Dementia and Geriatric Cognitive Disorders Extra最新文献

{"title":"COGNITIVE PROFILE IN PD DEMENTIA PATIENTS WITH LOW VERSUS NORMAL CSF AMYLOID BETA","authors":"Zeynep Tufekcioglu, Johannes Lange, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves, Murat Emre","doi":"10.1159/000534552","DOIUrl":"https://doi.org/10.1159/000534552","url":null,"abstract":"Background: In patients with Parkinson’s disease (PD) low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark of Alzheimer's disease (AD). Hence, low CSF Ab42 in patients with PD may indicate presence of co-morbid AD pathology and may predict a more AD-like cognitive profile when they develop dementia. Our study aims to investigate if low CSF Ab42 at baseline is associated with a more AD-like cognitive profile in PD patients with dementia. Methods: In a prospectively followed-up, population-based cohort of newly diagnosed PD patients, we compared the cognitive profile of dementia in those with a low CSF Ab42 level at baseline with that of patients who had normal levels, at the time when they developed dementia. Four different cognitive domain z scores (memory, attention, executive, visuospatial) were calculated. Patients were subdivided into three tertiles or categorized dichotomously, based on the baseline CSF Ab42 levels as measured by ECL and ELISA. Results: During 10-year follow-up, 37 patients met the inclusion criteria. Memory domain composite z-scores, memory subtests z-scores and the difference between long-delay free recall versus recognition scores were not significantly different between the groups. Composite z-scores of visuospatial functions significantly differed between the tertiles, which was not significant after Bonferroni correction. In the dichotomous group analysis, z-scores of visuospatial functions significantly differed between the two groups. The other cognitive domain z-scores were not significantly different. Conclusions: In patients with PD dementia low CSF Ab42 level at baseline is not associated with a specific cognitive profile.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136376961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence for Detection of Dementia Using Motion Data: A Scoping Review.","authors":"Lily Puterman-Salzman, Jory Katz, Howard Bergman, Roland Grad, Vladimir Khanassov, Genevieve Gore, Isabelle Vedel, Machelle Wilchesky, Narges Armanfard, Negar Ghourchian, Samira Abbasgholizadeh Rahimi","doi":"10.1159/000533693","DOIUrl":"10.1159/000533693","url":null,"abstract":"<p><strong>Background: </strong>Dementia is a neurodegenerative disease resulting in the loss of cognitive and psychological functions. Artificial intelligence (AI) may help in detection and screening of dementia; however, little is known in this area.</p><p><strong>Objectives: </strong>The objective of this study was to identify and evaluate AI interventions for detection of dementia using motion data.</p><p><strong>Method: </strong>The review followed the framework proposed by O'Malley's and Joanna Briggs Institute methodological guidance for scoping reviews. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist for reporting the results. An information specialist performed a comprehensive search from the date of inception until November 2020, in five bibliographic databases: MEDLINE, EMBASE, Web of Science Core Collection, CINAHL, and IEEE Xplore. We included studies aimed at the deployment and testing or implementation of AI interventions using motion data for the detection of dementia among a diverse population, encompassing varying age, sex, gender, economic backgrounds, and ethnicity, extending to their health care providers across multiple health care settings. Studies were excluded if they focused on Parkinson's or Huntington's disease. Two independent reviewers screened the abstracts, titles, and then read the full-texts. Disagreements were resolved by consensus, and if this was not possible, the opinion of a third reviewer was sought. The reference lists of included studies were also screened.</p><p><strong>Results: </strong>After removing duplicates, 2,632 articles were obtained. After title and abstract screening and full-text screening, 839 articles were considered for categorization. The authors categorized the papers into six categories, and data extraction and synthesis was performed on 20 included papers from the motion tracking data category. The included studies assessed cognitive performance (<i>n</i> = 5, 25%); screened dementia and cognitive decline (<i>n</i> = 8, 40%); investigated visual behaviours (<i>n</i> = 4, 20%); and analyzed motor behaviors (<i>n</i> = 3, 15%).