Journal of the American Society of Cytopathology最新文献

{"title":"Entrustable professional activities for cytopathology fellowship","authors":"Susanne K. Jeffus MD,&nbsp;Chien Chen MD, PhD,&nbsp;Taha Keskin MD,&nbsp;Nicole Massoll MD,&nbsp;Soheila Korourian MD,&nbsp;Felicia Allard MD","doi":"10.1016/j.jasc.2024.10.003","DOIUrl":"10.1016/j.jasc.2024.10.003","url":null,"abstract":"<div><div>Entrustable professional activities (EPAs) are an educational tool in the framework of competency-based medical education. EPAs are a relatively new concept in pathology. No studies to date exist on the utilization of EPAs during cytopathology fellowship training. This article reviews the recent literature on this topic and shares our institutional experience with the implementation of an EPA for fine needle aspirations and rapid on-site evaluations. While EPAs allow for tracking the competence of the cytopathology fellow toward independent practice for fine needle aspirations and rapid on-site evaluations, the required amount of documentation may represent a potential barrier for the widespread adoption of this new tool.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 1","pages":"Pages 5-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the WHO reporting system for soft tissue cytopathology with assessment of risk of malignancy: a retrospective study","authors":"Sana Ahuja MD,&nbsp;Adil Aziz Khan MD,&nbsp;Charanjeet Ahluwalia DNB,&nbsp;Sunil Ranga MD","doi":"10.1016/j.jasc.2024.09.004","DOIUrl":"10.1016/j.jasc.2024.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Soft tissue tumors are complex neoplasms requiring accurate diagnosis, often through fine needle aspiration (FNA). The World Health Organization (WHO) classification system aims to standardize cytopathological diagnoses and assess the risk of malignancy (ROM) for these tumors.</div></div><div><h3>Materials and methods</h3><div>This retrospective study reviewed cytological specimens from January 2022 to June 2023. Samples were categorized using the WHO classification into 6 categories: nondiagnostic, benign, atypical, soft tissue neoplasm of uncertain malignant potential, suspicious for malignancy (SFM), and malignant. Histopathological correlation was performed, and ROM, sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were calculated.</div></div><div><h3>Results</h3><div>A total of 203 samples were analyzed: 62.5% benign, 13.8% SFM, and 9.9% malignant. ROMs were 33.3% (nondiagnostic), 1.2% (benign), 40% (atypical), 25% (soft tissue neoplasm of uncertain malignant potential), 80% (SFM), and 100% (malignant). Histopathological correlation was available for 117 cases. Sensitivity and diagnostic accuracy were highest (77.3% and 93.9%) when SFM and malignant categories were combined as positive for malignancy. Specificity was highest (100%) when only malignant cases were considered positive. The interobserver agreement was moderate (Cohen’s kappa 0.45).</div></div><div><h3>Conclusions</h3><div>The WHO classification system for soft tissue cytopathology improves diagnostic accuracy and standardizes reporting. It effectively categorizes soft tissue tumors and guides clinical management, though further refinement is needed for broader applicability.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 1","pages":"Pages 44-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytology fine-needle aspiration and surgical pathology core needle biopsy reporting: blurred lines or battle lines?","authors":"Paul A. VanderLaan MD, PhD","doi":"10.1016/j.jasc.2024.10.002","DOIUrl":"10.1016/j.jasc.2024.10.002","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FNA diagnosis of secondary malignancies in the parotid gland: over 20 years of experience from a single institute","authors":"Aditya M. Bhatt BS ,&nbsp;Hector Mesa MD, PhD ,&nbsp;Shaoxiong Chen MD, PhD ,&nbsp;Brent Molden MD, PhD ,&nbsp;Tieying Hou MD, PhD","doi":"10.1016/j.jasc.2024.08.131","DOIUrl":"10.1016/j.jasc.2024.08.131","url":null,"abstract":"<div><h3>Introduction</h3><div>Metastatic solid tumors account for a significant portion of malignancies in the parotid gland. Fine-needle aspiration (FNA) is a primary tool to diagnose these tumors.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed 134 FNA cases of metastatic solid tumors affecting the parotid gland, spanning from 2000 to 2023 at our institute. We summarized the medical histories, cytology diagnoses, correlations with surgical resections, clinical treatments, and follow-up outcomes.