Wound Medicine最新文献_第8页

Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects—Rat full-thickness skin graft model 体外冲击波疗法作为闭合大面积全层缺损的辅助疗法——大鼠全层皮肤移植模型

Wound Medicine Pub Date : 2018-03-01 DOI: 10.1016/j.wndm.2017.11.001

Vlado Antonic , Bernd Hartmann , Peter Balks , Wolfgang Schaden , Christian Ottomann

引用次数: 1

Surgical approach choice and efficiency of complementary therapies in treatment of pilonidal cyst: Meta-analysis and treatment algorithm 互补疗法治疗毛囊肿的手术入路选择和疗效：Meta分析和治疗算法

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.10.002

Vladimir N. Obolenskiy

引用次数: 1

Development and characterization of nanofibrous mat from PVA/Tridax Procumbens (TP) leaves extracts PVA/Tridax Procumbens (TP)叶提取物纳米纤维毡的制备与表征

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.09.004

Ganesan P., Pradeepa P.

引用次数: 18

Dose regulated cutaneous wound healing potential of quercetin in male rats 剂量对雄性大鼠皮肤创面愈合电位的影响

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.10.004

Vinay Kant , Babu Lal Jangir , Ankit Nigam , Vinod Kumar , Sonu Sharma

{"title":"Dose regulated cutaneous wound healing potential of quercetin in male rats","authors":"Vinay Kant , Babu Lal Jangir , Ankit Nigam , Vinod Kumar , Sonu Sharma","doi":"10.1016/j.wndm.2017.10.004","DOIUrl":"10.1016/j.wndm.2017.10.004","url":null,"abstract":"<div><p><span><span>Quercetin has role in </span>angiogenesis and proliferation of epithelial cells and fibroblasts. So, it was hypothesized that exogenous application of quercetin could be beneficial in wound healing. In present study, experimentally-wounded male rats were equally divided into four groups. Quercetin as a 0.1, 1.0 and 10.0% concentration (w/v) solution was topically applied on the wounds of group 2, 3 and 4, respectively, once daily for 16</span> <span><span>days. However, dimethyl sulfoxide<span><span> (DMSO; 75%) alone was applied topically in group 1. Gross evaluation of wound revealed that topical application of 0.1% quercetin caused fastest wound closure, as compared to other </span>treatments in our study. The reduction in wound area and increased </span></span>wound contraction<span> were fastest in 0.1% quercetin group during the entire study. Histopathologically, the granulation tissue was of better quality and showed appropriate proliferation of fibroblasts in 0.1% quercetin-treated group in comparison to other groups. There was significant collagen deposition, which was better arranged and compacted in 0.1% quercetin-treated group. The 0.1% quercetin-treated group also showed regenerated epithelium layer, which was lacking in other groups. Histological score was significantly higher in 0.1% quercetin-treated group, as compared to DMSO and 10% quercetin-treated groups. Overall, there were no significant differences between the different treatment groups for the values of superoxide dismutase, total thiols, superoxide anion radicals, malondialdehyde<span> levels and total proteins. Only the catalase value was significantly decreased in DMSO-treated group, as compared to 0.1% quercetin treated group. In conclusion, quercetin at 0.1% concentration has pronounced pro-healing potential in male rats.</span></span></span></p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 82-87"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44773901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Hydroalcoholic extract from Lepidium meyenii (Black Maca) root exerts wound healing activity in Streptozotocin-induced diabetic rats 黑玛卡根水酒精提取物对链脲佐菌素诱导的糖尿病大鼠的伤口愈合作用

