Medicina Moderna - Modern Medicine最新文献_第4页

Multidisciplinary Healthcare Strategies in Pre-Labor Uterine Rupture after Minimal Invasive Procedures 微创手术后产前子宫破裂的多学科保健策略

Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.45

M. Dumitrașcu, Adina-Elena Nenciu, C. Nenciu, A. Baros, D. Secară, A. Albu, M. Cirstoiu

引用次数: 0

Uterine Transplant: A New Option to Restore Fertility 子宫移植:恢复生育能力的新选择

Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.7

V. Varlas, R. Bors, C. Mehedințu, M. Cirstoiu

引用次数: 0

Surgical Implications in the Pathology of Diabetes Mellitus – Review of the Literature 手术对糖尿病病理的影响-文献综述

Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.17

F. Bobircă, D. Dumitrescu, T. Georgescu, A. Bobircă, Carmen Iorgus, M. Georgescu, Ionut Melesteu, Cristina Alexandru, T. Pătraşcu, D. Georgescu

引用次数: 0

Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats 植物复合物对骨关节炎大鼠实验模型中软骨保护生物标志物作用的评价

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.329

S. Pandya, Chetan Savaliya, D. Nagore, V. Undale, Shubhada Khade, Nishant Mante

{"title":"Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats","authors":"S. Pandya, Chetan Savaliya, D. Nagore, V. Undale, Shubhada Khade, Nishant Mante","doi":"10.31689/rmm.2022.29.4.329","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.329","url":null,"abstract":"Osteoarthritis (OA) is most prevalent joint disease and major contributor to non-fatal burden in India, with prevalence rates of 22% - 39%. The use of conventional medication can be associated with insufficient clinical management and serious side effects. The present study aims to evaluate the anti-arthritic activity and chondrocytes protection and regeneration potential of Joint Support Product (JSP) in monosodium Iodoacetate induced Osteoarthritis rat model. Pain threshold, knee joint swelling, Blood inflammatory parameters like Tissue necrosis factor, Interlukin-6, Leukotriene B 4, C- reactive protein and arthritic biomarkers Matrix metalloproteinase-13 and Cartilage Oligomeric Matrix Protein, were estimated. Also Radiographic and histopathological evaluation were done to estimate the severity of OA. Treatment of JSP demonstrated significant increase in pain threshold by 68 % and decrease in knee joint swelling by 92 %. The inflammatory markers decreased significantly (p< .00001) after treatment with JSP. The Tissue necrosis factor decreased by 55 %, Interlukin-6 by 61%, Leukotriene B 4 by 57%, C- reactive protein by 69 % and arthritic biomarkers - Matrix metalloproteinase by 88% and Cartilage Oligomeric Matrix Protein by 37% as compared to disease control rats. Also the radiological evaluation and gross histopathology of rats showed improved chondrocytes structure. Thus JSP’s analgesic, anti-inflammatory, chondrocyte regeneration, and chondroprotective properties have therefore demonstrated an anti-arthritic impact.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127219781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound in Obstetrical and Gynecologic Emergencies 超声在妇产科急诊中的应用

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.279

A. Albu, Delia Maria Gradinaru, D. Secară, Doina Branescu, Alice Negru, O. Munteanu, A. Bălan, O. Teodor, Miruna Pirlog, Adriana Klein, B. Dorobat, M. Cirstoiu

{"title":"Ultrasound in Obstetrical and Gynecologic Emergencies","authors":"A. Albu, Delia Maria Gradinaru, D. Secară, Doina Branescu, Alice Negru, O. Munteanu, A. Bălan, O. Teodor, Miruna Pirlog, Adriana Klein, B. Dorobat, M. Cirstoiu","doi":"10.31689/rmm.2022.29.4.279","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.279","url":null,"abstract":"In Bucharest University Emergency Hospital every day we deal with difficult cases either presented per primam in our setting or, even more difficult situations, cases that were intended to be treated in other hospitals but due to lack of infrastructure are sent towards our multidisciplinary hospital, as a final stop. Conditions that our teams have to deal in a very restricted amount of time in the Emergency Room are: submucous myoma with heavy bleeding acquired uterine arteriovenous fistulae, ovarian ruptured cyst , ovarian hyperstimulation syndrome, adnexal torsion, tuboovarian abscess, classical tubal ectopic pregnancy, Cesarean scar ectopic pregnancy, molar pregnancy, incomplete abortion, ruptured uterus post minimally invasive procedures performed before pregnancy, placental abruption, placenta praevia with heavy bleeding, and the PAS – Placenta Accreta Spectrum. All these conditions recquire a rapid differential diagnosis where ultrasonography is useful in adopting a tailored management either conservative or radical, in avoidance of haemorhagic accidents or even death and, when needed, in fertility sparing.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130138921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Particularities of Patients Dignosed with Gout in Rheumatology Departament 风湿病科痛风诊断患者的特点

