Wound Medicine最新文献_第7页

Allogeneic fibroblast cell therapy in the treatment of recessive dystrophic epidermolysis bullosa 同种异体成纤维细胞治疗隐性营养不良大疱性表皮松解症

Wound Medicine Pub Date : 2018-06-01 DOI: 10.1016/j.wndm.2018.04.002

Alexey Kubanov , Arfenya Karamova , Vera Albanova , Vera Smoliannikova , Maria Nefedova , Vadim Chikin , Ekaterina Monchakovskaya

{"title":"Allogeneic fibroblast cell therapy in the treatment of recessive dystrophic epidermolysis bullosa","authors":"Alexey Kubanov , Arfenya Karamova , Vera Albanova , Vera Smoliannikova , Maria Nefedova , Vadim Chikin , Ekaterina Monchakovskaya","doi":"10.1016/j.wndm.2018.04.002","DOIUrl":"10.1016/j.wndm.2018.04.002","url":null,"abstract":"<div><h3>Background</h3><p>The non-healing wound is a characteristic clinical sign in recessive dystrophic epidermolysis bullosa (RDEB).</p></div><div><h3>Methods</h3><p>Six patients with recessive dystrophic epidermolysis bullosa were injected with suspension of allogeneic fibroblasts into erosion margins. Erosions (>1 month old) with surface area between 2 cm<sup>2</sup> and 28 cm<sup>2</sup><span> were selected for treatment. The patients were administered with 1 mL suspension of allogeneic fibroblasts with concentration 5 × 10</span><sup>6</sup> cells/ml, 10 × 10<sup>6</sup> cells/ml and 20 × 10<sup>6</sup><span> cells/ml. Paired erosions were injected with vehicle solution alone. All erosions were assessed for healing rate and biopsied at baseline and at two weeks after treatment. Immunofluorescence antigen mapping (IFM) was performed to detect C7 expression.</span></p></div><div><h3>Results</h3><p><span>An increase of healing rate was detected 14 days after fibroblasts and vehicle alone injections, in some cases with complete erosion closure. The results of the IFM in patients treated with allogeneic fibroblasts and vehicle solution demonstrated the increase of collagen VII expression in dermo-epidermal junction, more intensive in patients injected with 20 × 10</span><sup>6</sup> cells/ml.</p></div><div><h3>Conclusions</h3><p>Intradermal administration of allogeneic fibroblasts is a safe and effective method of treatment of non-healing wounds in recessive dystrophic epidermolysis bullosa.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"21 ","pages":"Pages 8-11"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48483340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of in vivo wound healing and anti-inflammatory activity of crude extract of the fruits of Brucea antidysentrica in mice 布氏果粗提物对小鼠体内创面愈合及抗炎作用的评价

