Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Synthesis of sulfated chitosan from cuttlebone of Sepia pharaonis (Ehrenberg, 1831) and its capacity to inhibit blood clotting","authors":"Hirshasri Ambalarajan Gunasekaran ,&nbsp;Annathai Pitchai ,&nbsp;Pasiyappazham Ramasamy","doi":"10.1016/j.bcdf.2025.100470","DOIUrl":"10.1016/j.bcdf.2025.100470","url":null,"abstract":"<div><div>The synthesis of sulfated chitosan from the cuttlebone of <em>Sepia pharaonis</em> (Ehrenberg, 1831) and its potential to inhibit blood clotting were investigated in this study. Cuttlebone-derived chitosan was chemically modified by sulfation to produce sulfated chitosan. This modification was achieved by introducing sulfate groups into the chitosan structure, thereby enhancing its biological properties. The synthesized sulfated chitosan demonstrated a significant capacity to inhibit blood clotting, indicating its potential application as an anticoagulant. Anticoagulant activity was evaluated through <em>in vitro</em> assays, where sulfated chitosan exhibited notable suppression of clot formation. Moreover, this study examined the structural and physicochemical properties (FTIR, XRD, FESEM) of the synthesized sulfated chitosan, providing insights into its potential mechanism of action. These findings suggest that sulfated chitosan derived from <em>Sepia pharaonis</em> cuttlebone holds promise as an effective and biocompatible anticoagulant, thereby presenting a potential avenue for the development of novel therapeutic interventions in the field of cardiovascular medicine and related disciplines.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Livaux® gold kiwifruit powder consumption at 600 mg per day for 28 days increases Faecalibacterium prausnitzii numbers and decreases bloating and hydrogenotrophic species numbers in healthy individuals, consistent with slow fermentation: A randomized controlled trial","authors":"Starin McKeen ,&nbsp;Susanne M. Henning ,&nbsp;Erin Lewis ,&nbsp;Malkanthi Evans ,&nbsp;Emma Graham ,&nbsp;Neville Jopson ,&nbsp;Jennifer Gu ,&nbsp;Doug Rosendale","doi":"10.1016/j.bcdf.2025.100468","DOIUrl":"10.1016/j.bcdf.2025.100468","url":null,"abstract":"<div><div>Kiwifruit is renowned for its benefits to laxation. Livaux® is a gold kiwifruit powder retaining whole fruit benefits, including high-methoxy pectin content. Livaux was previously shown to provide laxation support and increased faecal <em>F. prausnitzii</em>. <em>F. prausnitzii</em> is known to use high-methoxy pectin as substrate.</div><div>We aimed to determine the changes to laxation and faecal <em>F. prausnitzii</em> numbers from 600 mg of Livaux. We used a randomized, double-blinded, placebo-controlled parallel-arm study with 85 participants conducted across four North American sites, comparing 28 days of 600 mg Livaux consumption vs cellulose placebo. The study was powered for the primary outcome Complete Spontaneous Bowel Movements (CSBM).</div><div>Participants visited at screening, baseline and endpoint. Anthropometric measures, hematology, clinical chemistry and hematology and fecal samples for microbiome assessment were collected at baseline and endpoint. Clinical outcomes (CSBM, Bristol Stool Form Score (BSFS), spontaneous bowel movements (SBM) and participant-assessed constipation symptoms and quality of life), food diaries and adverse events were recorded daily throughout the study. Analysis of the intent-to-treat population assessed differences from baseline to endpoint using ANOVA with post-hoc Tukey's T-test, an assessment of change from baseline to days 7, 14, 21 and 28 using repeated measures ANCOVA.</div><div>Livaux supplemented participants showed significantly increased fecal <em>F. prausnitzii</em> relative abundance, whilst placebo did not. Participants also showed significantly improved CSBM, SBM, BSFS and constipation symptom and quality of life scores over baseline.</div><div>Livaux supplementation improved laxation and increased <em>F. prausnitzii</em> at the low dose of 600 mg.