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.301

A. Bobircă, Cristina Alexandru, Carmen Iorgus, Anca Boangiu, A. Florescu, A. Dumitru, F. Bobircă, I. Ancuta, M. Bojincă

{"title":"Particularities of Patients Dignosed with Gout in Rheumatology Departament","authors":"A. Bobircă, Cristina Alexandru, Carmen Iorgus, Anca Boangiu, A. Florescu, A. Dumitru, F. Bobircă, I. Ancuta, M. Bojincă","doi":"10.31689/rmm.2022.29.4.301","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.301","url":null,"abstract":"Gout is a chronic metabolic disease, characterized by joint inflammation caused by monosodium urate monohydrate crystals. The main objective of this study was to identify the prevalence of gout in a rheumatology department in Romania and secondary to describe the characteristics of patients diagnosed with this condition, with emphasis on the comorbidities. This is a longitudinal, retrospective study on 280 patients from the Department of Internal Medicine and Rheumatology, Dr I Cantacuzino Hospital, from January 2017 to May 2019, diagnosed with chronic or acute gout. The prevalence of gout in our hospital in 2 years period was 0.97%. Gouty attack was diagnosed in 38.2% of cases, while 61.8% were evaluated for chronic gout. Male frequency was 69.6%, alcohol consummation was observed in more than half of the cohort (53.2%) and 72.1% were retired persons. The most frequent comorbidity was hypertension (HBP) (82.1%) followed by dyslipidemia (65.3%), atherosclerotic disease(ATS) (55.0%) and chronic kidney disease (53.9%). There was a significant association between HBP, ATS and dyslipidemia with chronic gout (p=0.038, p=0.022 and p=0.009, respectively). The rate of gouty attack significantly increased with the serum level of uric acid (p<0.001). The therapeutic approach complies with international recommendations.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123137228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undifferentiated Pleomorphic Sarcoma. From Supposition to Certainty: a Case Report 未分化多形性肉瘤。从假设到确定:一个案例报告

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.339

Mihai MEHEDINTU-IONESCU, G. Alexa, Horia Toader, Costinela Cociu

{"title":"Undifferentiated Pleomorphic Sarcoma. From Supposition to Certainty: a Case Report","authors":"Mihai MEHEDINTU-IONESCU, G. Alexa, Horia Toader, Costinela Cociu","doi":"10.31689/rmm.2022.29.4.339","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.339","url":null,"abstract":"Second Opinion is a difficult problem for every doctor put in this situation. In this position, we must not let ourselves be influenced, in any way, by the judgment of the first clinician, who formed a diagnosis. But not judging the “evidence” that led to the formation of the first diagnosis is difficult. This case presentation reveals the influence of a diagnosis assumed to be correct from the first interpretation. The patient, from the rural area, presents herself to the doctor following a trauma from falling down the stairs. A soft tissue ultrasound is performed and it is interpreted to be a hematoma. Afterwards, the lesion stagnates in size without progressing towards resorption. After repeating the ultrasound, its interpretation is influenced by the first ultrasound investigation supporting the same diagnosis. As a result, the patient is not guided to make a radical therapeutic decision. The presentation in our clinic was decided by the patient for a “second opinion” and, as a result, all the investigations carried out did not take into account the results previously stated by the patient during the clinical examination in the specialized outpatient clinic. The tumor was one with unimpressive dimensions but disturbing in appearance, without influencing the functionality of the forearm. The patient does not complain of pain or paresthesia in the area occupied by the tumor. She was clinging to deep plans and immovable in front of them.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123006238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Dry Eye Disease in Undergraduate Medical Students and its Association with Online Overexposure Due to Coronavirus Disease (COVID-19) 医大学生干眼病患病率及其与COVID-19网络过度暴露的关系

