Journal of the American Society of Cytopathology最新文献

{"title":"Assessment of reprocessed ThinPrep cytology cases after glacial acetic acid wash procedure using the Hologic Genius Digital Diagnostics System.","authors":"Lakshmi Harinath, Jonee Matsko, Amy Colaizzi, Xianxu Zeng, Esther Elishaev, Rohit Bhargava, Liron Pantanowitz, Chengquan Zhao","doi":"10.1016/j.jasc.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.008","url":null,"abstract":"<p><strong>Introduction: </strong>This study focuses on ThinPrep Pap tests with a low to borderline number of cells and the performance of AI-assisted digital systems in cases that have undergone the acetic acid wash procedure (AAW).</p><p><strong>Materials and methods: </strong>Four hundred sixty-two cases initially interpreted as unsatisfactory and finally interpreted as satisfactory after AAW procedure were included in the study. These ThinPrep Pap slides were scanned using the Genius Digital Diagnostic System (GDDS).</p><p><strong>Results: </strong>Overall agreement between GDDS and Original ThinPrep Interpretation (OTPI) was 63.2% for diagnostic match (Negative for Intraepithelial Lesion, ASCUS, Low Grade Squamous Intraepithelial Lesion, Atypical Squamous Cells, High Grade, Atypical Glandular Cells, or unsatisfactory), and 66.0% when ASCUS + diagnoses are grouped. Out of the 462 cases, 364 (78.8%) were called Negative for Intraepithelial Lesion based upon the manual OTPI, as opposed to 310 (67.1%) reviewed using the GDDS. There were 17.5%, 1.3%, 0.9% and 1.5% cases called Atypical Squamous Cells of Undetermined Significance, Low Grade Squamous Intraepithelial Lesion, Atypical Squamous Cells, High Grade Cannot be Excluded, and Atypical Glandular Cells respectively on OTPI, as opposed to 24.7%, 3.0%, 0.6% and 1.5% respectively by the GDDS. Only 3.0% of the cases were deemed unsatisfactory by GDDS. All the cases with high grade results in the subsequent cervical biopsy were diagnosed as at least Atypical Squamous Cells of Undetermined Significance and above by the GDDS. The diagnostic agreement between GDDS and biopsy was 65.2% compared to 58.7% for OTPI, although this is not statistically significantly different, (χ² (1) = 0.415, P = 0.519).</p><p><strong>Conclusions: </strong>Our results demonstrate that the GDDS can be successfully used to screen ThinPrep Pap Tests that have undergone the AAW procedure.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing TBSRTC III thyroid nodules: evaluating repeat FNA, molecular testing, and surgery.","authors":"Christopher Dilli, William Mi, Daniel L Miller","doi":"10.1016/j.jasc.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.007","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid nodules are common, but most are benign. Concerning nodules undergo fine-needle aspiration (FNA) and are classified using The Bethesda System. Nodules with atypia of undetermined significance (AUS) [Bethesda III] have management options including surveillance, repeat FNA, molecular testing, and surgical evaluation. While molecular testing can reduce unnecessary surgeries, it is costly. This retrospective study assessed the feasibility of repeat FNA as a cost-effective alternative.</p><p><strong>Materials and methods: </strong>We conducted a multi-institutional retrospective study of AUS nodules from 5 hospitals between September 1, 2018, and March 1, 2024. Only initial FNA cases were included; pediatric cases and those lost to follow up were excluded. Nodules were stratified by initial diagnostic choice (repeat FNA, molecular testing, surgical intervention). Clinical and ultrasonography findings were reviewed to determine associations with malignancy rates. Costs were estimated based on Medicare reimbursement rates.</p><p><strong>Results: </strong>We identified 2649 nodules that underwent FNA, with 199 interpreted as AUS. Of these, 131 met the criteria. Repeat FNA resulted in a benign diagnosis in 48.7% of cases and AUS in 35.9%. Costs were lowest for nodules undergoing repeat FNA. There was no significant difference in rates of surgical intervention or malignancy compared to molecular testing. American College of Radiology Thyroid Imaging Reporting and Data System categories were not associated with malignancy rates. Only echogenic foci were significantly associated with malignancy (P = 0.03).