Revista de Senologia y Patologia Mamaria最新文献_第4页

Exploring the expression of cancer stem cell marker – Aldehyde dehydrogenase isoenzyme 1A1 (ALDH1A1) in various molecular subtypes of breast cancer 探讨肿瘤干细胞标志物乙醛脱氢酶同工酶1A1 （ALDH1A1）在乳腺癌不同分子亚型中的表达

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Revista de Senologia y Patologia Mamaria Pub Date : 2026-01-01 Epub Date: 2026-02-03 DOI: 10.1016/j.senol.2025.100729

Ramya Suresh , Krishnappa Amita , Kalappa Prashantha , Hamse Kameshwar Vivek , Geethanjali Anil Kumar Burbure , Kanakapura Paramesh Hrushikesh

{"title":"Exploring the expression of cancer stem cell marker – Aldehyde dehydrogenase isoenzyme 1A1 (ALDH1A1) in various molecular subtypes of breast cancer","authors":"Ramya Suresh , Krishnappa Amita , Kalappa Prashantha , Hamse Kameshwar Vivek , Geethanjali Anil Kumar Burbure , Kanakapura Paramesh Hrushikesh","doi":"10.1016/j.senol.2025.100729","DOIUrl":"10.1016/j.senol.2025.100729","url":null,"abstract":"<div><h3>Background</h3><div>Cancer stem cells (CSCs) are a subpopulation of cancer cells implicated in tumor proliferation and progression. Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cytosolic isoenzyme that oxidizes intracellular aldehydes and is critical for normal and tumor stem cell differentiation. The aim of this study was to determine the expression of CSC marker, ALDH1A1, and its prognostic potential in invasive breast carcinoma.</div></div><div><h3>Methods</h3><div>This was a diagnostic analytical study involving 50 cases of invasive breast carcinoma who underwent mastectomy from January 2021 up to June 2022. The tumors were classified into their histological and molecular subtypes by assessing ER, PR, Her2 and Ki67. ALDH1 expression was studied, scored and correlated with known clinicopathological parameters.</div></div><div><h3>Results</h3><div>Out of 50 tumors, 28 tumors (56%) showed ALDH1 positivity. ALDH1 expression was significantly associated with ER/PR overexpression and Her-2 negativity. No significant association was noted between ALDH1A1 and other clinicopathological parameters.</div></div><div><h3>Conclusion</h3><div>This study observed a high prevalence of ALDH1A1 positivity in invasive breast carcinoma. ALDH1 expression was significantly associated with ER/PR overexpression and HER-2 negativity. Assessment of ALDH1A1 expression might help identify a high-risk subgroup of breast cancers and favor the use of ALDH as an independent prognostic marker. <em>In-silico</em> analysis reveals that HER2 and PR with ALDH1A1 bind very tightly.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"39 1","pages":"Article 100729"},"PeriodicalIF":0.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hormone receptor (HR)- and HER2-dependent expression of hypoxia genes (HIF1A, HIF2A and HIF3A) at the transcriptional level in clinical breast tumor samples 临床乳腺肿瘤样本中缺氧基因（HIF1A、HIF2A和HIF3A）在转录水平上的激素受体（HR）和her2依赖性表达

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Revista de Senologia y Patologia Mamaria Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.senol.2026.100745

Berke Can Acar, Caglar Berkel

引用次数: 0

Therapeutic implications of antiangiogenic agents and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors in breast cancer: Current status and future perspectives 抗血管生成药物和多腺苷二磷酸核糖聚合酶（PARP）抑制剂在乳腺癌中的治疗意义：现状和未来展望

