Journal of the American Society of Cytopathology最新文献_第10页

The Performance of Anal Cytology for Screening Anal Intraepithelial Neoplasia in High-Risk Populations: A Single Institution's Experience Over the Past Five Years 肛门细胞学在高危人群中筛查肛门上皮内瘤变的表现：一个机构过去五年的经验

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.065

Connor Brown DO , April Hull MPH, CT(ASCP)cm , Antonio Galvao Neto MD , Tianhua Guo Cytopathology

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Risk of Malignancy in Thyroid Cytology Atypia of Undermined Significance 甲状腺细胞学非典型性的恶性肿瘤风险

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.037

Olabisi Afolayan-Oloye MD, MPH, Israh Akhtar MD, FIAC, Maria Gonzalez MD

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Retrospective Study Evaluating the Role of p16/Ki67 Dual-Stain in High-Risk HPV-Positive Patients with Follow Up Biopsy 评估p16/Ki67双染色在高危hpv阳性患者随访活检中的作用的回顾性研究

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.071

Lim Kah Ling CT(IAC), Tzy Harn Chua Bachelor of Medicine, Sangeeta Mantoo MBBS, FRCPath

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Incidence, Demographics, and Cytologic-Histologic Review of Bethesda III and IV Thyroid Nodules with Gene Fusions Bethesda III型和IV型甲状腺结节基因融合的发病率、人口统计学和细胞学组织学回顾

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.029

Tung Nguyen MD, Tatjana Antic MD

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Digital and Glass Slide Review for PD-L1 Scoring in Cell Blocks: A Comparative Reliability Study 细胞块中PD-L1评分的数字和玻片回顾：比较可靠性研究

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.122

Rong Xia MD, PhD , Fang Zhou MD , Andre Moreira MD, PhD , Fei Chen MD, PhD , Yan Shi MD, PhD , Negin Shafizadeh MD , Brendan Belovarac MD , Xiao-Jun Wei MD , Tamar Brandler MD, MS , Andrea Hernandez DO , Wei Sun MD , Aylin Simsir MD

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Cytomorphologic Subclassification of Salivary Gland Neoplasms of Undetermined Malignant Potential (SUMP): Implications for Risk Stratification and Surgical Timing 涎腺肿瘤未确定恶性潜能（SUMP）的细胞形态学亚分类：风险分层和手术时机的意义

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.039

Maryam Mehdipour Dalivand MD, Siham Hattab MD, PhD, Shabnam Samankan MD, Alec Corn BA, Mohadese Behtaj MD, Elham Arbzadeh

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Spontaneous clots in body fluids: can they cellblock? 体液中的自发血块：它们会阻塞细胞吗？

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.04.005

Jessica Rech CT (ASCP), Josh Howell MAOL, CT (IAC), SCT (ASCP), Alyssa Alford CT (ASCP), Jennifer Kernodle-Zimmer SCT (ASCP), CT (IAC), Leslie Huntsman SCT (ASCP), Kristen Ruddell CT (ASCP)

{"title":"Spontaneous clots in body fluids: can they cellblock?","authors":"Jessica Rech CT (ASCP), Josh Howell MAOL, CT (IAC), SCT (ASCP), Alyssa Alford CT (ASCP), Jennifer Kernodle-Zimmer SCT (ASCP), CT (IAC), Leslie Huntsman SCT (ASCP), Kristen Ruddell CT (ASCP)","doi":"10.1016/j.jasc.2025.04.005","DOIUrl":"10.1016/j.jasc.2025.04.005","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Cell blocks have become a critical component in the diagnostic and prognostic analysis of cytologic specimens. Yet, it is common for cell blocks to lack sufficient cellularity for assessment and </span>ancillary testing. Assessing cellularity in spontaneous clots that form in body fluids can aid in improving cell block utilization.</div></div><div><h3>Materials and methods</h3><div>Eighteen body fluid specimens originally submitted for cytologic evaluation were selected for processing. For each fluid, 2 cell blocks were made, 1 using the spontaneous clot (SC) and 1 using the cell pellet (CP) from only the concentrated fluid. A hematoxylin and eosin-stained slide for each block was assessed for cellularity and ranked on a scale from 0 to 3. A score of 0 represented no cells present, while a score of 3 represented abundant cells of interest present.</div></div><div><h3>Results</h3><div>For the CP blocks, 28% had a cellularity score of 0, 44% had a score of 1, 11% had a score of 2, and 17% had a score of 3. For the SC blocks, only 6% had a cellularity score of 0, 39% had a score of 1, 28% had a score of 2, and 28% had a score of 3.</div></div><div><h3>Conclusions</h3><div>Cell blocks prepared using the SC method resulted in an overall higher cellularity compared to the CP blocks. The SC blocks prepared from malignant fluids also showed denser areas of pure tumor nuclei. This resulted in adequate spontaneous clot blocks for genomic testing, while the corresponding CP block was only adequate for diagnostic purposes.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages 341-346"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cytopathology of Common and Uncommon Mesenchymal Neoplasms in the Gastrointestinal Tract 胃肠道常见和不常见间充质肿瘤的细胞病理学

Journal of the American Society of Cytopathology Pub Date : 2025-09-01 DOI: 10.1016/j.jasc.2025.07.021

Hannah Chen MD, PhD , Qun Wang MD, PhD

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Systematic review and meta-analysis of the diagnostic accuracy of the World Health Organization reporting system for soft tissue cytopathology. 世界卫生组织软组织细胞病理学报告系统诊断准确性的系统回顾和荟萃分析。

