In vivo models for assesment of wound healing potential: A systematic review

Introduction

The wound is defined as an injury of a living tissue, arose due to either an accidental injury like cut of the cells or skin or sometime, maybe broken the tissue, which may cause the anomalies in the cellular ability to exhibit the protective mechanism. Wound healing is process of regaining the integrity of cell structure and layers of the skin. The normal healing process of wounds are categorized in 4 phases which includes hemostatic, inflammatory, fibrolastic and maturation.

Purpose

The present manuscript embarks on up to date information on different methods being used for wound healing assessment including incision, excision, burn wound and dead space models. The biochemical parameter which acts as wound healing markers are collagen estimation (hydroxyproline), hexosamine, DNA estimation, total protein estimation, wound Index, contraction area, epithelization period and tensile strength etc. Histologic evaluations is also an integral part of wound healing evaluation which, help in evaluating the cellular and matrix detail within the wound.

Conclusion

At present, molecular approaches are important to heal the wound. For assessment of potential of any herbal drug/synthetic compound, incision wound model, excision wound model, burn wound model and dead space model and their parameter are used.