Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Aims and Scope & Editorial Board","authors":"","doi":"10.1016/S2212-6198(25)00011-7","DOIUrl":"10.1016/S2212-6198(25)00011-7","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100477"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guar galactomannan ameliorates radiation-induced intestinal injury in mice","authors":"Darshini Shivamogga Mohan ,&nbsp;Murali Badanthadka ,&nbsp;Anushri Umesh ,&nbsp;Bharath Basavapattana Rudresh ,&nbsp;Manjunatha Bukkambudhi Krishnaswamy ,&nbsp;Rashmi Kanugodu Vasappa ,&nbsp;Sahayog Narayan Jamdar ,&nbsp;Vidya Shimoga Muddappa","doi":"10.1016/j.bcdf.2024.100466","DOIUrl":"10.1016/j.bcdf.2024.100466","url":null,"abstract":"<div><div>Guar galactomannan (GGM), a widely used hydrocolloid in the food industry, was evaluated for its biological activity with respect to radioprotection. In an <em>in vitro</em> lymphocyte proliferation study, GGM showed significant proliferation of blood lymphocytes at a concentration of 50 μg/ml. The survival study of 30 days showed that GGM pre-treatment improves the survival in irradiated (7.5 Gy) mice to 70% which otherwise is just 30% in the control irradiated group. On day 3, the WBC count was maintained in the GGM pretreated IR mice group compared to the irradiated control group. Serum enzyme levels in the liver of the GGM pretreated irradiated group were reduced, spleen and thymus weight indices and antioxidant enzymes were increased in the intestine of the GGM pretreated irradiated group compared to the irradiated group. Histopathological studies of ileum and jejunum on day 3 revealed that there was less damage in the crypt and height of villi in the GGM pretreated IR mice group compared to the irradiated control group. In the differential gene expression of jejunum, a total of 43 genes showed differential expressions, suggesting their involvement in the biological response to the effect of galactomannan treatment on irradiated mice. Differential expression of genes shows that upregulation of the genes is related to limiting the damage to the intestine and stem cell genes involved in cell differentiation and function. Moreover, genes associated with apoptosis and inflammation were shown to be downregulated in the GGM-pretreated IR group. These results suggest that GGM improves mice from radiation-induced injury by increasing WBC count, reducing acute liver damage, maintaining spleen and thymus weight, increasing the levels of antioxidant enzymes and altering gene expression.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100466"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorghum cookies fortified with Garcinia mangostana peel extract: Formulation, characterization, and evaluation of antioxidant and antidiabetic activity","authors":"Anastasia Wheni Indrianingsih ,&nbsp;Yuniar Khasanah ,&nbsp;Cici Darsih ,&nbsp;Heru Pitria Hastuti ,&nbsp;Ade Erma Suryani ,&nbsp;Margi Hastuti ,&nbsp;Dwi Ni'maturrohmah ,&nbsp;Umi Laila ,&nbsp;Eka Noviana ,&nbsp;Eka Rahayu ,&nbsp;Tri Wiyono","doi":"10.1016/j.bcdf.2025.100467","DOIUrl":"10.1016/j.bcdf.2025.100467","url":null,"abstract":"<div><div>Increased consumption of processed food and sugary beverages is a major contributor to chronic diseases such as diabetes mellitus and cardiovascular diseases. This research aimed to develop sorghum-based cookie fortified with mangosteen (<em>Garcinia mangostana</em>) peel extract, as a healthy, yet convenient food alternative. Both sorghum and mangosteen are rich in phenolic compounds that have been shown to possess several biological activities including antioxidant and antidiabetic activities. The cookies were evaluated physically and chemically by performing sensory, color, texture, proximate, and chemical content analysis, determination of total phenolic content, and further characterizations using scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), and Fourier transform infrared spectroscopy (FTIR). The antioxidant and antidiabetic potencies of the cookies were assessed using radical scavenging and α-glucosidase inhibitory assays, respectively. The results showed that substituting wheat with sorghum flour and adding mangosteen peel extract to the cookie ingredients increased its antioxidant and antidiabetic activity. Several chemical compounds detected from the sorghum cookies included xanthones, phenolics, flavonoids, and alkaloids. The mangosteen peel extract-fortified sorghum cookies were well accepted by the panelists based on sensory and hedonic testing. Hence, sorghum flour and mangosteen peel can be used as excellent ingredients for making healthy cookies.