Dementia and Geriatric Cognitive Disorders Extra最新文献

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Nursing Staff's Knowledge and Attitudes toward Dementia: A Pilot Study from an Indian Perspective 护理人员对痴呆症的知识和态度:一项来自印度视角的初步研究
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-10-01 DOI: 10.1159/000502770
B. S. Strøm, K. Engedal, Lasse Andreassen
{"title":"Nursing Staff's Knowledge and Attitudes toward Dementia: A Pilot Study from an Indian Perspective","authors":"B. S. Strøm, K. Engedal, Lasse Andreassen","doi":"10.1159/000502770","DOIUrl":"https://doi.org/10.1159/000502770","url":null,"abstract":"Background: Despite the increased prevalence of dementia in India, reports indicate little awareness of the disease. Symptoms are often misinterpreted or neglected, which could lead to late diagnosis, reducing the choices available regarding future care. Considering that most nurses caring for the elderly will work with people with dementia in the future, there is concern surrounding their ability to meet the needs of these patients, requiring them to obtain the necessary knowledge and positive attitudes for treatment. Aims: To describe the knowledge of and attitudes toward dementia among nursing staff working in residential care facilities for elderly populations in India. Methods: A cross-sectional survey was conducted in 3 nursing homes in India in which 15 nursing staff conducted self-assessments of their knowledge and attitudes toward dementia using the Alzheimer’s Disease Knowledge Scale (ADKS) and the Attitude toward Alzheimer’s Disease and Related Dementias Scale (DAS) for each respective assessment. Descriptive statistics were used to describe staffs’ attitudes and knowledge concerning dementia. Continuous variables were presented as means ± SD, while the categorical variables were presented as percentages. Results: Although the majority of the participants answered that Alzheimer’s disease cannot be cured, about half reported that people with dementia, in rare cases, can recover from the disease. While all participants agreed that people with dementia can feel when others are kind to them, almost half disagreed that people living with dementia can enjoy life. Conclusion: These findings reveal that nursing staff have limited knowledge of dementia, but their attitudes toward people living with dementia tend to be positive.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"352 - 361"},"PeriodicalIF":2.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000502770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46765446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Effects of Cognitive Performance and Affective Status on Fatigue in Parkinson's Disease 认知表现和情感状态对帕金森病患者疲劳的影响
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-09-24 DOI: 10.1159/000498883
Susan Spirgi, A. Meyer, P. Calabrese, U. Gschwandtner, P. Fuhr
{"title":"Effects of Cognitive Performance and Affective Status on Fatigue in Parkinson's Disease","authors":"Susan Spirgi, A. Meyer, P. Calabrese, U. Gschwandtner, P. Fuhr","doi":"10.1159/000498883","DOIUrl":"https://doi.org/10.1159/000498883","url":null,"abstract":"Background: Fatigue is a common non-motor symptom in Parkinson’s disease (PD) and is typically assessed via self-reported questionnaires such as the Parkinson’s Fatigue Scale (PFS). The PFS captures the presence of subjective experience of physical fatigue as well as its impact on daily functioning. Objectives: We aimed to investigate whether different variables (cognition, neuropsychiatric symptoms, disease-related measures) are associated with the experience of physical fatigue in comparison to fatigue affecting daily functioning. Method: Sixty-two non-demented PD patients were evaluated through questionnaires assessing fatigue, daytime sleepiness, apathy, depression, anxiety, and cognition. Items of fatigue were classified and summarized into two index variables measuring either the subjective experience of physical fatigue or the impact of fatigue on daily functioning. Linear regression with a stepwise elimination procedure was conducted to select the significant predictors for each index variable separately. Results: Subjective experience of physical fatigue (Model 1; r2 = 0.46; p <0.01) was significantly associated with higher levels of depression (b =0.07; p <0.01), anxiety (b =0.03; p <0.05), and lower performances in verbal episodic memory (b =–0.16; p <0.05). Fatigue affecting daily functioning (Model 2; r2 = 0.44; p <0.05) was significantly related to higher levels of depression (b = 0.07; p < 0.01), anxiety (b = 0.03; p > 0.05), and lower motor functioning (b = 0.01; p = 0.05). Conclusions: In conclusion, our work supports associations between fatigue and other neuropsychiatric symptoms in PD and extends prior work suggesting that motor disturbances are specifically linked to fatigue-related impairment of daily functioning, but not to the subjective experience of physical fatigue.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"344 - 351"},"PeriodicalIF":2.3,"publicationDate":"2019-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000498883","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42365930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Polypharmacy Associated with Cognitive Decline in Newly Diagnosed Parkinson's Disease: A Cross-Sectional Study. 新诊断帕金森病患者认知能力下降的多药治疗:一项横断面研究。
