Schizophrenia Research-Cognition最新文献

{"title":"Evaluation of a brief online multi-index assessment for predicting increased psychotic-like experiences in the community: A perceptual, cognitive and affective approach.","authors":"Caroline Cullen ,&nbsp;Keith Gaynor ,&nbsp;Klaus Kessler","doi":"10.1016/j.scog.2025.100357","DOIUrl":"10.1016/j.scog.2025.100357","url":null,"abstract":"<div><div>Research has shown that impairments in perception, reasoning, and social cognition are evident across the psychosis continuum and are implicated in the transition from subclinical symptoms to clinical psychosis. In this pilot feasibility study, a brief computerised assessment of visual perception, reasoning, social cognition and emotion dysregulation was administered to 157 adults in the community alongside self-report measures of psychotic-like experiences. The feasibility, reliability, and the predictive validity of the assessment tool were examined. The assessment procedure was feasible, evidenced through high completion rates. However, reliability estimates were suboptimal for online assessment measures. Self-reported visual perception and state emotion dysregulation predicted psychotic-like experiences explaining 53% of the variance when controlling for age. This study provides preliminary evidence that state difficulties with emotion regulation and self-reported visual perception abnormalities can predict increased psychotic-like experiences in the community. Future adaptations could address technological issues encountered with assessment tasks and ensure measures are psychometrically robust when administered online. Brief online assessments hold potential for research of both cognition and affect along the psychosis continuum although caution must be exercised with the chosen methodology.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100357"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive predictors and genetic moderators of employment outcomes in people with schizophrenia","authors":"Rachael Keir Blackman ,&nbsp;Dwight Dickinson ,&nbsp;Michael D. Gregory ,&nbsp;Bhaskar S. Kolachana ,&nbsp;Daniel P. Eisenberg ,&nbsp;Karen F. Berman","doi":"10.1016/j.scog.2025.100356","DOIUrl":"10.1016/j.scog.2025.100356","url":null,"abstract":"<div><div>Although some individuals with schizophrenia are able to maintain gainful employment, many are not. To better understand this differential real-life outcome, we tested general and specific cognitive measures as predictors of future employment and genetic moderators of these relationships. One hundred and twenty-four patients with schizophrenia spectrum illness (31.5 % female, mean age 32.5 ± 10.5 years) participated in a research study at the National Institute of Mental Health Intramural Research Program's Clinical Center and were later recontacted regarding outcomes (average time to recontact = 8.6 ± 4.0 years). At the initial visit, patients completed a comprehensive battery of neuropsychological tests and provided blood samples for genotyping. Cognitive scores at the initial visit were tested as predictors of future employment status (employed vs. unemployed) at follow-up using logistic regressions, and polygenic risk scores for schizophrenia were tested as moderators. At follow-up, 45.2 % of individuals were employed. General cognitive ability indexes (“<em>g</em>” and IQ) and verbal memory were predictive of subsequent employment status. Additionally, polygenic risk for schizophrenia moderated the effect of working memory cognitive scores on the prediction of future employment. The results suggest that certain broad indexes of cognitive dysfunction may be particularly salient in targeting interventions to address real-world functioning in schizophrenia. These data also suggest that further investigation into the genetic underpinnings of real-life outcomes in this illness is warranted.