Xeno-free autologous platelet rich plasma for chronic wound management – Case series

Q1 Medicine

Wound Medicine Pub Date : 2018-03-01 DOI:10.1016/j.wndm.2018.01.004

Krishnaiah Kurapati , Praveen Kumar G.V. , Kavitha Anbarasu , Anand Kumar Vaggu , Vibhuda Nanduri , Syed Sultan Beevi , Vinod Kumar Verma

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引用次数: 0

Abstract

Background

In chronic wounds, healing process gets halted in inflammatory phase owing to lack of growth factors (GF). The concept of exogenous delivery of such GF as platelet rich plasma (PRP)/fibrin (PRF) could be logical strategy for their management. We evaluated efficacy of single dose of non-activated PRP and self- polymerized platelet rich fibrin (PRF) in subjects with chronic wounds.

Methods

35 Subjects with wounds of different depths and etiologies were administered with PRP or PRP + PRF and assessed with Bates-Jensen Wound Assessment Tool (BWAT).

Results

Majority of subjects in PRP group responded well and entered into regenerative zone. In PRP + PRF group, 36% subjects benefitted from this treatment.

Conclusion

Our study demonstrates that single dose of non-activated PRP is an efficacious treatment regime for chronic wounds. Further, it eliminates need for multiple doses due to continual release of growth factor over a long period of time, thus considerably reducing effective cost of procedure.

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用于慢性伤口管理的无异种自体富血小板血浆——案例系列

在慢性伤口中，由于缺乏生长因子(GF)，愈合过程在炎症期停止。外源性输送诸如富血小板血浆(PRP)/纤维蛋白(PRF)等GF的概念可能是其管理的逻辑策略。我们评估了单剂量非活化PRP和自聚合富血小板纤维蛋白(PRF)在慢性创伤患者中的疗效。方法对35例不同伤口深度、不同病因的患者分别给予PRP或PRP + PRF治疗，并用Bates-Jensen伤口评估工具(BWAT)进行评估。结果PRP组大部分患者反应良好，进入再生区。在PRP + PRF组中，36%的受试者从这种治疗中受益。结论单剂量非活化PRP是治疗慢性创伤的有效方法。此外，由于生长因子在很长一段时间内持续释放，它消除了多次剂量的需要，从而大大降低了手术的有效成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wound Medicine Medicine-Surgery

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