Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Corrigendum to “Dietary bioactive compounds poly-β-hydroxybutyrate, mannan oligosaccharide, and inulin affected the growth performance, gut microbiota, and body composition of African catfish (Clarias gariepinus, Burchell, 1822) larvae” [Bioactive Carbohydrates and Dietary Fibre 34 (2025) 1-1 100501]","authors":"Solomon Melaku , Abebe Getahun , Seyoum Mengestou , Akewake Geremew , Amha Belay","doi":"10.1016/j.bcdf.2025.100506","DOIUrl":"10.1016/j.bcdf.2025.100506","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100506"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of pectinase immobilized by encapsulation and entrapment and their effect on papaya juice clarification","authors":"Laishram Bhaktaraj Singh,&nbsp;Bhaskar Jyoti Kalita,&nbsp;Nandan Sit","doi":"10.1016/j.bcdf.2025.100489","DOIUrl":"10.1016/j.bcdf.2025.100489","url":null,"abstract":"<div><div>The present work explores the immobilization of pectinase through two methods: encapsulation in calcium alginate beads and matrix entrapment in agar cubes and evaluates their effectiveness in clarifying papaya juice compared to free pectinase. An immobilization efficiency of 72.59 ± 2.41 % for 2 % sodium alginate and 91.28 ± 3.62 % for 2 % agar were found to be the best. Optimal enzymatic activity for free pectinase was obtained at 40 °C and pH 6.0, and for both immobilized pectinase at 50 °C. The optimal pH was pH 8.0 for calcium alginate bead-encapsulated pectinase and pH 4.0 for agar cube-entrapped pectinase. The kinetic parameters for free pectinase, encapsulated pectinase and entrapped pectinase were K_m of 25.11 mg/mL, 16.29 mg/mL and 16.00 mg/mL and V_max of 4.57 μmol/mL/min, 2.79 μmol/mL/min and 1.92 μmol/mL/min respectively. The encapsulated pectinase and entrapped pectinase were reused for 5 cycles with 50.55 % and 80.03 % residual activity and remained stable for 15 days. In the application for papaya juice clarification tests, agar-entrapped pectinase significantly improved optical density and reduced viscosity, achieving the best results among the tested pectinase preparations.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100489"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic and anticancer properties of sun-dried fig (Ficus carica) stalk pectin: effects on intestinal glucose absorption and colon cancer cell growth","authors":"Filiz Başer ,&nbsp;Elif Çavdaroğlu ,&nbsp;Ahmet Yemenicioğlu ,&nbsp;Şükrü Güleç","doi":"10.1016/j.bcdf.2025.100497","DOIUrl":"10.1016/j.bcdf.2025.100497","url":null,"abstract":"<div><div>This study aims to characterize the physiological activity of fig stalk pectin (FSP) in terms of antidiabetic and anticancer activities. Also, the potency of FSP has been interpreted as a functional food ingredient in yogurt. The galacturonic acid content (65 %), degree of esterification (63 %), and enzymatic sugar analysis showed that FSP is a high methoxyl pectin rich in RG-I content (∼22 %). Anti-diabetic characteristics of FSP demonstrated that FSP inhibited 2-deoxyglucose uptake into CaCo-2 cells and reduced glucose absorption in the intestinal transport system after being added as an ingredient in yogurt at the concentration of 2 % (w/w). The antidiabetic activity of FSP was attributed to its capacity to modify the rheological properties of yogurt with a high-water binding capacity (10 g/g), and it increased the viscosity of digested yogurt samples considerably (from 89 to 110 Cp). Moreover, the characterization of anticancer properties showed that FSP inhibited the proliferation of colon cancer CaCo-2 cells by disturbing cell cycle progression, leading to S phase arrest, and showing apoptosis-inducing ability. Further research, including <em>in vivo</em> and clinical trials, is necessary to validate the observed health benefits of FSP.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100497"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterococcus hirae OL616073 glucan exopolysaccharide based cumin oil emulsion: Characterization and antibacterial activity","authors":"Swati Tiwari ,&nbsp;Digambar Kavitake ,&nbsp;Palanisamy Bruntha Devi ,&nbsp;Irshad Ahmad Shah ,&nbsp;Prathapkumar Halady Shetty","doi":"10.1016/j.bcdf.2025.100480","DOIUrl":"10.1016/j.bcdf.2025.100480","url":null,"abstract":"<div><div>This study aims to prepare the cumin essential oil-based emulsion stabilized by glucan exopolysaccharide (EPS) from <em>Enterococcus hirae</em> OL616073. The emulsion was prepared by optimizing different ratios of EPS to essential oil via vortexing, ultrasonication, and high shear homogenization. The concentration of EPS (among 0.5, 1, 1.5, and 2 %) and