eNeurologicalSci最新文献

{"title":"Nitrous oxide–related neurotoxicity: Clinical features, key investigations, and a proposed diagnostic approach from a single-center cohort","authors":"Si Tri Le ,&nbsp;Khang Vinh Nguyen ,&nbsp;Len Thi Duong ,&nbsp;Hung Hoang Dang ,&nbsp;Tinh Quang Dang ,&nbsp;Thang Ba Nguyen ,&nbsp;Umapathi Thirugnanam","doi":"10.1016/j.ensci.2026.100614","DOIUrl":"10.1016/j.ensci.2026.100614","url":null,"abstract":"<div><h3>Background</h3><div>Recreational use of nitrous oxide (N₂O) is a growing public health concern. Its neurological complications include peripheral neuropathy and posterior column myelopathy. Our study aims to characterize the clinical, laboratory, and radiological features of N₂O neurotoxicity, and to explore the clinical relevance of various commonly employed investigations in real-world setting.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of 52 consecutive patients diagnosed with N₂O-related neurological disorders admitted between 2019 and 2024. Clinical characteristics, serum markers, spinal MRI, and electrodiagnostic (EDX) data were collected. Analyses were primarily descriptive. Exploratory unadjusted associations between MRI findings, EDX classifications, homocysteine status, and symptom-onset variables were assessed using appropriate statistical tests.</div></div><div><h3>Results</h3><div>The median age was 24.0 [21.8;28.0] years, with a female-to-male ratio of 1.7:1. Acute onset (&lt; 4 weeks) was observed in 61.5% of cases. Sensory symptoms occurred in 94.2% and gait ataxia in 86.5%, with 88.5% exhibited a pattern of distal weakness exceeding proximal. Elevated homocysteine was present in 43 (89.6%), whereas low total B12 was found in only 10.4%. MRI abnormalities were detected in 31/48 (64.6%), with the “inverted V” sign in 17 cases (54.8%). Reduced CMAPS with intact sensory potentials was the most common EDX pattern 17 (32.7%), and needle electromyography showed ongoing denervation in 66%. Exploratory association analyses did not identify any significant relationships between EDX classifications, MRI findings, symptom onset, or homocysteine levels.</div></div><div><h3>Conclusion</h3><div>Nitrous oxide neurotoxicity is characterized by predominant sensory symptoms, gait ataxia and elevated homocysteine. EDX patterns are heterogenous and non-specific. A combined approach using spinal MRI, serum homocysteine and EDX could play a key role in differentiating this pathology from other mimickers and achieving a timely and accurate diagnosis.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"43 ","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive brainstem encephalopathy with isolated headache and blurred vision: A case report","authors":"Seo-Young Choi ,&nbsp;Jae-Hwan Choi ,&nbsp;Kwang-Dong Choi","doi":"10.1016/j.ensci.2025.100600","DOIUrl":"10.1016/j.ensci.2025.100600","url":null,"abstract":"<div><h3>Background</h3><div>Headache with papilledema is a critical neurological symptom that necessitates prompt evaluation for underlying central nervous system pathology. While often associated with conditions such as aneurysmal subarachnoid hemorrhage, hypertensive emergencies can also present with similar features and require immediate management to prevent end-organ damage.</div></div><div><h3>Case presentation</h3><div>A 41-year-old man with no significant medical history presented with acute severe headache, vomiting, and blurred vision in the left eye. His blood pressure was markedly elevated at 200/130 mmHg. Fundoscopic examination revealed optic disc swelling, flame-shaped hemorrhages, and exudates in both eyes. Brain MRI demonstrated asymmetric hyperintensities in the brainstem, consistent with hypertensive brainstem encephalopathy (HBE). Lumbar puncture revealed elevated intracranial pressure without evidence of infection or hemorrhage. Blood pressure control with intravenous calcium channel blockers resulted in rapid symptom resolution, and subsequent antihypertensive therapy led to complete recovery of brainstem lesions and significant improvement in papilledema.