难治性精神分裂症患者的语言和视觉学习能力:一年随访研究

IF 2.3 Q2 PSYCHIATRY
Urska Arnautovska , Kathryn Vitangcol , James P. Kesby , Nicola Warren , Susan L. Rossell , Erica Neill , Anthony Harris , Cherrie Galletly , David Castle , Dan Siskind
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引用次数: 1

摘要

目的在一般人群中,重复的认知测试会产生学习效果,并有可能提高测试成绩。目前尚不清楚重复认知测试对认知的同样影响是否适用于精神分裂症患者,这种情况通常与严重的认知障碍有关。本研究旨在评估精神分裂症患者的学习能力,并考虑到抗精神病药物会额外损害认知能力的证据,探索抗胆碱能负荷对言语和视觉学习的潜在影响。方法对86例精神分裂症患者进行氯氮平治疗,并有持续的阴性症状。在基线、第8周、第24周和第52周使用阳性和阴性综合征量表、霍普金斯言语学习测试-修订版(HVLT-R)和短暂视觉空间记忆测试-R(BVMT-R)对他们进行评估。氯氮平/去氯氮平的比例和抗胆碱能认知负荷都不能显著预测参与者的总学习。病态前智商与HVLT-R上的言语学习显著相关。结论这些发现促进了我们对精神分裂症患者认知表现的理解,并证明了难治性精神分裂症个体的学习表现有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Verbal and visual learning ability in patients with treatment-resistant schizophrenia: A 1-year follow-up study

Objective

In the general population, repeated cognitive testing produces learning effects with potential for improved test performance. It is currently unclear whether the same effect of repeated cognitive testing on cognition pertains to people living with schizophrenia, a condition often associated with significant cognitive impairments. This study aims to evaluate learning ability in people with schizophrenia and—considering the evidence that antipsychotic medication can additionally impair cognitive performance—explore the potential impact of anticholinergic burden on verbal and visual learning.

Method

The study included 86 patients with schizophrenia, treated with clozapine, who had persisting negative symptoms. They were assessed at baseline, weeks 8, 24 and 52 using Positive and Negative Syndrome Scale, Hopkins Verbal Learning Test–Revised (HVLT-R) and Brief Visuospatial Memory Test-R (BVMT-R).

Results

There were no significant improvements in verbal or visual learning across all measurements. Neither the clozapine/norclozapine ratio nor anticholinergic cognitive burden significantly predicted participants' total learning. Premorbid IQ was significantly associated with verbal learning on the HVLT-R.

Conclusions

These findings advance our understanding of cognitive performance in people with schizophrenia and demonstrate limited learning performance in individuals with treatment-refractory schizophrenia.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
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