Bioactive Carbohydrates and Dietary Fibre最新文献

{"title":"Functional and structural characteristic of plant protein isolates as emulsifier by ultrasound-assisted extraction: A review","authors":"Abdurohman Zakki,&nbsp;Nita Aryanti,&nbsp;Hadiyanto Hadiyanto","doi":"10.1016/j.bcdf.2024.100449","DOIUrl":"10.1016/j.bcdf.2024.100449","url":null,"abstract":"<div><p>Depletion of natural-based resources is a common problem in many countries. This worse condition is in line with the people suffering from malnutrition when consuming food. The Sustainable Development Goals (SDGs) challenge ensuring global food security. More exploration of underutilized sustainable protein resources is required to preserve the protein sources. Ultrasound-assisted extraction (UAE) is a model-promoting extraction to isolate the plant-based protein effectively. UAE is a green extraction technique that provides high-performance results with power and time variation of protein isolates. This study aims to review the impact of UAE on functional and structural characteristics of plant protein isolation (PPI). The previous review reveals the optimum condition of extraction variables, whereas the contribution of UAE in protein isolate. The mechanism of UAE focused on extracting plant protein isolates such as protein yield, solubility, water or oil holding capacity, surface hydrophobicity, foaming capacity, emulsifying activities, and zeta potential. The UAE effect successfully maintains emulsion stability by lowering surface tension and increasing protein solubility in the aqueous phase. The aggregation of protein film at the interface between hydrophilic and hydrophobic media affects its stability in obtaining homogeneous mixtures. The findings clarified that the UAE can enhance the functional characteristics of PPI to fit and proper processing in food industries and support SDGs.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100449"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of enzymatically derived manno-oligosaccharides on the growth of select lactobacillus strains under aerobic and anaerobic conditions","authors":"Erica Di Pede ,&nbsp;Oreoluwa Kolade ,&nbsp;Bradley Saville","doi":"10.1016/j.bcdf.2024.100445","DOIUrl":"10.1016/j.bcdf.2024.100445","url":null,"abstract":"<div><p>This study highlights the ability of beta-MOS derived from coconut processing residues (copra meal) to promote the <em>in vitro</em> growth of <em>Lactobacillus</em> probiotics. Enzymatic hydrolysis conditions were manipulated to produce Low Molecular Weight (LMW) and (HMW) Manno-oligosaccharide (MOS) extracts. The LMW MOS contained more mannose and mannobiose, and the HMW MOS contained more mannotriose and higher molecular weight oligosaccharides. The growth of <em>Limosilactobacillus reuteri</em>, <em>Lactiplantibacillus plantarum</em> and <em>Lacticaseibacillus rhamnosus GG</em> on the MOS Extracts was evaluated and compared with growth on Inulin, FOS and XOS. There was significant growth of each probiotic on the MOS extracts. Probiotic growth was similar on MOS extracts and on FOS, while growth was much lower on XOS and Inulin. Probiotic growth was greater under anaerobic than under aerobic conditions. The results confirm the value of a bioactive compound from copra meal to support human and animal health, while contributing to a circular bioeconomy.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100445"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212619824000457/pdfft?md5=b4e5cdedf905d92367880fdbc04e281e&pid=1-s2.0-S2212619824000457-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of Candida albicans phagocytosis and inhibitory potency of Alternative Complement Pathway by an arabinoxylan extracted from Plantago ciliata Desf. Seeds and its oligosaccharides","authors":"Aziza Safaa Chenine ,&nbsp;Zakaria Boual ,&nbsp;Mohamed Didi Ould Elhadj ,&nbsp;Noura Addoun ,&nbsp;Reguia Mahfoudi ,&nbsp;Aicha Khemili ,&nbsp;Djahida Bey ,&nbsp;Hakim Belkhalfa ,&nbsp;Youcef Rahmani ,&nbsp;Pascal Dubessay ,&nbsp;Cédric Delattre ,&nbsp;Guillaume Pierre ,&nbsp;Philippe Michaud","doi":"10.1016/j.bcdf.2024.100446","DOIUrl":"10.1016/j.bcdf.2024.100446","url":null,"abstract":"<div><p>Leveraging