</p><p><strong>Conclusions: </strong>Repeat FNA resolved approximately 50% of cases, with no significant differences in malignancy or surgical intervention rates compared to molecular testing. Repeat FNA is the most cost-effective initial step for managing AUS nodules. Prebiopsy ultrasonography had limited utility in stratifying malignancy risk for AUS nodules.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal utilization of paucicellular vitreous sample for diagnosis of primary vitreoretinal lymphoma.","authors":"Armughan S Khan, Anam Khan, Zarrin Hossein-Zadeh, Lawra Murray, Karen Chau, Atif Khan, Xinmin Zhang, Rubina S Cocker","doi":"10.1016/j.jasc.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.006","url":null,"abstract":"<p><strong>Introduction: </strong>Primary vitreoretinal lymphoma (PVRL) is a rare, aggressive, and intraocular non-Hodgkin lymphoma, typically manifesting as diffuse large B-cell lymphoma (95%). Vitreous fluid cytology is the gold standard for diagnosis; however, its utility is limited by poor preservation and low cellularity. Recent studies indicate that myeloid differentation primary response protein 88 (MYD88) mutation analysis is more sensitive and accurate on low-cellularity or poorly preserved samples. The incidence of PVRL has reportedly tripled with an annual average of ∼50 cases in the United States. Delayed diagnosis can lead to mortality within 2 years, underscoring the need for improved diagnostic methods.</p><p><strong>Materials and methods: </strong>We conducted a 5-year retrospective study of vitreous samples from 3 tertiary centers. A cytopathologist and a hematopathologist reviewed the samples and classified them as \"negative,\" \"atypical,\" or \"positive.\" Whole slide imaging (WSI) was incorporated to quantify atypical lymphocytes using an arbitrary cutoff (≥25% considered positive; <25% considered atypical) and to document necrosis and apoptosis. Ancillary tests included flow cytometry, immunohistochemistry (IHC), and MYD88 mutation analysis.</p><p><strong>Results: </strong>Of the 226 samples, 214 were diagnosed as negative, 6 as atypical, and 6 as positive. WSI enhanced the diagnosis by precisely quantifying atypical lymphocytes. Flow cytometry was conclusive in 2 of 8 cases, IHC in 7 of 8, and MYD88 analysis in 4 of 5 cases.</p><p><strong>Conclusions: </strong>While cytology remains the gold standard, a combination of WSI, targeted IHC, and MYD88 analysis enhances diagnostic precision in paucicellular samples. Flow cytometry should be reserved for cases with high cellularity and strong clinical suspicion.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scary but innocent \"blast-like\" cells-potentially helpful diagnostic feature for chronic lymphocytic thyroiditis.","authors":"Xiaofeng Zhao, Ruth Birbe","doi":"10.1016/j.jasc.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.004","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic lymphocytic thyroiditis (CLT), or Hashimoto thyroiditis, is the second most common thyroid disorder diagnosed on fine needle aspiration cytology (FNAC). Accurate diagnosis is important as patients may subsequently become hypothyroid and require lifelong thyroxin supplement. Cellular lymphoplasmacytes infiltrating follicular and oncocytic cells are diagnostic features of CLT on FNAC. \"Blast-like\" large lymphocytes can be appreciated on DQ smears in some CLT cases and are believed to represent cells from reactive lymphoid follicles.</p><p><strong>Materials and methods: </strong>The FNAC slides of CLT diagnosed between January 2022 and March 2024 were reviewed to evaluate the significance of \"blast-like\" cells in CLT. Correlation of their presence with clinical presentation of hypothyroidism was performed.</p><p><strong>Results: </strong>Fourteen of 35 CLT cases were found to have \"blast-like\" cells present on DQ smears, ranging from \"rare\" (≤5/3 HPF) in 4 cases to \"nonrare\" (>5/3 HPF) in 10 cases in lymphoid-rich areas. Eleven of these 14 patients were confirmed to have clinical hypothyroidism due to CLT, with a specificity of 82%, in contrast to only 7 of the 21 patients without these cells. The specificity increases to 94% if only cases with \"nonrare\" large \"blast-like\" lymphocytes present are counted.</p><p><strong>Conclusions: </strong>\"Blast-like\" cells admixed with polymorphic lymphoplasmacytic infiltrates are more frequently identified in full-blown CLT cases, and their presence shows high correlation with clinical hypothyroidism due to CLT and enhances the diagnosis. The diagnostic value of these \"blast-like\" cells in cases with insufficient diagnostic features for CLT requires more evaluation.