Journal of the American Society of Cytopathology最新文献

{"title":"Evaluation of Hologic Genius Digital Diagnostic System Six Months After Implementation in an Academic Medical Center","authors":"Katsiaryna Khatskevich MD, Natalie Beard MHSA, CT(ASCP), Muhammad Abdur Raafey MD, Maxwell Akorli DO, Jack Yang MD","doi":"10.1016/j.jasc.2026.08.008","DOIUrl":"10.1016/j.jasc.2026.08.008","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S11-S12"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creative Cytology Education to Address Current Cytology Workforce Challenges","authors":"Maheswari Mukherjee PhD, MSc, BPT, SCT(ASCP)CM, Diana Ramirez SCT, Sarah Johnson MPH, CT(ASCP)CM","doi":"10.1016/j.jasc.2026.08.042","DOIUrl":"10.1016/j.jasc.2026.08.042","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S22"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Cytology Count: Analyzing Pre-analytic Factors for NGS Success","authors":"Serena Walker MD, Salvatore Priore MD, PhD, Roseann Wu MD, MPH","doi":"10.1016/j.jasc.2026.08.047","DOIUrl":"10.1016/j.jasc.2026.08.047","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S26"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Grade Squamous Intraepithelial Lesion (HSIL) and Squamous Cell Carcinoma (SCC) in Women Age ≥65 Years: Is the Current Screening Paradigm Failing Older Women","authors":"Tiffany Santos, Carla Coleman CT(ASCP), Manali Bendre MD, PhD","doi":"10.1016/j.jasc.2026.08.077","DOIUrl":"10.1016/j.jasc.2026.08.077","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S43"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance and Risk Stratification of Combined Anal Cytology and hrHPV Testing for High-Grade Anal Intraepithelial Neoplasia","authors":"Afreen Karimkhan MD, Hadel Go MD, Wei Sun MD, Osvaldo Hernandez MD, Absia Jabbar MD, Fei Chen MD, PhD, Negin Shafizadeh MD, Sui Zee MD, Aylin Simsir MD, Rong Xia MD, PhD","doi":"10.1016/j.jasc.2026.08.027","DOIUrl":"10.1016/j.jasc.2026.08.027","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S7-S8"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Gland Neoplasm of Uncertain Malignant Potential (SUMP): 8-Year Retrospective Institutional Analysis of Risk of Malignancy with Radiologic Correlation","authors":"Travis Fenlon DO, Abdol Aziz Ould Ismail MD, Jonathan Marotti MD, Xiaoying Liu MD, MS, FIAC","doi":"10.1016/j.jasc.2026.08.091","DOIUrl":"10.1016/j.jasc.2026.08.091","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S49"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of an optimal quality control method for Pap test analysis using digital cytology and artificial intelligence","authors":"Lakshmi Harinath MD, MPH, Esther Elishaev MD, Jonee Matsko SCT, MB, Amy Colaizzi SCT, Haley Brown CT, Rohit Bhargava MD, Liron Pantanowitz MD, PhD, MHA, Chengquan Zhao MD","doi":"10.1016/j.jasc.2026.04.005","DOIUrl":"10.1016/j.jasc.2026.04.005","url":null,"abstract":"<div><ul><li><span>•</span><span><div>The aim of this study was to determine an optimal method for performing quality control (QC) on digitized Pap tests when utilizing an artificial intelligence-assisted digital diagnostics system.</div></span></li><li><span>•</span><span><div>This study demonstrated strong interobserver agreement between pathologists and moderate consistency between individual QC reads carried out serially.</div></span></li><li><span>•</span><span><div>Digital QC checks can consist of randomly selecting a subset of cases, rescanning and re-analyzing with AI and acquiring interpretations from 2 or more CPs once regulatory guidelines are updated.</div></span></li></ul></div><div><h3>Introduction</h3><div>The aim of this study was to determine an optimal method for performing quality control on Pap tests that adhere to CLIA ‘88 mandates that are applicable to employing an artificial intelligence (AI)-based system in routine practice.</div></div><div>The aim of this study was to determine an optimal method for performing quality control on Pap tests that adhere to CLIA ‘88 mandates that are applicable to employing an artificial intelligence (AI)-based system in routine practice.</div><div><h3>Materials and methods</h3><div>Four hundred ninety-seven archival ThinPrep Pap slides were retrieved and scanned with Genius Digital Diagnostics System. A cytologist and 3 cytopathologists (CP) performed initial interpretations (first read). Subsequently, all slides were rescanned and the new output was re-reviewed by another cytologist and the same 3 CP’s after a washout period of 14 months (second read). The result of serial reads of each pathologist was compared with the original ThinPrep Interpretation (OTPI) and with each other. Interobserver concordance was calculated for all reads.</div></div><div>Four hundred ninety-seven archival ThinPrep Pap slides were retrieved and scanned with Genius Digital Diagnostics System. A cytologist and 3 cytopathologists (CP) performed initial interpretations (first read). Subsequently, all slides were rescanned and the new output was re-reviewed by another cytologist and the same 3 CP’s after a washout period of 14 months (second read). The result of serial reads of each pathologist was compared with the original ThinPrep Interpretation (OTPI) and with each other. Interobserver concordance was calculated for all reads.</div><div><h3>Results</h3><div>Out of 497 cases 32.6%, 17.9%, 17.9%, 6.8%, 24.1%, and 0.6% were interpreted as negative for intraepithelial lesion or malignancy, atypical squamous cells of undetermined significance, low-grade squamous intraepithelial, atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion/squamous cell carcinoma, and atypical glandular cell/adenocarcinoma in situ/adenocarcinoma per OTPI. Kendall’s coefficient for concordance amongst the 3 CP’s for serial reads were 0.924 and 0.892, respectively. Conc","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages 369-377"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Profiling of Stromal Cells in Thyroid Fine-Needle Aspiration Biopsies Identifies Locally Invasive Tumors","authors":"Matthew Loberg PhD, Jonathan Trapani, Mohammed Alshalalfa MD, Taylor Cavazos PhD, Joshua Klopper MD, Richard Kloos MD, Ethan Lee MD, PhD, Vivian Weiss MD, PhD","doi":"10.1016/j.jasc.2026.08.022","DOIUrl":"10.1016/j.jasc.2026.08.022","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S5"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in HER2 Status in Serous Body Fluid Metastatic Breast Carcinoma in the Era of HER-low and Ultra-low","authors":"Anna-Lee Clarke MD, Zena Jameel MD, Ahmed Abdulrahim MD, Reza Eshraghi MD, Sana Tabbara MD","doi":"10.1016/j.jasc.2026.08.023","DOIUrl":"10.1016/j.jasc.2026.08.023","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S5-S6"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytology and Histology Findings of Non-Cisgender Female Patients: A Multi-Hospital, Single-Institution","authors":"Francisco Avila MD, Aswathy Cheriyan MD, MPH, Krisztina Hanley MD, Megan Dibbern MD, Brannan Griffin MD","doi":"10.1016/j.jasc.2026.08.073","DOIUrl":"10.1016/j.jasc.2026.08.073","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S40-S41"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}