</div></div><div><h3>Conclusion</h3><div>HBE can present with severe headache and papilledema but minimal neurological deficits despite striking MRI abnormalities. Early recognition through neuroimaging and prompt blood pressure management are crucial in preventing irreversible damage and optimizing patient outcomes.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100600"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum watershed strokes as initial manifestation of a rare co-occurrence of systemic lupus erythematosus and Takayasu Vasculitis: A case report of neuroimmunologic and literature review","authors":"Cédric Agbo-Panzo,&nbsp;Kadjo Cédric Kadjo,&nbsp;Chubaka Magala Gloire,&nbsp;Nancy Essoin,&nbsp;Delors Offoumou,&nbsp;Arlette AKA,&nbsp;Axel Toa,&nbsp;Davide Baugnan,&nbsp;Muriel Amon,&nbsp;Stephane Abbé,&nbsp;Samuel Yéo,&nbsp;Yves Broh,&nbsp;Constance Yapo,&nbsp;Christian Tanoh,&nbsp;Evelyne Aka,&nbsp;B. Assi","doi":"10.1016/j.ensci.2025.100597","DOIUrl":"10.1016/j.ensci.2025.100597","url":null,"abstract":"","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100597"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of myokymia in adult-onset hereditary spastic paraplegia type 79A: Implications for the phenotypic spectrum","authors":"Natsumi Toyoda ,&nbsp;Hiroyasu Komiya ,&nbsp;Yosuke Miyaji ,&nbsp;Shuhei Nishihama ,&nbsp;Mutsuki Takeda ,&nbsp;Tetsuya Asano ,&nbsp;Shunta Hashiguchi ,&nbsp;Keita Takahashi ,&nbsp;Yuichi Higashiyama ,&nbsp;Atsushi Fujita ,&nbsp;Naomichi Matsumoto ,&nbsp;Hiroshi Doi ,&nbsp;Fumiaki Tanaka","doi":"10.1016/j.ensci.2025.100603","DOIUrl":"10.1016/j.ensci.2025.100603","url":null,"abstract":"<div><div>Spastic paraplegia type 79 (SPG79) is a rare form of hereditary spastic paraplegia caused by variants in <em>ubiquitin C-terminal hydrolase L1</em> (<em>UCHL1</em>). SPG79B, an early-onset autosomal recessive subtype, frequently presents with lower motor neuron involvement, with myokymia as a characteristic feature. In contrast, SPG79A, a late-onset autosomal dominant form, rarely shows lower motor neuron signs, and myokymia has not previously been reported. We report the first documented case of myokymia in SPG79A.</div><div>A 74-year-old man with an 8-year history of progressive gait disturbance underwent detailed evaluation.</div><div>The patient exhibited slowly progressive spastic paraplegia and impaired proprioception in the lower extremities. Myokymia was observed in the extremities and trunk. Needle electromyography revealed spontaneous, repetitive discharges of motor unit potentials consistent with myokymia. Genetic testing identified a heterozygous nonsense variant in <em>UCHL1</em> (c.532C &gt; T: p. Arg178*), confirming a diagnosis of SPG79A.</div><div>The pathogenesis of both SPG79A and SPG79B likely involves partial loss of UCHL1 function, explaining their overlapping phenotypes. Symptom variability may reflect the extent of residual UCHL1 function, with SPG79B showing broader features, including myokymia. This case suggests that myokymia, though rare in hereditary spastic paraplegias, can also occur in SPG79A and may serve as a diagnostic clue.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100603"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected infectious complication following AVM embolization: E. coli brain abscess","authors":"Andrii Netliukh ,&nbsp;Andrian Sukhanov ,&nbsp;Nana Tchantchaleishvili","doi":"10.1016/j.ensci.2025.100594","DOIUrl":"10.1016/j.ensci.2025.100594","url":null,"abstract":"<div><h3>Background</h3><div>Brain arteriovenous malformations (AVMs) are rare vascular anomalies managed with surgery, radiosurgery, or endovascular embolization. Post-embolization intracranial infections are extremely uncommon, especially <em>Escherichia coli</em> abscesses in immunocompetent adults.