionally, JAP supplementation enhanced (P &lt; 0.05) the calves' response to lymphocyte proliferation during the post-weaning phase. Considering the improved nutrient digestibility, enhanced systemic immunity, and reduced epinephrine levels observed in the JAP supplemented groups, our findings suggest that JAP may have promising potential as a prebiotic for calves.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"31 ","pages":"Article 100423"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}