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Society of Cytopathology (ASC) study group recommendations for practicing ultrasound guided-fine needle aspiration (US-FNA).","authors":"Maoxin Wu, Poonam Vohra, Terrance Lynn, Zubair W Baloch, Ronald Balassanian, Daniel F I Kurtycz","doi":"10.1016/j.jasc.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.005","url":null,"abstract":"<p><strong>Introduction: </strong>Ultrasound-guided fine needle aspiration (US-FNA) performed by cytopathologists is an expanding domain of effort; however, the clinical practice varies significantly across institutions and practitioners. To address this variability, a study group of the American Society of Cytopathology (ASC) Product Innovation Committee has initiated efforts to help bring consistency to US-FNA endeavors.</p><p><strong>Materials and methods: </strong>In 2022, the ASC's Product Innovation Committee formed a study group as part of an initiative to standardize US-FNA practices. The group developed an online survey consisting of 32 questions related to US-FNA techniques and practices. The survey was distributed through the ASC and involved participation from several international cytopathology societies. The survey findings, combined with a literature review (spanning 50 articles over 36 years), on cytopathologist-performed US-FNA, served as the foundation for the group's recommendations.</p><p><strong>Results: </strong>The literature review supports the contention that US-FNA performed by cytopathologists enhances diagnostic accuracy, specificity, and negative predictive value. The survey revealed significant variability in US-FNA activities (report in a separate manuscript entitled \"Pathologist Performed Ultrasound Guided Fine Needle Aspiration: Current Status, Trends, and Insights from the American Society of Cytopathology Sponsored Survey\"). Based on these findings, the ASC study group developed 10 key recommendations for cytopathologist-performed US-FNA regarding procedure, documentation, and quality control.</p><p><strong>Conclusions: </strong>These recommendations are intended to provide a basis for evolving discussion among cytopathologists with the aim of creating consensus-driven practices in US-FNA.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of second opinion consultation in pancreaticobiliary cytopathology.","authors":"Bridgette E Nixon, Amy L Brady, Patrick J Fasulo, Kamal K Khurana","doi":"10.1016/j.jasc.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.002","url":null,"abstract":"<p><strong>Introduction: </strong>A few studies have highlighted the importance of cytopathology consultation in guiding patient care. In this study we have exclusively focused on consultation in pancreaticobiliary cytopathology, and its impact on patient management.</p><p><strong>Methods: </strong>We reviewed all consult cases related to pancreaticobiliary cytopathology between July 2021 and November 2023. We categorized the cases as major or minor diagnostic discrepancies based on a comparison between the original diagnoses and the consult diagnoses. A major diagnostic discrepancy was defined as a 2-step deviation on a scale of \"unsatisfactory, benign, atypical, suspicious, and malignant\" or a change in patient management.</p><p><strong>Results: </strong>Of 147 cases, including 49 bile duct brushings and 98 pancreatic fine needle aspirations (FNAs), we identified 49 (33%) discrepant cases: 15 (30.6%) major and 5 (10.2%) minor discrepancies in bile duct brushings, and 17 (17.3%) major and 11 (11.2%) minor discrepancies in pancreatic FNAs. There was a change in management in almost all major discrepancy cases for which follow-up information was available, with 12 of 15 biliary brushings resulting in chemotherapy (7), rebiopsy (2), and surgery (3), and 12 of 17 pancreatic FNAs leading to chemotherapy (5), rebiopsy (4), surgery (2), monitoring (1), and no change (1).</p><p><strong>Conclusions: </strong>Our major diagnostic discrepancy rates of 30.6% and 17.3% for bile duct brushing and pancreas, respectively, are higher than previously reported rates in general cytopathology/histopathologic consultations. Pancreaticobiliary-cytopathology poses significant diagnostic challenges. Hence, a second opinion at a tertiary institution may be particularly critical for pancreaticobiliary cytopathology samples, allowing for more reliable patient-care.