</div></div><div><h3>Case presentation</h3><div>We report a 37-year-old man with a giant left frontal AVM treated with staged Onyx® embolization. One month after the final session, he developed a left frontal brain abscess with motor aphasia and right-sided hemiparesis. Cultures grew hemolytic <em>E. coli</em> sensitive to multiple antibiotics. Recurrence after initial drainage necessitated complete AVM and nidus resection, followed by prolonged targeted antibiotic therapy, leading to resolution and neurological recovery.</div></div><div><h3>Literature review</h3><div>Intracranial <em>E. coli</em> infections and post-AVM embolization abscesses are rare, typically associated with systemic or local immunosuppression. Our case is among the first describing hemolytic <em>E. coli</em> abscess after Onyx® embolization in a healthy adult.</div></div><div><h3>Conclusion</h3><div>Retained embolic material, local inflammation, and blood–brain barrier disruption may facilitate infection. Early recognition and total removal, and prolonged targeted antibiotics are crucial to prevent recurrence and ensure favorable outcomes.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100594"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between DATSCAN-derived dopaminergic activity and cognitive performance and quality of life in Parkinson's disease: A cross-sectional study","authors":"Farzaneh Ramezani ,&nbsp;SeyedAli Mahmoudi ,&nbsp;Faezeh Safari","doi":"10.1016/j.ensci.2025.100599","DOIUrl":"10.1016/j.ensci.2025.100599","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms that substantially affect quality of life (QoL). While dopaminergic dysfunction is central to PD pathology, the cross-sectional relationship between striatal dopaminergic activity and clinical outcomes remains incompletely understood. This study investigated associations between dopaminergic activity, measured via DATSCAN imaging, and clinical outcomes including cognitive performance, mobility, and QoL.</div></div><div><h3>Methods</h3><div>In this <strong>cross-sectional observational study</strong>, PD patients (<em>n</em> = 146; age 37.9–85.6 years) and healthy controls (<em>n</em> = 37; age 32.2–86.7 years) were evaluated. Cognitive and communication-related QoL were assessed using Neuro-QoL, motor and non-motor symptoms were quantified with MDS-UPDRS, and cognitive performance was measured using COGSTATE and derived indices (COGDECLN, COGCHG). DATSCAN imaging quantified striatal dopaminergic activity in the caudate and putamen. Correlations between DATSCAN metrics and clinical outcomes were analyzed, accounting for multiple comparisons.</div></div><div><h3>Results</h3><div>DATSCAN metrics showed no significant associations with cognitive performance or QoL, and only modest correlations with mobility measures. Sensitivity analyses confirmed robustness of these findings. The limited predictive value of DATSCAN underscores the complexity of PD, including contributions of non-dopaminergic mechanisms.</div></div><div><h3>Conclusions</h3><div>Although DATSCAN is valuable for confirming PD diagnosis, its ability to predict clinical outcomes such as cognition, QoL, or motor complications is limited. These results highlight the multifactorial nature of PD and the need to integrate dopaminergic imaging with comprehensive clinical assessments for personalized patient care.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with the progression of disability (EDSS) among MS patients","authors":"Anibal Arteaga-Noriega ,&nbsp;Jose Zapata-Berruecos ,&nbsp;Johanna Gutiérrez-Vargas ,&nbsp;John Camilo Garcia ,&nbsp;Diego Rojas-Gualdron ,&nbsp;Manuela Restrepo-Botero","doi":"10.1016/j.ensci.2025.100602","DOIUrl":"10.1016/j.ensci.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>Multiple sclerosis is a chronic, inflammatory, autoimmune disease of the central nervous system. Accumulating neurological disability has a substantial impact on the lives of patients with MS. The Expanded Disability Status Scale is a method of quantifying disability in MS.