Medicina Moderna - Modern Medicine最新文献_第10页

Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy 潘多拉的盒子:自身免疫性甲状腺功能减退症在怀孕期间的治疗

Medicina Moderna - Modern Medicine Pub Date : 2021-12-22 DOI: 10.31689/rmm.2021.28.4.401

F. Păuleț, C. Mehedințu, M. Antonovici, M. Cirstoiu

引用次数: 0

Particularities of Surgical Treatment for the Neuropathic Diabetic Foot 神经性糖尿病足的外科治疗特点

Medicina Moderna - Modern Medicine Pub Date : 2021-12-22 DOI: 10.31689/rmm.2021.28.4.447

F. Bobircă, A. Bobircă, Cristina Jauca, A. Florescu, A. Mușetescu, D. Dumitrescu, Andra Bîrligea, Andreea Schveninger, T. Pătraşcu

引用次数: 0

Gain of Function Research: the Clairvoyant Lens on Pandemics 功能研究的收获:流行病的透视镜头

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.269

S. Bhandari, A. Dube, Bhoopendra Patel, A. Tak, Minal Kachhawa, J. Gupta, K. Gupta, Shivankan Kakkar

{"title":"Gain of Function Research: the Clairvoyant Lens on Pandemics","authors":"S. Bhandari, A. Dube, Bhoopendra Patel, A. Tak, Minal Kachhawa, J. Gupta, K. Gupta, Shivankan Kakkar","doi":"10.31689/rmm.2021.28.3.269","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.269","url":null,"abstract":"Pandemic influenza viruses have emerged three times in this century. It is important to examine the potential risk of novel microorganisms/viruses through the add-on research mechanism of Gain of Function Research (GoFR). This mechanism consists of the practice of serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism through the inclusive feature of selective pressure of culture medium. Although, the GoFR can be a double-edged sword that has the potential to give an insight and better appreciation of current and future pandemics with antecedent apprehension of initiating a pandemic, itself. Moreover, with its inherent potential to give a head start on a virus, GoFR has the potential to develop vaccines or therapeutics, before the virus emerges in its true virulent form. Likewise, the GoFR studies can be vital in research on antivirals and antimicrobial agents and can help inform the development of combination therapies. Passive immunotherapy, which often includes a combination of products, is particularly dependent on GoFR experiments for evaluating efficacy. GoFR if made use of meticulously and with caution could help Medical Sciences and Humankind tremendously.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131916947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antibody Response Against SARS-CoV-2 Following ChAdOx1 (Astezeneca AZD 1222) Vaccine in Health Care Workers in a Tertiary Care Hospital in India 印度某三级医院医护人员接种ChAdOx1(阿斯捷利康AZD 1222)疫苗后对SARS-CoV-2的抗体反应

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.307

F. Faizal, R. Joshi, R. Chattrjee, A. Ahuja

{"title":"Antibody Response Against SARS-CoV-2 Following ChAdOx1 (Astezeneca AZD 1222) Vaccine in Health Care Workers in a Tertiary Care Hospital in India","authors":"F. Faizal, R. Joshi, R. Chattrjee, A. Ahuja","doi":"10.31689/rmm.2021.28.3.307","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.307","url":null,"abstract":"BACKGROUND: The ChAdOx1 nCoV-19 vaccine against COVID-19 is a two-dose vaccine spread 3 to 4 weeks apart. This study aims to ascertain the antibody response to each dose with respect to age, previous infection status etc. METHODS: Baseline total COVID-19 antibody level was ascertained using Siemens SARS‑CoV‑2 Total Antibody assay in consenting health care workers before the first dose of vaccination. Adverse effects were noted in each individual and were monitored weekly for the total antibody titre following both doses. Descriptive statistical tests were used to analyse the changes in antibodies levels weekly after both doses. Association of previous COVID infection and age with antibody levels was assessed. RESULTS: Median (range) of age of the 30 study participants was 31.5 years.23% of the participants had a history of previous COVID-19 infection. Mild adverse events following immunisation were reported by 87% participants after first dose whereas only in 7% after second dose. Median baseline antibody titres were significantly higher among those with previous COVID infection as compared to previously uninfected individuals. Antibody titres increased consistently after first dose and showed a declining trend following the second dose in all participants and showed no significant association with previous COVID-19 infection or age. CONCLUSIONS: Antibody titre response was similar amongst the various age groups. Higher response in the previously infected individuals following first dose may make them ideal candidates for a single dose vaccine regimen. Individuals showing lower levels of neutralising antibodies can be ideal candidates for a booster dose.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"11 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134364164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Endoscopic Procedures In Patients Taking Novel Oral Anticoagulants 使用新型口服抗凝剂患者的内镜检查