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100356"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of iclepertin (BI 425809) with adjunctive computerized cognitive training in patients with schizophrenia","authors":"Philip D. Harvey ,&nbsp;Sean McDonald ,&nbsp;Eric Fu ,&nbsp;Corey Reuteman-Fowler","doi":"10.1016/j.scog.2024.100340","DOIUrl":"10.1016/j.scog.2024.100340","url":null,"abstract":"<div><div>Despite significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). This double-blind, placebo-controlled, parallel-group Phase II trial assessed the efficacy and safety of pharmacological augmentation of at-home computerized cognitive training (CCT) with iclepertin (BI 425809, a glycine transporter-1 inhibitor). Participants with schizophrenia (aged 18–50 years) on stable antipsychotic therapy, who were compliant with CCT during the run-in period, were enrolled. Patients were randomized (1:1) to once daily iclepertin 10 mg or placebo for 12 weeks, and all patients completed adjunctive CCT. At Week 12, the change from baseline in neurocognitive composite T-score of the MATRICS Consensus Cognitive Battery (primary endpoint), Schizophrenia Cognition Rating Scale interviewer total score, and Positive and Negative Syndrome Scale total score (secondary endpoints) were assessed. Performance was also assessed using Virtual Reality Functional Capacity Assessment Tool adjusted total time T-score. Of 200 randomized patients, 154 (77.0 %) completed the trial. At efficacy endpoint assessment, no differences were observed between treatment groups. Adverse events (AEs) were reported by 39 patients in the iclepertin 10 mg + CCT group and 57 patients in the placebo + CCT group; most AEs were mild to moderate. To our knowledge, this trial is the largest of its kind combining daily pharmacotherapy for CIAS with at-home CCT. Although efficacy was not demonstrated, the safety profile of iclepertin 10 mg was consistent with previous studies and no new risks were identified.</div></div><div><h3>Clinical trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> identifier: <span><span>NCT03859973</span><svg><path></path></svg></span></div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100340"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive dysfunctions in childhood-onset schizophrenia: A systematic review","authors":"A. Armita ,&nbsp;J. Guivarch ,&nbsp;E. Dor ,&nbsp;G. Laure ,&nbsp;R. Zeghari ,&nbsp;M. Gindt ,&nbsp;S. Thümmler ,&nbsp;F. Askenazy ,&nbsp;A. Fernandez","doi":"10.1016/j.scog.2024.100342","DOIUrl":"10.1016/j.scog.2024.100342","url":null,"abstract":"<div><h3>Objective</h3><div>To conduct a systematic review of neurocognitive dysfunctions in patients with childhood-onset schizophrenia (COS), a neuropsychiatric disorder that occurs before age 13 and is rarer and more severe than adult-onset schizophrenia.</div></div><div><h3>Method</h3><div>A search was made in the PubMed database. Sixty-seven studies (out of 543) which analyzed Intellectual Quotient (IQ), attentional, memory and executive functions were selected by two independent researchers. Study's appraisal was done according to the Mixed Methods Appraisal Tool (MMAT). This systematic review was registered on PROSPERO (CRD42024548945).</div></div><div><h3>Result</h3><div>COS shows neurocognitive dysfunction in IQ with mean scores ranging from one to two standard deviation lower than normative data. Attentional deficits are observed with longer reaction time, more errors of omission and commission and slower processing speed than controls. In addition, working memory and executive functions, such as planification and flexibility are impaired. COS exhibit significantly more neurocognitive deficits than adolescent and adult-onset forms and display deterioration in intellectual functioning between premorbid period and after onset of psychosis.</div></div><div><h3>Conclusion</h3><div>COS is characterized by major cognitive impairments, both before the onset of the disease and throughout its course. As in adult-onset schizophrenia, generalized cognitive impairment is found without the emergence of a specific profile, providing further support for the continuum hypothesis between early-onset and adult-onset schizophrenia. Collaborative research on a larger scale (including meta-analyses) and using complementary approaches (dimensional and multimodal) is needed to gain a better understanding of the cognitive impact of COS and pave the way for more precise and targeted cognitive remediation.