bioactive compounds with immunomodulatory effects to boost immune functions represents a promising strategy for therapeutic intervention. The main objective of this work was to investigate the influence of the partial acid hydrolysis of an arabinoxylan extracted from <em>Plantago ciliata</em> Desf. seeds into oligosaccharides on its immunomodulatory effect. The resulting oligosaccharides and their polymer were evaluated for their potential to improve the phagocytic capacity (PC) and the phagocytic activity (PA) of polymorphonuclear neutrophils (PMNs) through the uptake of <em>Candida albicans</em> and to moderate alternative complement pathway (ACP) activation. As a result, the arabinoxylan derived from <em>P. ciliata</em> seeds (AXPCs) and its oligosaccharides (AXOPCs) significantly enhanced the PC of PMN cells, with EC50 values of 0.14 ± 0.23 and 0.12 ± 0.10 mg/mL, respectively. Zymosan used as a reference exhibited the highest PC with an EC50 0.07 ± 0.08 mg/mL. However, for PA, zymosan still demonstrated the highest activity with an EC50 of 0.22 ± 0.46 mg/mL compared to 0.33 ± 1.36 and 0.30 ± 0.74 mg/mL for AXPCs and AXOPCs, respectively. Moreover, AXPCs and AXOPCs were tested as moderator inhibitors of the complement system, showing maximum inhibition percentages of 40.11 ± 8.38% and 50.57 ± 10.45% at 1 mg/mL, with IC50 values of 1.49 ± 0.40 and 1.02 ± 0.20 mg/mL, respectively, compared to 61.52 ± 7.17% and 70.89 ± 5.78% for heparin used as a reference. These results suggest that AXPCs and AXOPCs can serve as relevant therapeutic immunomodulatory factors.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and antioxidant activity of flaxseed mucilage and evaluation of its dietary supplementation in improving calcium absorption in vivo","authors":"Engy M. Akl ,&nbsp;Rasha S. Mohamed ,&nbsp;Sherein S. Abdelgayed ,&nbsp;Karem Fouda ,&nbsp;Mosaad A. Abdel-Wahhab","doi":"10.1016/j.bcdf.2024.100444","DOIUrl":"10.1016/j.bcdf.2024.100444","url":null,"abstract":"<div><p>Calcium is an essential element for bone's strength and structure. Flaxseed mucilage (FM) is an economic bioactive component with potential prebiotic capability. FM promotes the growth of probiotic bacteria and it is added to fermented dairy products to increase the survivability of probiotic strains. Mucilage was extracted from flaxseed meal, as an industrial by-product, with or without ethanol precipitation (MEP and MWEP, respectively). Characterization, antioxidant, and chemical composition of the extracted mucilage were assessed. Plain milk as well as 100 mg/kg b. w of MWEP or MEP-fortified milk were administrated for 4 weeks to growing female rats fed a calcium-deficient diet to assess the role of mucilage, as a prebiotic, in calcium absorption, growth, and bone health. The free radical scavenging activity and the total reducing capability were greater in MWEP (72.4% and 17.53 mg/g, respectively) than in MEP (22.1% and 4.29 mg/g, respectively). Animals that received the mucilage-fortified milk showed an improvement in calcium absorption, which was reflected in the increase in the femur calcium and the improvement in bone health, which was evident through the histopathological findings of the bone tissues, and an improvement in bone growth, which was obvious through an increase in estrogen and insulin growth factor 1. It could be concluded that in addition to being a functional antioxidant made from industrial waste, flaxseed mucilage is also recommended to improve calcium absorption and bone health.