Wound Medicine Pub Date : 2018-06-01 DOI: 10.1016/j.wndm.2018.05.005

Zenaw Tessema , Eyasu Makonnen , Asfaw Debella , Yalew Molla

{"title":"Evaluation of in vivo wound healing and anti-inflammatory activity of crude extract of the fruits of Brucea antidysentrica in mice","authors":"Zenaw Tessema , Eyasu Makonnen , Asfaw Debella , Yalew Molla","doi":"10.1016/j.wndm.2018.05.005","DOIUrl":"10.1016/j.wndm.2018.05.005","url":null,"abstract":"<div><h3>Background</h3><p><em>Brucea antidysentrica</em> is traditionally used to treat various conditions. Though, fruits of <em>B. antidysentrica</em> are claimed to promote wound healing; there is no scientific evidence that supports the traditional claim. Therefore, this study was aimed to evaluate the wound healing and anti-inflammatory activities of the extract.</p></div><div><h3>Methods</h3><p>Extracts were formulated as 1% and 2% ointments. Simple and nitrofurazone<span><span> (0.2%) ointments were used as controls for the wound healing. A dose of 100, 200 and 400 mg/kg body weight were used for anti-inflammatory activity tests using vehicle and indomethacin 10 mg/kg as controls. </span>Wound contraction<span> rate, complete epithelialization period, skin breaking strength and edema inhibition were evaluated.</span></span></p></div><div><h3>Results</h3><p>On last day of treatment, fruits extract showed a significant wound healing activity at strengths of 2% compared with negative control as. On the same day 1% MFE was found to increase the % wound contraction significantly (P < 0.01). Only 2% MFE resulted in a significant increase in tensile strength (p < 0.01). The 200 and 400 mg/kg doses were revealed a significant anti-inflammatory effect particularly at 3 and 4 h.</p></div><div><h3>Conclusion</h3><p>The extract supports traditional claims for wound healing and anti-inflammatory activity.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"21 ","pages":"Pages 16-21"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.05.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44872505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Development of antimicrobial colloidal silver incorporated lyophilized biopolymer wafers for wound care 冻干生物聚合物硅片用于伤口护理的抗菌胶体银的研制

Wound Medicine Pub Date : 2018-06-01 DOI: 10.1016/j.wndm.2018.04.001

Asma Tabassum, Sharon Caroline Furtado, S. Bharath

{"title":"Development of antimicrobial colloidal silver incorporated lyophilized biopolymer wafers for wound care","authors":"Asma Tabassum, Sharon Caroline Furtado, S. Bharath","doi":"10.1016/j.wndm.2018.04.001","DOIUrl":"10.1016/j.wndm.2018.04.001","url":null,"abstract":"<div><h3>Background</h3><p>The field of wound care has an increasing patient base and wound dressings form an important segment in the field of wound care worldwide. Wounds are subjected to infection by many microorganisms and thus use of antimicrobials to treat chronic infected wounds is essential. The use of biopolymers by incorporation of aqueous colloidal silver by application of lyophilization technique in formulation of wafer dressings is an innovative method in the field of wound management.</p></div><div><h3>Methods</h3><p>Wafers were formulated using natural biopolymers sodium alginate and chitosan with plasticizer glycerol in different concentrations with embedded colloidal silver by lyophilization technique.</p></div><div><h3>Results</h3><p>The formulated wafers were of uniform thickness, soft, flexible, posessing good tensile properties and flexibility. The ESEM studies indicated the porous morphological structure with silver embededment within the matrix. The percentage of wound contraction rate was significantly increased in wounds treated with colloidal silver incorporated wound wafers incontrast to wafers without colloidal silver and marketed gel formulation containing colloidal silver.</p></div><div><h3>Conclusion</h3><p>Lyophilized antimicrobial wafers were developed as a successful wound dressing for combating microbial infections at the site of application with enhanced wound healing activity.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"21 ","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48736080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Effective debridement with micro water jet technology (MWT): A retrospective clinical application observation of 90 patients with acute and chronic wounds 微水射流技术有效清创90例急慢性创面回顾性临床应用观察