the ratio of EPS to essential oil (among 1:0.5, 1:1, 1:1.5, and 1:2) were initially optimized using vortexing. Ultrasonication and high shear homogenization processes were applied to the vortexed samples and optimized the concentration of EPS and the ratio of EPS to essential oil combinations. The emulsion capacity, emulsion stability, the effect of various processing parameters (temperature and salt), and antimicrobial activity were determined for the emulsions prepared from vortexing, ultrasonication, and high shear homogenization. It was found that emulsion capacity and emulsion stability were better in ultrasonication and high shear homogenization treatment compared to vortexing. When these emulsions were treated with various temperatures and the effect of ionic strengths, the order of emulsion stability was recorded as ultrasonication &gt; high shear homogenization &gt; vortexing. Further, there was significant antimicrobial activity against four tested pathogens, namely <em>Listeria monocytogenes</em> (MTCC 1143), <em>S. aureus</em> (MTCC 1144), <em>E. coli</em> (MTCC 433), and <em>Shewanella putrefaciens</em> (MTCC 8104), but no antimicrobial activity against <em>Salmonella enterica</em> (950) was observed. Parameters such as type of emulsion, turbidity, pH, Fourier transform infrared (FT-IR) analysis, and microscopic analyses were also performed for emulsions. This EPS-based emulsion system can be further explored for functional applications in the field of food and health.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary bioactive compounds poly-β-hydroxybutyrate, mannan oligosaccharide, and inulin affected the growth performance, gut microbiota, and body composition of African catfish (Clarias gariepinus, Burchell, 1822) larvae","authors":"Solomon Melaku ,&nbsp;Abebe Getahun ,&nbsp;Seyoum Mengestou ,&nbsp;Akewake Geremew ,&nbsp;Amha Belay","doi":"10.1016/j.bcdf.2025.100501","DOIUrl":"10.1016/j.bcdf.2025.100501","url":null,"abstract":"<div><div>High mortality rates and sub-optimal growth performance during the early larval stage of African catfish (<em>Clarias gariepinus</em>) larviculture remain significant challenges, limiting its aquaculture in Ethiopia. In this study, the effects of three prebiotics, Mannan Oligosaccharide (MOS), Inulin, and Poly-β-hydroxybutyrate (PHB) on growth performance, survival, gut microbiota, and body composition of African catfish larvae were evaluated.</div><div>Results showed that PHB supplementation significantly enhanced survival rate (88.89 % ± 3.85 %), final weight (4.20 ± 1.128 g), final length (7.51 ± 0.406 cm), specific growth rate (4.08 ± 0.470 g/day), and daily weight gain (0.06 ± 0.0 g/day) compared to control and other prebiotic-treated groups. On the other hand, MOS and Inulin supplementation did not yield significant improvements in growth parameters compared to the control. Prebiotics supplementation did not affect whole-body proximate composition (P &gt; 0.05). In terms of microbial composition, PHB (1.46×10⁷±6.81×10⁵ CFU/mL) and MOS (1.45×10⁷±4.04×10⁵ CFU/mL) showed significantly lower TBC. LAB abundance was highest in MOS (3.00×10²±1.73×10²CFU/mL) and PHB (2.65×10²±1.53 ×10² CFU/mL) supplemented groups, whereas Inulin supplementation favored lower LAB growth of 3.00×10²±1.73×10² CFU/mL. There was no LAB growth in the intestines of the control group in this experiment. Total <em>Bacillus</em> count was highest in the PHB (2.67×10⁴±2.52×10² CFU/mL) supplemented groups of fish, followed by Inulin (1.83×10⁴±5.29×10² CFU/mL) and MOS (1.48×10⁴±2.52×10² CFU/mL). In contrast, the control (1.28×10⁴±3.06×10² CFU/mL) group exhibited the lowest presence of <em>Bacillus</em> bacteria. In conclusion, dietary prebiotic supplementation influenced growth performance, survival, and gut microbiota in African catfish larvae, with PHB demonstrating the most substantial benefits.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100501"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating IL-17-NFκB signaling and gut microbiota in Alzheimer's disease: Mechanism of forsythoside A and Lonicera japonica polysaccharide combination","authors":"Yanxia Shu ,&nbsp;Ke Li ,&nbsp;Zongshuo Li ,&nbsp;Weiran Feng ,&nbsp;Weidong Li","doi":"10.1016/j.bcdf.2025.100514","DOIUrl":"10.1016/j.bcdf.2025.100514","url":null,"abstract":"<div><div>This study investigated the combined therapeutic effects of Forsythoside A (FA) and <em>Lonicera japonica</em> polysaccharide (LP) on Alzheimer's disease (AD) through dual modulation of neuroinflammation and gut microbiota. HT22 cells were treated with Aβ_25-35 to establish an AD model for examining the synergistic concentration ratio