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical significance of atypical glandular cells in Papanicolaou tests: changes in diagnostic patterns over 15 years at a single institution.","authors":"Terri E Jones, Xianxu Zeng, Jonee Matsko, Lakshmi Harinath, Esther Elishaev, Rohit Bhargava, Chengquan Zhao","doi":"10.1016/j.jasc.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.003","url":null,"abstract":"<p><strong>Introduction: </strong>Detection of atypical glandular cells (AGCs) by Papanicolaou (Pap) test remains a significant challenge in gynecological cytology. We compared follow-up diagnoses, age groups, and human papillomavirus (HPV) results for AGC at our institution to that of our previous study (study period 2008-2013).</p><p><strong>Methods: </strong>AGC Paps diagnosed and HPV results between January 2020 and June 2024 were obtained from the database at UPMC Magee-Womens Hospital.</p><p><strong>Results: </strong>Of the total 188,320 Paps performed during the study period, 1025 had AGC diagnoses comprising 0.54% of the total. A total of 92.2% of cases had a companion HPV test, with positive HPV results seen in 32.9% of cases. Overall, 33.3% (286/859) of AGC cases had subsequent significant histologic findings (cervical intraepithelial neoplasia 2 and 3, adenocarcinoma in-situ, endocervical adenocarcinoma, endometrial lesions, metastatic carcinoma). Detection of cervical lesions was highest in women <30 years (50%) and significantly decreased with increasing age (P < 0.0001). Identification of endometrial lesions was highest in the ≥50-year group (P < 0.0001). Nearly half of AGC/HPV-positive cases had significant cervical findings, while these were detected in only 2.1% of AGC/HPV-negative cases (P < 0.0001). Endometrial lesions were identified in 25.7% of AGC/HPV-negative cases, but only in <1% of AGC/HPV-positive cases (P < 0.0001). Significant differences were identified comparing the 2 study periods: increased HPV testing (P < 0.0001), increased HPV-positivity (P = 0.0029), decreased AGC rate (P < 0.0001), and increased endometrial lesions on follow-up (P < 0.0001).</p><p><strong>Conclusions: </strong>Our findings continue to support HPV results and patient age as valuable data in triaging AGC. AGC/HPV-positive results frequently suggest a cervical/HPV-related lesion, often in younger patients. Conversely, AGC/HPV-negative results, especially in patients ≥50 years, support noncervical lesional origins.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathologist performed ultrasound guided fine needle aspiration (US-FNA): current status, trends, and insights from the American Society of Cytopathology Sponsored Survey.","authors":"Daniel F I Kurtycz, Zubair W Baloch, Ronald Balassanian, Terrance Lynn, Poonam Vohra, Maoxin Wu","doi":"10.1016/j.jasc.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.05.001","url":null,"abstract":"<p><strong>Introduction: </strong>Ultrasound-guided fine-needle aspiration (US-FNA) performed by cytopathologists represents prospects for expanding cytopathology practice. While there is a perceived need for further education and standardization to support future opportunities, this need remains insufficiently documented. The Product Innovation Committee of the American Society of Cytopathology conducted a survey to gather opinions and examine current practices in US-FNA.</p><p><strong>Materials and methods: </strong>An online survey of 32 questions focused on US-FNA practice was open from December 19, 2022, to March 19, 2023, promoted through national and international cytopathology professional societies, using Qualtrics survey software.</p><p><strong>Results: </strong>A total of 216 individuals accessed the survey, with 174 (68% from the USA) successfully completing a qualifying question. Data collected included information on certification, work setting, workload, and years of practice (mean: 16 years, range: 0-50 years). Fifty-nine percent (80/135) were certified in cytopathology by the American Board of Pathology or the International Academy of Cytology. Sixty-three percent (84/134) practiced in academia. Over one-half (70/123) worked in low-volume settings (0-50 US-FNA procedures/year), while 19% worked in medium-to-high volume settings (>300 US-FNA procedures/year). Responses showed variability in diagnostic practices and patient management. Nearly one-half (67/137) of respondents indicated that their pathologists performed US-FNA. Most, but not all, reported following standard procedures, including informed consent, site verification, procedure time-out, and documentation of both the procedure and ultrasound findings.