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.275

Raluca Anica Ionescu, A. Ghidersa, R. Sadagurschi, L. Negreanu, R. Babiuc

引用次数: 0

Composite Flap - Serratus Anterior with Rib Component – a Foot Salvage Solution after a Severe Crush Injury 复合皮瓣-前锯肌与肋骨成分-严重挤压伤后足部修复方案

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.333

M. Andrei, C. Giuglea, S. Marinescu, R. Mihai, B. Pharmacy

{"title":"Composite Flap - Serratus Anterior with Rib Component – a Foot Salvage Solution after a Severe Crush Injury","authors":"M. Andrei, C. Giuglea, S. Marinescu, R. Mihai, B. Pharmacy","doi":"10.31689/rmm.2021.28.3.333","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.333","url":null,"abstract":"Severe work accidents are one of the most frequent causes for physical disability in adults, alongside car accidents and war/gunshot injuries. In this article we present the case of a severe crush injury of the left foot that occurred in a 31 year-old patient who was involved in a work accident. After an unsuccessful tissue coverage using local flaps, the salvage solution was that of a composite free flap, aiming not only to cover, but also to restore stability to the foot. The treatment of choice was the serratus anterior muscle harvested together with osseous component (8th rib). The healing was difficult, due to wound dehiscence with bone exposure over a small area, but the problem was addressed using FGF (fibroblast growth factor) sponges, which enabled granulation and complete wound closure. The outcome of the case was favourable, gait being possible without any deficiency. For the cosmetic and functional reasons, the patient suffered one last surgical procedure to debulk the dorsal aspect of the foot. The final result was more than satisfactory, the patient being totally rehabilitated and socially and professionally reintegrated.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127328869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age Differences of Human Sphenoid Sinus Dimensions: a Comparative Study by Gross Anatomical Dissection and CT Scan Imaging 人蝶窦尺寸的年龄差异:大体解剖与CT扫描成像的比较研究

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.321

M. Abdalla

{"title":"Age Differences of Human Sphenoid Sinus Dimensions: a Comparative Study by Gross Anatomical Dissection and CT Scan Imaging","authors":"M. Abdalla","doi":"10.31689/rmm.2021.28.3.321","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.321","url":null,"abstract":"Introduction: The sphenoid sinus is a central skull cavity situated inside the sphenoid bone as a twin structure, separated by a complete bony septum. The aim of the study to measure the length, width, and height of human sphenoid sinus through dissection compared to CT scan images in different age groups of both genders. Methods: A prospective study of 360 human bodies including 110 dissected cadavers and 250 individuals with CT scan images during a period from January 2019 to February 2020. Results: In male cadavers, the mean value of length was (24.8±4.2) and (23.6±3.8) mm for right and left sides, while for females was (24.5±3.7) and (25.3±4.1) mm. Whereas, for CT cases were (25.4±3.1), (27.2±4.1), (21.3±4.2), and (24.4±3.8) mm respectively. Otherwise, the width was (15.8±3.2) and (19.2±4.5) mm for right and left sides in male cadavers; but for females was (18.2±3.8) and (22.7±3.7). In comparison to CT cases, were (19.6±4.1), (20.4±4.7), (17.3±5.2), and (19.2±5.6) mm respectively. In male cadavers, the height was (21.4±3.1) and (26.8±2.8) mm for right and left sides, while for females was (13.8±3.3) and (19.6±3.1) mm. Whereas, for CT cases were (16.7±2.5), (18.2±2.7), (14.6±2.9), and (15.8±3.3) mm respectively. Conclusion: Findings of both methods yield accurate anatomic sinus views, which may determine the age, gender, and race of alive or dead individuals.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121921755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Free Educational Android Mobile Application for Radiobiology 免费教育安卓移动应用程序放射生物学