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1016/j.senol.2024.100658

Muhammad Adil , Ghazanfar Abbas , Mavara Iqbal , Sarmad Rasheed , Shamsa Kanwal

{"title":"Therapeutic implications of antiangiogenic agents and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors in breast cancer: Current status and future perspectives","authors":"Muhammad Adil , Ghazanfar Abbas , Mavara Iqbal , Sarmad Rasheed , Shamsa Kanwal","doi":"10.1016/j.senol.2024.100658","DOIUrl":"10.1016/j.senol.2024.100658","url":null,"abstract":"<div><div>Angiogenesis exhibits an integral role in cancer development and metastasis, therefore, antiangiogenic therapy forms the basis of several promising treatment strategies for breast cancer. Moreover, DNA damage has long been exploited in cancer chemotherapy and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors constitute a novel group of drugs for the targeted disruption of DNA repair phenomenon attributed to breast cancer. Several antiangiogenic drugs and PARP inhibitors are effectively used as sole agents for the therapeutic management of early breast cancer and breast cancer gene mutation–induced breast cancer, respectively. Whereas, other antiangiogenic agents are employed for the ancillary therapy of metastatic breast cancer in conjunction with chemotherapeutic drugs. Likewise, some PARP inhibitors are recommended as adjuncts to chemotherapy against the triple-negative form of breast cancer. Combinations of PARP inhibitors with immunotherapy have also demonstrated favorable outcomes and offer an efficient treatment strategy for breast cancer. Currently, the combinations of antiangiogenic agents and PARP inhibitors are under investigation for prospective synergistic or additive effects in breast cancer. Despite being suggested for high-risk patients, the prophylactic use of PARP inhibitors has not been supported by means of preclinical or clinical studies. Finally, the identification of patient cohorts, determination of predictive biomarkers, optimization of dosing strategies, validation of long-term safety, and containment of resistance issues, necessitate proper attention for improving the clinical efficacy of potentially useful antiangiogenic agents and PARP inhibitors against breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100658"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Systemic cortisol correlates with poor prognosis parameters in women with breast cancer and excessive body fat 全身皮质醇与乳腺癌和体脂过多的妇女预后参数差相关

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-05-03 DOI: 10.1016/j.senol.2025.100700

Aedra Carla Bufalo Kawassaki , Carolina Coradi , Elaine Minatti , Janaina Carla da Silva , Daniel Rech , Thalita Basso Scandolara , Fernanda Tomiotto-Pelissier , Carolina Panis , Wander Rogerio Pavanelli

{"title":"Systemic cortisol correlates with poor prognosis parameters in women with breast cancer and excessive body fat","authors":"Aedra Carla Bufalo Kawassaki , Carolina Coradi , Elaine Minatti , Janaina Carla da Silva , Daniel Rech , Thalita Basso Scandolara , Fernanda Tomiotto-Pelissier , Carolina Panis , Wander Rogerio Pavanelli","doi":"10.1016/j.senol.2025.100700","DOIUrl":"10.1016/j.senol.2025.100700","url":null,"abstract":"<div><h3>Introduction</h3><div>Excessive body fat can lead to systemic hormonal deregulation associated with poor cancer prognosis. This study analyzed the relationship between systemic cortisol levels and clinicopathological parameters in breast cancer patients categorized by body mass index (BMI).</div></div><div><h3>Material and methods</h3><div>Peripheral blood samples were collected from 223 women with or without breast cancer to investigate daytime cortisol levels. Circulating cortisol was measured using an enzyme immunoassay kit and correlated with clinicopathological data. The Cancer Genome Atlas (TCGA) data were collected to visualize cortisol axis-related gene expression in breast tumors (<em>n</em> = 1215).</div></div><div><h3>Results</h3><div>No significant difference in cortisol levels was found concerning breast cancer diagnosis. However, when breast cancer patients were stratified by BMI, cortisol levels were significantly higher in obese patients compared to eutrophics. Eutrophic patients exhibited lower cortisol levels when they had Luminal A tumors compared to those with HER2-amplified tumors. Obese patients with Luminal B tumors had higher cortisol levels than those carrying Luminal A, HER2, or triple-negative tumors. Additionally, lymph node metastasis correlated with high cortisol levels and obesity, as did the presence of blood clots.</div></div><div><h3>Conclusions</h3><div>These findings suggest that obesity and systemic cortisol levels in breast cancer patients should be further explored to understand their relationship with clinicopathological parameters.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100700"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Radioterapia adyuvante en el cáncer de mama: análisis comparativo de la toxicidad de 2 esquemas de hipofraccionamiento 辅助放射治疗乳腺癌：2种低分馏方案的毒性比较分析

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-05-09 DOI: 10.1016/j.senol.2025.100697

Laura Vaya González, Clara Iglesias Melero, María Soledad Quesada Muñoz, María Domínguez Rodríguez, José Manuel Rico Pérez, Nuria Azahara Linares Mesa