</div><div>This study was registered at <span><span>https://clinicaltrials.gov/study/NCT03462199</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical characterization of starch from Maranta arundinacea L. (arrowroot) rhizomes and its inhibition of COX-2: In vivo validation","authors":"Nishaa Surendran ,&nbsp;Manikandan Vani Raju ,&nbsp;Meenakshi Kaniyur Chandrasekaran ,&nbsp;Rathi Muthaiyan Ahalliya ,&nbsp;Chella Perumal Palanisamy ,&nbsp;Geethadevi Chandrasekaran ,&nbsp;Gopalakrishnan Velliyur Kanniappan","doi":"10.1016/j.bcdf.2024.100465","DOIUrl":"10.1016/j.bcdf.2024.100465","url":null,"abstract":"<div><div><em>Maranta arundinacea</em> L. (<em>M. arundinacea</em> L.) that belongs to the family Marantaceae is an underutilized tuber. The starch from the rhizomatous tubers is highly commercial and medicinal value is uncharacterized. This study was aimed at isolating the starch from <em>Maranta arundinacea</em> L. rhizomes, analyzing its physiochemical properties and examine its influence on anti-inflammatory activity. The physicochemical properties like Moisture and ash content, water holding capacity, water absorption index, amylose content, light transmittance and structural morphology of starch granules. Anti-inflammatory activity of starch from <em>M. arundinacea</em> L. was evaluated in Wistar rats by carrageenan induced paw edema. The biochemical estimation of serum enzymes, lipid peroxidation, enzymatic antioxidants and histopathological studies of paw tissues were carried out in paw tissues. Molecular expression of proinflammatory COX-2 gene was also analyzed. <em>M. arundinacea</em> starch was found to contain 9.3% moisture, 1.36% ash and 26.3% amylose content. The light transmittance (%) decreased with an increase in time. Micrographs of SEM analysis showed variations in the shape of granules that appeared as spherical and irregular. The size of granules varied between 2.86 and 6.92 μm. Attenuation in paw edema on treatment with <em>M. arundinacea</em> L. starch (200 mg/kg) was observed in comparison with that of standard drug Diclofenac sodium, the serum enzymes and enzymatic antioxidants were brought to near normal. The potent anti-inflammatory activities were confirmed by Histopathological studies. Molecular expression of proinflammatory COX-2 gene was also down regulated. It can be concluded that the dietary supplementation of starch from <em>M. arundinacea</em> L. to mitigate inflammation and reduce chronic diseases.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100465"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorghum cookies fortified with Garcinia mangostana peel extract: Formulation, characterization, and evaluation of antioxidant and antidiabetic activity","authors":"Anastasia Wheni Indrianingsih ,&nbsp;Yuniar Khasanah ,&nbsp;Cici Darsih ,&nbsp;Heru Pitria Hastuti ,&nbsp;Ade Erma Suryani ,&nbsp;Margi Hastuti ,&nbsp;Dwi Ni'maturrohmah ,&nbsp;Umi Laila ,&nbsp;Eka Noviana ,&nbsp;Eka Rahayu ,&nbsp;Tri Wiyono","doi":"10.1016/j.bcdf.2025.100467","DOIUrl":"10.1016/j.bcdf.2025.100467","url":null,"abstract":"<div><div>Increased consumption of processed food and sugary beverages is a major contributor to chronic diseases such as diabetes mellitus and cardiovascular diseases. This research aimed to develop sorghum-based cookie fortified with mangosteen (<em>Garcinia mangostana</em>) peel extract, as a healthy, yet convenient food alternative. Both sorghum and mangosteen are rich in phenolic compounds that have been shown to possess several biological activities including antioxidant and antidiabetic activities. The cookies were evaluated physically and chemically by performing sensory, color, texture, proximate, and chemical content analysis, determination of total phenolic content, and further characterizations using scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), and Fourier transform infrared spectroscopy (FTIR). The antioxidant and antidiabetic potencies of the cookies were assessed using radical scavenging and α-glucosidase inhibitory assays, respectively. The results showed that substituting wheat with sorghum flour and adding mangosteen peel extract to the cookie ingredients increased its antioxidant and antidiabetic activity. Several chemical compounds detected from the sorghum cookies included xanthones, phenolics, flavonoids, and alkaloids. The mangosteen peel extract-fortified sorghum cookies were well accepted by the panelists based on sensory and hedonic testing. Hence, sorghum flour and mangosteen peel can be used as excellent ingredients for making healthy cookies.