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100444"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142075861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of indigestible carbohydrates and plant polyphenols on the gut microbiota profile and metabolite alterations of obese patients","authors":"Narinphop Chuaykarn ,&nbsp;Nattha Tampanna ,&nbsp;Piyanun Wangkulangkul ,&nbsp;Worrawit Wanitsuwan ,&nbsp;Kamthorn Yolsuriyanwong ,&nbsp;Santad Wichienchot","doi":"10.1016/j.bcdf.2024.100443","DOIUrl":"10.1016/j.bcdf.2024.100443","url":null,"abstract":"<div><p>This research aims to investigate the effects of indigestible carbohydrates and plant polyphenols on the alteration of gut microbiota and their metabolites in obese patients. The results showed that resistant starch type II had the highest diversity index, while banana inflorescence powder had the lowest diversity index of the gut microbiota. The gut microbiota profile exhibited that palm oil residue increased the abundance of Bacteroidetes from 23% to 44% and decreased the abundance of Firmicutes from 63% to 21%. This led to the lowest Firmicutes-to-Bacteroidetes (F/B) ratio of 0.5, followed by gnetum leaf powder (1.1), dragon fruit oligosaccharide (1.2), banana inflorescence powder (1.2), and resistance starch type II (1.6) compared to the initial fecal sample (F/B) ratio of 2.7. The isomaltooligosaccharide had an F/B ratio of 9.4. Palm oil residue could reduce the relative abundance of nucleotide biosynthesis, amino acid biosynthesis, aromatic compound synthesis, and peptidoglycan biosynthesis, all of which are related to obesity metabolic pathways. The short-chain fatty acids analysis showed that gnetum leaf powder and isomaltooligosaccharide exhibited the highest production of acetic acid (19.37 mM) and butyric acid (11.27 mM). Palm oil residue and gnetum leaf powder significantly impacted propionic acid production (10.93 and 10.08 mM, respectively). In the gut microbiota of obese humans, 3-(3-hydroxyphenyl) propionic acid derived from phenolic metabolites was detected during the fermentation of palm oil residue. In summary, our study demonstrated that plant polyphenols are more effective than indigestible carbohydrates, suggesting a novel alternative approach for the treatment of obesity.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100443"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amaranth fiber acts as fermentable substrate for children's fecal microbiota","authors":"Ana Clara Sabbione ,&nbsp;Ana Agustina Bengoa ,&nbsp;Graciela Liliana Garrote ,&nbsp;Adriana Scilingo ,&nbsp;María Cristina Añón ,&nbsp;Analía Graciela Abraham","doi":"10.1016/j.bcdf.2024.100447","DOIUrl":"10.1016/j.bcdf.2024.100447","url":null,"abstract":"<div><p>Fiber has an important role in modulating the intestinal microbiota and its metabolic activity. Since amaranth seeds are a good source of dietary fiber, this study aimed to evaluate the potential prebiotic capacity of fibers obtained from amaranth flour (AFF), a protein isolate (APIF), and a beverage (ABF) to modulate children's fecal microbiota in an <em>in vitro</em> fermentation model. Changes induced in fecal microbiota and the profile of short-chain fatty acids (SCFA) were evaluated after 24, 48, and 72h. APIF and ABF samples reached levels of 60 mM acetate, 35 mM propionate, and 8 mM butyrate, with significant increases in acetate and butyrate at 24 and 72h, and in propionate at the three times evaluated. Regarding AFF, significant increases of SCFA were observed after 72h with levels of 55 mM, 25 mM, and 6 mM for acetate, propionate, and butyrate respectively. Moreover, DGGE profiles at 24h fermentation of amaranth samples showed a high similarity (90%), locating in a cluster separated from inulin and basal medium. However, after 72h fermentation, AFF showed slight differences in the profile with 74% similarity with APIF and ABF. Sequencing results of 24h fermentation of amaranth fibers showed a marked decrease in <em>Fusobacterium</em> and enterobacteria compared with basal medium, accompanied by a significant increase in <em>Bacteroides</em> and <em>Parabacteroides</em>. These results constitute an important contribution in the search for new compounds that promote a healthy gut microbiota. Thereby, the incorporation of these new prebiotics into the diet could lead to the establishment of a widely diverse microbiota usually associated with a healthier state.