Journal of Biomedical Physics and Engineering最新文献

{"title":"Investigating miR-16-5p: The Tumor Suppressor That Influences Cell Cycle Genes in Colorectal Cancer.","authors":"Seyedeh Nasibeh Mousavikia, Maryam M Matin, Mohammad Taghi Bahreyni-Toossi, Seyed Hamid Aghaee-Bakhtiari, Hosein Azimian","doi":"10.31661/jbpe.v0i0.2501-1874","DOIUrl":"10.31661/jbpe.v0i0.2501-1874","url":null,"abstract":"<p><strong>Background: </strong>Colorectal Cancer (CRC) remains a major health challenge, with perturbation in the cell cycle playing a crucial role in its progression. Hsa-miR-16-5p (miR-16-5p) is a crucial tumor suppressor, but its precise role in modulating cell cycle genes, particularly in the presence of ionizing radiation, is not fully understood.</p><p><strong>Objective: </strong>This study investigated the role of miR-16-5p in modulating the expression of cell cycle genes in colorectal cancer cells exposed to ionizing radiation.</p><p><strong>Material and methods: </strong>In this experimental study, HT-29 cells were transfected with miR-16-5p using the polyfectamine transfection reagent. Expression levels of miR-16-5p, <i>Cyclin-Dependent Kinase 4 (CDK4), Cyclin E1 (CCNE1),</i> and <i>Cyclin D1 (CCND1)</i> were quantified by real-time Polymerase Chain Reaction (PCR). To assess the changes after irradiation, cells were exposed to 4 Gy.</p><p><strong>Results: </strong>Ionizing radiation significantly downregulated miR-16-5p compared to controls, while transfection of miR-16-5p significantly increased its expression level. However, irradiation of 4 Gy did not significantly alter <i>CCND1</i> or <i>CCNE1</i>, but decreased <i>CDK4</i> expression. The miR-16-5p transfection significantly suppressed <i>CCND1, CCNE1</i> and <i>CDK4</i> compared to controls. The expression of <i>CCND1, CCNE1,</i> and <i>CDK4</i> significantly decreased when miR-16-5p transfection was performed before 4 Gy irradiation compared to both 4 Gy irradiation alone and the control group.</p><p><strong>Conclusion: </strong>Our results highlight the role of miR-16-5p in modulating key cell cycle genes in CRC. Increasing miR-16-5p expression could improve radiosensitivity and represent a therapeutic strategy for the treatment of CRC.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"451-458"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Histology Staining of Skin Tissue using Ex Vivo Confocal Microscopy and Deep Learning.","authors":"Mahmoud Bagheri, Alireza Ghanadan, Mobin Saboohi, Maryam Daneshpazhooh, Fatemeh Atyabi, Marjaneh Hejazi","doi":"10.31661/jbpe.v0i0.2307-1642","DOIUrl":"10.31661/jbpe.v0i0.2307-1642","url":null,"abstract":"<p><strong>Background: </strong>The use of Hematoxylin-and-Eosin (H&E) staining is widely accepted as the most reliable method for diagnosing pathological tissues. However, the conventional H&E staining process for tissue sections is time-consuming and requires significant labor. In contrast, Confocal Microscopy (CM) enables quick and high-resolution imaging with minimal tissue preparation by fluorescence detection. However, it seems harder to interpret images from CM than H&E-stained images.</p><p><strong>Objective: </strong>This study aimed to modify an unsupervised deep-learning model to generate H&E-like images from CM images.</p><p><strong>Material and methods: </strong>This analytical study evaluated the efficacy of CM and virtual H&E staining for skin tumor sections related to Basal Cell Carcinoma (BCC). The acridine orange staining, combined with virtual staining techniques, was used to simulate H&E dyes; accordingly, an unsupervised CycleGAN framework, trained to virtually stain CM images was implemented. The training process incorporated adversarial and cycle consistency losses to ensure a precise mapping between CM and H&E images without compromising image content. The quality of the generated images was assessed by comparing them to the original images.</p><p><strong>Results: </strong>The CM images, specifically focusing on subtyping BCC and evaluating skin tissue characteristics, were qualitatively assessed. The H&E-like images generated from CM using the CycleGAN model exhibited both qualitative and quantitative similarities to real H&E images.</p><p><strong>Conclusion: </strong>The integration of CM with deep learning-based virtual staining provides advantages for diagnostic applications by streamlining laboratory staining procedures.