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100467"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guar galactomannan ameliorates radiation-induced intestinal injury in mice","authors":"Darshini Shivamogga Mohan ,&nbsp;Murali Badanthadka ,&nbsp;Anushri Umesh ,&nbsp;Bharath Basavapattana Rudresh ,&nbsp;Manjunatha Bukkambudhi Krishnaswamy ,&nbsp;Rashmi Kanugodu Vasappa ,&nbsp;Sahayog Narayan Jamdar ,&nbsp;Vidya Shimoga Muddappa","doi":"10.1016/j.bcdf.2024.100466","DOIUrl":"10.1016/j.bcdf.2024.100466","url":null,"abstract":"<div><div>Guar galactomannan (GGM), a widely used hydrocolloid in the food industry, was evaluated for its biological activity with respect to radioprotection. In an <em>in vitro</em> lymphocyte proliferation study, GGM showed significant proliferation of blood lymphocytes at a concentration of 50 μg/ml. The survival study of 30 days showed that GGM pre-treatment improves the survival in irradiated (7.5 Gy) mice to 70% which otherwise is just 30% in the control irradiated group. On day 3, the WBC count was maintained in the GGM pretreated IR mice group compared to the irradiated control group. Serum enzyme levels in the liver of the GGM pretreated irradiated group were reduced, spleen and thymus weight indices and antioxidant enzymes were increased in the intestine of the GGM pretreated irradiated group compared to the irradiated group. Histopathological studies of ileum and jejunum on day 3 revealed that there was less damage in the crypt and height of villi in the GGM pretreated IR mice group compared to the irradiated control group. In the differential gene expression of jejunum, a total of 43 genes showed differential expressions, suggesting their involvement in the biological response to the effect of galactomannan treatment on irradiated mice. Differential expression of genes shows that upregulation of the genes is related to limiting the damage to the intestine and stem cell genes involved in cell differentiation and function. Moreover, genes associated with apoptosis and inflammation were shown to be downregulated in the GGM-pretreated IR group. These results suggest that GGM improves mice from radiation-induced injury by increasing WBC count, reducing acute liver damage, maintaining spleen and thymus weight, increasing the levels of antioxidant enzymes and altering gene expression.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100466"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of curdlan use on the improving textural, cooking and sensory quality, and predicted glycemic index of high-fiber pasta added with watermelon rind","authors":"Dien Quang Long ,&nbsp;Thi Thu Tra Tran ,&nbsp;Nu Minh Nguyet Ton ,&nbsp;Van Viet Man Le","doi":"10.1016/j.bcdf.2024.100464","DOIUrl":"10.1016/j.bcdf.2024.100464","url":null,"abstract":"<div><div>Addition of watermelon rind powder into pasta formulation enhances dietary fiber and antioxidant contents of the fortified pasta but reduces its textural, cooking and sensory quality. In the literature, curdlan has been extensively studied to improve the quality of noodles but its use in the making of durum wheat semolina pasta and high-fiber pasta has not been considered. This study sought to examine the impacts of curdlan addition on the rheological characteristics of dough as well as on the textural and cooking quality, predicted glycemic index, in-vitro protein digestibility and sensory acceptance of high-fiber pasta. In this investigation, different dosages of curdlan were used in the making of high-fiber pasta fortified with watermelon rind and the resulting pasta quality was assessed. When the dosage of curdlan rose from 0 to 2.5% of the blend weight, the breaking strength and breaking distance of raw high-fiber pasta increased significantly. The cohesiveness, hardness, chewiness, elongation rate, tensile strength, cooking quality, and overall acceptability of the supplemented pasta were improved, while the adhesiveness decreased by 76% when comparing pasta samples added with 0% and 2.5% curdlan. The incorporation of curdlan did not have a considerable effect on color of the uncooked pasta samples. Nevertheless, the in-vitro protein digestibility was reduced with increasing curdlan dosage. Importantly, the predicted glycemic index of high-fiber pasta added with 2.5% curdlan was reduced by 1.5 times compared to the pasta sample without curdlan addition, highlighting the potential of curdlan as a food hydrocolloid for enhancing human health. Generally, curdlan was considered a prospective hydrocolloid to improve textural, cooking and sensory quality as well as health effect of the high-fiber pasta fortified with watermelon rind powder.