Dementia and Geriatric Cognitive Disorders Extra最新文献

{"title":"Visualising Dementia Knowledge for Educating Middle-Aged and Older Adults: A 2-Year Cross-Sectional Survey of a Japanese Community.","authors":"Junko Hoshino, Koji Tamakoshi, Rika Usami, Kaori Saeki, Naomi Furukawa","doi":"10.1159/000553420","DOIUrl":"10.1159/000553420","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to assess Japanese community members' knowledge of dementia and its association with sex, age, and caregiving experience through multiple correspondence analysis. Clarifying these relationships can inform future efforts to determine target strategies and the audience for disseminating dementia knowledge effectively.</p><p><strong>Methods: </strong>Data were obtained from a prior cross-sectional study (2021 and 2023) involving 466 middle-aged and older adults (>40 years) in Japan. A self-administered, anonymous questionnaire collected information on dementia knowledge, age, sex, and caregiving experience, using the Japanese-Language Dementia Knowledge Assessment Scale (DKAS-J; 18 items).</p><p><strong>Results: </strong>The mean DKAS-J score was 16.2 ± 7.9. Higher scores were associated with being younger, female, employed, and more highly educated, living in Aichi, and having caregiving experience. Half of the DKAS-J items had correct response rates of ≤60%, indicating knowledge gaps. The lowest correct response rates were observed for items related to behavioural symptoms and unmet needs. Significant differences in knowledge were found among individuals based on age, sex, and caregiving experience. Females aged ≥75 years and males in general demonstrated lower knowledge levels. Individuals with caregiving experience at work had significantly higher correct response rates across many items. Multiple correspondence analysis revealed specific knowledge clusters linked to caregiving experience and younger age. Work-related caregiving was associated with knowledge of dementia, while family caregiving was associated with broader dementia knowledge. Work experience was associated with treatment, symptoms, and family experience to life.</p><p><strong>Conclusions: </strong>Dementia education should be targeted and content-specific, considering the backgrounds of males, older adults aged >75 years, and experienced caregivers.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"95-107"},"PeriodicalIF":1.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enlarged Centrum Semiovale Perivascular Spaces as a Noninvasive Imaging Marker of Vascular Amyloid Deposition in Amyloid-Positive Individuals without Cerebral Amyloid Angiopathy-Related Hemorrhages.","authors":"Takashi Kasai, Kentaro Akazawa, Fukiko Kitani-Morii, Yuki Naeshiro, Hiroki Suo, Yuzo Fujino, Maika Yoshida, Tatsuki Shimizu, Koji Sakai, Keita Watanabe, Ikuko Mizuta, Tomoyuki Ohara","doi":"10.1159/000552381","DOIUrl":"10.1159/000552381","url":null,"abstract":"<p><strong>Introduction: </strong>Anti-amyloid therapy has increased the need for noninvasive methods to assess vascular amyloid. Reductions in cerebrospinal fluid (CSF) Aβ40 and Aβ42 are characteristic of cerebral amyloid angiopathy (CAA), but lumbar puncture limits their use in routine practice. Magnetic resonance imaging-visible perivascular spaces in the centrum semiovale (CSO-PVS) have emerged as a potential imaging marker, although their relevance in amyloid-positive individuals without CAA-related hemorrhages remains uncertain.</p><p><strong>Methods: </strong>We retrospectively analyzed 30 patients with mild cognitive impairment due to Alzheimer's disease (AD) or mild AD who exhibited reduced CSF Aβ42/40 ratio and no CAA-related hemorrhagic findings. CSO-PVS were visually quantified and dichotomized into high- and low-degree groups using the median raw count. CSF Aβ40, Aβ42, and p-tau181 levels were compared between groups.</p><p><strong>Results: </strong>Patients with high-degree CSO-PVS demonstrated significantly lower CSF Aβ40 levels than those with low-degree CSO-PVS (<i>p</i> = 0.0235), while CSF Aβ42 showed a borderline reduction (<i>p</i> = 0.0502). The composite index Aβ40 × Aβ42 was also reduced in the high-degree group (<i>p</i> = 0.0264). CSF p-tau181 levels were significantly lower in the high-degree group than in the low-degree group (<i>p</i> = 0.0264).</p><p><strong>Conclusion: </strong>A higher CSO-PVS burden was associated with lower CSF Aβ40 and Aβ42 levels, suggesting that CSO-PVS dilation may serve as a noninvasive surrogate marker of vascular amyloid deposition in amyloid-positive patients undergoing anti-amyloid therapy.