eNeurologicalSci最新文献

Corrigendum to “Oral minocycline therapy as first-line treatment in patients with Myalgic encephalomyelitis and long COVID: A pilot study” [eNeurologicalSci 38 (2025) 100537].

eNeurologicalSci Pub Date : 2025-03-01 DOI: 10.1016/j.ensci.2025.100557

Kunihisa Miwa

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Erratum regarding missing consent statements in previously published articles

eNeurologicalSci Pub Date : 2025-03-01 DOI: 10.1016/j.ensci.2025.100556

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Erratum regarding missing conflict of interests statements in previously published articles

eNeurologicalSci Pub Date : 2025-03-01 DOI: 10.1016/j.ensci.2025.100555

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Cutting-edge stroke prevention strategies

eNeurologicalSci Pub Date : 2025-02-17 DOI: 10.1016/j.ensci.2025.100561

Lisa Kaindl , Julian Frederic Hotz , Julia Ferrari

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Anemia and outcome of patients with ischemic stroke in a referral hospital in Cameroon

eNeurologicalSci Pub Date : 2025-02-14 DOI: 10.1016/j.ensci.2025.100560

Yacouba Njankouo Mapoure , Elodie Dorothée Ebogo Fouda , Daniel Gams Massi , Caroline Kenmegne , Bertrand Hugo Ngahane Mbatchou

{"title":"Anemia and outcome of patients with ischemic stroke in a referral hospital in Cameroon","authors":"Yacouba Njankouo Mapoure , Elodie Dorothée Ebogo Fouda , Daniel Gams Massi , Caroline Kenmegne , Bertrand Hugo Ngahane Mbatchou","doi":"10.1016/j.ensci.2025.100560","DOIUrl":"10.1016/j.ensci.2025.100560","url":null,"abstract":"<div><h3>Background</h3><div>Stroke and anemia are major public health concerns in Sub-Saharan Africa. However, few data are available on anemia and acute ischemic stroke in our setting.</div></div><div><h3>Purpose</h3><div>To assess the impact of anemia on the outcome of patients with ischemic stroke.</div></div><div><h3>Methods</h3><div>We collected retrospectively data of patients >15 years hospitalized for ischemic stroke at the Douala General Hospital over a period of 9 years, in whom full blood count was done. Anemia was classified as mild, moderate and severe. Multivariate analysis was used to determine predictive factors of poor outcome at 3 months (mortality and poor functional recovery) in ischemic stroke patients with anemia.</div></div><div><h3>Results</h3><div>A total of 691 patients (male, 53.3 %) male were included. Anemia was found in 44.4 % of cases (severe anemia, 10.4 %). Severe anemia was significantly associated with poor functional recovery at 3 months (OR:4.43, 95 %CI:1.02–12.24, <em>p</em> = 0.04). We found no difference in mortality at 3 months between patients with (4.6 %, <em>n</em> = 14) and without (3.9 %, <em>n</em> = 15) anemia (OR:1.48, 95 %CI:0.69–3.14, <em>p</em> = 0.330). Age > 60 years, diastolic blood pressure > 90 mmHg, NIHSS score ≥ 15, and INR > 1.2 were predictive factors of mortality at 3 months in ischemic stroke patients with anemia.</div></div><div><h3>Conclusion</h3><div>Anemia is common in ischemic stroke cases and must be systematically screened.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100560"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent developments in consensus diagnostic criteria for amyotrophic lateral sclerosis

eNeurologicalSci Pub Date : 2025-02-01 DOI: 10.1016/j.ensci.2025.100559

Matthew C. Kiernan

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Recognizing familial Huntington's disease in an Asian cohort: Insights from the Philippines

eNeurologicalSci Pub Date : 2025-01-26 DOI: 10.1016/j.ensci.2025.100558

Jao Jarro B. Garcia , Gilbert J. Cabataña Jr , Iris Ditan , Karl Josef Niño J. Separa , Ida Ingrid Rocha-Tulagan , Han-I Lin , Chin-Hsien Lin , Melanie Leigh D. Supnet-Wells , Alejandro F. Diaz , Arlene R. Ng , Roland Dominic G. Jamora , Gerard Saranza

