Journal of the American Society of Cytopathology最新文献

{"title":"Role of ascitic and peritoneal fluid effusion cytology in predicting intraperitoneal metastasis of malignant ovarian germ cell tumors","authors":"Ridhi Sood MBBS, MD, DM, Sathish Kumar A MBBS, Seema Singhal MBBS, MS, MCh, FACS, FCLS, Jyoti Meena MBBS, MS, Ruchi Rathore MBBS, MD, Asit Ranjan Mridha MBBS, MD, Sudheer Arava MBBS, MD, Deepali Jain MBBS, MD, FIAC, FRCPath, Venkateswaran K. Iyer MBBS, MD, Sandeep R. Mathur MD, FIAC, MNAMS","doi":"10.1016/j.jasc.2026.04.002","DOIUrl":"10.1016/j.jasc.2026.04.002","url":null,"abstract":"<div><ul><li><span>•</span><span><div>Malignant ovarian germ cell tumors are rarely detected in peritoneal cytology.</div></span></li><li><span>•</span><span><div>Biomarkers, cytohistology, and immunohistochemistry help avoid adenocarcinoma misdiagnosis.</div></span></li><li><span>•</span><span><div>Positive cytology correlates with intraperitoneal spread and advanced stage.</div></span></li><li><span>•</span><span><div>Cell block with IHC improves classification of atypical cytology cases.</div></span></li><li><span>•</span><span><div>Equivocal (TIS3) cytology shows limited short-term clinical impact.</div></span></li></ul></div><div><h3>Introduction</h3><div>Peritoneal cytology (PC) is a useful predictor of ovarian surface involvement and intraperitoneal metastasis in epithelial malignancies. Most malignancies involving serous cavity effusions are adenocarcinomas; however, nonepithelial tumors such as lymphomas and germ cell tumors (GCTs) rarely cause malignant effusion. Data on PC in malignant ovarian germ cell tumor (MOGCT) are limited to isolated case reports with lack of systematic cytohistologic correlation, hence the need for this study.</div></div><div>Peritoneal cytology (PC) is a useful predictor of ovarian surface involvement and intraperitoneal metastasis in epithelial malignancies. Most malignancies involving serous cavity effusions are adenocarcinomas; however, nonepithelial tumors such as lymphomas and germ cell tumors (GCTs) rarely cause malignant effusion. Data on PC in malignant ovarian germ cell tumor (MOGCT) are limited to isolated case reports with lack of systematic cytohistologic correlation, hence the need for this study.</div><div><h3>Materials and methods</h3><div>All PC samples of surgically resected MOGCTs were classified using The International System (TIS) for the Reporting of Serous Cytopathology. Immunohistochemistry (IHC) was performed on cell blocks of all atypical and malignant cases. Tumor markers and histopathological parameters of surgical resection specimen were correlated with cytology findings using statistical tests.</div></div><div>All PC samples of surgically resected MOGCTs were classified using The International System (TIS) for the Reporting of Serous Cytopathology. Immunohistochemistry (IHC) was performed on cell blocks of all atypical and malignant cases. Tumor markers and histopathological parameters of surgical resection specimen were correlated with cytology findings using statistical tests.</div><div><h3>Results</h3><div>Nine (19%) of 48 MOGCTs showed features suspicious or definitive for metastasis on PC with three cases initially misdiagnosed as carcinomas. Spalt-like transcription factor 4 IHC resulted in upgradation of one TIS3 category case to TIS4/5. Cytological detection of metastasis correlated with intra-abdominal spread, omental involvement, and advanced pathological stage (<em>P</em>< 0.05).</div></div><div>Nine (19%) of 48 MOGCTs showed features suspicious or definitive for meta","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages 340-352"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Endometrial Cells (EMs) in Prospective Rescreening Post Genius™ Digital Diagnostics System (GDDS) Implementation","authors":"Joelle Tarquinio CT(ASCP), Kayleigh Bucci CT(ASCP)CM, Dawn Underwood MEd, CT(ASCP), Jennifer Brainard MD","doi":"10.1016/j.jasc.2026.08.035","DOIUrl":"10.1016/j.jasc.2026.08.035","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S18"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPS1 Expression in Gastrointestinal Stromal Tumors Correlates with Morphologic Subtype","authors":"Ahmed Abdulrahim MD, Barbara Centeno MD, Nini Khin MD, Sana Tabbara MD","doi":"10.1016/j.jasc.2026.08.070","DOIUrl":"10.1016/j.jasc.2026.08.070","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S38-S39"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are All NILM Anal Cytology Specimens Adequate? A Bethesda-Based Review","authors":"Daisy Maharjan MBBS, Kendall Wilson MD, Devon Rotramel MD, Ben Shuler CT(ASCP), Melissa Randolph SCT(ASCP) CM, Tieying Hou MD, PhD, Sheila Segura MD","doi":"10.1016/j.jasc.2026.08.075","DOIUrl":"10.1016/j.jasc.2026.08.075","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S42"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CIN2+ in ASC-H Cytology: hPV status","authors":"James Dawson DO, Muhammad Moseeb Ali Hashim MD, Wedad Alfarkh MD","doi":"10.1016/j.jasc.2026.08.078","DOIUrl":"10.1016/j.jasc.2026.08.078","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S43-S44"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Unattended Digital Urine Cytology: AI-Guided Quality Control for Whole-Slide Image Acquisition","authors":"En-Yu Hsu MS, Cheng-Hung Yeh, Guowei Shao, Wei-Lei Yang, Shih-Wen Hsu, Yi-Siou Liu, Barbara Crothers, Tien-Jen Liu, Samuel Chen","doi":"10.1016/j.jasc.2026.08.033","DOIUrl":"10.1016/j.jasc.2026.08.033","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S17"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Risk HPV (hrHPV) Positivity in Women ≥65 Years: A Study of Concurrent Pap Smear Findings and Prior hrHPV Screening History","authors":"Finn Lennerth BS, Barbara Hanna BS, Carla Coleman CT(ASCP), Manali Bendre MD, PhD","doi":"10.1016/j.jasc.2026.08.082","DOIUrl":"10.1016/j.jasc.2026.08.082","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S45"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guiding the Needle, Defining the Diagnosis: Interventional Pathology's Ultrasound-Guided Fine Needle Aspiration Journey in Buenos Aires, Argentina (3,610 Cases, 2020–2025)","authors":"Pilar Garcia MD, Andrea Gerstein MD, Astorino Walter MD, Florencia Capuccio MD, Florencia Ramirez March CT, Laura Rubinato CT","doi":"10.1016/j.jasc.2026.08.057","DOIUrl":"10.1016/j.jasc.2026.08.057","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S31-S32"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiologic Culture of Fine Needle Biopsies: Are We Wasting Tissue?","authors":"Talal Arshad MD, Dana Richards MD","doi":"10.1016/j.jasc.2026.08.055","DOIUrl":"10.1016/j.jasc.2026.08.055","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S31"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASC/SIL Ratio in the Era of Primary HPV Screening: A Three-Year Institutional Experience","authors":"Tiffany Levine MD, Tawnie Vo CT(ASCP), Rebeca Alvarez MD, Sophia Shaddy MD, Rebecca Yoda MD, Eric Huang MD, PhD","doi":"10.1016/j.jasc.2026.08.024","DOIUrl":"10.1016/j.jasc.2026.08.024","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S6"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}