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"479-490"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Clinics to Cosmos: Radiotherapy as a Selector for Stress-Resistant Microbiota.","authors":"Seyed Mohammad Javad Mortazavi, Joseph J Bevelacqua, Maryam Arshadi, James Welsh","doi":"10.31661/jbpe.v0i0.2509-1985","DOIUrl":"10.31661/jbpe.v0i0.2509-1985","url":null,"abstract":"","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"409-410"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation between First Metacarpal Head Morphology and First Metacarpophalangeal Joint Degenerative Joint Disease: A Computer Model.","authors":"Hamid Namazi, Saleh Behzadi, Shahin Heidari","doi":"10.31661/jbpe.v0i0.2503-1907","DOIUrl":"10.31661/jbpe.v0i0.2503-1907","url":null,"abstract":"<p><strong>Background: </strong>Degenerative Joint Disease (DJD) of the first Metacarpophalangeal (MCP) joint, can severely impair hand function due to pain, stiffness, and reduced range of motion. Anatomical variations in metacarpal head morphology may play a critical role in altering joint biomechanics and stress distribution, potentially accelerating cartilage wear and osteoarthritis progression.</p><p><strong>Objective: </strong>This study aimed to evaluate the biomechanical impact of different first metacarpal head morphologies on stress distribution within the MCP joint under various positions using computer simulation.</p><p><strong>Material and methods: </strong>In this computer simulation study, three-dimensional models of the thumb MCP joint were reconstructed from Computed Tomography (CT) scans of healthy subjects. The models were adjusted to represent flat, biplanar, and convex metacarpal head morphologies and were simulated in three positions: neutral, 20° flexion, and 20° extension. Computer simulation was performed using Analysis System (ANSYS) to calculate von Mises stress distributions. Descriptive statistics and one-way Analysis of Variance (ANOVA) were applied to compare stress values between groups.</p><p><strong>Results: </strong>The flat metacarpal head exhibited the highest stress concentrations, peaking at 138 MPa in 20° extension. Biplanar morphology showed moderate stresses, while the convex shape demonstrated the lowest stress, with a maximum of 58 MPa. The analysis confirmed significant differences between groups (<i>P</i>-value=0.039). Stress increased notably in flexion and extension positions compared to neutral across all morphologies.</p><p><strong>Conclusion: </strong>Metacarpal head morphology and joint positioning significantly influence MCP joint biomechanics. Flat and biplanar shapes increase stress concentration, potentially elevating DJD risk. Convex morphology offers better stress dispersion, indicating a biomechanical advantage.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"459-466"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of Nonalcoholic Fatty Liver Grades using Pre-Trained Convolutional Neural Networks and a Random Forest Classifier on B-Mode Ultrasound Images.","authors":"Amir Reza Naderi Yaghouti, Ahmad Shalbaf","doi":"10.31661/jbpe.v0i0.2307-1646","DOIUrl":"10.31661/jbpe.v0i0.2307-1646","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic Fatty Liver Disease (NAFLD) as a prevalent condition can significantly have health implications. Early detection and accurate grading of NAFLD are essential for effective management and treatment of the disease.</p><p><strong>Objective: </strong>The current study aimed to develop an advanced hybrid machine-learning model to classify NAFLD grades using ultrasound images.</p><p><strong>Material and methods: </strong>In this analytical study, ultrasound images were obtained from 55 highly obese individuals, who had undergone bariatric surgery and used histological results from liver biopsies as a reference for NAFLD grading. The features were extracted from the ultrasound images using popular pretrained Convolutional Neural Network (CNN) models, including VGG19, MobileNet, Xception, Inception-V3, ResNet-101, DenseNet-121, and EfficientNet-B7. The fully connected layers were removed from the CNN models and also used the remaining structure as a feature extractor. The most relevant features were then selected using the minimum Redundancy Maximum Relevance (mRMR) method. We then used four classification algorithms: Linear Discriminant Analysis (LDA), Support Vector Machine (SVM), Multilayer Perceptron (MLP) neural network, and Random Forest (RF) classifiers, to categorize the ultrasound images into four groups based on liver fat level (healthy liver, low fat liver, moderate fat liver, and high-fat liver).</p><p><strong>Results: </strong>Among the different CNN models and classification methods, EfficientNet-B7 and RF achieved the highest accuracy. The average accuracies of the LDA, MLP, SVM, and RF classifiers for the feature extraction method with EfficientNet-B7 were 88.48%, 93.15%, 95.47%, and 96.83%, respectively. The proposed automatic model can classify NAFLD grades with a remarkable accuracy of 96.83%.</p><p><strong>Conclusion: </strong>The proposed automatic classification model using EfficientNet-B7 for feature extraction and a Random Forest classifier can improve NAFLD diagnosis, especially in regions, in which access to professional and experienced medical experts is limited.