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100467"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The specificity of family 4 carbohydrate-binding modules (CBMs) of BpGH16MLG influences the binding and utilization of β-glucans in a human gut bacterium, Blautia producta","authors":"Harshita Gupta ,&nbsp;Chandani Gajera ,&nbsp;Prachi Kumari,&nbsp;Ravindra Pal Singh","doi":"10.1016/j.bcdf.2025.100475","DOIUrl":"10.1016/j.bcdf.2025.100475","url":null,"abstract":"<div><div>Several thousand bacterial communities reside in the human gut environment and have acquired numerous genes during co-evolution for trapping dietary nutrients. Many of Gram-positive bacteria encode extracellular cell wall membrane-bound endolytic enzymes with non-catalytic carbohydrate-binding modules (CBMs) that recognize cognate glycan(s). Much remains unknown about how these organisms recognize nutrients in the gut environment. <em>Blautia producta</em> JCM 1471^T expresses a cell membrane-tethered endo-acting enzyme (<em>Bp</em>GH16_MLG-digesting barley-β-glucan, lichenan, and laminarin) with four carbohydrate-binding modules (CBM4_1, CBM4_2, CBM4_3, and CBM4_4). Each CBM4 and its dual combinations were cloned, characterized, and assessed with three distinct β-glucans (barley-β-glucan, lichenan, and laminarin). It was observed that each CBM4 recognizes barley-β-glucan and lichenan with approximately equal affinity. Dual combination, CBM4_1-CBM4_2 exhibited a substantial predilection for barley-β-glucan, whereas CBM4_3-CBM4_4 had an affinity for barley-β-glucan and lichenan. None of the dual combinations showed an affinity for laminarin. Intriguingly, a mutant (E384A-catalytic base) version of <em>Bp</em>GH16_MLG with all CBM4 domains showed high binding to barley-β-glucans and lichenan, but moderate binding to laminarin. This understanding provides insights into how <em>B. producta</em> recognizes and likely traps specific nutrient in the gut environment. Furthermore, the study may have implications for the development of innovative biocatalysis.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100475"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary prebiotic combination improves immunological and hematological parameters in weaned pigs","authors":"Patrícia Versuti Arantes Alvarenga ,&nbsp;Vinicius Ricardo Cambito de Paula ,&nbsp;Mayra Anton Dib Saleh ,&nbsp;Silvia Letícia Ferreira ,&nbsp;Filipe Garcia Telles ,&nbsp;Ricardo de Oliveira Orsi ,&nbsp;Carlos Roberto Padovani ,&nbsp;Urbano dos Santos Ruiz ,&nbsp;Marcos Livio Panhoza Tse","doi":"10.1016/j.bcdf.2025.100473","DOIUrl":"10.1016/j.bcdf.2025.100473","url":null,"abstract":"<div><div>As antimicrobial resistance is a global public health problem and as known the use of prebiotics on animal nutrition have antimicrobial effects, we hypothesized the use of prebiotic additives can be an alternative to in-feed antibiotics for piglets to control sanitary challenge. Thus, the aim of this study was to evaluate the inclusion of prebiotics mannan<strong>-</strong>oligosaccharide (MOS), β-glucan, fructooligosaccharide (FOS) and galacto-oligosaccharides (GOS) to replace antibiotics as growth promoters, on immunological and hematological parameters of 21d-old weaned pigs challenged with intramuscular injection of 30 μg kg⁻¹ body weight of <em>Escherichia coli</em> lipopolysaccharide (LPS). Forty weaned piglets (7.2 kg) fed: CON = basal diet (BD) plus 120 ppm of halquinol; Mβ = BD plus a blend of MOS and β-glucan; F₉G₁ = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 9:1); F₇G3 = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 7:3); F₅G₅ = BD plus a blend of MOS and β-glucan and a blend of FOS/GOS (ratio 5:5). After LPS challenge, the animals fed F₉G₁ had higher hydrogen peroxide (H₂O₂) and the same nitric oxide (NO) serum concentration than CON. Animals fed Mβ and F₉G₁ showed similar serum C-reactive protein (CP) concentration than CON and serum cytokine tumor necrosis factor alpha (TNF-α) concentration were higher in animals fed F₉G₁ or F₅G₅ than CON. In general, we concluded that treatment F₉G₁, is better for immune response during immunological challenge, because more effective immunological variables were affected (H₂O₂, NO, CP and TNF-α).