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100342"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the association between executive functions and social disabilities in people with a psychotic disorder","authors":"B.C. van Aken ,&nbsp;R. Rietveld ,&nbsp;A.I. Wierdsma ,&nbsp;Y. Voskes ,&nbsp;G.H.M. Pijnenborg ,&nbsp;J. van Weeghel ,&nbsp;C.L. Mulder","doi":"10.1016/j.scog.2025.100349","DOIUrl":"10.1016/j.scog.2025.100349","url":null,"abstract":"<div><h3>Background</h3><div>Social recovery (SR) in people with psychotic disorders involves taking on social roles and completing daily tasks. Functional recovery (FR), particularly executive functions, is critical for these roles. Psychotic disorder patients often experience severe cognitive impairments, especially in executive functions. This study investigates the relationship between functional and social recovery in individuals with psychotic disorders and examines the effect of employment status on this association.</div></div><div><h3>Method</h3><div>This cross-sectional study involved people with a psychotic disorder. SR was measured using the WHO-DAS, divided into Daily Functioning (DF) and Social Functioning (SF) scales. FR was measured using the BRIEF-A and the TOL. Employment status was categorized into Non-active, Otherwise Active, and Active. The Likelihood-ratio Test (LRT) was used for model selection.</div></div><div><h3>Results</h3><div>Data from 251 participants (mean age 41.5) showed that the BRIEF-A affected both DF and SF, while the TOL only affected DF. Only being Otherwise Active influenced DF. Employment status had no influence on SF. Being Otherwise Active positively influenced perceived disabilities in Daily Functioning.</div></div><div><h3>Conclusion</h3><div>Measuring executive functions using both performance-based and self-report measures is important. Both measures are associated differently with perceived disabilities in daily and social functioning. Being a volunteer or looking for a job positively influences perceived disabilities in Daily Functioning.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100349"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenomenology of dissociative symptoms: A comparison between individuals with dissociative disorders and high and low dissociative schizophrenia spectrum disorders","authors":"V.E. de Vries ,&nbsp;R.J.C. Huntjens ,&nbsp;B.E. Sportel ,&nbsp;J.J. Arends ,&nbsp;G.H.M. Pijnenborg","doi":"10.1016/j.scog.2025.100348","DOIUrl":"10.1016/j.scog.2025.100348","url":null,"abstract":"<div><h3>Background</h3><div>The distinction between dissociative disorders (DDs) and schizophrenia spectrum disorders (SSDs) in different categories since DSM-III presumes a clear-cut distinction between both disorders. However, empirical studies did not reveal a clear distinction between the disorders on a symptom level. The aim of the current study was to further examine the overlap and differences in symptoms between DDs and SSDs<strong>.</strong></div></div><div><h3>Methods</h3><div>Levels and types of dissociative and psychotic symptoms were compared between 27 DD patients and 51 SSD patients using MANOVA. For a more fine-grained insight, a subgroup analysis was performed with the DD group and 12 individuals with SSD who report many dissociative experiences (SSD-H). Finally, a discriminant analysis was performed to explore if there are symptoms discriminating between the DD group and both SSD groups.</div></div><div><h3>Results</h3><div>Results showed that the DD group experienced higher levels of each type of dissociative symptoms than the total SSD group. The symptoms self-states alters, discontinuities of time, flashbacks, voices, and depersonalization were found to best discriminate between the groups. These differences did not hold in the subgroup analysis between the DD group and SSD-H group, where only differences on the validity scales rare symptoms, attention seeking and factitious behavior were found.</div></div><div><h3>Conclusion</h3><div>It can be stated that none of the dissociative and psychotic symptoms is specific to DDs or SSDs. Therefore it is advisable to be cautious with classifying based on the presence of (certain) symptoms. A transdiagnostic approach towards assessment and treatment, regardless of classification, is indicated.