</p><p><strong>Conclusions: </strong>We presented evidence of AI systems being employed in the detection of dementia, showcasing the promising potential of motion tracking within this domain. Although some progress has been made in this field recently, there remain notable research gaps that require further exploration and investigation. Future endeavors need to compare AI interventions using motion data with traditional screening methods or other tech-enabled dementia detection mechanisms. Besides, future works should aim at understanding how gender and sex, and ethnic and cultural sensitivity can contribute to refining AI interventions, ensuring they are accessible, equitable, and beneficial across all society.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71486958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients.","authors":"Jedsada Khieukhajee,&nbsp;Arada Rojana-Udomsart,&nbsp;Pinnakarn Srisarakorn,&nbsp;Tanaphon Wongsurit,&nbsp;Saharat Aungsumart","doi":"10.1159/000531743","DOIUrl":"10.1159/000531743","url":null,"abstract":"<p><strong>Introduction: </strong>Numerous reports regarding cognitive deficits after the coronavirus disease 2019 (COVID-19), described as \"brain fog,\" have been published. However, the clinical presentations and risk factors of post-COVID-19 cognitive impairment are controversial. This study aimed to assess (a) the prevalence of cognitive impairment after COVID-19 hospitalization, (b) characteristics of the cognitive deficits, (c) risk factors of post-COVID-19 cognitive impairment, and (d) comparison of cognitive function between post-COVID-19 patients and healthy people.</p><p><strong>Methods: </strong>The study comprised 34 SARS-CoV-2-infected patients, admitted to the Neurological Institute of Thailand during the peak of COVID-19 pandemic in 2021-2022. These patients came for neuropsychological and clinical evaluations at 2-week follow-up visit. The cognitive impairment and characteristics were measured by TMSE and MoCA. Clinical risk factors and post-COVID-19 cognitive impairment were assessed. The comparison of cognitive function in post-acute COVID-19 patients and 22 healthy controls was also performed.</p><p><strong>Results: </strong>The prevalence of post-COVID-19 cognitive impairment defined by a total MoCA score below 25 points was 61.76%. Years of education were the only predictive factors related to cognitive impairment. Our multivariate analysis revealed no statistical difference in cognitive outcomes between post-acute COVID-19 patients and healthy controls.</p><p><strong>Conclusion: </strong>This study showed a moderate prevalence of cognitive dysfunction after COVID-19 hospitalization similar to previous reports. However, there was no significant difference in cognitive measurements between these patients and healthy people. Whether SARS-CoV-2 infection causes cognitive dysfunction is a myth or fact that still has a long way to prove via further longitudinal study.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42353012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Online Version of Physical Exercise with Musical Accompaniment Might Facilitate Participation by Subjects Who Cannot Participate in Person: A Questionnaire-Based Study.","authors":"Masayuki Satoh, Ken-Ichi Tabei, Jun-Ichi Ogawa, Makiko Abe, Chiaki Kamikawa, Yoshinori Ota","doi":"10.1159/000529192","DOIUrl":"10.1159/000529192","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several interesting differences were found in the characteristics of the online participants compared with our previous in-person interventions.</p><p><strong>Participants and methods: </strong>The total number of subjects was 88 (71.2 ± 4.9 years old; male 42, female 46). The questionnaire included the attributes of the participants, the perceived advantages of the exercise classes, and the presence or absence of noticeable changes in cognitive and physical function after participating in the classes.