</div></div><div><h3>Results</h3><div>The patient cohort included 107 male and 27 female patients, with a median age of 71 years (range: 4-96 years). Eighty-five percent of metastases (113 of 134) originated from head and neck (H&amp;N) malignancies, comprising 66% from cutaneous source and 19% from mucosal sites. The most frequent primary sites outside the H&amp;N were lung (4%), kidney (2%), and non-H&amp;N skin (2%). Sixty-eight percent of metastases (92 of 134) were squamous cell carcinoma (SqCC) including 61% conventional type and 7% human papillomavirus–related SqCC. Melanoma is the second most common metastatic malignancy (28 of 134, 21%). The median time from primary diagnosis to metastasis was 10 months (range: 0 to 132 months). During clinical follow-up, 59 (44%) patients died from the disease in a median follow-up of 10 months (range: 2 to 56 months).</div></div><div><h3>Conclusions</h3><div>This study represents one of the largest series of secondary malignancies in the parotid gland collected from a single institution. Most of these tumors are metastases from H&amp;N malignancies, with cutaneous SqCC being the most prevalent primary site and histology. Accurate diagnosis relies heavily on clinical history, morphologic evaluation, and ancillary studies.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 1","pages":"Pages 36-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of core-needle biopsy and repeat fine-needle aspiration biopsy for thyroid nodules with initially inconclusive findings: a systematic review, diagnostic accuracy meta-analysis, and meta-regression","authors":"Hendra Zufry MD, PhD ,&nbsp;Timotius Ivan Hariyanto MD","doi":"10.1016/j.jasc.2024.12.006","DOIUrl":"10.1016/j.jasc.2024.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The rate of nondiagnostic and indeterminate cytology findings from fine-needle aspiration biopsy (FNAB) is quite high, resulting in repeated puncture and unnecessary surgery. The primary objective of this investigation is to compare diagnostic accuracy of core-needle biopsy (CNB) with repeat FNAB for thyroid nodules with initially inconclusive (nondiagnostic and/or atypia of undetermined significance) FNAB results.</div></div><div><h3>Materials and methods</h3><div>A thorough search was performed on the Cochrane Library, Scopus, Europe PMC, and Medline databases until October 20th, 2024, employing a combination of pertinent keywords. This review incorporates literature that examines the comparison between CNB and repeat FNAB for thyroid nodule. Pooled odds ratio (OR) of nondiagnostic and inconclusive findings of CNB and repeat FNAB were calculated. A meta-analysis was conducted to assess the diagnostic accuracy of both biopsy methods for malignancy diagnosis utilizing a bivariate random-effects model.</div></div><div><h3>Results</h3><div>A total of 9 studies were incorporated. The results of our meta-analysis indicated lower rate of nondiagnostic (OR 0.12; 95% confidence interval [CI]: 0.06-0.23, <em>P</em> &lt; 0.00001), atypia of undetermined significance (OR 0.34; 95%CI: 0.21-0.56, <em>P</em> &lt; 0.0001), and inconclusive (OR 0.12; 95%CI: 0.07-0.22, <em>P</em> &lt; 0.00001) findings from CNB compared to repeat FNAB. CNB also exhibited markedly superior cumulative sensitivity estimates (75.1%) compared to repeat FNAB (56.5%), however cumulative specificity did not show a significant difference between CNB (99.9%) and repeat FNAB (99.7%). No patients who received CNB or repeat FNAB encountered any major complications.</div></div><div><h3>Conclusions</h3><div>Our study suggests that CNB can be employed to diagnose thyroid nodules that were previously inconclusive on FNAB, rather than repeating the FNAB procedure.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 3","pages":"Pages 159-169"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytologic testing for mismatch repair deficiency/microsatellite instability and NTRK gene fusion is not routinely indicated in primary pancreaticobiliary carcinoma cell block material","authors":"Courtney F. Connelly MD ,&nbsp;William S. Towne MD ,&nbsp;Niyati Desai MD ,&nbsp;Marie C. Smithgall MD, PhD ,&nbsp;Adela Cimic MD ,&nbsp;Swikrity U. Baskota MD","doi":"10.1016/j.jasc.2024.08.130","DOIUrl":"10.1016/j.jasc.2024.08.130","url":null,"abstract":"<div><h3>Introduction</h3><div>Pancreaticobiliary carcinomas rarely harbor targetable genetic alterations, including microsatellite instability (MSI) or neurotrophic tyrosine receptor kinase (<em>NTRK</em>) gene fusions. As these malignancies are typically present at an advanced stage and have suboptimal response to chemotherapy, the discovery of an actionable genomic alteration provides an additional avenue of treatment for chemotherapy-refractory cases.</div></div><div><h3>Materials and methods</h3><div>In this study, we evaluate 319 cases of pancreaticobiliary carcinoma diagnosed on fine-needle aspiration biopsy or biliary brushing for DNA mismatch repair (MMR) protein deficiency and pan-TRK overexpression by immunohistochemistry (IHC) and compare these results to MSI and <em>NTRK</em> gene fusion molecular testing.