Journal of the American Society of Cytopathology最新文献

Combined Fine Needle Aspiration (FNA) and Intraoperative Frozen Consultation Improve Clinical Management of Salivary Gland Lesions of Undetermined Malignant Potential (SUMP) 细针抽吸联合术中冷冻会诊改善涎腺恶性潜能未定病变的临床治疗

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.042

Daisy Maharjan MBBS , Sheila Segura MD , Shaoxiong Chen MD, PhD , Brent Molden MD, PhD , Dongwei Zhang MD, PhD , Tieying Hou MD, PhD

引用次数: 0

Reassessing the Cytopathologic Diagnostic Approach to the Evaluation of Ascitic Fluid in Cirrhosis: Do We Really Need Cell Blocks? 重新评估肝硬化腹水的细胞病理学诊断方法：我们真的需要细胞阻滞吗？

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.083

Katrina Collins MD , Mohamed Mustafa MD , Tieying Hou MD, PhD , Sheila Segura MD , Mohammed Saad MD , Harvey Cramer MD , Omer Saeed MBBS

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Scary but innocent “blast-like” cells—potentially helpful diagnostic feature for chronic lymphocytic thyroiditis 可怕但无害的“细胞样”细胞——慢性淋巴细胞性甲状腺炎的潜在诊断特征。

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.05.004

Xiaofeng Zhao MD, PhD, Ruth Birbe MD

{"title":"Scary but innocent “blast-like” cells—potentially helpful diagnostic feature for chronic lymphocytic thyroiditis","authors":"Xiaofeng Zhao MD, PhD, Ruth Birbe MD","doi":"10.1016/j.jasc.2025.05.004","DOIUrl":"10.1016/j.jasc.2025.05.004","url":null,"abstract":"<div><h3>Introduction</h3><div><span><span>Chronic lymphocytic thyroiditis (CLT), or Hashimoto thyroiditis, is the second most common thyroid disorder diagnosed on </span>fine needle aspiration cytology (FNAC). Accurate diagnosis is important as patients may subsequently become hypothyroid and require lifelong </span>thyroxin<span> supplement. Cellular lymphoplasmacytes infiltrating follicular and oncocytic cells are diagnostic features of CLT on FNAC. “Blast-like” large lymphocytes can be appreciated on DQ smears in some CLT cases and are believed to represent cells from reactive lymphoid follicles.</span></div></div><div><h3>Materials and methods</h3><div>The FNAC slides of CLT diagnosed between January 2022 and March 2024 were reviewed to evaluate the significance of “blast-like” cells in CLT. Correlation of their presence with clinical presentation of hypothyroidism was performed.</div></div><div><h3>Results</h3><div>Fourteen of 35 CLT cases were found to have “blast-like” cells present on DQ smears, ranging from “rare” (≤5/3 HPF) in 4 cases to “nonrare” (>5/3 HPF) in 10 cases in lymphoid-rich areas. Eleven of these 14 patients were confirmed to have clinical hypothyroidism due to CLT, with a specificity of 82%, in contrast to only 7 of the 21 patients without these cells. The specificity increases to 94% if only cases with “nonrare” large “blast-like” lymphocytes present are counted.</div></div><div><h3>Conclusions</h3><div>“Blast-like” cells admixed with polymorphic lymphoplasmacytic infiltrates are more frequently identified in full-blown CLT cases, and their presence shows high correlation with clinical hypothyroidism due to CLT and enhances the diagnosis. The diagnostic value of these “blast-like” cells in cases with insufficient diagnostic features for CLT requires more evaluation.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages 327-333"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Basics to Benchmarks: Evaluating Sample Adequacy, PD-L1 Expression, and Molecular Profiling in Effusion Samples of Lung Adenocarcinoma 从基础到基准：评估样本充分性，PD-L1表达和肺腺癌积液样本的分子谱

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.078

Harpreet Virk MBBS, MD , Claire Michael MD , Jasmeen Kaur MBBS , Navid Sadri MD , Omid Savari , Aparna Harbhajanka MD

引用次数: 0

Long Read Sequencing Metagenomic Approach to Cervical Cytology Specimens 宫颈细胞学标本的长读测序宏基因组方法

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.119

Jessica Alvarez Lesmes PGY-6, Valentina Lopez MD, Roberto Ruiz-Cordero MD

引用次数: 0

Efficacy of Telecytologic Rapid On-Site Evaluation (ROSE) of Lung Fine Needle Aspiration (FNA)/Core Needle Biopsy(CNB): A 5-Year Retrospective Analysis 肺细针穿刺(FNA)/核心针活检（CNB）的远程快速现场评价（ROSE）的疗效：5年回顾性分析