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"85-94"},"PeriodicalIF":1.5,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data.","authors":"Dean Kyne","doi":"10.1159/000550830","DOIUrl":"10.1159/000550830","url":null,"abstract":"<p><strong>Introduction: </strong>Geographic disparities in Alzheimer's disease and related dementias (ADRDs) remain insufficiently understood at the national scale, limiting efforts to address inequities in dementia burden across USA communities. This study examined county-level variation in ADRD prevalence and mortality and evaluates the association between social vulnerability and these outcomes.</p><p><strong>Methods: </strong>This cross-sectional ecological study analyzes 2020 county-level ADRD prevalence and all-cause mortality among Medicare beneficiaries from the NORC Dementia DataHub. The analytic sample included 3,108 USA counties in the contiguous USA and the District of Columbia. ADRD outcomes included (1) prevalence of highly likely ADRD and (2) prevalence of all determinations, as defined in NORC's validated case-classification algorithm using Medicare administrative claims. Mortality was defined as 2020 all-cause deaths among prevalent ADRD cases. Social vulnerability was measured using the CDC/ATSDR Social Vulnerability Index (SVI), including overall SVI and its four domains. Hotspot analysis using Getis-Ord Gi* identified spatial clusters. Multiscale geographically weighted regression (MGWR) estimates spatially varying associations between SVI and ADRD prevalence and mortality, reported with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Counties had a mean prevalence of 65.3 per 1,000 (SD 15.5) for highly likely ADRD and 123.5 per 1,000 (SD 27.0) for all determinations. The mean all-cause mortality rate among ADRD cases was 22.1 per 1,000 (SD 6.6). Hotspot analysis revealed significant high-prevalence and high-mortality clusters in the South, with cold spots in the Mountain West and Upper Midwest. MGWR results indicate that higher county-level social vulnerability was significantly associated with higher ADRD prevalence (overall β range ≈ 0.42-1.87; 95% CI: 0.31-1.98) and mortality (β range ≈ 0.55-2.12; 95% CI: 0.44-2.26), with the strongest, most spatially consistent effects observed for mortality. The magnitude and direction of associations varied regionally, with the largest positive effects in the South, Southwest, and West.</p><p><strong>Discussion: </strong>Substantial geographic disparities exist in ADRD prevalence and mortality, with disproportionately higher burdens in socially vulnerable counties. Social vulnerability, particularly socioeconomic disadvantage, is strongly and spatially heterogenously associated with ADRD outcomes, underscoring the importance of targeted public health and policy interventions in high-burden, high-vulnerability regions.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"56-70"},"PeriodicalIF":1.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13218717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between COVID-19 Severity, Cognitive Impairment, and Quality of Life in Individuals in Need of Care: Results from the Multicentre Registry Study BaCoM.","authors":"Karoline Lukaschek, Sophia Hofbauer, Tobias Dreischulte, Michael Drey, Marietta Rottenkolber, Susanne Winter, Maria Sebastião, Daniel Teupser, Ildikó Gágyor, Anita Hausen, Michael Hoelscher, Christian Janke, Thomas Kühlein, Jochen Gensichen","doi":"10.1159/000551288","DOIUrl":"10.1159/000551288","url":null,"abstract":"<p><strong>Introduction: </strong>Older adults in need of care are at high risk for severe COVID-19 and cognitive impairment. This study investigates the association between COVID-19 severity, quality of life, and cognitive impairment in individuals requiring care.</p><p><strong>Methods: </strong>Data from 531 participants (68.4% female; <i>n</i> = 363; median age = 82.0 years, interquartile range = 13.0) of the Bavarian ambulatory COVID-19 Monitor (BaCoM) - all of whom were in need of care and had a prior SARS-CoV-2 infection - were analysed. We compared sociodemographic and health-related characteristics, cognitive performance, COVID-19 disease features, and quality of life between 80 individuals hospitalized for COVID-19 and 451 individuals who were infected but not hospitalized. Associations between cognitive impairment and COVID-19 severity were examined using binary logistic regressions with the MoCA Blind and Six-Item Screener as dependent variables. The association between quality of life and COVID-19 severity was analysed using multiple linear regression with the EQ VAS as the dependent variable.