</div></div><div><h3>Results and Conclusion</h3><div>Although we find a high concordance between MMR protein IHC and MSI molecular testing in the evaluation of MMR deficiency and between pan-TRK IHC and <em>NTRK</em> fusion testing by next-generation sequencing, the low prevalence of either of these genetic alterations in our cohort casts doubt on the value of screening cases of pancreaticobiliary carcinoma for MMR protein deficiency and <em>NTRK</em> fusions.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 413-419"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of serous fluid volume on next-generation sequencing: a significant step forward for optimization of serous fluid sample collection","authors":"Shaham Beg MD,&nbsp;Kemin Xu MD,&nbsp;James P. Solomon MD,&nbsp;Susan A. Alperstein CT (ASCP),&nbsp;Momin T. Siddiqui MD","doi":"10.1016/j.jasc.2024.07.001","DOIUrl":"10.1016/j.jasc.2024.07.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Current literature lacks data regarding the influence of serous fluid volume (SFV) on next-generation sequencing (NGS) performed on malignant cases. In this study, we highlight the impact of SFV and other parameters influencing the outcome of NGS analysis.</div></div><div><h3>Materials and methods</h3><div>We evaluated 827 samples of serous fluids from 607 patients. Of these, 72 samples underwent NGS analysis. Effusion volume, tumor cellularity, DNA, and RNA quality metrics, as well as clinicopathologic and molecular data were evaluated. Pleural fluid accounted for 56.3% of the fluid samples collected. The most common primary tumor site was gastrointestinal/pancreatobiliary, adenocarcinoma was the most common histologic type. Overall mean volume was 293 mL. The mean Qubit DNA of the 72 effusion samples that underwent NGS analysis was 14.3 ng/μL and mean Qubit RNA was 28.2 ng/μL. The mean Qubit DNA concentration increases in SFV up to 100 mL only.</div></div><div><h3>Results</h3><div>No correlation exists between SFV and mean tumor cellularity. In addition, 74.6% (50 of 67) of sequenced samples showed oncogenic drivers; <em>KRAS</em> was the most common driver followed by <em>EGFR.</em> Three cases displayed <em>ALK</em> fusions, and 1 case displayed <em>NTRK1</em> fusion. The DNA yield is higher in SFV of 100 mL as a cutoff. Beyond 100 mL, there is no impact of SFV on DNA yield. SFV does not impact RNA yield and mean tumor cellularity. Effusion samples should be submitted for molecular testing despite low tumor cellularity.</div></div><div><h3>Conclusions</h3><div>Our results as a pilot study are important in optimization of SFV for both diagnosis as well as NGS analysis for improving management.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 397-405"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytopathology and clinicopathological correlation of renal neuroendocrine neoplasms","authors":"Xiaoqi Lin MD, PhD ,&nbsp;Tatjana Antic MD ,&nbsp;Tieying Hou MD ,&nbsp;Behtash G. Nezami MD","doi":"10.1016/j.jasc.2024.06.001","DOIUrl":"10.1016/j.jasc.2024.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a lack of documentation regarding cytopathology<span> of renal neuroendocrine neoplasms (NENs) due to their rarity.</span></div></div><div><h3>Materials and methods</h3><div>Five cytology cases were gathered from 3 institutes.</div></div><div><h3>Results</h3><div><span><span><span><span>Cohort consisted of 4 females and 1 male. Fine needle aspiration biopsy and touch preparation slides of </span>core needle biopsy revealed cellular samples, composed of round, plasmacytoid, or columnar cells. Tumor cells were present in nested, acinar, 3D cluster, and individual cell patterns. Tumor cells in 3 cases exhibited uniformly round to oval small nuclei with inconspicuous </span>nucleoli, finely granular chromatin, and smooth </span>nuclear membranes<span><span>, whereas 2 other cases showed pleomorphic nuclei with conspicuous nucleoli, nuclear molding, and irregular nuclear membranes. Tumor cells displayed pale or granular cytoplasm, with 1 case showing small </span>vacuoles<span>. Examination of cores and cell blocks demonstrated tumor cells in sheets, nests, or acini. All tumor cells were positive for neuroendocrine immunomarkers. Based on mitotic count, Ki-67 index and morphology, 3 tumors were graded as well-differentiated neuroendocrine tumor (WDNET) (1 grade [G] 3, 1 G2, 1 G1) and 2 as </span></span></span>large cell neuroendocrine carcinoma<span><span>. Deletion of 7q, 10q, and 19q was detected in WDNETs. Two patients with large cell neuroendocrine carcinoma and 1 with WDNET G3 underwent chemotherapy due to aggressiveness, whereas nephrectomy was performed for patients with WDNET G1 and 2 without </span>metastasis.</span></div></div><div><h3>Conclusions</h3><div>Cytopathological characteristics of renal NENs closely resemble those affecting other organs. Despite its rarity, renal NENs should be kept in mind when confronted with morphological resemblances to NENs, to prevent misdiagnosis and inappropriate therapeutic interventions.