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-09-10 eCollection Date: 2019-09-01 DOI: 10.1159/000502351
Nobuyuki Ishii, Hitoshi Mochizuki, Katsuya Sakai, Go Ogawa, Kazutaka Shiomi, Masamitsu Nakazato
{"title":"Polypharmacy Associated with Cognitive Decline in Newly Diagnosed Parkinson's Disease: A Cross-Sectional Study.","authors":"Nobuyuki Ishii,&nbsp;Hitoshi Mochizuki,&nbsp;Katsuya Sakai,&nbsp;Go Ogawa,&nbsp;Kazutaka Shiomi,&nbsp;Masamitsu Nakazato","doi":"10.1159/000502351","DOIUrl":"https://doi.org/10.1159/000502351","url":null,"abstract":"<p><strong>Aims: </strong>Polypharmacy is well known to affect cognitive function in community-dwelling older adults. However, the effect of polypharmacy on cognitive function in patients with newly diagnosed Parkinson's disease remains unknown. Here, we evaluated the association between polypharmacy and cognitive function in patients with newly diagnosed Parkinson's disease.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 131 consecutive hospitalized patients with newly diagnosed Parkinson's disease. Cognitive function was evaluated with the Mini-Mental State Examination and analyzed between groups of patients with or without polypharmacy. Comparisons were adjusted for confounders by performing inverse probability weighting with propensity scores.</p><p><strong>Results: </strong>After inverse probability weighting, patients in the polypharmacy group had a significantly lower Mini-Mental State Examination score than patients in the nonpolypharmacy group (26.2 vs. 27.7, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Polypharmacy was associated with cognitive decline in patients with newly diagnosed Parkinson's disease. This finding suggests that medication reduction might serve as a promising intervention to prevent the development of dementia in patients with early Parkinson's disease. Further prospective studies are needed to determine whether medication reduction improves cognitive function in patients with newly diagnosed Parkinson's disease.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 3","pages":"338-343"},"PeriodicalIF":2.3,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000502351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Social Networks, Community Engagement, and Cognitive Impairment among Community-Dwelling Chinese Older Adults 中国社区居住老年人的社会网络、社区参与与认知障碍
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-09-10 DOI: 10.1159/000502090
Jinlei Li, Zijuan Wang, Z. Lian, Zhikai Zhu, Yuanli Liu
{"title":"Social Networks, Community Engagement, and Cognitive Impairment among Community-Dwelling Chinese Older Adults","authors":"Jinlei Li, Zijuan Wang, Z. Lian, Zhikai Zhu, Yuanli Liu","doi":"10.1159/000502090","DOIUrl":"https://doi.org/10.1159/000502090","url":null,"abstract":"Aims: To examine the association of social networks and community engagement with cognitive impairment among community-dwelling Chinese older adults. Methods: From November 2017 to May 2018, we selected 1,115 elderly individuals from 3 Chinese communities (Beijing, Hefei, and Lanzhou) using a random-cluster sampling method, and recorded data on demographics, social network characteristics, community activities, and cognitive function. The odds ratios (ORs) of these associations were adjusted for potential confounders in logistic regression models. Results: The prevalence of cognitive impairment was 25.7% (n = 287). An adequate social network (OR 0.55; 95% confidence interval [CI] 0.33–0.91) and enough social support from friends (OR 0.43; 95% CI 0.29–0.62) were negatively associated with cognitive impairment. Family support was not significantly associated with cognitive impairment (OR 0.64; 95% CI 0.34–1.21). Taking part in elderly group travel, communication with others using WeChat, and community activities such as Tai Chi and walking together were negatively associated with cognitive impairment. Conclusion: Social network characteristics and community engagement were found to be related to cognitive function among community-dwelling Chinese elderly adults.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"330 - 337"},"PeriodicalIF":2.3,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000502090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41504763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Psychometric Properties of the Czech Version of the Falls Efficacy Scale-International in Patients with Early-Stage Dementia 国际瀑布疗效量表捷克版对早期痴呆患者的心理测量特性
