{"title":"用于慢性伤口管理的无异种自体富血小板血浆——案例系列","authors":"Krishnaiah Kurapati , Praveen Kumar G.V. , Kavitha Anbarasu , Anand Kumar Vaggu , Vibhuda Nanduri , Syed Sultan Beevi , Vinod Kumar Verma","doi":"10.1016/j.wndm.2018.01.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>In chronic wounds, healing process gets halted in inflammatory phase owing to lack of growth factors (GF). The concept of exogenous delivery of such GF as platelet rich plasma (PRP)/fibrin (PRF) could be logical strategy for their management. We evaluated efficacy of single dose of non-activated PRP and self- polymerized </span>platelet rich fibrin (PRF) in subjects with chronic wounds.</p></div><div><h3>Methods</h3><p>35 Subjects with wounds of different depths and etiologies were administered with PRP or PRP + PRF and assessed with Bates-Jensen Wound Assessment Tool (BWAT).</p></div><div><h3>Results</h3><p>Majority of subjects in PRP group responded well and entered into regenerative zone. In PRP + PRF group, 36% subjects benefitted from this treatment.</p></div><div><h3>Conclusion</h3><p>Our study demonstrates that single dose of non-activated PRP is an efficacious treatment regime for chronic wounds. Further, it eliminates need for multiple doses due to continual release of growth factor over a long period of time, thus considerably reducing effective cost of procedure.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"20 ","pages":"Pages 54-57"},"PeriodicalIF":0.0000,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.004","citationCount":"0","resultStr":"{\"title\":\"Xeno-free autologous platelet rich plasma for chronic wound management – Case series\",\"authors\":\"Krishnaiah Kurapati , Praveen Kumar G.V. , Kavitha Anbarasu , Anand Kumar Vaggu , Vibhuda Nanduri , Syed Sultan Beevi , Vinod Kumar Verma\",\"doi\":\"10.1016/j.wndm.2018.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span>In chronic wounds, healing process gets halted in inflammatory phase owing to lack of growth factors (GF). The concept of exogenous delivery of such GF as platelet rich plasma (PRP)/fibrin (PRF) could be logical strategy for their management. We evaluated efficacy of single dose of non-activated PRP and self- polymerized </span>platelet rich fibrin (PRF) in subjects with chronic wounds.</p></div><div><h3>Methods</h3><p>35 Subjects with wounds of different depths and etiologies were administered with PRP or PRP + PRF and assessed with Bates-Jensen Wound Assessment Tool (BWAT).</p></div><div><h3>Results</h3><p>Majority of subjects in PRP group responded well and entered into regenerative zone. In PRP + PRF group, 36% subjects benefitted from this treatment.</p></div><div><h3>Conclusion</h3><p>Our study demonstrates that single dose of non-activated PRP is an efficacious treatment regime for chronic wounds. Further, it eliminates need for multiple doses due to continual release of growth factor over a long period of time, thus considerably reducing effective cost of procedure.</p></div>\",\"PeriodicalId\":38278,\"journal\":{\"name\":\"Wound Medicine\",\"volume\":\"20 \",\"pages\":\"Pages 54-57\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.wndm.2018.01.004\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wound Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221390951730068X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221390951730068X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Xeno-free autologous platelet rich plasma for chronic wound management – Case series
Background
In chronic wounds, healing process gets halted in inflammatory phase owing to lack of growth factors (GF). The concept of exogenous delivery of such GF as platelet rich plasma (PRP)/fibrin (PRF) could be logical strategy for their management. We evaluated efficacy of single dose of non-activated PRP and self- polymerized platelet rich fibrin (PRF) in subjects with chronic wounds.
Methods
35 Subjects with wounds of different depths and etiologies were administered with PRP or PRP + PRF and assessed with Bates-Jensen Wound Assessment Tool (BWAT).
Results
Majority of subjects in PRP group responded well and entered into regenerative zone. In PRP + PRF group, 36% subjects benefitted from this treatment.
Conclusion
Our study demonstrates that single dose of non-activated PRP is an efficacious treatment regime for chronic wounds. Further, it eliminates need for multiple doses due to continual release of growth factor over a long period of time, thus considerably reducing effective cost of procedure.
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