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 406-412"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and efficacy of Ion robotic-assisted bronchoscopic fine needle aspiration of lung lesions","authors":"Bernadette M. Boac MD ,&nbsp;Manita Kanathanavanich MD ,&nbsp;Xiaomo Li MD ,&nbsp;Taryne Imai MD ,&nbsp;Xuemo Fan MD, PHD ,&nbsp;Ann E. Walts MD ,&nbsp;Alberto M. Marchevsky MD ,&nbsp;Shikha Bose MD","doi":"10.1016/j.jasc.2024.08.129","DOIUrl":"10.1016/j.jasc.2024.08.129","url":null,"abstract":"<div><h3>Introduction</h3><div>The Ion Endoluminal Platform (ION) (IEPI Intuitive, Sunnyvale, CA), a minimally invasive robotic-assisted bronchoscopy platform, was recently US Food and Drug Administration approved for the performance of fine needle aspirations (FNAs) and biopsies of peripheral lung lesions. Rapid on-site intraoperative diagnosis (IOD) of FNAs and/or frozen section of biopsies help surgeons confirm adequate sampling of the targeted lesion and allow definitive treatment in selected cases.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed our experience with all FNAs of lung lesions sampled by interventional pulmonologists and thoracic surgeons using Ion from September 2020 to December 2022. IOD rendered during adequacy assessment were compared with final cytology diagnoses (Cyto-FD) and the ultimate final diagnoses (U-FD). The U-FD was based on the sum of all clinical, imaging, cytologic, and histologic diagnoses of the lung lesion which the clinical team used to treat the patient.</div></div><div><h3>Results</h3><div>The IOD and Cyto-FD were concordant in 62% of the 423 lesions that underwent intraoperative evaluation, yielding a sensitivity of 67% and a specificity of 99% for malignancy. The Cyto-FD and U-FD were concordant in 51% of the lesions with a sensitivity and specificity for malignancy of 66% and 100%, respectively.</div></div><div><h3>Conclusions</h3><div>IODs rendered during Ion were highly accurate but only moderately sensitive for a diagnosis of malignancy.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 420-430"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cytology in endometrial cancer patients with Lynch syndrome: opportunities for early detection and limitations","authors":"Yongsang Park MD ,&nbsp;Megan E. Dibbern MD ,&nbsp;Kari L. Ring MD ,&nbsp;Anne M. Mills MD","doi":"10.1016/j.jasc.2024.08.002","DOIUrl":"10.1016/j.jasc.2024.08.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Timely detection of endometrial carcinoma in Lynch syndrome patients ensures prompt treatment and appropriate cancer screening for the patient and impacted family members. While cervical cytology is utilized primarily in cervical cancer screening, endometrial glandular abnormalities can be identified as part of routine cervical cancer screening or during work-up for abnormal uterine bleeding.</div></div><div><h3>Materials and Methods</h3><div>We retrospectively evaluated cervical cytology samples from Lynch syndrome patients with endometrial carcinoma to determine how often atypical/malignant glandular cells were identified on prior/concurrent cytology.</div></div><div><h3>Results</h3><div>We identified 14 Lynch syndrome patients with cervical cytology available within a year of endometrial carcinoma diagnosis. The average patient age was 55 years (36-73). Cervical cytology preceded diagnostic biopsy in 57% and was concurrent in 43%. A glandular abnormality was identified on original diagnosis in 43% and ranged from atypical glandular cells (AGC), not otherwise specified to adenocarcinoma consistent with endometrial primary. In 4 cases, abnormal cervical cytology triggered the subsequent biopsy. Evaluation of 8 cases with accessible cytology slides revealed 2 previously unrecognized glandular abnormalities, leading to an abnormal rate of 63% among cases reviewed retrospectively and a final glandular abnormality detection rate of 57% based on either original or review diagnosis.</div></div><div><h3>Conclusions</h3><div>In summary, abnormal glandular cells were commonly identified in endometrial cancer patients with Lynch syndrome and led to endometrial cancer work-up and diagnosis in a subset. These results suggest that cervical cytology may have utility in endometrial cancer screening in this population and indicate that awareness of the patient’s familial cancer risk is important for maximizing sensitivity of this test. They also caution against primary human papillomavirus screening in the Lynch syndrome population, as this may result in missed opportunities for early endometrial carcinoma detection among these high-risk individuals.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 438-443"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}