</div></div><div><h3>Objective</h3><div>The aim of this study was to analyze the disability trajectory across years of patients living with MS seen at the Neurological Institute and to explore factors associated with the rate of change per year.</div></div><div><h3>Methods</h3><div>A single-center study was conducted at the Neurological Institute located in the city of Medellin based on medical records obtained from 2013 to 2021. The clinical and demographic characteristics were analyzed using descriptive statistics. To recognize changes in the rate of increase in disability measured by the EDSS with increasing time lived with the disease, a polynomial model was used.</div></div><div><h3>Results</h3><div>Disability measured by the EDSS was not linear over time, there were times when disability progressed more rapidly and other times when it was slower. The bivariate model showed that variables such as gait medications and botulinum toxin had the highest beta values; however, the multivariate model showed that clinical and sociodemographic variables such as initial cerebellar symptoms and sex had the highest significant beta values.</div></div><div><h3>Conclusion</h3><div>This type of study facilitates predictions of natural history within the risk scheme. Prognostic models for chronic diseases are needed to guide management decisions and counseling of patients and their families. Such models can consider outcomes ranging from response to treatment to changes in disability.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"42 ","pages":"Article 100602"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight loss remains a challenge for idiopathic intracranial hypertension patients: A retrospective case series from Kenya","authors":"Zian Muikamba ,&nbsp;Jaskirat Sokhi ,&nbsp;Jasmit Shah ,&nbsp;Sheila Marco ,&nbsp;Juzar Hooker ,&nbsp;Dilraj Sokhi","doi":"10.1016/j.ensci.2025.100592","DOIUrl":"10.1016/j.ensci.2025.100592","url":null,"abstract":"<div><h3>Background</h3><div>Idiopathic intracranial hypertension (IIH) is a neurological condition characterized by elevated intracranial CSF pressure without demonstratable evident causes. The mechanisms leading to a particular predilection for women of childbearing age who are overweight and obese or who have recent rapid weight changes remain imprecisely described. If undiagnosed, it can progress to disabling irreversible visual loss. Weight loss is useful in addition to medical therapy in treating the condition. There is a rise of obesity in sub-Saharan Africa (SSA) but there is little published on IIH.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cross-sectional study at our tertiary regional referral neurology centre in Nairobi, Kenya. Data were extracted from medical files of patients meeting the diagnostic criteria for IIH aged &gt;18 years who were diagnosed or managed at AKUHN from January 2011 to December 2022.</div></div><div><h3>Results</h3><div>We identified 152 patients: female-to-male ratio was 9:1, mean age 34.2 years. Mean body mass index (BMI) was 31.2 kgs/m2. Almost a third (32.2 %) had compromised vision at presentation in at least one eye. None had other medical comorbidities to precipitate IIH. H2O. 80.2 % had brain MRI, of which 78.4 % had ancillary IIH findings on imaging. Median cerebrospinal fluid opening pressure was 31 cm. Treatment was acetazolamide alone in 44 %, topiramate alone in 15 %, and combined in 30 %. 9.8 % were referred for neurosurgical evaluation, mainly due to refractory symptoms or intolerance/contraindications to medical therapy. Only 49.3 % had symptom improvement at one year. 52.6 % did not have a formal documented weight loss plan. Mean BMI at one year was 30.9 kg/m².</div></div><div><h3>Conclusion</h3><div>Our study describes the first cohort of IIH patients from the East Africa region. Demographics are concordant with those reported internationally. However, our patients failed to lose weight, and emphasizes the need to formally incorporate weight loss plans (diet and exercise) in IIH care.