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.321

L. Singh, Aashna Agarwal, S. Gupta

{"title":"Prevalence of Dry Eye Disease in Undergraduate Medical Students and its Association with Online Overexposure Due to Coronavirus Disease (COVID-19)","authors":"L. Singh, Aashna Agarwal, S. Gupta","doi":"10.31689/rmm.2022.29.4.321","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.321","url":null,"abstract":"Objectives: To understand the prevalence of dry eye disease (DED) in undergraduate medical students and assess its association with online overexposure due to COVID-19. Materials and methods: The study was carried out with 200 medical undergraduate students aged 18-25 years at North Indian Medical College during the third and fourth weeks of September, 2021 & enquired regarding the online exposure pattern, type of device used and presence of eight dry eye symptoms (foreign body sensation, vision difficulties, discharge, itching, ocular pain, redness, photophobia, watering) followed by Schirmer’s strips examination. Cut off for dry eye disease was <10 mm. Data was analyzed using SPSS 21.0 package & Chi-square test for comparisons. Results: Mean age was 21.00±1.93 years. Majority were females (54.5%). Prevalence of dry eye symptoms was 85.5%. Vision difficulties (54.0%), itching (56.0%), watering (51.5%) were the most common symptoms. Majority (64.0%) had >3 symptoms. Use of mobile device, >4 hours of online exposure for other than study purposes and >1.5 increase in online exposure after COVID-19 were associated with presence of >3 dry eye symptoms. On Schirmer’s test, prevalence of dry eye disease was 12.0%. Conclusion: Longer duration of online exposure and increase in online activities as a result of COVID-19 was associated with an increased risk of dry eye disease and its prevalence in undergraduate medical students.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122882579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delta-radiomics Entropy Based on Tumor Heterogeneity Concept – Response Predictor to Irradiation for Unresectable/recurrent Glioblastoma 基于肿瘤异质性概念的δ放射组学熵——不可切除/复发胶质母细胞瘤辐照反应预测因子

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.273

C. Mireștean, R. Iancu, D. Iancu

{"title":"Delta-radiomics Entropy Based on Tumor Heterogeneity Concept – Response Predictor to Irradiation for Unresectable/recurrent Glioblastoma","authors":"C. Mireștean, R. Iancu, D. Iancu","doi":"10.31689/rmm.2022.29.4.273","DOIUrl":"https://doi.org/10.31689/rmm.2022.29.4.273","url":null,"abstract":"Although adjuvant radiotherapy in combination with Temozolomide administration has clearly demonstrated the benefit in improving the prognosis of patients with multiforme glioblastoma, radiotherapy as only treatment or in combination with systemic treatment is one of the best supportive in unresectable cases. For recurrent cases, the salvage radiotherapy option (re-irradiation) can be chosen in carefully selected cases so that the benefit is greater than the toxicities. Radiomics, a new subdomain of artificial intelligence (AI), relies on advanced analysis in high-resolution medical imaging to establish diagnostic, prognostic and predictive models for clinical medicine. The variation of the delta-radiomics parameters analyzed within a tumor volume may be via tumor heterogeneity indirectly correlated with the response to treatment. The aim of the study is to propose a delta-radiomic based on entropy algorithm to allow the non-invasive pre-therapeutic identification of patients with unresectable or recurrent multiform glioblastoma who will benefit from irradiation and/or salvage re-irradiation.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126057372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Gastrointestinal Stromal Tumor of the Abdominal Wall 罕见的腹壁胃肠道间质瘤1例

Medicina Moderna - Modern Medicine Pub Date : 2022-12-14 DOI: 10.31689/rmm.2022.29.4.343

F. Bobircă, D. Dumitrescu, Lidia Belega-Mursoi, A. Bobircă, Cristina Alexandru, H. Doran, T. Pătraşcu

引用次数: 0