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of functional compounds from agro-industrial residues of Brazilian's tropical fruits extracted by sustainable methods in alginate-chitosan microparticles","authors":"Luiz Eduardo Nochi Castro ,&nbsp;Tiago Linhares Cruz Tabosa Barroso ,&nbsp;Vanessa Cosme Ferreira ,&nbsp;William Gustavo Sganzerla ,&nbsp;Vitória Helisa Burgon ,&nbsp;Matheus Queiroz ,&nbsp;Leomara Floriano Ribeiro ,&nbsp;Tânia Forster-Carneiro","doi":"10.1016/j.bcdf.2024.100441","DOIUrl":"10.1016/j.bcdf.2024.100441","url":null,"abstract":"<div><p>The extraction and encapsulation of bioactive compounds have emerged as promising strategies to enhance their utility in various industrial applications. This study explores functional compounds derived from tropical fruit waste, including grape pomace, jabuticaba, and dragon fruit. These compounds were extracted using sustainable methods such as ultrasound-assisted extraction, maceration, and pressurized liquid extraction for incorporation into alginate and chitosan microparticles. Among the extraction methods employed, pressurized liquid extraction demonstrated the highest efficiency in recovering phenolic compounds, anthocyanins, and betalains. The optimized microparticles were tailored to specific fruit sources, with chitosan concentrations of 0.19%, 0.27%, and 0.34%, and alginate concentrations of 2.26%, 1.79%, and 1.73% for grape pomace, dragon fruit husk, and jabuticaba peel, respectively. These microparticles exhibited encapsulation efficiencies ranging from 98.43% to 99.78%. Furthermore, they displayed low solubility (0.23%–0.39%) and high hygroscopicity (38.92%–41.01%). In vitro gastrointestinal digestibility tests showed that the bioaccessibility of the phenolic compounds reached up to 95%. This finding suggests that the encapsulated bioactive compounds remain highly bioavailable, making them potentially valuable in the development of pharmaceutical and health products as well as functional foods. In conclusion, this research underscores the significance of valorizing tropical fruit by-products in Brazil through pressurized liquid extraction, followed by their efficient encapsulation within alginate and chitosan matrices. This process not only reduces waste but also opens up exciting avenues for applications in the food and pharmaceutical sectors.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100441"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro fecal fermentation characteristics and dynamic changes in physicochemical and structural properties of oat β-glucan","authors":"Jixiang Zhang ,&nbsp;Huanhuan Liu ,&nbsp;Sijia Yin ,&nbsp;Nifei Wang ,&nbsp;Shujun Wang ,&nbsp;Changlu Wang ,&nbsp;Ji Kang ,&nbsp;Abhishek Gupta ,&nbsp;Qingbin Guo ,&nbsp;Yanfang Liu","doi":"10.1016/j.bcdf.2024.100432","DOIUrl":"10.1016/j.bcdf.2024.100432","url":null,"abstract":"<div><p>Oat β-glucan (OG) is a common food in many diets, but the relationship between the structural changes of dietary fibre and the dynamic shifts in gut microbiota composition remains unclear. In this study, the dynamic variations of physicochemical and structural characteristics of OG at different fermentation stages were studied using an <em>in vitro</em> porcine colonic digestion model. lMeanwhile, the correlation between the molecular structure changes of OG and its regulation of gut microorganisms during fermentation was studied. The molecular weight of OG decreased with the prolongation of fermentation time due to the decomposition of the glucoside bond by gut microorganisms. Methylation analysis showed that the sugar residues in OG mainly included T-Glc<em>p</em>, 3-Glc<em>p</em> and 4-Glc<em>p</em>, while the proportions of 3-Glc<em>p</em> and 4-Glc<em>p</em> did not change significantly during the process of fermentation, demonstrating that gut microorganisms could equally decompose β-(1, 3) and β-(1, 4) glucoside bonds. During the fermentation process, OG inhibited the growth of harmful bacteria while promoting the growth of beneficial bacteria, especially <em>Lactobacillus</em>. Compared with gum arabic, hawthorn pectin, arabinoxylan, guar gum and dendrobium officinale polysaccharide, OG showed the fastest fermentation rate and highest <em>Lactobacillus</em> abundance. This study's results offer a scientific foundation for enhancing the conversion of oat β-glucan (OG) into prebiotics within the functional food industry. Additionally, they provide valuable insights into the reciprocal regulation between other structural polysaccharides and gut microorganisms.