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-08-29 DOI: 10.1159/000501676
Helena Kisvetrová, D. Školoudík, R. Herzig, K. Langová, Petra Kurková, J. Tomanová, Yukari Yamada
{"title":"Psychometric Properties of the Czech Version of the Falls Efficacy Scale-International in Patients with Early-Stage Dementia","authors":"Helena Kisvetrová, D. Školoudík, R. Herzig, K. Langová, Petra Kurková, J. Tomanová, Yukari Yamada","doi":"10.1159/000501676","DOIUrl":"https://doi.org/10.1159/000501676","url":null,"abstract":"Introduction: A fear of falling marks an important psychological factor connected with a reduction in the life space of people with dementia. The Czech version of the Falls Efficacy Scale-International (FES-I) has not been validated in patients with early-stage dementia. Methods: The tests were administered to 282 patients with early-stage dementia. The test battery included the following: the FES-I, the Short Physical Performance Battery, the Geriatric Depression Scale, the Bristol Activity Daily Living Scale, and the Quality of Life-Alzheimer’s Disease Scale. Internal reliability (Cronbach’s α and intraclass correlation [ICC]), Pearson’s and Spearman’s correlations, exploratory factor analysis, and a t test for independent samples were used for statistical analyses. Results: The Czech version of the FES-I had excellent internal and test-retest reliability (Cronbach’s α = 0.98, ICC = 0.90; 95% CI 0.82–0.94). Factor analysis suggested 2 relevant factors. A significantly higher FES-I score was associated with patients with early-stage dementia who were older (p = 0.003) or female (p = 0.001), lived alone (p = 0.0001), spent >8 h a day alone (p = 0.032), used mobility aids (p < 0.0001), or had severe hearing (p = 0.004) or vision impairment (p < 0.0001) or a lower education (r = –0.16, p = 0.007). Conclusion: The Czech version of the FES-I had very good reliability and validity and may be useful in future cross-cultural comparisons in research among patients with early-stage dementia.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"319 - 329"},"PeriodicalIF":2.3,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41803041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan 轻度至中度阿尔茨海默病患者从口服胆碱酯酶抑制剂转为利匹的明透皮贴剂1步滴定的疗效、安全性和耐受性:一项在日本进行的24周开放标签多中心研究
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-08-15 DOI: 10.1159/000501364
Kengo Ueda, S. Katayama, T. Arai, Nobuo Furuta, S. Ikebe, Y. Ishida, K. Kanaya, S. Ouma, H. Sakurai, M. Sugitani, Makio Takahashi, Toshihisa Tanaka, N. Tsuno, Y. Wakutani, Ankita Shekhawat, Ayan Das Gupta, Kazuki Kiyose, Kazuhiro Toriyama, Yu Nakamura
{"title":"Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan","authors":"Kengo Ueda, S. Katayama, T. Arai, Nobuo Furuta, S. Ikebe, Y. Ishida, K. Kanaya, S. Ouma, H. Sakurai, M. Sugitani, Makio Takahashi, Toshihisa Tanaka, N. Tsuno, Y. Wakutani, Ankita Shekhawat, Ayan Das Gupta, Kazuki Kiyose, Kazuhiro Toriyama, Yu Nakamura","doi":"10.1159/000501364","DOIUrl":"https://doi.org/10.1159/000501364","url":null,"abstract":"Background: Few studies have investigated treatment options for patients with Alzheimer’s disease (AD) showing a poor response to oral cholinesterase inhibitors (ChEIs) in Japan. Objective: To investigate the efficacy and safety of switching from oral ChEIs to rivastigmine transdermal patch in patients with AD. Methods: In this multicenter, open-label, phase IV study in outpatient clinics in Japan, patients with mild-moderate AD who had a poor response to or experienced difficulty in continuing donepezil or galantamine were switched to rivastigmine transdermal patch (5 cm2; loaded dose 9 mg, delivery rate 4.6 mg/24 h) with a 1-step titration in week 4 (10 cm2; loaded dose 18 mg, delivery rate 9.5 mg/24 h), which was continued for 4 weeks in the titration period and 16 weeks in a maintenance period. The primary endpoint was the change in Mini-Mental State Examination (MMSE) total score from baseline to week 24. Results: A total of 118 patients were enrolled and switched to rivastigmine, of which 102 completed the 24-week study. The MMSE total score was essentially unchanged during the study, with a least-square mean change (SD) of −0.35 (2.64) at week 24 (p = 0.1750). Exploratory analysis with a mixed-effect model comparing changes in MMSE between the pre- and post-switch periods suggested that switching to rivastigmine prevented a worsening of MMSE. Application site skin reactions/irritations occurred in 30.5% of patients overall, in 22.0% in the 8-week titration period, and in 10.2% in the 16-week maintenance period. Conclusion: Within-class switching from an oral ChEI to rivastigmine transdermal patch might be an efficacious and tolerable option for AD patients showing a poor or limited response to a prior oral ChEI.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"302 - 318"},"PeriodicalIF":2.3,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43041201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Accuracy of the Cognitive Assessment Battery in a Primary Care Population 初级保健人群认知评估的准确性