</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of sulfated chitosan from cuttlebone of Sepia pharaonis (Ehrenberg, 1831) and its capacity to inhibit blood clotting","authors":"Hirshasri Ambalarajan Gunasekaran ,&nbsp;Annathai Pitchai ,&nbsp;Pasiyappazham Ramasamy","doi":"10.1016/j.bcdf.2025.100470","DOIUrl":"10.1016/j.bcdf.2025.100470","url":null,"abstract":"<div><div>The synthesis of sulfated chitosan from the cuttlebone of <em>Sepia pharaonis</em> (Ehrenberg, 1831) and its potential to inhibit blood clotting were investigated in this study. Cuttlebone-derived chitosan was chemically modified by sulfation to produce sulfated chitosan. This modification was achieved by introducing sulfate groups into the chitosan structure, thereby enhancing its biological properties. The synthesized sulfated chitosan demonstrated a significant capacity to inhibit blood clotting, indicating its potential application as an anticoagulant. Anticoagulant activity was evaluated through <em>in vitro</em> assays, where sulfated chitosan exhibited notable suppression of clot formation. Moreover, this study examined the structural and physicochemical properties (FTIR, XRD, FESEM) of the synthesized sulfated chitosan, providing insights into its potential mechanism of action. These findings suggest that sulfated chitosan derived from <em>Sepia pharaonis</em> cuttlebone holds promise as an effective and biocompatible anticoagulant, thereby presenting a potential avenue for the development of novel therapeutic interventions in the field of cardiovascular medicine and related disciplines.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of curdlan use on the improving textural, cooking and sensory quality, and predicted glycemic index of high-fiber pasta added with watermelon rind","authors":"Dien Quang Long ,&nbsp;Thi Thu Tra Tran ,&nbsp;Nu Minh Nguyet Ton ,&nbsp;Van Viet Man Le","doi":"10.1016/j.bcdf.2024.100464","DOIUrl":"10.1016/j.bcdf.2024.100464","url":null,"abstract":"<div><div>Addition of watermelon rind powder into pasta formulation enhances dietary fiber and antioxidant contents of the fortified pasta but reduces its textural, cooking and sensory quality. In the literature, curdlan has been extensively studied to improve the quality of noodles but its use in the making of durum wheat semolina pasta and high-fiber pasta has not been considered. This study sought to examine the impacts of curdlan addition on the rheological characteristics of dough as well as on the textural and cooking quality, predicted glycemic index, in-vitro protein digestibility and sensory acceptance of high-fiber pasta. In this investigation, different dosages of curdlan were used in the making of high-fiber pasta fortified with watermelon rind and the resulting pasta quality was assessed. When the dosage of curdlan rose from 0 to 2.5% of the blend weight, the breaking strength and breaking distance of raw high-fiber pasta increased significantly. The cohesiveness, hardness, chewiness, elongation rate, tensile strength, cooking quality, and overall acceptability of the supplemented pasta were improved, while the adhesiveness decreased by 76% when comparing pasta samples added with 0% and 2.5% curdlan. The incorporation of curdlan did not have a considerable effect on color of the uncooked pasta samples. Nevertheless, the in-vitro protein digestibility was reduced with increasing curdlan dosage. Importantly, the predicted glycemic index of high-fiber pasta added with 2.5% curdlan was reduced by 1.5 times compared to the pasta sample without curdlan addition, highlighting the potential of curdlan as a food hydrocolloid for enhancing human health. Generally, curdlan was considered a prospective hydrocolloid to improve textural, cooking and sensory quality as well as health effect of the high-fiber pasta fortified with watermelon rind powder.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100464"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143147342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring potential of aloe vera and sterculia gum dietary fibers to develop functional hydrogels for drug delivery applications","authors":"Diwanshi Sharma,&nbsp;Baljit Singh","doi":"10.1016/j.bcdf.2025.100474","DOIUrl":"10.1016/j.bcdf.2025.100474","url":null,"abstract":"<div><div>Now days the main focus of carbohydrate research is to design functional hydrogels for biomedical applications. The aloe vera (AV) and sterculia gum (SG) are therapeutically active dietary fibers. Herein, these polysaccharides were explored to develop network hydrogels by covalent and non-covalent interactions for use in drug delivery (DD) and wound dressing (WD) applications. These