eNeurologicalSci最新文献_第2页

Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping

eNeurologicalSci Pub Date : 2025-01-09 DOI: 10.1016/j.ensci.2025.100549

Abdullah M. Al-Qudah , Pooja S. Tallapaneni , Donald J. Crammond , Jeffrey Balzer , Katherine M. Anetakis , Varun Shandal , Jingyuan Biaesch , Malik Ghannam , Neelesh Nadkarni , Bradley A. Gross , Michael Lang , Kathirvel Subramanium , Senthilkumar Sadhasivam , Parthasarathy D. Thirumala

{"title":"Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping","authors":"Abdullah M. Al-Qudah , Pooja S. Tallapaneni , Donald J. Crammond , Jeffrey Balzer , Katherine M. Anetakis , Varun Shandal , Jingyuan Biaesch , Malik Ghannam , Neelesh Nadkarni , Bradley A. Gross , Michael Lang , Kathirvel Subramanium , Senthilkumar Sadhasivam , Parthasarathy D. Thirumala","doi":"10.1016/j.ensci.2025.100549","DOIUrl":"10.1016/j.ensci.2025.100549","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to evaluate the diagnostic accuracy of significant intraoperative neurophysiological monitoring (IONM) changes as an independent predictor of postoperative delirium (POD) in patients undergoing aneurysm clipping.</div></div><div><h3>Methods</h3><div>IONM and clinical data from 273 patients who underwent craniotomy for aneurysm clipping from 2019 until 2021 were retrospectively reviewed. Significant IONM changes and POD were respectively evaluated based on visual review of data and clinical documentation. POD was assessed multiple times in the ICU using the Intensive Care Delirium Screening Checklist (ICDSC).</div></div><div><h3>Results</h3><div>Of the 273 patients undergoing craniotomy with IONM, 83 had POD (30.4 %). Significant IONM changes were noted in 42 patients, of which 19 patients had POD (45.2 %). In contrast, 231 patients had no IONM changes during surgery, of which 64 (27.7 %) patients had POD. Multivariable analysis showed that significant IONM changes were associated with POD, OR: 2.09 (95 % CI 1.01–4.43, <em>p</em>-value: 0.046). Additionally, somatosensory evoked potentials (SSEP) changes were significantly associated with POD (p-value: 0.044).</div></div><div><h3>Conclusion</h3><div>Significant IONM changes are associated with an increased risk of POD in patients undergoing craniotomy for aneurysm clipping. Our findings offer a strong basis for future research and analysis of EEG and SSEP monitoring to detect and possibly prevent POD.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100549"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a link between Hepatitis A virus and Guillain-Barré syndrome? A systematic review of case reports

eNeurologicalSci Pub Date : 2025-01-06 DOI: 10.1016/j.ensci.2025.100551

Amirhosein Ghasemi , Nima Broomand Lomer , Alia Saberi

{"title":"Is there a link between Hepatitis A virus and Guillain-Barré syndrome? A systematic review of case reports","authors":"Amirhosein Ghasemi , Nima Broomand Lomer , Alia Saberi","doi":"10.1016/j.ensci.2025.100551","DOIUrl":"10.1016/j.ensci.2025.100551","url":null,"abstract":"<div><h3>Introduction</h3><div>Guillain-Barré syndrome (GBS) is an inflammatory disorder of the peripheral nervous system, causing acute flaccid paralysis. There have been occasional reports linking Hepatitis A virus (HAV) to GBS. Here we aimed to evaluate the current literature on the association between GBS and HAV, exploring potential mechanisms and clinical implications.</div></div><div><h3>Methods</h3><div>We conducted a systematic search using PRISMA guidelines in PubMed, Web of Science, Embase, and Scopus. Only published case reports or conference abstracts presenting cases of confirmed HAV infection and GBS were included. Data extraction was performed independently by two reviewers, and quality assessment was conducted using the Joanna Briggs Institute critical appraisal tool.</div></div><div><h3>Results</h3><div>Out of 581 studies identified, 46 studies encompassing 47 cases met the inclusion criteria. The mean age of patients was 29.47 years, with a male predominance (70.2 %). Geographically, most cases were reported in Asia (74.5 %). Clinical manifestations of HAV included fever, malaise, and jaundice, while GBS presented with muscle weakness and areflexia. Laboratory findings showed albuminocytological dissociation in 76.2 % of cases. Nerve conduction studies predominantly indicated AIDP subtype (32/46, 69.6 %). Treatment involved IVIG, plasmapheresis, and supportive care, with recovery times ranging from one week to 18 months. One fatality was reported.</div></div><div><h3>Conclusions</h3><div>This review suggests a potential link between HAV infection and GBS, proposing a mechanism: molecular mimicry. It emphasizes the need for increased awareness and preventive measures, especially in areas with lower health standards. However, further research is needed to clarify the possible mechanisms and deepen our understanding.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100551"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in MS and AQP4-NMOSD: Advancing clinical applications.