{"title":"Radioterapia adyuvante en el cáncer de mama: análisis comparativo de la toxicidad de 2 esquemas de hipofraccionamiento","authors":"Laura Vaya González, Clara Iglesias Melero, María Soledad Quesada Muñoz, María Domínguez Rodríguez, José Manuel Rico Pérez, Nuria Azahara Linares Mesa","doi":"10.1016/j.senol.2025.100697","DOIUrl":"10.1016/j.senol.2025.100697","url":null,"abstract":"<div><h3>Objective</h3><div>Adjuvant radiotherapy (RT) for breast cancer has been given in 1.8–2 Gy daily fractions for decades. Protracted schemes have proven as effective and safe as conventional. Schemes involving 5 fractions once a week are as safe as those involving one daily fraction for three weeks. We compared acute and late toxicity of two hypofractionated regimes.</div></div><div><h3>Material and methods</h3><div>Retrospective single-center observational study involving 100 unselected patients, treated with adjuvant radiotherapy for breast cancer with either 40 Gy/15 fr/3 weeks or 28,5 Gy/5 fr/5 weeks (1:1 ratio). Statistical tests used: Mann–Whitney U and Chi-square (χ<sup>2</sup>). Toxicity (assessed by physicians/nurses using RTOG/CTCAE Score at end of treatment, one month and six months later) was retrieved from patients notes.</div></div><div><h3>Results</h3><div>Median follow-up: 16.6 months. Average age: 59 years. The comparison between the 15-session and 5-session groups revealed the following results: boost: 24% vs. 2%; lumpectomy: 62% vs. 92%; mastectomy 38% vs. 14%; lymphadenectomy 36% vs. 14%; RT to SCF + level III: 54% vs. 8%; acute skin toxicity 70% vs. 60%; acute odynophagia: 16% vs. 2%; late toxicity (induration, edema, deformity-distortion, telangiectasias, hyperpigmentation) 30% vs. 52%.</div></div><div><h3>Conclusion</h3><div>Odynophagia was more frequent in weekly treatments. Prophylactic nodal irradiation rates could be a confounding factor. A modest excess of G1 breast induration in 5 fractions schemes was detected. To summarize, both schemes are similar concerning acute and late toxicity.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100697"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Transición al inglés de la Revista de Senología: en desacuerdo 《血清学杂志》英文翻译：不同意

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI: 10.1016/j.senol.2025.100728

Josep Asensi Pérez

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Hipofraccionamiento y ultrahipofraccionamiento: cuando menos es realmente más en la radioterapia moderna del cáncer de mama 低分馏和超分馏：在现代乳腺癌放射治疗中，少即是多

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-10-14 DOI: 10.1016/j.senol.2025.100727

Angel Montero , Manuel Algara

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Cirugía oncoplástica reconstructiva: reconstrucción prepectoral inmediata y matrices acelulares dérmicas. Revisión sistemática, indicaciones y resultados 重建肿瘤成形术：立即脑部前重建和皮肤细胞基质。系统审查、指标和结果

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-05-14 DOI: 10.1016/j.senol.2025.100702

Manuel Nogueira Sixto, Gonzalo de Castro Parga, Vanesa Rodríguez Fernández

{"title":"Cirugía oncoplástica reconstructiva: reconstrucción prepectoral inmediata y matrices acelulares dérmicas. Revisión sistemática, indicaciones y resultados","authors":"Manuel Nogueira Sixto, Gonzalo de Castro Parga, Vanesa Rodríguez Fernández","doi":"10.1016/j.senol.2025.100702","DOIUrl":"10.1016/j.senol.2025.100702","url":null,"abstract":"<div><div>In the last decade, we have witnessed an exponential increase in the use of acellular dermal matrices (ADMs) as a result of increased rates of immediate prepectoral breast reconstruction (IPBR) after mastectomy. We performed a systematic search on IPBR with ADMs with the aim of understanding the results obtained and identifying which subgroup of patients benefit from the use of ADMs in IPBR. We recorded the anthropometric characteristics and medical history of the patients, the therapy carried out, and the results obtained.</div><div>A total of 159 articles were identified, of which 46 were selected. These describe a reduction in the onset of global complications after IPBR with ADMs from 27.5% to 23.3%, and a reduction in the incidence of capsular contracture from 12.4% to 2.3%, as well as the disappearance of animation deformity. In this review, the following factors were found to be risk factors for morbidity and/or worse aesthetic results: adjuvant radiotherapy, smoking, larger volume mastectomy, and axillary surgery. BMI > 30, diabetes, age >50, and prosthetic volume have not been confirmed as risk factors. Mastectomies >1000 g have been described as protective factors. Prepectoral breast reconstruction with ADMs is a safe technique with good functional and aesthetic results. At present, it is not possible to determine which ADM provides the best results.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100702"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Subutilización de los colgajos perforantes en cirugía oncoplástica: análisis clínico y barreras terminológicas 肿瘤成形术中穿刺垫使用不足：临床分析和术语障碍

