采用一步核酸扩增法（OSNA）检测的淋巴结总肿瘤负担与早期乳腺癌中进行腋下淋巴结切除术的决定之间的相关性

IF 0.2 Q4 OBSTETRICS & GYNECOLOGY

Revista de Senologia y Patologia Mamaria Pub Date : 2025-02-05 DOI:10.1016/j.senol.2025.100667

Paula Chamocho Lloro , María Dolores Rodríguez Garnica , Beatriz Sánchez Jimenez , Sergio Rodriguez Lobalzo , Angel Calvo Tudela , Alejandro J. Rohde Calleja , Francisco Rivas Ruiz , José C. Maañón di Leo

{"title":"采用一步核酸扩增法（OSNA）检测的淋巴结总肿瘤负担与早期乳腺癌中进行腋下淋巴结切除术的决定之间的相关性","authors":"Paula Chamocho Lloro , María Dolores Rodríguez Garnica , Beatriz Sánchez Jimenez , Sergio Rodriguez Lobalzo , Angel Calvo Tudela , Alejandro J. Rohde Calleja , Francisco Rivas Ruiz , José C. Maañón di Leo","doi":"10.1016/j.senol.2025.100667","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to determine the correlation between total lymph load (TLL) analyzed by one step nucleic acid amplification (OSNA) and the results obtained in our clinical practice, and whether TTL is a useful tool for selecting patients who should undergo axillary lymph node dissection.</div></div><div><h3>Material and methods</h3><div>The study has a retrospective cohort design, conducted at the Hospital Costa de Sol on 92 patients with (GC+) analyzed by OSNA, between 2012 and 2017.</div></div><div><h3>Results</h3><div>Disease-free survival was analyzed classifying patients into micro-metastatic, macro-metastatic with less than 25,000 copies of mRNA-CK19/ul, and macro-metastatic with more than 25,000 copies of mRNA-CK19/ul, with no statistical significance found between groups (log-rank test 0.266266).</div></div><div><h3>Discussion</h3><div>The recommendation of axillary lymph node dissection (ALND) in conservatively operated patients with clinically (or radiologically) negative axilla and high tumor load as determined by OSNA is not related to local disease control.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100667"},"PeriodicalIF":0.2000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlación entre la carga tumoral total de los ganglios linfáticos analizada mediante One Step Nucleic Acid Amplification (OSNA) y la decisión de realizar una linfadenectomía axilar en el cáncer de mama temprano\",\"authors\":\"Paula Chamocho Lloro , María Dolores Rodríguez Garnica , Beatriz Sánchez Jimenez , Sergio Rodriguez Lobalzo , Angel Calvo Tudela , Alejandro J. Rohde Calleja , Francisco Rivas Ruiz , José C. Maañón di Leo\",\"doi\":\"10.1016/j.senol.2025.100667\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>The aim of this study was to determine the correlation between total lymph load (TLL) analyzed by one step nucleic acid amplification (OSNA) and the results obtained in our clinical practice, and whether TTL is a useful tool for selecting patients who should undergo axillary lymph node dissection.</div></div><div><h3>Material and methods</h3><div>The study has a retrospective cohort design, conducted at the Hospital Costa de Sol on 92 patients with (GC+) analyzed by OSNA, between 2012 and 2017.</div></div><div><h3>Results</h3><div>Disease-free survival was analyzed classifying patients into micro-metastatic, macro-metastatic with less than 25,000 copies of mRNA-CK19/ul, and macro-metastatic with more than 25,000 copies of mRNA-CK19/ul, with no statistical significance found between groups (log-rank test 0.266266).</div></div><div><h3>Discussion</h3><div>The recommendation of axillary lymph node dissection (ALND) in conservatively operated patients with clinically (or radiologically) negative axilla and high tumor load as determined by OSNA is not related to local disease control.</div></div>\",\"PeriodicalId\":38058,\"journal\":{\"name\":\"Revista de Senologia y Patologia Mamaria\",\"volume\":\"38 2\",\"pages\":\"Article 100667\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2025-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista de Senologia y Patologia Mamaria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0214158225000039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de Senologia y Patologia Mamaria","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0214158225000039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

本研究的目的是确定一步核酸扩增（one - step nucleic acid amplification， OSNA）分析的总淋巴负荷（total lymph load， TLL）与临床实践结果的相关性，以及TTL是否可以作为选择需要进行腋窝淋巴结清扫的患者的有用工具。材料和方法该研究采用回顾性队列设计，于2012年至2017年在太阳海岸医院对92名（GC +）患者进行了OSNA分析。结果将患者的无病生存率分为微转移、大转移（mRNA-CK19/ul小于25000拷贝）和大转移（mRNA-CK19/ul大于25000拷贝），组间差异无统计学意义（log-rank检验0.266266）。讨论对于临床（或放射学）腋窝阴性和高肿瘤负荷的OSNA保守手术患者，推荐腋窝淋巴结清扫术（ALND）与局部疾病控制无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Correlación entre la carga tumoral total de los ganglios linfáticos analizada mediante One Step Nucleic Acid Amplification (OSNA) y la decisión de realizar una linfadenectomía axilar en el cáncer de mama temprano

Introduction

The aim of this study was to determine the correlation between total lymph load (TLL) analyzed by one step nucleic acid amplification (OSNA) and the results obtained in our clinical practice, and whether TTL is a useful tool for selecting patients who should undergo axillary lymph node dissection.

Material and methods

The study has a retrospective cohort design, conducted at the Hospital Costa de Sol on 92 patients with (GC +) analyzed by OSNA, between 2012 and 2017.

Results

Disease-free survival was analyzed classifying patients into micro-metastatic, macro-metastatic with less than 25,000 copies of mRNA-CK19/ul, and macro-metastatic with more than 25,000 copies of mRNA-CK19/ul, with no statistical significance found between groups (log-rank test 0.266266).

Discussion

The recommendation of axillary lymph node dissection (ALND) in conservatively operated patients with clinically (or radiologically) negative axilla and high tumor load as determined by OSNA is not related to local disease control.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Revista de Senologia y Patologia Mamaria Medicine-Obstetrics and Gynecology

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

63 days