hydrogel dressings were impregnated with antibiotic drug moxifloxacin for better wound care. Slow and sustained diffusion of drug was found with a non-Fickian mechanism and release profile was best explained by Higuchi kinetic model. Additionally, various physiological and biomedical properties of hydrogels were also evaluated. The dressings exhibited an impressive wound fluid absorption tendency under simulated conditions. The network structure demonstrated mucoadhesive properties and required 97 ± 6.00 mN forces for the detachment of dressings from mucosal surface. Dressing revealed significant antioxidant activity which demonstrated 49.14 ± 0.32 % free radical scavenging in DPPH assay. The dressings were non-toxic and were permeable to O₂ &amp; H₂O. The characterization of hydrogel dressings was performed through Field emission scanning electron microscopy/Energy dispersive spectroscopy (FESEM/EDS), Atomic force microscopy (AFM), ¹³Carbon Nuclear magnetic resonance spectroscopy (¹³C NMR), Fourier transform infrared spectroscopy (FTIR) &amp; X-ray diffraction (XRD) techniques to establish the structural aspects of copolymers. Overall, physicochemical &amp; biochemical findings suggested that these hydrogels could be applied in DD applications. These hydrogels developed from bioactive AV and SG could be applied as wound dressings encapsulated with antibiotic drug for better wound healing.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100474"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Characterization and antioxidant activity of flaxseed mucilage and evaluation of its dietary supplementation in improving calcium absorption in vivo” [Journal: Bioactive Carbohydrates and Dietary Fibre 32 (2024) 100444]","authors":"Engy M. Akl ,&nbsp;Rasha S. Mohamed ,&nbsp;Sherein S. Abdelgayed ,&nbsp;Karem Fouda ,&nbsp;Mosaad A. Abdel-Wahhab","doi":"10.1016/j.bcdf.2025.100471","DOIUrl":"10.1016/j.bcdf.2025.100471","url":null,"abstract":"","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100471"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitumor activity of polysaccharides obtained from guavira fruit industrial waste on murine melanoma cells","authors":"Rafaella Fernanda Angeli ,&nbsp;Amanda Plaça Bialli ,&nbsp;Suelen Cristina Soares Baal ,&nbsp;Elisvânia Freitas dos Santos ,&nbsp;Paulo Sérgio Loubet Filho ,&nbsp;Vanessa Suzane Schneider ,&nbsp;Luiz Cláudio Fernandes ,&nbsp;Katya Naliwaiko ,&nbsp;Lucimara Mach Côrtes Cordeiro ,&nbsp;Fabíola Iagher","doi":"10.1016/j.bcdf.2025.100469","DOIUrl":"10.1016/j.bcdf.2025.100469","url":null,"abstract":"<div><div>Melanoma is an aggressive type of cancer with increasing incidence worldwide. Chemotherapy drugs are associated with several side effects that lead to lost quality of life for patients undergoing treatment. This fact has encouraged the search for compounds capable of acting as adjuvants in cancer treatment with fewer side effects. Pectins are soluble polysaccharides with diverse molecular structures and important biological properties, which can be obtained from fruit parts often discarded by the food industry. The present study investigated the antitumor effect of pectins present in guavira pomace flour (<em>Campomanesia adamantium</em> and <em>C. pubescens</em>) on B16F10 cells. The assays evaluated viability, cell death, proliferation rate, migratory ability, and potential for colony formation. The results showed that pectins (CPW fraction) at concentrations of 5 and 100 μg/mL reduced the viability of tumor cells (∼20–40%, respectively, when compared to the untreated group), with less cytotoxicity on non-tumor cells (BALB/c 3T3) than the chemotherapy drug Doxorubicin (p &lt; 0.05). Similarly, the proliferation rate was decreased in B16F10 cells in the presence of two CPW concentrations (∼33 and 40%, respectively). In the flow cytometry assay, the CPW treatment did not increase the number of dead cells, suggesting cell cycle arrest. In addition, the CPW fraction reduced the migratory capacity of tumor cells (∼8 and 12%, respectively) and the number of new colonies formed (∼30 and 70%, respectively). Taken together, these results suggest that the pectins of guavira pomace flour, a discarded industrial material, have important antitumor activity with adjuvant therapeutic potential for cancer treatment.</div></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"33 ","pages":"Article 100469"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143296550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}