</p><p><strong>Results: </strong>Hospitalized individuals had significantly lower MoCA Blind scores than non-hospitalized peers (17.0 vs. 19.0, <i>p</i> = 0.039), while SIS scores showed no difference. EQ VAS scores were similar between the groups, but hospitalized individuals had lower EQ-5D-5L Index scores (0.57 vs. 0.75, <i>p</i> = 0.004). COVID-19 severity (hospitalization, symptom duration) was not associated with MoCA Blind <18 or with the EQ VAS.</p><p><strong>Conclusion: </strong>The study found lower MoCA-Blind scores and reduced quality of life in hospitalized individuals, but adjusted analyses showed no significant link between COVID-19 severity and cognition or quality of life.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"71-84"},"PeriodicalIF":1.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Analysis of Change in Church Activity with Cognitive, Functional, and Mental Health among Black and White Older Adults.","authors":"Katherine C Britt, Fanghong Dong, Jill B Hamilton, Lauren Massimo, Nancy Hodgson, Dawn Mechanic-Hamilton, Shana D Stites","doi":"10.1159/000551303","DOIUrl":"10.1159/000551303","url":null,"abstract":"<p><strong>Introduction: </strong>Stable religious participation may have beneficial contributions to cognitive and mental health; however, less is known about how changes in religious participation, such as disengagement or increased engagement in church activities, affect these health outcomes and whether there are differences between racial groups. This study aimed to examine the association between changes in church activity and cognitive, functional, and mental health in older adults, and explore differences by race.</p><p><strong>Methods: </strong>Using data from the University of Pennsylvania Alzheimer's Disease Research Center Aging Brain Cohort in 2021-2022, we examined associations between self-reported change in church activity with cognitive and functional health (Global Clinical Dementia Score [CDR] and Total CDR) and neuropsychiatric symptoms (Neuropsychiatric Inventory) in cognitively normal older adults (<i>n</i> = 158). We used multivariable regression analysis, controlling for self-reported age, sex, education, and social interaction, to examine differences between individuals who identified as either Black or White.</p><p><strong>Results: </strong>Controlling for covariates, Black participants who reported substantially more or less church activity in the last year had lower cognition and function (Global CDR, <i>β</i> = 0.19, 95% CI: [0.04, 0.34], <i>p</i> < 0.05) and Total CDR (<i>β</i> = 0.30, 95% CI: [0.01, 0.58], <i>p</i> = 0.042), and more neuropsychiatric symptoms (<i>β</i> = 0.63, 95% CI: [0.02, 1.24], <i>p</i> < 0.045). No significance was found in White older adults. Black older adults reporting major changes in church activity experienced lower cognitive, functional, and mental health.</p><p><strong>Conclusion: </strong>To explore if church activity changes could be an early sign of cognitive, functional, and mental health decline, longitudinal studies are needed.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"46-55"},"PeriodicalIF":1.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Sensor Technologies Accurately Detect and Monitor Behavioural and Psychological Symptoms of Dementia? A Systematic Review.","authors":"Khalid Abdul Jabbar, Sing Qin Ting, Shze Yee Choo, Yasmin Lynda Munro, Shian Ming Tan, Iris Rawtaer","doi":"10.1159/000551112","DOIUrl":"10.1159/000551112","url":null,"abstract":"<p><strong>Introduction: </strong>Although sensor technologies hold potential for addressing challenges for the detection and management of behavioural and psychological symptoms of dementia (BPSD), their application in this context remains in its early stages. This review evaluated the accuracy of sensor technologies to detect and/or monitor neuropsychiatric symptoms in individuals with dementia, particularly in real-world home settings.</p><p><strong>Methods: </strong>Systematic searches were conducted in five databases on February 20, 2025. Two independent reviewers performed data extraction, with a third reviewer resolving any disagreements.