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2018.01.001

M. Reber , P. Nussbaumer

{"title":"Effective debridement with micro water jet technology (MWT): A retrospective clinical application observation of 90 patients with acute and chronic wounds","authors":"M. Reber , P. Nussbaumer","doi":"10.1016/j.wndm.2018.01.001","DOIUrl":"10.1016/j.wndm.2018.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>This retrospective clinical application observation study shall demonstrate the effect of a wound debridement using micro water jet technology (MWT) as an efficient method promoting wound healing. The final goal is to accomplish a decrease in wound size (reepithelization) due to debridement with MWT. Through the application of MWT, the wound shall receive a healing stimulus. Besides the use of MWT, there are other water-based cleaning/rinsing systems available.</p></div><div><h3>Method</h3><p>From two wound care centers (Kantonsspital Obwalden, Spital Lachen), all data from patients treated with MWT and different types of wound, over a time period of 3 years, were retrospectively analyzed. All patients, except one, could be treated in an outpatient setting. Fewest of the patients did receive a local anesthetic. Included were all patients, independent from gender and age.</p></div><div><h3>Results</h3><p><span>The retrospective data analysis was carried out on 90 patients (46 m/44 f) with an average age of 68.5 years (17/93 years) and a total of 95 different wounds. 58 wounds were completely closed at exit from the wound care center within a median treatment time of 59 days (8.4 weeks). The average treatment time for all 95 wounds was 39 days (5.6 weeks) per wound at the end of debridement, the average wound size 6.1 cm</span><sup>2</sup>. The reduction of healing time compared to traditional methods was approximately 30%.</p></div><div><h3>Conclusion</h3><p>The result of the retrospective data analysis on patients with predominantly chronic and persistent wounds shows that debriding with micro water jet technology is an efficient, tissue-preserving, precise and time-saving method for outpatient wound care – with excellent healing outcomes. Patient safety was high and we have seen no adverse effects. The MWT is comparable to other water jet-based cleaning/rinsing systems.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 35-42"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44293481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prevalence of MDR Pseudomonas aeruginosa of war-related wound and burn ward infections from some conflict areas of Western Yemen 也门西部一些冲突地区战争创伤和烧伤病房感染耐多药铜绿假单胞菌的患病率

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2018.02.001

Mahfouz Nasser , Mahmoud Ogali , Arun S. Kharat

{"title":"Prevalence of MDR Pseudomonas aeruginosa of war-related wound and burn ward infections from some conflict areas of Western Yemen","authors":"Mahfouz Nasser , Mahmoud Ogali , Arun S. Kharat","doi":"10.1016/j.wndm.2018.02.001","DOIUrl":"10.1016/j.wndm.2018.02.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The antibiotic resistant <span><em>Pseudomonas aeruginosa</em></span><span> affecting war-related wound injuries is a serious problem with regional and global implications, which requires antibiotic susceptibility testing on a regular basis. The primary aim of this study was to determine the prevalence for multi-drug resistance </span><em>Pseudomonas aeruginosa</em> of war-related wound infections from conflict areas in Hodiedah, Western Yemen.</p></div><div><h3>Methods and materials</h3><p>A study was undertaken with ninety-nine wound swabs from war-related wound infections patients those were hospitalized to Wound Burn Centre at Organization The General AL-Thawra Hospital, Hodiedah Western Yemen. The isolates were cultured and identified by standard microbiological techniques and with the use of Kirby- Bauer disc diffusion antibiotic susceptibility testing was done.</p></div><div><h3>Results</h3><p>Out of 99 swab isolates 46 were <em>P. aeruginosa</em><span><span> (46.46%). Highest incidence of 63.1% was found in the age group of 20–40 years. Isolates exhibited resistance to aminoglycosides<span>; Gentamycin (87%), </span></span>Tobramycin<span> (78.2%) and Amikacin (82.6%). Curiously, 65.2% </span></span><em>P. aeruginosa</em> isolates were multidrug resistance (MDR).</p></div><div><h3>Conclusion</h3><p>This is the first report documenting enhanced MDR <em>P. aeruginosa</em> from war-related wound infections from Yemen. The sampling, timing of medical intervention plays crucial role in preventing nosocomial transmission of MDR <em>P. aeruginosa</em> strains.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 58-61"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44185670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Modulation of collagen population under honey assisted wound healing in diabetic rat model 蜂蜜对糖尿病大鼠创伤愈合模型中胶原蛋白的调节作用

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2017.12.001

Satarupa Sarkar , Amrita Chaudhary , Tanmoy Kumar Saha , Amit Kumar Das , Jyotirmoy Chatterjee