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"437-450"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Mobile Technologies on the Quality of Sleep.","authors":"Zuzana Slezáková, Jozef Baláž, Soňa Wimmerová, Martina Valachovičová","doi":"10.31661/jbpe.v0i0.2311-1685","DOIUrl":"10.31661/jbpe.v0i0.2311-1685","url":null,"abstract":"<p><p>The extensive usage of mobile phones across all age brackets, including children and teenagers, leads to significant exposure to Radiofrequency Electromagnetic Fields (RF-EMF). This exposure raises concerns about potential adverse effects on sleep. The current study aimed to explore the influence of mobile phone-emitted RF-EMFs on the duration and quality of sleep in a cohort of medical students. Participants alternated between sleeping with and without a mobile phone for two-week intervals, while their sleep patterns were monitored using smartwatches. The study results indicated no statistically significant disparities in sleep quality between sleeping with and without a mobile phone. However, exposure to radiofrequency electromagnetic fields had a notable impact on the minimum and average blood oxygen saturation levels.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"491-496"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutron Attenuation and Mechanical Properties of Lithium-Cadmium Oxide-Polyester Resin Composites for Space Applications.","authors":"Hassan Vafapour, Seyed Mohammad Javad Mortazavi","doi":"10.31661/jbpe.v0i0.2507-1956","DOIUrl":"10.31661/jbpe.v0i0.2507-1956","url":null,"abstract":"<p><strong>Background: </strong>Long-duration space missions expose astronauts to hazardous radiation, including Galactic Cosmic Rays (GCRs) and Solar Particle Events (SPEs), producing secondary neutrons that penetrate spacecraft. Traditional aluminum shielding is inefficient and generates secondary particles, necessitating lightweight, multifunctional composites for effective radiation protection.</p><p><strong>Objective: </strong>This study aims to optimize neutron shielding composites using Cadmium (Cd) and Lithium (Li) compounds within an Unsaturated Polyester Resin (UPS) matrix, targeting maximum attenuation of fast and thermal neutrons, validated through both experimental measurements and Geant4 simulations, while assessing mechanical properties for spacecraft use.</p><p><strong>Material and methods: </strong>This study combined experimental and simulation methods. Seven composites, each with 90 weight percentage (wt%) UPS and 10 wt% Cd and Li compounds (LiOH or LiBr), were synthesized. Neutron attenuation was tested using a ²³⁹Pu-Be source, measuring thermal (<0.5 eV) and fast (>0.5 MeV) neutron fluxes. Mechanical properties were evaluated via nanoindentation, with Geant4 Monte Carlo simulations providing comparative data.</p><p><strong>Results: </strong>The Cd₅_LiOH₅ composite achieved 92.35% thermal neutron attenuation (99.65% simulated) at 25 mm, while Cd₂.₅_LiOH₇.₅ exhibited 36.2% fast neutron attenuation (38.7% simulated) at 25 mm. Simulations demonstrated strong agreement with experiments across most composites, with relative differences generally below 10%, except for thin samples or materials with heterogeneous filler distribution. The Cd₂.₅_LiBr₇.₅ composite showed superior hardness (0.10 GPa) and modulus (0.7 GPa).</p><p><strong>Conclusion: </strong>UPS-based composites with Cd and Li offer effective neutron shielding and enhanced mechanical properties, validated by Geant4 simulations. These materials are promising for radiation protection in deep space missions.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"411-422"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Existence of Dynamic Functional Connectivity Variations of Brain Networks in Psychogenic Non-Epileptic Seizures Through Resting-state Functional Magnetic Resonance Imaging.","authors":"Mojtaba Vardian, Mohammad Ali Oghabian, Mohammad Arbabi, Habib Ganjgahi","doi":"10.31661/jbpe.v0i0.2306-1627","DOIUrl":"10.31661/jbpe.v0i0.2306-1627","url":null,"abstract":"<p><strong>Background: </strong>Psychogenic Non-Epileptic Seizures (PNES), is a type of seizure that is caused by emotional factors. Symptoms of PNES are similar to epileptic seizures including disturbance in involuntary movement. Previous studies showed that neural activity altered in PNES detected through the resting-state functional Magnetic Resonance Imaging (rs-fMRI) thus this study was designed for a better understanding of PNES pathophysiology using the rs-fMRI technique.</p><p><strong>Objective: </strong>This study was conducted to examine dynamic Functional Connectivity (dFC) in the brain networks between PNES and healthy control subjects.</p><p><strong>Material and methods: </strong>In this experimental study, the rs-fMRI was collected from 16 PNES subjects and 16 healthy subjects. After surrogating data, the sliding window technique was used for dFC detection in nine brain networks which chosen from Stanford Findlab.