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"41 ","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-stroke fatigue and its consequences in young adults: The Norwegian Stroke in the Young Study II","authors":"Mohamad Farah ,&nbsp;Beenish Nawaz ,&nbsp;Annette Fromm ,&nbsp;Sahrai Saeed ,&nbsp;Nicolas Martinez-Majander ,&nbsp;Jukka Putaala ,&nbsp;Ulrike Waje-Andreassen ,&nbsp;Halvor Næss","doi":"10.1016/j.ensci.2025.100593","DOIUrl":"10.1016/j.ensci.2025.100593","url":null,"abstract":"<div><h3>Background</h3><div>Fatigue is a prevalent and disabling consequence of ischemic stroke in young adults, yet its multifactorial nature and impact on recovery remain underexplored. This study investigates predictors of post-stroke fatigue and association with return to work (RTW) and other variables at a one-year follow-up (1y-FU) after ischemic stroke.</div></div><div><h3>Methods</h3><div>We analysed data from 130 patients aged 15–49 years with MRI-confirmed acute ischemic stroke enrolled in the Norwegian Stroke in Young Study II. Fatigue and cognitive symptoms were assessed using standardized self-report and clinical evaluations at 1y-FU. Multivariable logistic regression identified independent predictors of persistent fatigue, adjusting for age, sex, and stroke severity.</div></div><div><h3>Results</h3><div>At 1y-FU, 50 % of patients reported persistent fatigue. Fatigue was independently associated with failure to RTW (OR 3.2, 95 % CI 1.8–5.6), migraine without aura (OR 2.1, 95 % CI 1.3–3.4), hearing difficulties (OR 2.0, 95 % CI 1.1–3.8), concentration problems (OR 2.4, 95 % CI 1.5–4.0), and pain (OR 2.6, 95 % CI 1.5–4.5). Patients with resolved fatigue were significantly more likely to RTW (65.9 %) compared to those with persistent symptoms (34.2 %, <em>p</em> &lt; 0.001). Cognitive impairment at admission was common (45.9 %), and among these patients, 52.2 % reported persistent deficits at 1y-FU. Fatigue severity was not associated with educational attainment but increased with age and NIHSS score.</div></div><div><h3>Conclusions</h3><div>Fatigue affects half of young ischemic stroke survivors after 1 year, substantially hindering RTW. Novel associations with migraine, hearing and cognitive deficits, and pain suggest underrecognized contributors that may be amenable to individually targeted rehabilitation. Integration of fatigue management into early stroke rehabilitation programs, with a focus on cognitive, sensory, and pain-related domains, may help optimize vocational and functional outcomes.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"41 ","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recreational nitrous oxide abuse and myeloneuropathy among Vietnamese youth: A descriptive study of 35 cases","authors":"Duc Nguyen Dang ,&nbsp;Anh Lam Nguyen Hong ,&nbsp;Bach Nguyen Dang","doi":"10.1016/j.ensci.2025.100588","DOIUrl":"10.1016/j.ensci.2025.100588","url":null,"abstract":"<div><h3>Background</h3><div>Nitrous oxide (N₂O) misuse has become increasingly prevalent among young adults in Vietnam, with growing reports of neurological complications.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 35 patients with N₂O-induced neurotoxicity admitted to Bach Mai Hospital from 2022 to 2024.</div></div><div><h3>Results</h3><div>Patients were mostly female (65.7 %), median age 22, with students and office workers being the predominant occupations. Neurological symptoms included paresthesias (88.6 %), weakness (82.9 %), and unsteadiness (77.1 %). MRI revealed dorsal column lesions in 60 %. All patients received B12 therapy. Full recovery occurred in 91.4 %; 8.6 % had mild persistent symptoms.</div></div><div><h3>Conclusions</h3><div>N₂O misuse is an emerging threat in Vietnam. Despite favorable treatment outcomes, prevention through public education and policy is essential. Our findings contribute important local data to support future regulation and health promotion efforts.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"41 ","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}