{"title":"Modulation of collagen population under honey assisted wound healing in diabetic rat model","authors":"Satarupa Sarkar , Amrita Chaudhary , Tanmoy Kumar Saha , Amit Kumar Das , Jyotirmoy Chatterjee","doi":"10.1016/j.wndm.2017.12.001","DOIUrl":"10.1016/j.wndm.2017.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Diabetic wound with impaired healing attributes owing to inappropriate synthesis and alignment of collagen fibrils with aberrant post translational modifications impose substantial economic burden. Honey: a recognized natural collagen pro-synthetic healing agent; stimulates rapid healing with its anti-inflammatory and anti-scarring approach. Present study investigates the effect of honey on collagen population in diabetic wound model.</p></div><div><h3>Methodology</h3><p>Full thickness wound was created on rat and divided into three groups: normal saline treated group (N), diabetic honey treated group (H), diabetic povidone iodine treated group (PI). Biopsies were collected from wound edges for collagen characterization.</p></div><div><h3>Main findings</h3><p>Histological attributes of collagen fibers in N and H group biopsy displayed proximity. Ultrastructure analysis using scanning electron microscope (SEM) revealed that the D-Spacing and collagen diameter under honey treatment were in close resemblance to normal skin collagen. FTIR spectra confirmed secondary structure of collagen with a greater peak height in PI group exhibiting excessive glycation than H group. Nano-indentation profiling showed decreased displacement in PI samples resulting from increased rigidity when compared to honey treated ones. Molecular expression of collagen I and III exhibited optimum ratio in H group similar to N group.</p></div><div><h3>Conclusions</h3><p>Based on these findings, it might be opined that honey predominantly helps in regulating synthesis, glycation and deposition followed by mechanical quality of collagen alike normal skin and its application also accelerated diabetic healing process.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 7-17"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41245304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Xeno-free autologous platelet rich plasma for chronic wound management – Case series 用于慢性伤口管理的无异种自体富血小板血浆——案例系列

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2018.01.004

Krishnaiah Kurapati , Praveen Kumar G.V. , Kavitha Anbarasu , Anand Kumar Vaggu , Vibhuda Nanduri , Syed Sultan Beevi , Vinod Kumar Verma

{"title":"Xeno-free autologous platelet rich plasma for chronic wound management – Case series","authors":"Krishnaiah Kurapati , Praveen Kumar G.V. , Kavitha Anbarasu , Anand Kumar Vaggu , Vibhuda Nanduri , Syed Sultan Beevi , Vinod Kumar Verma","doi":"10.1016/j.wndm.2018.01.004","DOIUrl":"10.1016/j.wndm.2018.01.004","url":null,"abstract":"<div><h3>Background</h3><p><span>In chronic wounds, healing process gets halted in inflammatory phase owing to lack of growth factors (GF). The concept of exogenous delivery of such GF as platelet rich plasma (PRP)/fibrin (PRF) could be logical strategy for their management. We evaluated efficacy of single dose of non-activated PRP and self- polymerized </span>platelet rich fibrin (PRF) in subjects with chronic wounds.</p></div><div><h3>Methods</h3><p>35 Subjects with wounds of different depths and etiologies were administered with PRP or PRP + PRF and assessed with Bates-Jensen Wound Assessment Tool (BWAT).</p></div><div><h3>Results</h3><p>Majority of subjects in PRP group responded well and entered into regenerative zone. In PRP + PRF group, 36% subjects benefitted from this treatment.</p></div><div><h3>Conclusion</h3><p>Our study demonstrates that single dose of non-activated PRP is an efficacious treatment regime for chronic wounds. Further, it eliminates need for multiple doses due to continual release of growth factor over a long period of time, thus considerably reducing effective cost of procedure.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 54-57"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43718303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo models for assesment of wound healing potential: A systematic review 评估伤口愈合潜力的体内模型:系统综述

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2018.01.003

Alankar Shrivastav , Arun Kumar Mishra , Syed Salman Ali , Aftab Ahmad , Mohammed F. Abuzinadah , Najam Ali Khan