eNeurologicalSci Pub Date : 2025-01-06 DOI: 10.1016/j.ensci.2025.100550

Sara Samadzadeh , Roy D. Sleator

引用次数: 0

The world federation of neurology digital neurology update (WNU)

eNeurologicalSci Pub Date : 2025-01-05 DOI: 10.1016/j.ensci.2025.100548

Wolfgang Grisold, Stephen L. Lewis

引用次数: 0

Randomized clinical trial (RCT): An overview

eNeurologicalSci Pub Date : 2025-01-02 DOI: 10.1016/j.ensci.2025.100547

Giancarlo Logroscino

引用次数: 0

Deterioration of preexisting myoclonus following nifedipine use in parkinsonian syndrome: A case report 硝苯地平治疗帕金森综合征后原有肌阵挛恶化1例报告。

eNeurologicalSci Pub Date : 2024-12-15 DOI: 10.1016/j.ensci.2024.100545

Gohei Yamada , Takanari Toyoda , Eiichi Katada , Noriyuki Matsukawa

{"title":"Deterioration of preexisting myoclonus following nifedipine use in parkinsonian syndrome: A case report","authors":"Gohei Yamada , Takanari Toyoda , Eiichi Katada , Noriyuki Matsukawa","doi":"10.1016/j.ensci.2024.100545","DOIUrl":"10.1016/j.ensci.2024.100545","url":null,"abstract":"<div><div>L-type calcium channel antagonists are uncommon causes of myoclonus, and the underlying mechanism remains unclear. Here, we report a case of parkinsonian syndrome with deterioration of preexisting myoclonus after nifedipine use. A 96-year-old woman was administered a single dose of sustained-release nifedipine for chest pain. One hour later, the patient developed shock-like jerky movements in the trunk and upper and lower limbs. Neurological examination revealed myoclonus, intention tremor in both hands, facial hypomimia, stooped posture, short stride length, absent arm swing during walking, and muscle rigidity in the neck, left arm, and both legs. Brain magnetic resonance imaging showed no causative lesions, suggesting a nifedipine-induced movement disorder. Myoclonic movements almost completely resolved within 24 h. Despite no further administration of nifedipine, a neurological examination one week later revealed parkinsonism with mild myoclonus and intention tremor. It appeared that preexisting myoclonus and intention tremor transiently worsened with nifedipine use. The patient was diagnosed with parkinsonian syndrome with deterioration of myoclonus due to nifedipine administration. This case suggests that the corticostriatal pathways may have already been impaired and were further affected by nifedipine. Nifedipine-induced alterations in dopaminergic and serotonergic systems may have contributed to the deterioration of myoclonus and intention tremor. When patients present with myoclonus after taking an L-type calcium channel antagonist, underlying neurological disorders should be carefully investigated.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100545"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral foot drop as presenting feature of facioscapulohumeral muscular dystrophy type 1 双侧足下垂为1型面肩肱肌营养不良的表现特征。

eNeurologicalSci Pub Date : 2024-12-13 DOI: 10.1016/j.ensci.2024.100546

Martin Krenn , Veronika Vetchy , Gregor Kasprian , Wolfgang Grisold

引用次数: 0

Neuroepidemiology: Basic concepts and population surveys 神经流行病学：基本概念和人口调查。

eNeurologicalSci Pub Date : 2024-12-03 DOI: 10.1016/j.ensci.2024.100544

Walter A. Rocca

引用次数: 0

Oral minocycline therapy as first-line treatment in patients with Myalgic encephalomyelitis and long COVID: A pilot study 口服二甲胺四环素作为肌痛性脑脊髓炎和长COVID患者的一线治疗：一项初步研究。

eNeurologicalSci Pub Date : 2024-12-02 DOI: 10.1016/j.ensci.2024.100537

Kunihisa Miwa

{"title":"Oral minocycline therapy as first-line treatment in patients with Myalgic encephalomyelitis and long COVID: A pilot study","authors":"Kunihisa Miwa","doi":"10.1016/j.ensci.2024.100537","DOIUrl":"10.1016/j.ensci.2024.100537","url":null,"abstract":"<div><h3>Background</h3><div>Myalgic encephalomyelitis (ME) is associated with long COVID and also untoward sequelae after anti-coronavirus vaccination. Recently, oral minocycline therapy has been reported to ameliorate symptoms in patients with ME, particularly at the initial stage of the disease.</div></div><div><h3>Methods</h3><div>Oral minocycline (100 mg × 2 on the first day, followed by 100 mg/day for 41 days) was administered to 55 patients with ME that emerged during the “Corona era,” including 19 patients with long COVID and 5 patients diagnosed with untoward sequalae following coronavirus vaccination.</div></div><div><h3>Results</h3><div>Acute adverse effects including nausea and/or dizziness caused four (7 %) patients to discontinue treatment in the first few days. Among the other 51 patients who completed therapy, favorable effects were observed, including a decrease in performance status score or index for restricted activities of daily living ≥2 points in 41 (80 %) patients. Disease duration was inversely associated with the favorable therapeutic effects (<em>p</em> = 0.02) and the disease duration within 6 months was significantly associated with the favorable therapeutic effects (27/30, 90 %, <em>p</em> = 0.02, hazard ratio: 3.6, 95 % confidence interval, 1.2<strong>–</strong>10.6). The favorable effects were observed in 16 (89 %) of 18 patients with long COVID. Significant amelioration of subjective symptoms of fatigue, post-exertional malaise, unrefreshing sleep, brain fog, disequilibrium, orthostatic intolerance, and neuropathic pain were observed.</div></div><div><h3>Conclusions</h3><div>Oral minocycline was effective at ameliorating symptoms in patients with ME including long COVID and post-coronavirus vaccination sequalae. It represents an effective first-line therapeutic option for these patients in the initial stage.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100537"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathy and the metabolic syndrome 神经病变和代谢综合征。

eNeurologicalSci Pub Date : 2024-11-28 DOI: 10.1016/j.ensci.2024.100542

Nicoló Piccolo , Astrid Wiggers , Emily J. Koubek, Eva L. Feldman

引用次数: 0