of FA and LP. An APP/PS1 double-transgenic AD mouse model was developed. The anti-AD activities of FA + LP were evaluated through behavioral testing, measuring amyloid-beta (Aβ) and phosphorylated Tau (p-Tau) protein levels in the hippocampus and cortex, and assessing serum inflammatory factors. Transcriptomic analysis, coupled with quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting, was used to validate the molecular mechanism by which FA + LP improved AD pathology in mice. Finally, 16S rRNA sequencing technology was used to explore the anti-AD mechanisms of FA + LP from a gut microecology perspective. We found the optimal FA:LP synergistic ratio was 1:5. FA + LP treatment significantly improved cognitive function in behavioral tests while reducing Aβ and p-Tau accumulation in the hippocampus and cortex. Serum analysis showed decreased levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Mechanistic studies revealed FA + LP downregulated the IL-17-NFκB pathway, evidenced by reduced mRNA expression of <em>Il-17a</em>, <em>Act1</em>, <em>Iκba</em>, <em>Nfκb p65</em>, and <em>Cox2</em>, along with decreased IL-17A and NFκB p65 protein levels. Gut microbiota analysis demonstrated FA + LP increased beneficial bacteria (Lachnospiraceae and <em>Muribaculum</em>) while normalizing the Firmicutes/Bacteroidetes ratio. The combination therapy outperformed single treatments across all evaluated parameters. Our results demonstrate FA + LP (1:5) alleviates AD pathology through: suppressing neuroinflammation via IL-17-NFκB signaling inhibition, and restoring gut microbiota balance.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100514"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, purification and structural characterization of inulin-type fructans from different selected Asparagus species","authors":"Deshani C. Mudannayake ,&nbsp;Wasantha K. Meegahawaththa ,&nbsp;Ashinshana U. Illippangama ,&nbsp;Herath M.J.C. Pitawala ,&nbsp;Kuruppu M.S. Wimalasiri ,&nbsp;Kahandage F.S.T. Silva","doi":"10.1016/j.bcdf.2025.100486","DOIUrl":"10.1016/j.bcdf.2025.100486","url":null,"abstract":"<div><div>Inulin is a naturally occurring fructose polysaccharide and soluble dietary fiber, found in various plants, commonly used in the food industry for its excellent prebiotic properties and as a fat or sugar substitute. Commercial inulin is largely extracted from Chicory plant, which is grown only in temperate parts of the world. This study chemically and structurally investigated the potential of four Asparagus species <em>A. falcatus</em>, <em>A. racemosus</em>, <em>A. officinalis</em>, and <em>A. gonocladus</em> as alternative inulin sources for the food industry. Inulins were extracted using either hot water extraction or microwave-assisted extraction. Asparagus inulin powders were analyzed for inulin content, total phenolics, total flavonoids, radical scavenging activity and mineral composition. <em>A. falcatus</em>, <em>A. gonocladus</em> and <em>A. racemosus</em> fresh roots contained considerably high inulin contents (23.61 ± 1.04, 17.08 ± 2.58, 12.22 ± 1.51 % FW, respectively). The highest inulin content in their powders (92.31 ± 2 0.89 %) was shown by microwave-assisted extracted <em>A. gonocladus</em> inulin powder. The molecular structure and phase behavior of inulin contained in roots of Asparagus were confirmed by FTIR and XRD respectively, and the thermal behavior was confirmed by DSC data. The results suggest that Asparagus inulin possesses significant potential for use in food applications as an alternative inulin source.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100486"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential therapeutic applications of marine polysaccharides in the treatment of inflammatory diseases","authors":"Meivelu Moovendhan","doi":"10.1016/j.bcdf.2025.100502","DOIUrl":"10.1016/j.bcdf.2025.100502","url":null,"abstract":"<div><div>Marine polysaccharides, derived from various algae and marine organisms, have emerged as promising therapeutic agents for the treatment of inflammatory diseases due to their diverse biological properties, particularly anti-inflammatory effects. This review explores the potential of marine polysaccharides, such as fucoidans, carrageenans, ulvans and laminarin, in managing inflammatory conditions. Their structural diversity, characterized by varying degrees of sulfation and molecular weight, contributes to their unique biological activities. We discuss the mechanisms of action through which these polysaccharides exert their effects, including modulation of key inflammatory pathways, regulation of gut microbiota, antioxidant activities, and effects on the gut-brain axis. Special attention is given to their applications in inflammatory bowel disease (IBD) and other inflammatory conditions, highlighting their role in reducing inflammation, enhancing intestinal barrier integrity, and promoting beneficial gut bacteria. Additionally, the potential of marine polysaccharides in addressing comorbid conditions, such as neuroinflammation and metabolic diseases, is examined. Overall, this review underscores the therapeutic potential and safety of marine polysaccharides, positioning them as attractive candidates for future drug development in the treatment of inflammatory diseases.