阿尔茨海默病心血管危险因素的Meta - Meta分析

Q3 Neuroscience

eNeurologicalSci Pub Date : 2025-10-04 DOI:10.1016/j.ensci.2025.100590

Olalla Saiz-Vazquez , Silvia Ubillos-Landa , Alicia Puente-Martínez

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引用次数: 0

摘要

背景：阿尔茨海默病（AD）是老年痴呆症最常见的病因。确定阿尔茨海默病的一些心血管危险因素可能对初级预防至关重要，有助于减少阿尔茨海默病的发病率。目的：我们旨在对3项研究进行meta-meta分析，以评估胆固醇、血压和卒中对AD诊断的影响。方法：研究仅限于最近三年的荟萃分析，评估胆固醇、血压、中风和阿尔茨海默病。我们应用了PRISMA指南。结果胆固醇对阿尔茨海默病风险的总影响具有显著性和异质性。亚组分析显示LDL-C水平影响AD的发展。收缩压高与AD有关。对参数（性别、年龄、研究设计、地区和血压测量）的探索表明，只有地区显著调节了血压和AD之间的关系。结果显示缺血性卒中（IS）、出血性卒中（HS）和微梗死（MI）与AD的风险有显著相关性。结论心血管疾病相关的危险因素增加了AD的发病风险。此外，调节分析支持我们的结果的稳健性。因此，未来的研究应该使用其他不受控制的因素，如糖尿病，来解释这些变量之间的关系。

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Meta meta-analysis of cardiovascular risk factors in Alzheimer's disease

Background

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Identifying some of the cardiovascular risk factors for AD could be crucial for primary prevention and help reduce the incidence of AD. Objective: We aimed to perform a meta-meta-analysis of 3 studies to assess the effect of cholesterol, blood pressure and stroke on diagnosis of AD.

Methods

The search was restricted to meta-analyses in the last three years assessing cholesterol, blood pressure, stroke and Alzheimer's disease. We applied the PRISMA guidelines.

Results

The total effect of cholesterol on risk of AD was significant and heterogeneous. Subgroup analysis shows that LDL-C levels influence the development of AD. High SBP is associated with AD. The exploration of parameters (sex, age, study design, region, and BP measurements) shows that only region significantly moderates the relationship between BP and AD. Results report significant association between ischemic stroke (IS), hemorrhagic stroke (HS) and microinfarcts (MI) with the risk of AD.

Conclusions

These results strengthen the evidence that the risk factors related to cardiovascular diseases increase risk for AD. Moreover, moderator analysis supports the robustness of our results. Therefore, future studies should use other uncontrolled factors, such as diabetes, to explain the relationship between these variables.

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来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

期刊介绍： eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.