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100348"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel measure of subjective cognition","authors":"Kristoffer Grimstad ,&nbsp;Håkon Sørensen ,&nbsp;Anja Vaskinn ,&nbsp;Christine Mohn ,&nbsp;Stine Holmstul Olsen ,&nbsp;Ole A. Andreassen ,&nbsp;Trine Vik Lagerberg ,&nbsp;Ingrid Melle ,&nbsp;Merete Glenne Øie ,&nbsp;Torill Ueland ,&nbsp;Beathe Haatveit","doi":"10.1016/j.scog.2025.100345","DOIUrl":"10.1016/j.scog.2025.100345","url":null,"abstract":"<div><div>Cognitive dysfunction is a well-documented feature of schizophrenia (SZ) and bipolar (BD) disorder. The person's subjective experience of cognitive difficulties is less investigated. Here we investigated subjective cognition in SZ and BD compared to healthy controls (HC).</div><div>Subjective and objective cognition were assessed in 91 SZ participants, 55 BD participants and 55 HC, applying a novel measure of subjective cognition, the self-assessed cognitive complaints scale (SACCS) and a clinically relevant neuropsychological test battery. The psychometric properties of SACCS were investigated. The relationship between subjective and objective cognition, and subjective cognition and clinical variables were explored in SZ and BD.</div><div>The SACCS showed adequate psychometric properties. Clinical groups reported significantly more cognitive complaints than HCs, without differences between SZ and BD. There were no significant associations between subjective and objective cognitive measures. There was a small trend association between subjective cognition and insight in SZ participants, and moderate sized associations between subjective cognition and general psychopathology and functioning in BD participants.</div><div>Although SZ participants are more cognitively impaired than BD participants, the two groups report similar levels of subjective cognitive complaints, with no association between subjective and objective cognition. Our results suggest that the expression of subjective cognition is associated with different clinical factors in SZ and BD.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100345"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders","authors":"Akke Ganse-Dumrath ,&nbsp;Anya Chohan ,&nbsp;Steven Samuel ,&nbsp;Paul Bretherton ,&nbsp;Corinna Haenschel ,&nbsp;Anne-Kathrin Fett","doi":"10.1016/j.scog.2025.100351","DOIUrl":"10.1016/j.scog.2025.100351","url":null,"abstract":"<div><div>Non-affective psychotic disorders are marked by cognitive and sensory processing abnormalities, including in early visual processing and social cognition. Understanding the relationships between these deficits and their impact on daily-life functional outcomes may help to improve outcomes in affected individuals. This systematic review and meta-analysis aimed to summarise the existing evidence on the relationships between early visual processing, social cognition, and functional outcomes, and to assess the evidence regarding the mediating role of social cognition in the association between early visual processing and functional outcomes in individuals with schizophrenia spectrum disorders. A comprehensive search across five databases identified 364 potentially eligible studies, with eight articles meeting all inclusion criteria. Meta-analytic techniques were employed to synthesise effect sizes and assess a meta-mediation model. Three random-effects meta-analyses revealed significant associations between all three domains of interest. Social cognition partially mediated the relationship between early visual processing and functional outcomes. The direct effect of early visual processing on functional outcomes remained significant, albeit with a reduced effect size. The findings suggest that interventions targeting both early visual processing and social cognition concurrently may improve functional outcomes more effectively than focusing on either domain alone.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100351"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations","authors":"Qian Guo ,&nbsp;Zexin Zhao ,&nbsp;Wenzheng Wang ,&nbsp;Xiaonan Hu ,&nbsp;Hao Hu ,&nbsp;Yao Hu ,&nbsp;Lihua Xu ,&nbsp;Xu Liu ,&nbsp;Xiaohua Liu ,&nbsp;Guanjun Li ,&nbsp;Zhongying Shi ,&nbsp;Jijun Wang","doi":"10.1016/j.scog.2025.100344","DOIUrl":"10.1016/j.scog.2025.100344","url":null,"abstract":"<div><div>Evidence suggests that attenuated mismatch negative (MMN) waves have a close link to auditory verbal hallucinations (AVH) and their clinical outcomes, especially impaired neural oscillations such as θ, β representing attentional