</p><p><strong>Results: </strong>The personal computers used to attend the online classes were operated by the participants themselves. About 42% of the participants felt that their sense of day of the week and volition were improved by attending the exercise classes for 3 months. The most frequent answer to the reason for participation was because it was free (81.8%). The second most frequent answer was because the classes were held online (75.0%). Almost half of the participants answered that they would not participate if it was held in person because of the risk of COVID-19 infection (75.0%) and the difficulty getting to the site where the exercise classes were held (59.1%).</p><p><strong>Conclusion: </strong>Online physical exercise with musical accompaniment improved the perceived orientation, volition, activity, exercise habits, and health condition in 30-40% of the participants and also stimulated greater participation by males compared to classes held in person.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Cognitive Decline and Daily Life Gait among Elderly People Living in the Community: A Preliminary Report.","authors":"Tetsuya Yamagami, Motoi Yagi, Shigeya Tanaka, Saori Anzai, Takuya Ueda, Yoshitsugu Omori, Chika Tanaka, Yoshitaka Shiba","doi":"10.1159/000528507","DOIUrl":"10.1159/000528507","url":null,"abstract":"<p><strong>Introduction: </strong>Early detection and intervention are important to prevent dementia. Gait parameters have been recognized as a potentially easy screening tool for mild cognitive impairment (MCI); however, differences in gait parameters between cognitive healthy individuals (CHI) and MCI are small. Daily life gait change may be used to detect cognitive decline earlier. In the present study, we aimed to clarify the relationship between cognitive decline and daily life gait.</p><p><strong>Methods: </strong>We performed 5-Cog function tests and daily life and laboratory-based gait assessments on 155 community-dwelling elderly people (75.5 ± 5.4 years old). Daily life gait was measured for 6 days using an iPod-touch with an accelerometer. Laboratory-based 10-m gait (fast pace) was measured using an electronic portable walkway.</p><p><strong>Results: </strong>The subjects consisted of 98 CHI (63.2%) and 57 cognitive decline individuals (CDI; 36.8%). Daily life maximum gait velocity in the CDI group (113.7 [97.0-128.5] cm/s) was significantly slower than that in the CHI group (121.2 [105.8-134.3] cm/s) (<i>p</i> = 0.032). In the laboratory-based gait, the stride length variability in the CDI group (2.6 [1.8-4.1]) was significantly higher than that in the CHI group (1.8 [1.2-2.7]) (<i>p</i> < 0.001). The maximum gait velocity in daily life gait was weakly but significantly correlated with stride length variability in laboratory-based gait (<i>ρ</i> = -0.260, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>We found an association between cognitive decline and slower daily life gait velocity among community-dwelling elderly people.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/5d/dee-2023-0013-0001-528507.PMC9987256.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Working Memory Capacity with Cognitive Flexibility, Cognitive Emotion Regulation, and Learning Styles of University Students: A Domain General View.","authors":"Kahraman Guler,&nbsp;Aylin Aydin","doi":"10.1159/000526226","DOIUrl":"https://doi.org/10.1159/000526226","url":null,"abstract":"<p><strong>Introduction: </strong>The goal of this study was to investigate the relationship of working memory capacity with the use of cognitive emotion regulation strategies, cognitive flexibility level, and learning styles of university students.</p><p><strong>Methods: </strong>In the present study (<i>N</i> = 39), the participants completed the Emotion Regulation Questionnaire, Cognitive Flexibility Scale, Kolb Learning Styles Inventory, and Vermunt Learning Styles Inventory and three WM capacity (WMC) tasks that are Rotation Span Task, Operation Span Task, and Symmetry Span Task. Their WMCs were assessed, and the relationship of it was compared with cognitive emotion regulation, cognitive flexibility, and learning styles.</p><p><strong>Results: </strong>The results indicated that there is a significant difference and negative correlation (<i>r= -</i>0.341) between Operation Span Task and refocus on planning. Findings of the research indicated correlations between emotion regulation strategies and between cognitive flexibility and two emotion regulation strategies that are refocus on planning (<i>r</i> = 0.528) and positive reappraisal (<i>r</i> = 0.574). Only one learning style that is Processing Strategies in Vermunt Learning Style Inventory was found significantly different in terms of the cognitive flexibility level of the participants. The results also indicated a positive correlation between verbal and spatial WM tasks which support the domain general view for WMC.