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100464"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synbiotics: Effects of prebiotics on the growth and viability of probiotics in food matrices","authors":"Priyanka Parhi ,&nbsp;Shao Quan Liu ,&nbsp;Wee Sim Choo","doi":"10.1016/j.bcdf.2024.100462","DOIUrl":"10.1016/j.bcdf.2024.100462","url":null,"abstract":"<div><div>Synbiotics are a combination of prebiotics and probiotics that have a unique effect on their respective counterparts and the host. Probiotics, which are beneficial live microorganisms, have been extensively studied and commercially explored in multiple products worldwide. Numerous scientific studies have established their positive effects on human and animal health. Incorporating prebiotics into probiotic food products has shown different effects on the growth and viability of probiotics. Prebiotics have shown growth-promoting, partial inhibition, dose-dependent, or no effect on the growth and viability of probiotics in different food products. This review discusses synbiotics, probiotics, prebiotics, and specifically the effect of prebiotics on the growth and viability of probiotics in different food matrices. The outcomes depend on multiple factors, including the type and concentration of prebiotics, probiotic strains, and food matrix. Optimization of these parameters can lead to the development of effective synbiotic products that offer numerous human health benefits.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal notice to “Development of synbiotic juice by spray drying of Lactobacillus paracaesii sub sp. tolerans N2-45 along with galacto-oligossacharides using different carrier materials” [Bioactive Carbohydrates and Dietary Fibre 31 (2024) 100413]","authors":"N.V. Kanimozhi,&nbsp;M. Sukumar","doi":"10.1016/j.bcdf.2024.100451","DOIUrl":"10.1016/j.bcdf.2024.100451","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100451"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims and Scope & Editorial Board","authors":"","doi":"10.1016/S2212-6198(24)00063-9","DOIUrl":"10.1016/S2212-6198(24)00063-9","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KEFIRAN in vitro biological activity on enterocytes and mesodermal origin cell lines: Focus on adenocarcinoma cells HT29","authors":"Micaela Medrano ,&nbsp;Claudio Cordova ,&nbsp;Belén Rodriguez ,&nbsp;Nicolás Simonelli ,&nbsp;Pablo Olivero ,&nbsp;Analía Graciela Abraham","doi":"10.1016/j.bcdf.2024.100457","DOIUrl":"10.1016/j.bcdf.2024.100457","url":null,"abstract":"<div><div>Kefiran, the exopolysaccharide found in the fermented milk named “kefir” has been receiving attention over the last years due to its interesting biological and functional properties. It is a non-digestible branched glucogalactan with a molecular weight higher than 1 10⁶ Da. Kefiran was isolated from kefir grains and its biological activity was assessed on different cell lines. Proliferation (trypan blue exclusion assay), mitochondrial activity (MTT assay), viability (Alive-Vulnerable-Dead model, AVD) and cell death were studied. It was found that proliferation was not inhibited in mesodermal cell line MC3 (osteoblast cell line) or in not-invasive colonocytes (Caco-2/TC7 cell line); on the contrary, the high invasive HT29 cell line and the UMR106 osteosarcoma cell line were sensitive to kefiran 0.5 mg/mL, and a significant diminishment on cell proliferation was found by trypan blue dye exclusion assay. Kefiran maintained mitochondrial activity while increased cell death processes in a dose-dependent way in HT29 cell line. When viability was assessed by AVD model, it was found that kefiran increased vulnerability status of neoplasic cell line HT29. In summary, in the present work, we shown that kefiran has a different effect on tumor and non-tumor cell lines. Our results contribute to the understanding of kefiran effect on the empirical antitumoral effect attributed to kefir consumption.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100457"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}