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.315

C. Mireștean, A. Zară, R. Iancu, D. Iancu

{"title":"Free Educational Android Mobile Application for Radiobiology","authors":"C. Mireștean, A. Zară, R. Iancu, D. Iancu","doi":"10.31689/rmm.2021.28.3.315","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.315","url":null,"abstract":"The use of mobile devices and applications dedicated to different medical fields has improved the quality and facilitated medical care, especially in the last 10 years. The number of applications running on the software platforms of smart phones or other smart devices is constantly growing. Radiotherapy also benefits from applications (apps) for TNM staging of cancers, for target volume delineation and toxicity management but also from radiobiological apps for calculating equivalent dose schemes for different dose fractionation regimens. In the context of the increasingly frequent use of altered fractionation schemes, the use of radiobiological models and calculations based on the linear quadratic model (LQ) becomes a necessity. We aim to evaluate free radiobiology apps for the Android software platform. Given the global educational deficit, the lack of experts and the concordance between radiobiology education and the need to use basic clinical notions of modern radiotherapy, the existence of free apps for the Android platform running on older generation processors can transform even an old smart device in a powerful “radiobiology station.” Apps for radiobiology can help the radiation oncologist and medical physicist with responsibilities in radiotherapy treatment planning in the context of accelerated adoption of hypo-fractionation regimens and calculation of the effect of treatment gaps, a topic of interest in the COVID-19 pandemic context. Radiobiology apps can also partially fill the educational gap in radiobiology by arousing the interest of young radiation oncologists to deepen the growing universe of fundamental and clinical radiobiology.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126999897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating Congenital Diaphragmatic Hernia with ECMO: First Successful Case in Romania ECMO治疗先天性膈疝:罗马尼亚首例成功病例

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.339

A. Gaiduchevici, C. Georgescu, Carmen Mariana Heriseanu, A. Bizubac, C. Filip, I. Mărgărint, I. Cernea, Cirstoveanu Catalin Gabriel, B. Pharmacy

{"title":"Treating Congenital Diaphragmatic Hernia with ECMO: First Successful Case in Romania","authors":"A. Gaiduchevici, C. Georgescu, Carmen Mariana Heriseanu, A. Bizubac, C. Filip, I. Mărgărint, I. Cernea, Cirstoveanu Catalin Gabriel, B. Pharmacy","doi":"10.31689/rmm.2021.28.3.339","DOIUrl":"https://doi.org/10.31689/rmm.2021.28.3.339","url":null,"abstract":"We present the first successful case of extracorporeal membrane oxygenation (ECMO) at „M.S. Curie” Emergency Clinical Hospital for Children, Newborn Intensive Care Unit: a term neonate with cardiorespiratory failure secondary to left sided congenital diaphragmatic hernia. The patient was placed on veno-venous ECMO at three days of life; however, on the fourth day, due to unstable right ventricular function, conversion to veno-arterial ECMO was mandatory. At one week of life, the patient was operated on-site for diaphragmatic hernia without ECMO support and then reintroduced on ECMO immediately after the surgical procedure, being on ECMO support for a total of 8 days. Antithrombotic treatment was administered for significant occlusion of the right common carotid artery and right internal jugular vein (complication of the cannulation for ECMO) and also long term treatment for Persistent Pulmonary Hypertension was needed. The patient was discharged at the age of four months with moderate neurodevelopmental delay. The literature review indicates that neonatal ECMO procedure in Romania is still in its early stages. Despite this state, our current case proves that ECMO can be successfully performed with increased chances of survival for neonates with severe prognosis after failure of conventional therapy.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"50 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131001483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Helicobacter Pyori – an Overview of Current Strategies of Diagnostic and Treatment 幽门螺杆菌的治疗——当前诊断和治疗策略综述

Medicina Moderna - Modern Medicine Pub Date : 2021-09-01 DOI: 10.31689/rmm.2021.28.3.263

R. Babiuc, Raluca Anica Ionescu, L. Negreanu

引用次数: 0