</p><p><strong>Conclusions: </strong>Further studies are advised to be conducted between cognitive emotion regulation strategies and working memory capacity as these findings may have significant implications for understanding the correlation between memory and emotion.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/7f/dee-0012-0131.PMC9710454.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35253499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Patients with Alzheimer's Disease and a History of Traumatic Brain Injury.","authors":"Suzan van Amerongen,&nbsp;Dewi K Caton,&nbsp;Yolande A L Pijnenburg,&nbsp;Philip Scheltens,&nbsp;Everard G B Vijverberg","doi":"10.1159/000526243","DOIUrl":"https://doi.org/10.1159/000526243","url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer's disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms (NPSs) in AD patients.</p><p><strong>Methods: </strong>Biomarker-proven AD patients (CSF or amyloid PET) were selected from the Amsterdam Dementia Cohort. TBI events were classified by age at injury (TBI <25 or ≥25 years) and TBI severity (loss of consciousness, multiple events). Cognitive composite scores were calculated from results of a neuropsychological test battery. NPSs were assessed with the Neuropsychiatric Inventory Questionnaire (NPI-Q). Linear regression analyses were utilized to examine associations between TBI, TBI characteristics, and clinical outcome measures.</p><p><strong>Results: </strong>Among the 1,755 selected AD patients (mean age = 65.2 years), 166 (9.5%) had documented ≥1 TBI in their medical history. Overall, TBI history was not related to differences in age of disease onset, but age at injury <25 years old was associated with 2.3 years earlier age at symptom onset (<i>B</i> = -2.34, <i>p</i> = 0.031). No significant associations were found between TBI history or TBI characteristics and differences in cognition or NPSs.</p><p><strong>Conclusion: </strong>Our results underscore previous findings on the vulnerability of the brain during critical maturation phases and suggest that an early TBI may contribute to lower resilience to neurodegenerative changes.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/b5/dee-0012-0122.PMC9574209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured Pre-Consultation Interview at the First Call of Caregiver Regarding Memory Consultation: Effects on Caregiver Burden, Expectations, and Quality of Life.","authors":"Isabelle Guillard,&nbsp;Florence Saillour,&nbsp;Aurélie Lafargue,&nbsp;Fabien Salesses,&nbsp;Claire Roubaud Baudron,&nbsp;Valérie Berger,&nbsp;Isabelle Bourdel-Marchasson","doi":"10.1159/000526669","DOIUrl":"https://doi.org/10.1159/000526669","url":null,"abstract":"<p><strong>Introduction: </strong>Case managers can guide caregivers during their search for care for relatives with neurocognitive disorders. The present study aimed to evaluate the effects of this procedure on caregiver burden and quality of life.</p><p><strong>Methods: </strong>Family caregivers searching for care at a memory clinic before the first consultation were provided written information and they provided verbal consent to participate in this pre-post intervention study. Intervention was a structured pre-consultation phone call interview given by the case manager to inform and organize individualize pathway of care. The mini-Zarit Burden Interview and the EuroQol five-dimensional questionnaire quality of life scores were recorded by an independent assessor before the intervention and 1 month thereafter. An expectation questionnaire was also completed during the assessments. The pre and post scores were compared using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>In total, 45 participants were enrolled and 35 were assessed twice. There was no significant change in the total mini-Zarit Burden Interview score; however, the levels of stress due to caring and meeting familial responsibilities (<i>p</i> = 0.025), and the fear of what the future holds for the participants' relative (<i>p</i> = 0.01) was lower at 1 month. The need for information about the pathways of care decreased, but no change in support satisfaction was observed. Quality of life was good and did not change.