Utility of Easy Z-Score Imaging System-Assisted SPECT in Detecting Onset Age-Dependent Decreases in Cerebral Blood Flow in the Posterior Cingulate Cortex, Precuneus, and Parietal Lobe in Alzheimer's Disease with Amyloid Accumulation.

IF 1.4 Q4 CLINICAL NEUROLOGY
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2020-06-10 eCollection Date: 2020-05-01 DOI:10.1159/000507654
Hiroshi Hayashi, Ryota Kobayashi, Shinobu Kawakatsu, Daichi Morioka, Koichi Otani
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引用次数: 7

Abstract

Background: Easy Z-score imaging system (eZIS)-assisted SPECT accurately detects decreases in cerebral blood flow in the posterior cingulate cortex (PCC), precuneus, and parietal lobe, the cerebral regions deeply implicated in Alzheimer's disease (AD). Several studies suggested onset age-dependent decreases in cerebral blood flow in these regions in AD, but these studies did not screen for amyloid accumulation, suggesting inclusion of non-AD patients in their subjects.

Objective: By applying eZIS-SPECT to patients with amyloid deposition, it was the aim of this study to clarify onset age-dependent decreases in cerebral blood flow in the regions critical to AD.

Methods: We retrospectively analyzed eZIS-SPECT data on 34 AD patients with amyloid retention confirmed by 11C-Pittsburgh compound B-PET. The subjects were divided into an early-onset group (n = 16) and a late-onset group (n = 18). The three indicators of the eZIS that had discriminated between AD patients and normal controls in previous studies were compared between the two groups.

Results: The mean values for the respective indicators were significantly higher in the early-onset group than in the late-onset group. Also, the proportion of patients with abnormalities in all indicators was significantly higher in the early-onset group (93.8%) than in the late-onset group (50.0%).

Conclusions: The present study, applying eZIS-SPECT to amyloid-positive AD patients, suggests that reduced cerebral blood flow in the PCC, precuneus, and parietal lobe is more pronounced in the early-onset type than in the late-onset type of the disease.

利用Easy Z-Score成像系统辅助SPECT检测淀粉样蛋白堆积的阿尔茨海默病后扣带皮层、楔前叶和顶叶脑血流的年龄依赖性减少。
背景:Easy Z-score成像系统(eZIS)辅助SPECT准确检测脑后扣带皮层(PCC)、楔前叶和顶叶的脑血流减少,这些大脑区域与阿尔茨海默病(AD)有密切关系。几项研究表明,阿尔茨海默病患者发病时,这些区域的脑血流量随年龄而减少,但这些研究没有筛查淀粉样蛋白积累,这表明非阿尔茨海默病患者也包括在研究对象中。目的:通过对淀粉样蛋白沉积患者应用eZIS-SPECT,本研究的目的是阐明AD关键区域脑血流量的发病年龄依赖性减少。方法:回顾性分析34例经11C-Pittsburgh复合B-PET证实淀粉样蛋白滞留的AD患者的eZIS-SPECT数据。研究对象分为早发型组(n = 16)和晚发型组(n = 18)。比较以往研究中区分AD患者与正常对照的eZIS三项指标。结果:早发组各项指标的平均值明显高于晚发组。各指标异常的患者比例早发型组(93.8%)明显高于晚发型组(50.0%)。结论:本研究将eZIS-SPECT应用于淀粉样蛋白阳性AD患者,表明早发型AD患者的PCC、楔前叶和顶叶脑血流量减少比晚发型AD患者更为明显。
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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
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