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-08-14 DOI: 10.1159/000501365
A. S. Kvitting, Maria M. Johansson, J. Marcusson
{"title":"Accuracy of the Cognitive Assessment Battery in a Primary Care Population","authors":"A. S. Kvitting, Maria M. Johansson, J. Marcusson","doi":"10.1159/000501365","DOIUrl":"https://doi.org/10.1159/000501365","url":null,"abstract":"Background: There are several cognitive assessment tools used in primary care, e.g., the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment. The Cognitive Assessment Battery (CAB) was introduced as a sensitive tool to detect cognitive decline in primary care. However, primary care validation is lacking. Therefore, we investigated the accuracy of the CAB in a primary care population. Objective: To investigate the accuracy of the CAB in a primary care population. Methods: Data from 46 individuals with cognitive impairment and 33 individuals who visited the primary care with somatic noncognitive symptoms were analyzed. They were investigated with the MMSE, the CAB, and a battery of neuropsychological tests; they also underwent consultation with a geriatric specialist. The accuracy of the CAB was assessed using c-statistics and the area under the receiver operating characteristic curve (AUC) was used to quantify the binary outcomes (“no cognitive impairment” or “cognitive impairment”). Results: The “cognitive impairment” group was significantly different from the unimpaired group for all the subtests of the CAB. When accuracy was based on binary significant reduction or not in one or several domains of the CAB, the AUC varied between 0.685 and 0.772. However, when a summation or logistic regression of several subcategories was performed, using the numerical values for each subcategory, the AUC was >0.9. For comparison, the AUC for the MMSE was 0.849. Conclusions: The accuracy of the CAB in a primary care population is poor to good when using binary cutoffs. Accuracy can be improved to high when using a summation or logistic regression of the numerical data of the subcategories. Considering CAB time, lack of adequate age norms, and a good accuracy for the MMSE, implementation of the CAB in primary care is not recommended at present based on the results of this study.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"294 - 301"},"PeriodicalIF":2.3,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43248331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Responding to Varying Levels of Certainty about Pain in People with Dementia after Initial Pain Assessment 痴呆症患者初始疼痛评估后对不同程度疼痛确定性的反应
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-08-13 DOI: 10.1159/000501030
Mohammad J Rababa, M. Aldalaykeh
{"title":"Responding to Varying Levels of Certainty about Pain in People with Dementia after Initial Pain Assessment","authors":"Mohammad J Rababa, M. Aldalaykeh","doi":"10.1159/000501030","DOIUrl":"https://doi.org/10.1159/000501030","url":null,"abstract":"Introduction: Pain is still inadequately treated in people with dementia (PWD) due to the complexity of assessing it. Pain assessment in PWD is still challenging because of patient-related or nurse-related factors. The patient-related factors have been studied extensively. However, the nurse-related factors, e.g., nurses’ certainty regarding suspected pain in PWD, have been given little attention by researchers. Purpose: This study aims to investigate how the degree of nurses’ certainty is compromised after pain assessment and how this affects levels of pain and agitation in PWD. Method: A descriptive, correlational design was used, and a convenience sample of 104 nursing home residents with dementia were recruited. Results: This study found that nurses’ certainty after the pain assessment mediates the relationship between the type of pain assessment and patient outcomes when the nurses had a high initial certainty. When nurses had a low initial certainty, their certainty after the assessment and the type of assessment predicted the levels of pain and agitation in PWD. Conclusion: Understanding how nurses’ certainty can be compromising after pain assessment and how this relates to pain management in PWD is crucial.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"271 - 280"},"PeriodicalIF":2.3,"publicationDate":"2019-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49298652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Association between Chronic Obstructive Pulmonary Disease and Dementia: Systematic Review and Meta-Analysis of Cohort Studies 慢性阻塞性肺疾病与痴呆的关系:队列研究的系统回顾和荟萃分析
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-07-11 DOI: 10.1159/000496475