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.048

Mikiyas Negash MD , Ashlynn Carney , Pamela Tauchi-Nishi MD

引用次数: 0

Integrated Versus Cell Block Diagnosis of Pancreatic Biopsies: A Comparative Study Using the 2022 WHO Reporting System 胰腺活检的综合与细胞阻断诊断：使用2022年WHO报告系统的比较研究

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.016

Nikka Khorsandi MD, MPH, Alexander Craig MD, MPhil, Grace E. Kim MD, Vimal Krishnan MD

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Risk of Malignancy in the Indeterminate Categories of Fine Needle Aspiration from Cervical Lymph Nodes 颈部淋巴结细针抽吸不确定类别的恶性肿瘤风险

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.053

Adeyinka Akinsanya MD, Sheila Segura MD, Shaoxiong Chen MD, PhD, Brent Molden MD, PhD, Tieying Hou MD, PhD

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The International System for Reporting Serous Fluid Cytopathology survey data reveal substantial variability in the reporting and utilization of pelvic washing and peritoneal fluid specimens among pathologists and gynecologic oncologists 国际浆液细胞病理学报告系统调查数据显示，病理学家和妇科肿瘤学家在盆腔洗涤和腹膜液标本的报告和使用方面存在很大差异。

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.04.002

Christopher J. VandenBussche MD, PhD , Amanda Jackson MD , Zaibo Li MD, PhD , Chengquan Zhao MD , Ashish Chandra MD , Fernando Schmitt MD, PhD, FIAC , Daniel F.I. Kurtycz MD , Barbara Crothers DO

{"title":"The International System for Reporting Serous Fluid Cytopathology survey data reveal substantial variability in the reporting and utilization of pelvic washing and peritoneal fluid specimens among pathologists and gynecologic oncologists","authors":"Christopher J. VandenBussche MD, PhD , Amanda Jackson MD , Zaibo Li MD, PhD , Chengquan Zhao MD , Ashish Chandra MD , Fernando Schmitt MD, PhD, FIAC , Daniel F.I. Kurtycz MD , Barbara Crothers DO","doi":"10.1016/j.jasc.2025.04.002","DOIUrl":"10.1016/j.jasc.2025.04.002","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Pelvic and peritoneal washings<span> (PW) are often taken during gynecologic resections when the presence of a neoplastic process is known or suspected. A positive PW may upstage a patient and/or impact a patient's prognosis and treatment. Two surveys were created to inform The International System for </span></span>Serous Fluid<span> Cytology, a standardized reporting system, regarding the practice and utilization of PW cytology.</span></div></div><div><h3>Materials and methods</h3><div>Pathologists and cytotechnologists (n = 475) responded to a survey which examined their reporting preferences. Gynecologic oncologists (GONC) (n = 168) answered a separate survey which examined how they utilized PW specimens.</div></div><div><h3>Results</h3><div>Most pathologists/cytotechnologists felt that bland-appearing epithelial cells of unknown origin should be classified as benign. Most favored reporting psammomatous calcification without associated epithelial cells as benign (64.1%), whereas 8.6% did not report this finding at all, 20.5% would report as atypical, and 6.8% would report as suspicious of a neoplasm. Most GONCs (63.9%) routinely obtained PW specimens during endometrial cancer staging; of those, 53% reported that a positive cytology result could change their management. Sixty-six percent of GONCs indicated that they treat indeterminate PW results as negative. Others indicated that an indeterminate PW may result in review of slides with the pathologist, counseling the patient, and/or closer observation. Most GONCs did not find utility in the reporting of psammomatous calcifications, presence of mucin, atypical cells favored to be benign, endometrial cells, or iatrogenic material.</div></div><div><h3>Conclusions</h3><div>Substantial variability exists among pathologists in how PW specimens are reported, as well as how gynecologic oncologists utilize these specimens.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages 309-316"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cytology, Histology, and Molecular Correlations of Metastatic Tumors to the Thyroid Gland: A Ten-Year Institution Review 甲状腺转移性肿瘤的细胞学、组织学和分子相关性：十年机构回顾

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.036

Holly Mitzel MD, Jacqueline Peck MD, Terrance Lynn MD, Ana Yuil-Valdes MD

引用次数: 0