{"title":"Recognizing familial Huntington's disease in an Asian cohort: Insights from the Philippines","authors":"Jao Jarro B. Garcia , Gilbert J. Cabataña Jr , Iris Ditan , Karl Josef Niño J. Separa , Ida Ingrid Rocha-Tulagan , Han-I Lin , Chin-Hsien Lin , Melanie Leigh D. Supnet-Wells , Alejandro F. Diaz , Arlene R. Ng , Roland Dominic G. Jamora , Gerard Saranza","doi":"10.1016/j.ensci.2025.100558","DOIUrl":"10.1016/j.ensci.2025.100558","url":null,"abstract":"<div><div>Huntington's Disease (HD) is an autosomal-dominant, neurodegenerative condition characterized by extrapyramidal, psychiatric, and cognitive disturbances. In the Philippines, only one genetically confirmed sporadic case had been previously reported. This study aims to present ten additional cases of genetically proven familial HD. All cases were of pure Filipino descent, aged 27–65. Six were males, and nine had at least one relative who manifested with the same symptomatology. The youngest age at onset was 21 years old. Nine initially manifested with chorea, whereas one manifested initially with behavioral change. At the time of consult, eight already had cognitive changes exemplified by memory lapses, while six also manifested behavioral or psychiatric disturbances. Workup revealed caudate atrophy in six and cerebral atrophy in five of the cases. All tested positive on genetic testing with the CAG trinucleotide spanning 41 to 53 repeats. The clinical profile of our patients did not differ from the known and published natural course of HD. To date, HD remains underrecognized in the Philippines. Although rare in Asian countries, it should still be a differential for a patient with chorea, cognitive decline, behavioral changes, and a strong family history of the same symptomatology.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Update in multiple sclerosis

eNeurologicalSci Pub Date : 2025-01-11 DOI: 10.1016/j.ensci.2025.100553

Bassem Yamout

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Bilateral optic neuritis as an atypical presentation of juvenile Behcet syndrome: A case report

eNeurologicalSci Pub Date : 2025-01-10 DOI: 10.1016/j.ensci.2025.100554

Armin Adibi , Iman Adibi , Saeed Bahramian , Saba Naghavi , Fatemeh Gholami

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Early diagnosis of cryptococcal meningoencephalitis in HIV-negative patients: Integration of brain MRI and clinical findings

eNeurologicalSci Pub Date : 2025-01-09 DOI: 10.1016/j.ensci.2025.100552

Kosei Nakamura, Masato Kanazawa, Yuka Koike, Takuya Konno, Osamu Onodera

{"title":"Early diagnosis of cryptococcal meningoencephalitis in HIV-negative patients: Integration of brain MRI and clinical findings","authors":"Kosei Nakamura, Masato Kanazawa, Yuka Koike, Takuya Konno, Osamu Onodera","doi":"10.1016/j.ensci.2025.100552","DOIUrl":"10.1016/j.ensci.2025.100552","url":null,"abstract":"<div><h3>Purpose</h3><div>Cryptococcal meningoencephalitis (CM) in human immunodeficiency virus (HIV)-negative patients are often diagnosed later than in HIV-infected patients, which increases mortality rates concerning the former. Consequently, early diagnosis and treatment are crucial for improving clinical prognosis in HIV-negative patients. This study investigated the utility of magnetic resonance imaging (MRI) in combination with clinical and laboratory findings for early diagnosis of CM in HIV-negative patients.</div></div><div><h3>Methods</h3><div>This retrospective cohort analysis included consecutive patients diagnosed with central nervous system (CNS) infections. Demographic profiles, laboratory findings, admission symptoms, and MRI findings were assessed. A comparative analysis between CM and other CNS infections was performed.</div></div><div><h3>Results</h3><div>Twelve HIV-negative patients were diagnosed with CM, while 38 exhibited other CNS infections (two fungal, 23 bacterial, 12 viral, one parasitic). Pseudocysts on MRI (<em>p</em> = 0.002), absence of fever (<em>p</em> = 0.001), headache (<em>p</em> = 0.005), and normal C-reactive protein (CRP) levels (<em>p</em> = 0.020) were specific findings in CM. By applying a cut-off value of one point in combination of pseudocysts, absence of fever, headache, and normal CRP levels in differentiating CM from other CNS infections, the sensitivity and specificity were calculated as 76.3 % and 91.7 %, respectively.</div></div><div><h3>Conclusion</h3><div>Integrating pseudocysts, absence of fever, headache, and normal CRP levels predicts early CM diagnosis, potentially improving outcomes.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100552"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0