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.10.003

B.V.B. Bramara , H.S. Vasavi , H.V. Sudeep , K. Shyam Prasad

{"title":"Hydroalcoholic extract from Lepidium meyenii (Black Maca) root exerts wound healing activity in Streptozotocin-induced diabetic rats","authors":"B.V.B. Bramara , H.S. Vasavi , H.V. Sudeep , K. Shyam Prasad","doi":"10.1016/j.wndm.2017.10.003","DOIUrl":"10.1016/j.wndm.2017.10.003","url":null,"abstract":"<div><h3>Background</h3><p><em>Lepidium meyenii</em>, a Peruvian plant commonly known as Maca has been valued for high nutritional value since ancient times.</p></div><div><h3>Objective</h3><p>The present study was intended to evaluate the wound-healing potential of the hydroalcoholic extract of <em>L. meyenii</em> (black maca) root (BME) in diabetic rats.</p></div><div><h3>Methods</h3><p>Diabetes was induced to the experimental animals by the administration of streptozotocin (STZ) (50mg/kg, i.p.) prepared in citrate buffer (4.5pH). The healing property of BME was evaluated by the excision wound model. The diabetic animals were divided into four groups: Group I, diabetic control treated with simple ointment; Group II, received topical Povidone iodine ointment (0.1% w/w); Groups III and IV, were treated with ointments prepared from BME of 5% and 10% w/w respectively daily, and Group V treated with BME 200mg/kg b.w. orally daily for 21days. Wound-healing parameters such as the rate of wound contraction, wound index, dry and wet granulation weights, bacterial load assessment, and concentration of hydroxyproline and hexosamine contents were measured and compared with diabetic control. The statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s test using GraphPad Prism (Version5.0).</p></div><div><h3>Results</h3><p>Rats treated with BME both topically and orally had shown a significant (<em>p<</em> <!-->0.01) increase in the percentage of wound closure, wound index, dry and wet granulation weights, decrease in bacterial counts, increase in hydroxyproline and hexosamine contents of the granulation tissue when compared with the diabetic control, in a dose-dependent pattern.</p></div><div><h3>Conclusion</h3><p>The present study is the first report on wound healing properties of BME in diabetic rats.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 75-81"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48607691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Clinical and economic effectiveness of the use of platelet-rich plasma in the treatment of chronic wounds 富血小板血浆治疗慢性伤口的临床和经济效果

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.09.001

Vladimir N. Obolenskiy , Darya A. Ermolova , Leonid A. Laberko

{"title":"Clinical and economic effectiveness of the use of platelet-rich plasma in the treatment of chronic wounds","authors":"Vladimir N. Obolenskiy , Darya A. Ermolova , Leonid A. Laberko","doi":"10.1016/j.wndm.2017.09.001","DOIUrl":"10.1016/j.wndm.2017.09.001","url":null,"abstract":"<div><p><span><span><span>The paper presents the results of the clinical use of platelet-rich plasma in the treatment of long-term non-healing wounds of various etiologies </span>in patients on inpatient treatment and outpatient monitoring in the department of </span>surgical infections<span> of the State-financed health institution, City clinical hospital No. 13, Moscow Health Department, from 2011 to 2016: test group and control group of 50 patients per each, comparable by gender, age, nature of pathology and area of wounds. When analyzing the data obtained, it was found that a significant reduction in the duration of patients treatment was achieved in the test group: the average epithelialization time for the wounds was 42.3</span></span>              <!-->0.0001). The economic effect averaged 736.81 Euro in savings per patient.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 27-32"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44037272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The WISO trial: Subcutaneous fluid collections are no indication for surgical site infections WISO试验:皮下积液不是手术部位感染的指征

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.09.002

Julius Pochhammer , Auda Auda , Michael Schäffer

{"title":"The WISO trial: Subcutaneous fluid collections are no indication for surgical site infections","authors":"Julius Pochhammer , Auda Auda , Michael Schäffer","doi":"10.1016/j.wndm.2017.09.002","DOIUrl":"10.1016/j.wndm.2017.09.002","url":null,"abstract":"<div><h3>Background</h3><p>Whether postoperative subcutaneous fluid collection increases the risk of surgical site infection<span> (SSI) has not been elucidated. Therefore, the aim of this study was to investigate whether clinically asymptomatic subcutaneous fluid collection increases the risk of SSI by evaluating postoperative wounds using ultrasonography.</span></p></div><div><h3>Methods</h3><p>Adults who underwent laparotomy<span> with wounds at high-risk for SSI were included in this trial. Incision area was evaluated using ultrasonography on postoperative days 1, 2, and 4. Presence and volume of fluid collection, as well as occurrence of SSI were evaluated.</span></p></div><div><h3>Results</h3><p>A total of 59 patients were enrolled in this study. Of these, 5 were excluded as they underwent relaparotomy within 14days. The primary endpoint (SSI) occurred in 18 (33.3%) of the 54 analyzed patients. There were no significant differences in baseline or intraoperative characteristics between patients with and without SSI. All patients received prophylactic antibiotics prior to incision. Subcutaneous fluid collection on at least one ultrasound was observed in 47 (87.0%) of 54 patients. There was no association between volume of fluid collection at all time points and occurrence of SSI. Furthermore, there was no association between change in volume of fluid collection at each time point and occurrence of SSI.</p></div><div><h3>Conclusion</h3><p>We found no correlations between presence of subcutaneous fluid collection or its volume and occurrence of SSI. Furthermore, prediction of SSI using ultrasonography in the early postoperative stage seems unlikely.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 23-26"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43691357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A systematic review of whirlpool as an adjunctive treatment for cellulitis 漩涡作为蜂窝织炎辅助治疗的系统综述