Ying Wang, Xiaotong Li, Biying Wei, T. Tung, P. Tao, Ching-Wen Chien
{"title":"Association between Chronic Obstructive Pulmonary Disease and Dementia: Systematic Review and Meta-Analysis of Cohort Studies","authors":"Ying Wang, Xiaotong Li, Biying Wei, T. Tung, P. Tao, Ching-Wen Chien","doi":"10.1159/000496475","DOIUrl":"https://doi.org/10.1159/000496475","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a common disease among the elderly, which has been linked to cognitive decline. However, the relationship between COPD and dementia remains unclear. Summary: We conducted a systematic literature review by searching databases such as Pubmed, Embase, EBSCO, and Cochrane Library (from inception to April 18, 2018) for studies on COPD that also investigated the prevalence of dementia. We found 3 cohort studies including a total of 39,392 COPD patients. Then we applied the Newcastle-Ottawa Scale to evaluate the risk of bias. Key Messages: COPD patients faced a higher risk of dementia (HR 1.46; 95% CI 1.22–1.75; p < 0.001). Subgroup analysis on gender determined that the association between COPD and dementia was stronger in male patients (HR 1.49, 95% CI 1.20–1.86, p < 0.001) than in female patients (HR 1.41, 95% CI 1.27–1.57, p < 0.001). A subset study of patients aged >65 years revealed that the HR was greater for patients aged ≥75 years (HR 1.46, 95% CI 1.07–2.00, p = 0.02) than for those aged 65–74 years (HR 1.40, 95% CI 1.28–1.53, p < 0.001). The cohort studies included were from similar population-based databases, suggesting possible regional limitations and publication bias.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 1","pages":"250 - 259"},"PeriodicalIF":2.3,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000496475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45252238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Associations between Frailty and Delirium among Older Patients Admitted to an Emergency Department. 急诊科老年患者虚弱和谵妄的关系。
IF 2.3
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2019-06-21 eCollection Date: 2019-05-01 DOI: 10.1159/000499707
Sandra Choutko-Joaquim, Nadine Tacchini-Jacquier, Géraldine Pralong D'Alessio, Henk Verloo
{"title":"Associations between Frailty and Delirium among Older Patients Admitted to an Emergency Department.","authors":"Sandra Choutko-Joaquim,&nbsp;Nadine Tacchini-Jacquier,&nbsp;Géraldine Pralong D'Alessio,&nbsp;Henk Verloo","doi":"10.1159/000499707","DOIUrl":"10.1159/000499707","url":null,"abstract":"<p><strong>Background: </strong>Switzerland's demographic trends show, as elsewhere on the planet, increasing numbers of older and very old adults. This suggests that its healthcare system will suffer serious repercussions, including in the use of care and especially the use of emergency services. Significant numbers of older adults will be at risk of developing multiple chronic conditions including one or more geriatric syndromes, such as frailty and delirium. Few studies to date have documented associations between frailty and delirium.</p><p><strong>Aim: </strong>To explore the relationships between frailty and delirium in older adult patients consulting (<i>n</i> = 114) at an emergency department (ED) in Switzerland.</p><p><strong>Method: </strong>A cross-sectional study was conducted in a peripheral hospital ED in the French-speaking part of Switzerland. Frailty was assessed using the Tilburg Frailty Indicator (TFI). Delirium was assessed using the Confusion Assessment Method (CAM). Participants' cognitive states were assessed using the 6-item Cognitive Impairment Test (6CIT) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQ-CODE), completed by the participant's most significant informal caregiver.</p><p><strong>Results: </strong>The mean participant age was 77.6 years (SD = 7.7); the majority of the subjects were women (54%). The participants took an average of 4.7 different medications a day (SD = 3.2, median = 4). More than half (62%) of the participants were frail; 2 and 14% presented signs and symptoms of delirium and subsyndromal delirium, respectively. A weak but significant association between scores for frailty and delirium (<i>p</i> < 0.05) was demonstrated, and clinical observation confirmed this. A 4-h follow-up measurement of delirium in the ED revealed no significant or clinical difference.</p><p><strong>Conclusion: </strong>Although the literature describes strong associations between frailty and delirium in surgical units and community care settings, the present study only demonstrated a weak-to-moderate association between frailty and delirium in our ED.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":"9 2","pages":"236-249"},"PeriodicalIF":2.3,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000499707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37420242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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