帕金森病患者使用抗帕金森药物调节条件疼痛的变化

Q3 Neuroscience

eNeurologicalSci Pub Date : 2025-07-14 DOI:10.1016/j.ensci.2025.100574

Eiichirou Urasaki , Yasushi Miyagi , Junji Kishimoto

{"title":"帕金森病患者使用抗帕金森药物调节条件疼痛的变化","authors":"Eiichirou Urasaki , Yasushi Miyagi , Junji Kishimoto","doi":"10.1016/j.ensci.2025.100574","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with Parkinson's disease (PD) highly complain of pain, probably due to the lowered pain threshold caused by dopamine deficiency. Nonetheless, only a few studies have investigated the effects of anti-PD medications on “pain inhibits pain” ability. This study aimed to evaluate conditioned pain modulation (CPM) using the cutaneous silent period (CSP) and the numerical rating scale (NRS) and to investigate the effect of anti-PD medications on CPM.</div></div><div><h3>Materials and methods</h3><div>The CSP was recorded in 40 patients with PD under drug-on and drug-off conditions. Changes in the CSP elicited by electrical test stimulation and in the NRS when the patients experienced pain with cold pressure as a conditioned stimulus were assessed. A shortened CSP duration or reduced CSP score due to cold pressure were interpreted as objective CPM responses.</div></div><div><h3>Results</h3><div>The CSP latency was analyzed in 22 patients when the electromyographic contamination in the CSP waveform was low. The CSP duration shortening during cold pressure was significantly greater under the drug-on condition than under the drug-off condition. The change in CSP duration exhibited a significant correlation with the change in the NRS scores. CSP score analysis was performed on 18 patients in whom latency analysis was difficult owing to electromyographic contamination. In the drug-on state, conditioned cold-pressure pain significantly decreased the CSP score.</div></div><div><h3>Conclusions</h3><div>Dynamic changes in the CSP caused by cold pressure in patients with PD suggest that anti-PD medications may enhance CPM ability.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100574"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes in conditioned pain modulation using anti-Parkinson drugs in patients with Parkinson's disease\",\"authors\":\"Eiichirou Urasaki , Yasushi Miyagi , Junji Kishimoto\",\"doi\":\"10.1016/j.ensci.2025.100574\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Patients with Parkinson's disease (PD) highly complain of pain, probably due to the lowered pain threshold caused by dopamine deficiency. Nonetheless, only a few studies have investigated the effects of anti-PD medications on “pain inhibits pain” ability. This study aimed to evaluate conditioned pain modulation (CPM) using the cutaneous silent period (CSP) and the numerical rating scale (NRS) and to investigate the effect of anti-PD medications on CPM.</div></div><div><h3>Materials and methods</h3><div>The CSP was recorded in 40 patients with PD under drug-on and drug-off conditions. Changes in the CSP elicited by electrical test stimulation and in the NRS when the patients experienced pain with cold pressure as a conditioned stimulus were assessed. A shortened CSP duration or reduced CSP score due to cold pressure were interpreted as objective CPM responses.</div></div><div><h3>Results</h3><div>The CSP latency was analyzed in 22 patients when the electromyographic contamination in the CSP waveform was low. The CSP duration shortening during cold pressure was significantly greater under the drug-on condition than under the drug-off condition. The change in CSP duration exhibited a significant correlation with the change in the NRS scores. CSP score analysis was performed on 18 patients in whom latency analysis was difficult owing to electromyographic contamination. In the drug-on state, conditioned cold-pressure pain significantly decreased the CSP score.</div></div><div><h3>Conclusions</h3><div>Dynamic changes in the CSP caused by cold pressure in patients with PD suggest that anti-PD medications may enhance CPM ability.</div></div>\",\"PeriodicalId\":37974,\"journal\":{\"name\":\"eNeurologicalSci\",\"volume\":\"40 \",\"pages\":\"Article 100574\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"eNeurologicalSci\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405650225000280\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"eNeurologicalSci","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405650225000280","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}

引用次数: 0

摘要

目的帕金森病（PD）患者对疼痛的主诉较多，可能与多巴胺缺乏引起的痛觉阈降低有关。然而，只有少数研究调查了抗pd药物对“疼痛抑制疼痛”能力的影响。本研究旨在通过皮肤沉默期（CSP）和数值评定量表（NRS）评估条件疼痛调节（CPM），并探讨抗pd药物对CPM的影响。材料与方法记录40例PD患者在开、停药状态下的CSP。评估了电测试刺激引起的CSP变化，以及当患者经历冷压疼痛作为条件刺激时NRS的变化。冷压导致的CSP持续时间缩短或CSP评分降低被解释为客观CPM反应。结果分析22例CSP波形中肌电图污染较低时的CSP潜伏期。冷压条件下，有药组CSP持续时间缩短明显大于无药组。CSP持续时间的变化与NRS评分的变化呈显著相关。对18例因肌电图污染而难以进行潜伏期分析的患者进行CSP评分分析。在药物状态下，条件冷压疼痛显著降低CSP评分。结论PD患者冷压引起的CSP动态变化提示抗PD药物可增强CPM能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Changes in conditioned pain modulation using anti-Parkinson drugs in patients with Parkinson's disease

查看原文本刊更多论文

Changes in conditioned pain modulation using anti-Parkinson drugs in patients with Parkinson's disease

Objectives

Patients with Parkinson's disease (PD) highly complain of pain, probably due to the lowered pain threshold caused by dopamine deficiency. Nonetheless, only a few studies have investigated the effects of anti-PD medications on “pain inhibits pain” ability. This study aimed to evaluate conditioned pain modulation (CPM) using the cutaneous silent period (CSP) and the numerical rating scale (NRS) and to investigate the effect of anti-PD medications on CPM.

Materials and methods

The CSP was recorded in 40 patients with PD under drug-on and drug-off conditions. Changes in the CSP elicited by electrical test stimulation and in the NRS when the patients experienced pain with cold pressure as a conditioned stimulus were assessed. A shortened CSP duration or reduced CSP score due to cold pressure were interpreted as objective CPM responses.

Results

The CSP latency was analyzed in 22 patients when the electromyographic contamination in the CSP waveform was low. The CSP duration shortening during cold pressure was significantly greater under the drug-on condition than under the drug-off condition. The change in CSP duration exhibited a significant correlation with the change in the NRS scores. CSP score analysis was performed on 18 patients in whom latency analysis was difficult owing to electromyographic contamination. In the drug-on state, conditioned cold-pressure pain significantly decreased the CSP score.

Conclusions

Dynamic changes in the CSP caused by cold pressure in patients with PD suggest that anti-PD medications may enhance CPM ability.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

期刊介绍： eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.