脑脊液β淀粉样蛋白低与正常pd痴呆患者的认知特征

IF 1.4 Q4 CLINICAL NEUROLOGY
Zeynep Tufekcioglu, Johannes Lange, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves, Murat Emre
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引用次数: 0

摘要

背景:在帕金森病(PD)患者中,基线时低脑脊液(CSF)淀粉样蛋白β 1-42 (Ab42)是最一致的脑脊液生物标志物,是发生痴呆的危险因素。然而,低脑脊液Ab42是阿尔茨海默病(AD)的典型标志。因此,PD患者脑脊液Ab42水平低可能表明存在共病性AD病理,并可能预测当他们发展为痴呆时更像AD的认知特征。我们的研究旨在调查基线时低CSF Ab42是否与PD合并痴呆患者更类似ad的认知特征相关。方法:在一项前瞻性随访的、基于人群的新诊断PD患者队列中,我们比较了基线时CSF Ab42水平低的患者与基线时CSF Ab42水平正常的患者在痴呆发生时的认知特征。计算了四种不同的认知领域z分数(记忆、注意、执行、视觉空间)。根据ECL和ELISA测定的基线CSF Ab42水平,将患者细分为三分位数或二分类。结果:在10年随访中,37例患者符合纳入标准。记忆领域复合z-得分、记忆子测试z-得分以及长延迟自由回忆与识别得分之间的差异在组间无显著差异。视觉空间功能的综合z-分数在三分位之间差异显著,经Bonferroni校正后差异不显著。在二分类组分析中,两组的视觉空间功能z分数差异显著。其他认知领域z-score差异不显著。结论:在PD痴呆患者中,基线时低CSF Ab42水平与特定的认知特征无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COGNITIVE PROFILE IN PD DEMENTIA PATIENTS WITH LOW VERSUS NORMAL CSF AMYLOID BETA
Background: In patients with Parkinson’s disease (PD) low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark of Alzheimer's disease (AD). Hence, low CSF Ab42 in patients with PD may indicate presence of co-morbid AD pathology and may predict a more AD-like cognitive profile when they develop dementia. Our study aims to investigate if low CSF Ab42 at baseline is associated with a more AD-like cognitive profile in PD patients with dementia. Methods: In a prospectively followed-up, population-based cohort of newly diagnosed PD patients, we compared the cognitive profile of dementia in those with a low CSF Ab42 level at baseline with that of patients who had normal levels, at the time when they developed dementia. Four different cognitive domain z scores (memory, attention, executive, visuospatial) were calculated. Patients were subdivided into three tertiles or categorized dichotomously, based on the baseline CSF Ab42 levels as measured by ECL and ELISA. Results: During 10-year follow-up, 37 patients met the inclusion criteria. Memory domain composite z-scores, memory subtests z-scores and the difference between long-delay free recall versus recognition scores were not significantly different between the groups. Composite z-scores of visuospatial functions significantly differed between the tertiles, which was not significant after Bonferroni correction. In the dichotomous group analysis, z-scores of visuospatial functions significantly differed between the two groups. The other cognitive domain z-scores were not significantly different. Conclusions: In patients with PD dementia low CSF Ab42 level at baseline is not associated with a specific cognitive profile.
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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
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