</p><p><strong>Results: </strong>Of 109 records meeting the inclusion criteria for full-text review, 17 studies were included. Sensor-based detection of agitation (number of studies, <i>n</i> = 6) and other common BPSD, specifically sleep (<i>n</i> = 5) and Activities of Daily Living (ADLs) (<i>n</i> = 3), shows early promise, particularly when multimodal data and machine learning techniques are employed. However, the current evidence base is limited by small, predominantly observational studies and inconsistent accuracy across studies. Predictive capabilities remain underdeveloped (<i>n</i> = 3), and the generalizability of findings across different settings is unproven.</p><p><strong>Conclusions: </strong>This review highlights that the application of sensor technology for detecting and monitoring BPSD remains at an early stage, with existing evidence largely confined to a small subset of symptoms and providing limited clinimetric validation. Additionally, it emphasizes the need for consensus on standard definitions, outcome measures, and validation methodologies to guide and inform future research, which can then leverage these technologies to improve the care and quality of life of persons with dementia and their caregivers.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"21-45"},"PeriodicalIF":1.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Multimodal Day-Care Intervention for Mild Cognitive Impairment with Lewy Bodies: A Prospective 3-Year Comparative Cognitive Trajectory Study.","authors":"Miyuki Nemoto, Kiyotaka Nemoto, Miho Ota, Hiroyuki Sasai, Haruhiko Midorikawa, Aya Sekine, Ayako Kitabatake, Tetsuaki Arai","doi":"10.1159/000551066","DOIUrl":"10.1159/000551066","url":null,"abstract":"<p><strong>Introduction: </strong>Mild cognitive impairment with Lewy bodies (MCI-LB) is generally associated with more rapid cognitive decline than mild cognitive impairment due to Alzheimer's disease (MCI-AD). However, evidence regarding the potential cognitive trajectories of individuals with MCI-LB participating in structured non-pharmacological multimodal programs remains limited. The aim of the study was to preliminarily examine cognitive changes over time among individuals with MCI-LB and MCI-AD undergoing a multimodal intervention.</p><p><strong>Methods: </strong>Conducted at the University of Tsukuba Hospital between April 2013 and February 2020, this prospective study enrolled 74 participants (MCI-LB: 14; MCI-AD: 60) in the Cognitive Improvement Day-Care (CIDC) program. The CIDC was a multimodal intervention offering structured sessions including physical exercise, cognitive training, music therapy, and art-based activities. Participants attended the program, mostly once a week, and underwent annual cognitive assessments for up to 3 years using the Japanese version of Mini-Mental State Examination (MMSE-J). Linear mixed-effects models were used to analyze longitudinal changes in MMSE-J scores.</p><p><strong>Results: </strong>The overall annual cognitive decline was -0.36 points/year (95% CI: -0.63, 0.10). The annual decline was -0.44 points/year (95% CI: -0.95, 0.06) for the MCI-LB group and -0.34 points/year (95% CI: -0.64, -0.03) for the MCI-AD group. No significant group-by-time interaction was observed over the 3-year follow-up (<i>p</i> = 0.97).</p><p><strong>Conclusions: </strong>These findings suggest that individuals with MCI-LB exhibited longitudinal cognitive trajectories under a structured multimodal intervention that were comparable to those observed in individuals with MCI-AD, at least as assessed by the MMSE-J. Future studies with larger samples and more detailed cognitive assessments are needed to clarify potential subtype-specific responses.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"11-20"},"PeriodicalIF":1.5,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Concomitant Use of Selective Serotonin Reuptake Inhibitors and Anti-Amyloid Treatment in Alzheimer's Disease: Balancing Benefits and Risks.","authors":"Polona Rus Prelog, Matija Zupan, Milica Gregorič Kramberger, Senta Frol","doi":"10.1159/000549621","DOIUrl":"10.1159/000549621","url":null,"abstract":"","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"1-3"},"PeriodicalIF":1.5,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Burden in Prion Disease.","authors":"Alexsandra Kovacevich, John Thomas Martin, Kathleen Glisic, Paula Ogrocki, Brian S Appleby","doi":"10.1159/000549584","DOIUrl":"10.1159/000549584","url":null,"abstract":"<p><strong>Introduction: </strong>Caregiver burden significantly impacts patient and caregiver outcomes and is an important treatment consideration in dementia. Previous research has demonstrated that like behavioral variant frontotemporal dementia, prion disease has higher levels of caregiver burden than other forms of dementia; however, limited prospective research has investigated this specifically. Here, we aimed to describe caregiver well-being and caregiver burden in prion disease and determine whether demographic features, support group attendance, or features of the disease process predicted higher caregiver burden.