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-05-07 DOI: 10.1016/j.senol.2025.100698

Pablo Sciuto , Maite Campos , Daniel Gonzalez

{"title":"Subutilización de los colgajos perforantes en cirugía oncoplástica: análisis clínico y barreras terminológicas","authors":"Pablo Sciuto , Maite Campos , Daniel Gonzalez","doi":"10.1016/j.senol.2025.100698","DOIUrl":"10.1016/j.senol.2025.100698","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the safety, efficacy, and esthetic outcomes of chest wall perforator flaps in breast-conserving surgery and to analyze the terminological barriers affecting their adoption.</div></div><div><h3>Materials and methods</h3><div>A retrospective observational study was conducted on 27 patients treated between 2020 and 2024 with breast-conserving surgery and partial breast reconstruction using perforator flaps of the lateral intercostal artery (LICAP, Lateral Intercostal Artery Perforator), lateral thoracic artery (LTAP, Lateral Thoracic Artery Perforator), and medial intercostal artery (MICAP, Medial Intercostal Artery Perforator). Clinical variables, flap selection, complications, and esthetic outcomes were analyzed using the Harvard Scale. Follow-up included immediate postoperative assessment and evaluation at one year.</div></div><div><h3>Results</h3><div>A total of 85.2% of patients achieved good or excellent esthetic outcomes, with no changes in Harvard Scale scores at one year. No patient requested symmetry surgery. Eight complications were reported (29.6%), mostly minor (seromas, hematomas, partial fat necrosis), all managed conservatively. One case of flap necrosis required mastectomy. No surgical site infections or wound dehiscence were documented. The complication rate and esthetic success were comparable to international series.</div></div><div><h3>Conclusion</h3><div>Chest wall perforator flaps represent a safe and effective option in breast-conserving surgery, with low morbidity and excellent esthetic acceptance. The lack of consensus in nomenclature remains a barrier to widespread adoption. Standardization and structured training programs are essential to optimize their clinical application.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100698"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Insights into breast cancer education concerning knowledge, awareness, and perceptions: A cross-sectional study among young adult girls 关于乳腺癌知识、意识和观念教育的见解：一项对年轻成年女孩的横断面研究

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-10-01 Epub Date: 2025-06-17 DOI: 10.1016/j.senol.2025.100707

Anmar Al-Taie , Ali N. Hussein , Asma K. Allah

{"title":"Insights into breast cancer education concerning knowledge, awareness, and perceptions: A cross-sectional study among young adult girls","authors":"Anmar Al-Taie , Ali N. Hussein , Asma K. Allah","doi":"10.1016/j.senol.2025.100707","DOIUrl":"10.1016/j.senol.2025.100707","url":null,"abstract":"<div><h3>Introduction</h3><div>In developing countries, mortality from breast cancer (BC) is higher due to changes in lifestyle that produce a rise in incidence, with over half of patients receiving advanced-stage diagnoses. Young girls have a significant impact on women's knowledge and awareness of BC in their communities and their motivation needs to be evaluated.</div></div><div><h3>Objective</h3><div>The aim of this study was to assess the level of knowledge of BC regarding potential risk factors, awareness about the most common warning signs, diagnostic and screening, and perceptions towards BC treatment outcomes among young adult girls in Northern Cyprus.</div></div><div><h3>Methods</h3><div>A cross-sectional, observational study was conducted among young adult girls in three major provinces of Northern Cyprus: Nicosia, Kyrenia, and Famagusta, using a structured, validated questionnaire with five parts.</div></div><div><h3>Results</h3><div>A total of 300 young adult girls were enrolled in this study, with a mean age of 22.37 years. There was a significant lack of knowledge about BC risk factors and diagnosis (score = 8.4, <em>P</em> < 0.0001); (score = 5.7, <em>P</em> < 0.0001, respectively). There was also a significant lack of awareness of the BC signs (score = 6.6, <em>P</em> < 0.0001), and perceptions towards treatment (score = 5.3, <em>P</em> < 0.0001).</div></div><div><h3>Conclusion</h3><div>This study found that most young adult girls in Northern Cyprus had lower than expected knowledge of BC risk factors, warning signs, and early cancer diagnosis and screening. The study population, on the other hand, had fairly positive perceptions of BC management.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100707"},"PeriodicalIF":0.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0