</p><p><strong>Conclusions: </strong>Pathologist performed US-FNA represents an opportunity for growth, but there are significant barriers to adoption including: training, equipment, reimbursement, and procedural variability. This survey stands as an initial step to developing recommendations on best practices.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous clots in body fluids: can they cellblock?","authors":"Jessica Rech, Josh Howell, Alyssa Alford, Jennifer Kernodle-Zimmer, Leslie Huntsman, Kristen Ruddell","doi":"10.1016/j.jasc.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.04.005","url":null,"abstract":"<p><strong>Introduction: </strong>Cell blocks have become a critical component in the diagnostic and prognostic analysis of cytologic specimens. Yet, it is common for cell blocks to lack sufficient cellularity for assessment and ancillary testing. Assessing cellularity in spontaneous clots that form in body fluids can aid in improving cell block utilization.</p><p><strong>Materials and methods: </strong>Eighteen body fluid specimens originally submitted for cytologic evaluation were selected for processing. For each fluid, 2 cell blocks were made, 1 using the spontaneous clot (SC) and 1 using the cell pellet (CP) from only the concentrated fluid. A hematoxylin and eosin-stained slide for each block was assessed for cellularity and ranked on a scale from 0 to 3. A score of 0 represented no cells present, while a score of 3 represented abundant cells of interest present.</p><p><strong>Results: </strong>For the CP blocks, 28% had a cellularity score of 0, 44% had a score of 1, 11% had a score of 2, and 17% had a score of 3. For the SC blocks, only 6% had a cellularity score of 0, 39% had a score of 1, 28% had a score of 2, and 28% had a score of 3.</p><p><strong>Conclusions: </strong>Cell blocks prepared using the SC method resulted in an overall higher cellularity compared to the CP blocks. The SC blocks prepared from malignant fluids also showed denser areas of pure tumor nuclei. This resulted in adequate spontaneous clot blocks for genomic testing, while the corresponding CP block was only adequate for diagnostic purposes.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-informed experiences in an interventional cytopathology clinic: how can we maximize patient satisfaction.","authors":"Nikka Khorsandi, Aaron Blevins, Elham Khanafshar","doi":"10.1016/j.jasc.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.04.004","url":null,"abstract":"<p><strong>Introduction: </strong>The pathologist-performed fine needle aspiration biopsy has been shown to be a diagnostically excellent study when performed by trained individuals. However, the patient perspective of pathology-performed fine needle aspiration biopsy, also known as interventional cytopathology, is less described.</p><p><strong>Materials and methods: </strong>This study investigates patient satisfaction at a single interventional cytopathology clinic between 2020 and 2023. The 34-question survey evaluated various aspects of patient satisfaction and included qualitative feedback to better understand factors contributing to patient satisfaction. Among the 682 survey respondents, the majority were Caucasian and English-speaking females ages 65-79 years, with either private insurance or Medicare.</p><p><strong>Results: </strong>Results demonstrated high satisfaction levels across all domains. Qualitative analysis identified key themes that improve patient satisfaction, including reduced anxiety, confidence in providers, perceived efficacy of the procedure, and overall procedural satisfaction.</p><p><strong>Conclusions: </strong>Based on these themes, we propose a conceptual model in which effective communication, a relaxed atmosphere, and thorough explanations play a crucial role in enhancing patient satisfaction. Our findings underscore the importance of patient-centered approaches in designing interventional cytopathology clinics. Clear communication between patients, providers, and care teams, along with adequate appointment time, is essential for improving patient experiences.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}