</p><p><strong>Methods: </strong>Thirty patients with prion disease and their caregivers were assessed longitudinally through the Teleneurology Assessment Program for Creutzfeldt-Jakob Disease. Caregivers were administered the Neuropsychiatric Inventory Questionnaire (NPI-Q), MRC Prion Disease Rating Scale, Outcome Evaluation of the National Family Caregiver Support Program, and other assessment instruments. We performed descriptive and inferential statistics to examine the progression of caregiver burden and to identify features that impacted caregiver burden severity.</p><p><strong>Results: </strong>Thirty caregiver-patient dyads were followed longitudinally. Prion disease duration averaged 7.88 months. Mean initial NPI-Q distress score was 15. Qualitatively, distress increased from the time of study enrollment until peaking on average half-way through study participation and then declined. Higher burden (4-item Zarit Burden Interview) was associated with younger age at disease onset. Burden was not predicted by disease type, duration, caregiver demographics, relationship to the patient, MRC Prion Rating Scale scores, NPI-Q, or support group attendance.</p><p><strong>Conclusion: </strong>These findings confirm significant caregiver distress in prion disease and help better describe the course of caregiver burden throughout the disease. Statistical analyses were limited by small sample size and phenotypic heterogeneity, and future research would benefit from larger sample sizes.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"16 1","pages":"4-10"},"PeriodicalIF":1.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Landscapes and Gaps in Neuropsychiatric Assessment for Neurodegenerative Diseases: A Bibliometric Study on Huntington's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy.","authors":"Haoyun Tang, Ping Jiang, Jianhua Chen","doi":"10.1159/000548720","DOIUrl":"10.1159/000548720","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to provide a comprehensive overview of the current application of tools used for assessing neuropsychiatric symptoms (NPSs) in patients with Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and multiple system atrophy (MSA) through bibliometric analysis.</p><p><strong>Methods: </strong>Publications published between 2014 and 2023 were searched using the Web of Science Core Collection database (WoSCC). Only articles and reviews published in the English language were included. CiteSpace was used to analyze the countries, keyword patterns, and reference co-citations. A detailed full-text analysis was further conducted across all studies to assess the usage of NPS assessment tools.</p><p><strong>Results: </strong>Our analysis included 530 publications demonstrating consistent annual growth, reflecting rising global interest in NPSs within neurodegenerative and neuroinflammatory diseases. However, these studies reveal research deficiency in current assessment methodologies that demands more attention. Research output remains predominantly concentrated in developed nations with aging populations, particularly the USA, which leads in both publication volume and quality. The primary focus of current research involves evaluating the validity of existing assessment tools, while emerging investigations explore next-generation assessment tools designed to enhance diagnostic precision and enable personalized treatment strategies. Despite these advances, widespread clinical adoption remains limited, and further validation studies are required to establish their reliability across diverse populations and disease stages.</p><p><strong>Conclusion: </strong>This study highlights the growing importance of NPSs in neurodegenerative diseases, particularly in HD, ALS, and MSA. We identify hotspots and deficiencies in the research field of validating NPS assessment tools, integrating NPSs into the diagnostic framework and elucidating neurobiological mechanisms. These findings will contribute to enhanced diagnostic and therapeutic approaches for neurodegenerative diseases.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"15 1","pages":"174-191"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12659634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}