</p><p><strong>Conclusions: </strong>During the pre-consultation intervention, the case manager may fulfill several needs of caregivers, particularly to obtain personalized information, which should be implemented in memory clinics.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/cc/dee-0012-0150.PMC9841797.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10604655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' Pain Assessment Practices for Cognitively Intact and Impaired Older Adults in Intensive Care Units.","authors":"Mohammad Rababa,&nbsp;Shatha Al-Sabbah","doi":"10.1159/000525477","DOIUrl":"https://doi.org/10.1159/000525477","url":null,"abstract":"<p><strong>Introduction: </strong>Pain is still under-recognized and undertreated among intensive care unit (ICU) patients, such as those being intubated or with dementia, cognitive impairments, or communication deficits due to inability to self-report. This study aimed to describe nurses' pain assessment practices for cognitively intact and impaired older adult ICU patients.</p><p><strong>Methods: </strong>A descriptive correlational study of a convenience sample of 200 registered nurses was conducted in private, public, and university-affiliated hospitals in Irbid, Jordan. Descriptive statistics, such as mean, standard deviation, and frequency, were used to analyze the study data.</p><p><strong>Results: </strong>Statistically significant differences were found in the proportion of nurses who assessed and documented pain every 1-4 h in cognitively intact patients than those with cognitive impairment (<i>n</i> = 67, 63.21% vs. <i>n</i> = 39, 36.79%), <i>p</i> = 0.002, compared to the proportion of nurses who never assessed and document pain in cognitively impaired patients than those without cognitive impairment (<i>n</i> = 38, 76.0% vs. <i>n</i> = 12, 24%), <i>p</i> < 0.001.</p><p><strong>Discussion/conclusion: </strong>Our study results showed that the majority of participant nurses felt that the use of pain assessment tools for cognitively intact and impaired older adult ICU patients to self-report is somewhat not at all important. This study also reported that nurses perceived themselves as the individuals who accurately rate the pain in cognitively intact patients, followed by the patients themselves.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/81/dee-0012-0115.PMC9294931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia.","authors":"Maria Lage Barca,&nbsp;Dag Alnæs,&nbsp;Knut Engedal,&nbsp;Karin Persson,&nbsp;Rannveig Sakshaug Eldholm,&nbsp;Nikias Siafarikas,&nbsp;Ina Selseth Almdahl,&nbsp;Maria Stylianou-Korsnes,&nbsp;Ingvild Saltvedt,&nbsp;Geir Selbæk,&nbsp;Lars T Westlye","doi":"10.1159/000521114","DOIUrl":"https://doi.org/10.1159/000521114","url":null,"abstract":"<p><strong>Introduction: </strong>Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>A sample of 492 patients from Norwegian memory clinics (<i>n</i> = 363) and Old Age Psychiatry services (<i>n</i> = 129) was studied. The assessment included the Cornell Scale for Depression in Dementia (CSDD), Instrumental Activities of Daily Living Scale, Mini Mental State Examination, and MRI of the brain, processed with FreeSurfer to derive ROI measures of cortical thickness, volume, and area using the Desikan-Killiany parcellation, as well as subcortical volumes. Dementia was diagnosed according to ICD-10 research criteria. Correlates of brain morphometry using multiple linear regression were examined.</p><p><strong>Results: </strong>Higher scores on the CSDD were associated with larger cortical volume (β = 0.125; <i>p</i> value = 0.003) and area of the left isthmus of the cingulate gyrus (β = 0.151; <i>p</i> value = <0.001) across all patients. Inclusion of an interaction term (dementia × CSDD) revealed a smaller area in the left temporal pole (β = -0.345; <i>p</i> value = 0.001) and right-transverse temporal cortex (β = -0.321; <i>p</i> value = 0.001) in patients with dementia and depressive symptoms.</p><p><strong>Discussion/conclusion: </strong>We confirm the previous findings of structural brain changes in temporal regions among patients with dementia and concomitant depressive symptoms. This may contribute to a better understanding of the mechanisms underlying depression in dementia. To the best of our knowledge, this is the largest study conducted on this topic to date.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/58/dee-0012-0107.PMC9251457.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}