Recreational nitrous oxide abuse and myeloneuropathy among Vietnamese youth: A descriptive study of 35 cases

Q3 Neuroscience

eNeurologicalSci Pub Date : 2025-09-13 DOI:10.1016/j.ensci.2025.100588

Duc Nguyen Dang , Anh Lam Nguyen Hong , Bach Nguyen Dang

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引用次数: 0

Abstract

Background

Nitrous oxide (N₂O) misuse has become increasingly prevalent among young adults in Vietnam, with growing reports of neurological complications.

Methods

We conducted a retrospective analysis of 35 patients with N₂O-induced neurotoxicity admitted to Bach Mai Hospital from 2022 to 2024.

Results

Patients were mostly female (65.7 %), median age 22, with students and office workers being the predominant occupations. Neurological symptoms included paresthesias (88.6 %), weakness (82.9 %), and unsteadiness (77.1 %). MRI revealed dorsal column lesions in 60 %. All patients received B12 therapy. Full recovery occurred in 91.4 %; 8.6 % had mild persistent symptoms.

Conclusions

N₂O misuse is an emerging threat in Vietnam. Despite favorable treatment outcomes, prevention through public education and policy is essential. Our findings contribute important local data to support future regulation and health promotion efforts.

查看原文本刊更多论文

娱乐性一氧化二氮滥用和脊髓神经病在越南青年：一个描述性研究35例

一氧化二氮（N₂O）滥用在越南年轻人中越来越普遍，神经系统并发症的报道也越来越多。方法回顾性分析巴赫迈医院2022 ~ 2024年收治的35例n2致神经毒性患者。结果患者以女性为主（65.7%），年龄中位数为22岁，以学生和上班族为主。神经系统症状包括感觉异常（88.6%）、虚弱（82.9%）和不稳定（77.1%）。MRI显示60%为背柱病变。所有患者均接受B12治疗。全回收率为91.4%；8.6%有轻度持续性症状。结论在越南，滥用二氧化硫是一个新出现的威胁。尽管治疗效果良好，但通过公共教育和政策进行预防至关重要。我们的发现为支持未来的监管和健康促进工作提供了重要的本地数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

期刊介绍： eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.