control. In current study, thirty patients with schizophrenia and AVH (SZ) and twenty-nine healthy controls (HC) underwent multi-feature MMN paradigm measurements including frequency and duration deviant stimuli (fMMN and dMMN). Clinical symptoms and MMN paradigm were followed up among SZ group after 8-week treatment. Results demonstrated that hallucinating patients exhibited attenuated dMMN amplitudes across Fz (p = 0.010), F1 (p = 0.020) and F2 (p = 0.014) electrodes, which were trendily recovered after treatment. Meanwhile, θ band and TBR at frontal fMMN and right temporal dMMN were significantly reduced in SZs. After treatment, SZs showed reduced scores of Hoffman's Auditory Hallucinations Rating Scale (AHRS), with a remarkable recovery in right temporal TBR of dMMN (p = 0.042) and a trending change in frontal TBR of fMMN (p = 0.090). The β band was decreased in dMMN (p = 0.035) by time. Additionally, P3 scores of Positive and Negative Syndrome Scale (PANSS) were negatively correlated with θ band of fMMN at baseline. Baseline scores of AHRS negatively predicted changes of dMMN amplitude after treatment, and changes of β band in left temporal dMMN predicted the reduction in scores of PANSS negative scale. These findings supported that deficits in θ oscillation and TBR during auditory attention process were crucial to clinical progression of schizophrenia with AVH.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100344"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study","authors":"Aishwarya Raje ,&nbsp;Abhijit R. Rozatkar ,&nbsp;Urvakhsh Meherwan Mehta ,&nbsp;Ritu Shrivastava ,&nbsp;Ameya Bondre ,&nbsp;Manaal Amir Ahmad ,&nbsp;Anshika Malviya ,&nbsp;Yogendra Sen ,&nbsp;Deepak Tugnawat ,&nbsp;Anant Bhan ,&nbsp;Tamonud Modak ,&nbsp;Nabagata Das ,&nbsp;Srilakshmi Nagendra ,&nbsp;Erlend Lane ,&nbsp;Juan Castillo ,&nbsp;John A. Naslund ,&nbsp;John Torous ,&nbsp;Soumya Choudhary","doi":"10.1016/j.scog.2025.100347","DOIUrl":"10.1016/j.scog.2025.100347","url":null,"abstract":"<div><h3>Introduction</h3><div>Cognitive deficits represent a core symptom of schizophrenia and a principal contributor to illness disability, yet evaluating cognition in routine clinical settings is often not feasible as cognitive assessments take longer than a standard doctor's visit. Using smartphones to assess cognition in schizophrenia offers the advantages of convenience in that patients can complete assessments outside of the clinic, temporality in that longitudinal trends can be identified, and contextuality in that cognitive scores can be interpreted with other measures captured by the phone (e.g. sleep). The current study aims to design a battery of cognitive assessments corresponding to the MATRICs Consensus Battery of Cognition (MCCB), in partnership with people living with schizophrenia.</div></div><div><h3>Methodology</h3><div>Focus group discussions (FGDs) and interviews were conducted with people diagnosed with schizophrenia across three sites (Boston, Bhopal, and Bangalore) to help design, refine, and assess the proposed smartphone battery of cognitive tests on the mindLAMP app. Interviews were conducted between December 2023 and March 2024. Inductive thematic analysis was used to analyze data.</div></div><div><h3>Results</h3><div>Participants found the app and its proposed cognitive assessments to be acceptable, helpful, and easy to use. They particularly found the gamified nature of the cognitive tests to be appealing and engaging. However, they also proposed ways to further increase engagement by including more information about each cognitive test, more visual instructions, and more information about scoring. Across all sites, there were many similarities in themes.</div></div><div><h3>Discussion &amp; conclusion</h3><div>People living with schizophrenia, from different sites in the US and India, appear interested in using smartphone apps to track their cognition. Thematic analysis reinforces the importance of feedback and data sharing, although this presents a challenge, given the novel nature of smartphone-based cognitive measures that have not yet been standardized or validated.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"40 ","pages":"Article 100347"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143242305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}