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100502"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive roles of lactic acid bacteria in enhancing corn silage quality and ruminant dietary fiber utilization: A comprehensive review","authors":"Seangla Cheas,&nbsp;Chanon Suntara,&nbsp;Anusorn Cherdthong","doi":"10.1016/j.bcdf.2025.100512","DOIUrl":"10.1016/j.bcdf.2025.100512","url":null,"abstract":"<div><div>This review explores the bioactive roles of lactic acid bacteria (LAB) in enhancing corn silage quality and ruminant dietary fiber utilization, emphasizing their impact on fermentation, chemical composition, and livestock performance. Corn silage, valued for its high energy content, balanced fiber, and palatability, supports both milk production and weight gain. However, its quality can be compromised by mycotoxins, microbial imbalances, and reduced aerobic stability, lowering its nutritional value. LAB strains, both homofermentative and heterofermentative, improve silage by boosting lactic acid production (10 % of dry matter), reducing pH (3.50–4.02), and minimizing ammonia nitrogen (NH₃-N) levels. These actions enhance dry matter content, reduce fermentation losses, and improve stability and shelf life. LAB also lowers neutral detergent fiber (NDF) and acid detergent fiber (ADF) levels, increasing digestibility. Homofermentative LAB (<em>Lactobacillus plantarum</em>) improves silage palatability, intake, digestibility, and ruminant growth. Heterofermentative LAB (<em>Lactobacillus buchneri</em>) enhances intake but shows limited effects on development. Combining LAB with additives like carbohydrate-degrading enzymes or molasses further improves fermentation and digestibility. Despite these benefits, LAB inoculants have inconsistently boosted milk yield or composition in dairy cows. Future innovations in LAB strains or their integration with dietary fibers could enhance fiber degradation, carbohydrate availability, and silage nutrition, particularly in tropical systems. These advancements would help optimize milk production and quality, addressing challenges in livestock feeding systems.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100512"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different proteins on the structure and digestibility of complexes extruded with high amylose maize starch","authors":"Lufei Wang,&nbsp;Zekai Li,&nbsp;Wafaa K. Abo Ghaneima,&nbsp;Mingcong Fan,&nbsp;Yan Li,&nbsp;Li Wang,&nbsp;Haifeng Qian","doi":"10.1016/j.bcdf.2025.100493","DOIUrl":"10.1016/j.bcdf.2025.100493","url":null,"abstract":"<div><div>High amylose maize starch is a natural maize starch with an amylose content exceeding 50 % of the total starch. It has garnered attention for its green health benefits and widespread industrial applications. The purpose of this research is to explore the effects of different proteins on the structural properties, physicochemical properties, and in vitro starch digestibility of complexes extruded with high amylose maize starch. We use proteins (soybean protein isolate, wheat gluten, rice protein) and high amylose maize starch in co-extrusion. Extrusion significantly disrupted the microstructure of the starch granules, leading to protein denaturation, starch gelatinization, and crosslinking, forming a dense particle structure. Experimental results indicated that co-extrusion led to a transformation of the starch crystalline structure to a B + V type. The complexes formed with wheat gluten had a higher relative crystallinity, greater short-range order, and higher double-helix content, with smaller molecular volumes. The structure of the complex was more uniform, and the molecular size was more consistent. This compact structure helps resist the penetration of water and amylase, resulting in a gentler digestion curve, which promotes the slow release of glucose, making it more suitable for low GI foods.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"34 ","pages":"Article 100493"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}