</p><p><strong>Results: </strong>Our results indicate that there were no differences in the presence or absence of dFC between the PNES group and the control group in the ventral Default Mode Network (vDMN), Language Network (LN), and Visuospatial Network (VSN). However, dFC was elevated in the PNES group in comparison to the normal control group within the Sensorimotor Network (SMN), Posterior Salience Network (PSN), and Anterior Salience Network (ASN).</p><p><strong>Conclusion: </strong>The findings suggest that dFC analyses hold significant potential for uncovering abnormal patterns of brain network connections in the PNES. This offers a promising finding for a better comprehension of PNES.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"467-478"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonotherapy Using Folic Acid-Ag-Bi2O3 Nanocomposites in 2D and 3D Cultural C540 Melanoma Cells.","authors":"Mina Sarani, Paria Tamaddon, Hanieh Haghighi, Hossein Heli, Majid Darroudi, Arash Safari, Mohammad Reza Sardashti Birjandi, Gholamhossein Tondro, Zahra Kayani, Naghmeh Sattarahmady","doi":"10.31661/jbpe.v0i0.2505-1922","DOIUrl":"10.31661/jbpe.v0i0.2505-1922","url":null,"abstract":"<p><strong>Background: </strong>Sonodynamic Therapy (SDT) is increasingly recognized as an innovative, non-invasive cancer modality in which low-intensity Ultrasound (U) energizes sonosensitizers, provoking a burst of Reactive Oxygen Species (ROS) that culminate in apoptotic destruction of tumor cells.</p><p><strong>Objective: </strong>Silver-bismuth oxide nanocomposites (AgB NCs) and their folic acid-functionalized counterparts (FAgB NCs) studied as sono-sensitizers for improving in treatment route of melanoma cancer.</p><p><strong>Material and methods: </strong>In this experimental research, AgB NCs and FAgB NCs were synthesized via a green route using <i>Rheum turkestanicum</i> extract. Comprehensive physicochemical characterizations-including Field-Emission Scanning Electron Microscopy (FESEM), Energy-Dispersive X-ray spectroscopy (EDX), Ultraviolet visible spectrometer (UV-vis), Powder X-ray Diffraction (PXRD), and Fourier-Transform Infrared spectroscopy (FT-IR)-confirmed the successful formation and functionalization of the nanocomposites.</p><p><strong>Results: </strong>(3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) (MTT) assays on C540 melanoma cells revealed dose-dependent cytotoxicity, with F-AgBi NCs exhibiting significantly lower IC₅₀ values compared to AgB NCs. Upon U exposure, nanocomposites induced substantial ROS generation, mitochondrial dysfunction, and increased apoptosis, as verified by flow cytometry. Moreover, the FAgB NCs effectively suppressed cell migration and inhibited spheroid formation in 3D cultures, indicating potent antitumor activity in both monolayer and 3D models.</p><p><strong>Conclusion: </strong>These findings underscore the synergistic potential of folic acid-functionalized AgB nanocomposites as efficient sonosensitizers for targeted melanoma therapy. Their enhanced ROS-mediated cytotoxicity, combined with folate receptor-targeted delivery, supports their application in advanced nanomedicine and SDT-based cancer treatment.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"423-436"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance Characteristics of a New Automatic Chip TLD Reader.","authors":"Sajjad Betyar, Seyed Mahdi Hosseini Pooya, Meysam Divsalar","doi":"10.31661/jbpe.v0i0.2506-1937","DOIUrl":"10.31661/jbpe.v0i0.2506-1937","url":null,"abstract":"<p><p>The TR5500 Thermoluminescent Dosimeter (TLD) reader was specifically designed and developed for the automated and efficient readout of Thermoluminescent (TL) chips and pellets in Iran. In accordance with International Atomic Energy Agency (IAEA) requirements for dosimetry laboratories, implementing a comprehensive Quality Management System (QMS) is essential to ensure adherence to standard criteria. This study aimed to evaluate key characteristics of the reader, including response non-linearity, Coefficients of Variation (COV), readout stability over time, and the reproducibility of TLD measurements. LiF: Mg, Cu, P TLDs were exposed to a standard photon radiation field and subsequently read using the TR5500 reader. The characteristics were then calculated and compared against the relevant criteria outlined in International Electrotechnical Commission (IEC) and American Society for Testing and Materials (ASTM) standards, such as ASTM E668-10 and IEC 62387. The reader met the key international standard requirements and, in certain aspects, even surpassed them. The device exhibited excellent stability and reproducibility in readouts, confirming its robust reliability and long-term suitability for routine use in various accredited dosimetry laboratories.</p>","PeriodicalId":38035,"journal":{"name":"Journal of Biomedical Physics and Engineering","volume":"15 5","pages":"497-502"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}