Journal of the American Society of Cytopathology Pub Date : 2025-08-21 DOI: 10.1016/j.jasc.2025.08.003

Sana Ahuja, Marzieh Fattahi-Darghlou, Pragun Ahuja, Rhea Ahuja, Sufian Zaheer

{"title":"Systematic review and meta-analysis of the diagnostic accuracy of the World Health Organization reporting system for soft tissue cytopathology.","authors":"Sana Ahuja, Marzieh Fattahi-Darghlou, Pragun Ahuja, Rhea Ahuja, Sufian Zaheer","doi":"10.1016/j.jasc.2025.08.003","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.08.003","url":null,"abstract":"<p><strong>Introduction: </strong>The WHO recently proposed a standardized reporting system for soft tissue cytopathology to enhance diagnostic consistency, malignancy risk stratification, and communication between clinicians and pathologists. This 6-tiered system-nondiagnostic, benign, atypical, soft tissue neoplasm of uncertain malignant potential (STNUMP), suspicious for malignancy, and malignant-assigns estimated risks of malignancy to each category. Its diagnostic performance in soft tissue fine-needle aspiration (FNA) has not yet been comprehensively evaluated.</p><p><strong>Materials and methods: </strong>We conducted a systematic review and meta-analysis to assess the diagnostic performance of the WHO system in soft tissue FNAs. PubMed and EMBASE were searched through April 30, 2025. Included studies evaluated FNAs of soft tissue lesions with histopathology/clinicoradiologic follow-up as reference. Diagnostic performance was assessed at 3 thresholds: (1) \"Malignant\", (2) \"Suspicious for malignancy\" and above, and (3) \"STNUMP\" and above. Pooled sensitivity, specificity, area under the curve (AUC), and diagnostic odds ratios were calculated using a random-effects model.</p><p><strong>Results: </strong>Four studies met inclusion criteria. ROMs ranged from 4% (\"Benign\") to 98% (\"Malignant.\") Sensitivity and specificity were 59% and 99% (AUC: 77%) for the \"Malignant\"-only threshold. Including \"Suspicious\" improved sensitivity to 75% (specificity: 98%, AUC: 84%). The broadest threshold yielded 85% sensitivity and 94% specificity (AUC: 82%). DORs ranged from 84.99 to 289.02. \"Nondiagnostic\" cases had a 33% ROM.</p><p><strong>Conclusions: </strong>The WHO system shows robust diagnostic accuracy for soft tissue FNA. Optimal performance occurs when \"Suspicious\" and higher categories are treated as positive. High ROM in nondiagnostic cases highlights the need for adequate sampling.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social media and cytopathology (#cytopath) education: developing a curated online resource index and exploring the evolution of e-learning. 社会媒体和细胞病理学（#cytopath）教育：开发策划在线资源索引，探索电子学习的演变。

Journal of the American Society of Cytopathology Pub Date : 2025-08-11 DOI: 10.1016/j.jasc.2025.08.002

Swikrity Upadhyay Baskota, Muhammad Ahsan, Sarah Mohamed, Casey P Schukow, Meredith K Herman, Hafsa Nebbache, Lavisha S Punjabi, Brandon D Metcalf, Deepama Upreti, Luca Cima, Fnu Poombal, Muhammad Moseeb Ali Hashim, Xiaoyin Sara Jiang

{"title":"Social media and cytopathology (#cytopath) education: developing a curated online resource index and exploring the evolution of e-learning.","authors":"Swikrity Upadhyay Baskota, Muhammad Ahsan, Sarah Mohamed, Casey P Schukow, Meredith K Herman, Hafsa Nebbache, Lavisha S Punjabi, Brandon D Metcalf, Deepama Upreti, Luca Cima, Fnu Poombal, Muhammad Moseeb Ali Hashim, Xiaoyin Sara Jiang","doi":"10.1016/j.jasc.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.jasc.2025.08.002","url":null,"abstract":"<p><p>In recent years, social media (SoMe) has revolutionized medical education within the field of pathology; however, its performance in cytopathology has not been explored in detail. This systematic review aims to analyze SoMe trends, hashtag metrics, and online resources within cytopathology over the period of 7 years. A systematic review of 4 databases (PubMed, Medline, Embase, and Scopus) was conducted between January 1st, 2017, and December 22nd, 2022, in order to identify relevant English-language articles about SoMe and cytopathology. An index for online cytopathology (#cytopath) resources was created and posted on Knowledge In Knowledge Out on May 12, 2025. Sixteen studies were included for final analysis, dating from 2017 to 2023. The most commonly cited SoMe platforms used among cytopathologists were X (Twitter) (42%) and Facebook (26%) (P = 0.002). A variety of hashtags were used across posts: #Cytology (24%), #Cytopath (24%), #FNAFriday (24%), #Pathology (16%), and #Cytopathology (12%) (P = 0.865). Two studies discussed the use of SoMe in cytopathology during the COVID-19 pandemic, highlighting its role as a rapid communication tool in times of crisis. The most highly followed cytopathology accounts on X were @cytopathology (10,510), @IACytology (3639), and @britishcytology (3062). This systematic review shows how SoMe is enhancing networking, case discussion, and education in cytopathology. Although it could revolutionize professional communication, it still poses issues regarding privacy and possible misinformation. Future research and guidelines are necessary to optimize the use of SoMe in cytopathology.</p>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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