{"title":"In vivo models for assesment of wound healing potential: A systematic review","authors":"Alankar Shrivastav , Arun Kumar Mishra , Syed Salman Ali , Aftab Ahmad , Mohammed F. Abuzinadah , Najam Ali Khan","doi":"10.1016/j.wndm.2018.01.003","DOIUrl":"10.1016/j.wndm.2018.01.003","url":null,"abstract":"<div><h3>Introduction</h3><p><span>The wound is defined as an injury of a living tissue, arose due to either an accidental injury like cut of the cells or skin or sometime, maybe broken the tissue, which may cause the anomalies in the cellular ability to exhibit the protective mechanism. Wound healing is process of regaining the integrity of cell structure and layers of the skin. The normal healing process of wounds are categorized in 4 phases which includes </span>hemostatic, inflammatory, fibrolastic and maturation.</p></div><div><h3>Purpose</h3><p>The present manuscript embarks on up to date information on different methods being used for wound healing assessment including incision<span>, excision, burn wound and dead space models. The biochemical parameter which acts as wound healing markers are collagen estimation (hydroxyproline), hexosamine<span>, DNA estimation, total protein estimation, wound Index, contraction area, epithelization period and tensile strength etc. Histologic evaluations is also an integral part of wound healing evaluation which, help in evaluating the cellular and matrix detail within the wound.</span></span></p></div><div><h3>Conclusion</h3><p>At present, molecular approaches are important to heal the wound. For assessment of potential of any herbal drug/synthetic compound, incision wound model, excision wound model, burn wound model and dead space model and their parameter are used.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 43-53"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41852248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Therapeutic effects of a pulsed electromagnetic device in chronic cutaneous ulcers of the lower limbs 脉冲电磁装置治疗下肢慢性皮肤溃疡的疗效观察

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2017.12.003

Edoardo Raposio , Nicolò Bertozzi , Francesco Simonacci , Michele P. Grieco

引用次数: 1

Lifetime cost of chronic ulcers requiring hospitalization in Ontario, Canada: A population-based study 加拿大安大略省需要住院治疗的慢性溃疡终生费用:一项基于人群的研究

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2018.01.002

Brian C.F. Chan , Suzanne M. Cadarette , Walter P. Wodchis , Nicole Mittmann , Murray D. Krahn

{"title":"Lifetime cost of chronic ulcers requiring hospitalization in Ontario, Canada: A population-based study","authors":"Brian C.F. Chan , Suzanne M. Cadarette , Walter P. Wodchis , Nicole Mittmann , Murray D. Krahn","doi":"10.1016/j.wndm.2018.01.002","DOIUrl":"10.1016/j.wndm.2018.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the lifetime cost-of-illness of chronic ulcers<span> from the perspective of the Ontario public health care payer.</span></p></div><div><h3>Methods</h3><p>We calculated health care costs for a cohort of individuals hospitalized for a diabetic foot ulcer<span><span>, pressure ulcer or </span>leg ulcer between 2005 and 2011 using Ontario administrative health care data. Lifetime costs for this cohort were estimated using phase-based costing methods. Net cost was determined by calculating the difference in lifetime costs between the chronic ulcer cohort and a matched non-chronic ulcer cohort. Matching was conducted using a combination of hard matching and propensity score methods. The chronic ulcer cohort represents all individuals residing in Ontario, Canada.</span></p></div><div><h3>Results</h3><p>A total of 7316 individuals with chronic ulcers were identified and matched with a non-chronic ulcer cohort (5583 diabetic foot ulcer, 1470 pressure ulcer, 262 leg ulcer). Lifetime net modeled cost of diabetic foot ulcer was $619,300 (95% CI $593,900–$642,800), for pressure ulcer $98,500 (95% CI $88,300–$109,100) and for leg ulcer $548,100 (95% CI $524,400–$569,500).</p></div><div><h3>Conclusions</h3><p>Chronic ulcers present a substantial economic burden to the health care system. Health care decision makers are encouraged to consider additional resources to preventative interventions for chronic ulcers to reduce downstream costs.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 21-34"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48648618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4