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.10.001

Melanie Mendiola-So, Robert Eugene Larson, David Vernier

{"title":"A systematic review of whirlpool as an adjunctive treatment for cellulitis","authors":"Melanie Mendiola-So, Robert Eugene Larson, David Vernier","doi":"10.1016/j.wndm.2017.10.001","DOIUrl":"10.1016/j.wndm.2017.10.001","url":null,"abstract":"<div><h3>Background</h3><p>Patients with cellulitis<span> are referred to physical therapy for whirlpool as an adjunctive treatment.</span></p></div><div><h3>Objective</h3><p>The purpose of this systematic review is to determine if whirlpool, as an adjunctive therapy, provides an additional benefit in adult patients with cellulitis.</p></div><div><h3>Data sources</h3><p>Data was collected from the following electronic databases: CINAHL (Cumulative Index to Nursing and Allied Health Literature) – EBSCO Host, Cochrane Library, OVID-Medline, PEDro (Physiotherapy Evidence Database), ProQuest, and PubMed.</p></div><div><h3>Study selection</h3><p>Studies published in English within the last ten years on adult human subjects (19 years and older) with cellulitis as the main skin condition and have received whirlpool as a form of adjunctive treatment were selected.</p></div><div><h3>Data extraction</h3><p>Data was collected from October 20, 2016 until January 25, 2017. Boolean search terms included: “cellulitis AND adjunct AND whirlpool”; “cellulitis AND whirlpool”, “cellulitis AND physical therapy”, and “cellulitis AND hydrotherapy.”</p></div><div><h3>Results</h3><p>After reviewing 478 studies from the search results, none of the studies could be used based on the inclusion criteria.</p></div><div><h3>Limitations</h3><p>Studies in English published within the last ten years, based on adult human subjects aged 19 years old and above with cellulitis and with whirlpool as an adjunctive treatment for cellulitis were considered for the review.</p></div><div><h3>Conclusions</h3><p>No conclusion could be reached from this systematic review since no study met the eligibility criteria from the results generated.</p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 47-74"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43948490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Human microflora, probiotics and wound healing 人体菌群，益生菌和伤口愈合

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.09.006

Christos G. Tsiouris , Maria G. Tsiouri

引用次数: 40

Wound healing activity of 3, 3′, 4′-Trihydroxyflavone, isolated from Justicia wynaadensis 怀叶Justicia wynaadensis中3，3′，4′-三羟基黄酮的伤口愈合活性

Wound Medicine Pub Date : 2017-12-01 DOI: 10.1016/j.wndm.2017.09.003

Dorin Dsouza, Lakshmidevi Nanjaiah

{"title":"Wound healing activity of 3, 3′, 4′-Trihydroxyflavone, isolated from Justicia wynaadensis","authors":"Dorin Dsouza, Lakshmidevi Nanjaiah","doi":"10.1016/j.wndm.2017.09.003","DOIUrl":"10.1016/j.wndm.2017.09.003","url":null,"abstract":"<div><p><span>The objective of the present study was to determine the wound healing activity of 3,3′, 4′-Trihydroxyflavone by excision wound model in diabetic rats. Diabetes induced rats (blood glucose level >250</span>    <span><span>days. The blood glucose level and </span>wound contraction rate was measured at weekly intervals. Histopathological studies were carried out on skin, excised from the wound area after the experimental period. Blood glucose levels remained above 250</span>  <span><span>mg/kg BW dose of 3,3′,4′-Trihydroxyflavone when compared to normal, diabetic control, and standard drug<span>, framycetin<span>. Normal control rats showed normal healing process and were fully recovered during the experimental period. Diabetic control group showed abnormal recovery phase and the percentage of healing was less than 50% at the end of experimental period. Histopathological findings of skin of rats treated with 3,3′,4′-Trihydroxyflavone provided additional positive results and sufficient insights on the healing process with normal recovery stages. The dermis with proliferating capillaries and </span></span></span>skeletal muscle<span> were replaced by cellular fibrous tissue and collagen fibers. Overall, the results show that 3,3′,4′-Trihydroxyflavone isolated from </span></span><em>J. wynaadensis</em><span><span> is an interesting biopharmaceutical agent that possess significant antibacterial and wound healing properties against </span>pathogens associated with diabetes.</span></p></div>","PeriodicalId":38278,"journal":{"name":"Wound Medicine","volume":"19 ","pages":"Pages 10-14"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wndm.2017.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42221512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1