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100432"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New trends in the valuation of micro and nanocrystalline cellulose and their derivatives extracted from the wastes of palm frond for curing of peptic ulcers","authors":"Tamer I.M. Ragab ,&nbsp;Sally A. El Awdan ,&nbsp;Alaa M. Ali ,&nbsp;Gehan T. El-Bassyouni ,&nbsp;Wafa A. Helmy ,&nbsp;Al Shimaa G. Shalaby","doi":"10.1016/j.bcdf.2024.100440","DOIUrl":"10.1016/j.bcdf.2024.100440","url":null,"abstract":"<div><p>The current study was directed to explore new natural products that alleviate inflammation with the least harming effects on the gastric mucosa. This study examined the anti-ulcerative properties of micro and nanocrystalline cellulose (MCC, NCC) palm frond and their chemically modified samples (sulfated (SMCC and SNCC), methylated (MMCC and MNCC) and phosphorylated (PMCC and PNCC)). The lowest prebiotic index (I) was recorded in case of the MMCC and MNCC extract with <em>L. Reuteri</em> (I = 1) while the higher prebiotic index was recorded in case of the PMCC against <em>L. casei</em> (I = 3.7). All treated groups showed significant improvements in the ulcer scores (P &lt; 0.05) compared to the control (indomethacin) group. However, MMCC showed marked effects similar to ranitidine. A significant decrease was found in pro-inflammatory cytokines (IL-6 and TNF-α) and pro-apoptotic gene (Bax) in all treated groups compared to the ulcer-induced group. In conclusion, the histopathological evaluation of MNCC, PNCC and SNCC had superior ameliorating effect on gastric ulcer induced in rats when compared to Omeprazole 20 mg/kg and other treated groups (MMCC, PMCC, SMCC).</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100440"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing carrageenan-based hydrogels for drug delivery applications: Evaluation of physiochemical and biomedical properties","authors":"Nistha Thakur ,&nbsp;Baljit Singh ,&nbsp;Sohini Sharma ,&nbsp;Shamsher Singh Kanwar","doi":"10.1016/j.bcdf.2024.100439","DOIUrl":"10.1016/j.bcdf.2024.100439","url":null,"abstract":"<div><p>This research article presents the potential of naturally occurring seaweed polysaccharides in developing functional materials for use in biomedical applications, focusing on sustainable development. Herein, Carrageenan (CG) was utilized to design hydrogels for use in drug delivery (DD) applications. These hydrogels were prepared by copolymerization reaction of poly(bis[<em>2</em>-(methacryloyloxy)ethyl] phosphate and poly(acrylamide) onto CG by covalent and supramolecular interactions. Copolymers were characterized by Field emission-scanning electron micrographs (FE-SEM), Energy dispersive X-ray analysis (EDAX), Fourier transform infrared spectroscopy (FTIR), ¹³C nuclear magnetic resonance (NMR), X-ray diffraction (XRD). FESEM images revealed uneven heterogeneous morphology while XRD revealed development of amorphous short range orders of polymer chains. The hydrogel revealed 177 % RD cell viability which indicated non-cytotoxicity to mammalian cells. The hydrogels also promoted proliferation of cells which is useful for cell adhesion, wound dressings and tissue engineering applications. The release of antibiotic drug vancomycin from hydrogels occurred in sustained manner and obeyed non-Fickian diffusion mechanism. The drug release data was best described by Higuchi kinetic model. Drug encapsulated hydrogel exhibited antimicrobial activity against <em>P. aeruginosa, E. coli and S. aureus</em> bacteria. The copolymers revealed biocompatibility during polymer-blood interaction while polymer-mucus membrane interaction demonstrated their mucoadhesive nature. Antioxidant nature of copolymers was demonstrated in DPPH free radicals scavenging assay. These properties suggested that hydrogel could be explored to design drug delivery systems.</p></div>","PeriodicalId":38299,"journal":{"name":"Bioactive Carbohydrates and Dietary Fibre","volume":"32 ","pages":"Article 100439"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141624020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}