新生儿脑脓肿手术引流的经验:病人系列及文献回顾

Q3 Neuroscience
Sunil Kumar , Pradeep Kumar , Vivek Sanker , Savvy Aujla , Kanika Handu , Riya Mary Richard , S. Gayathri , Tirth Dave
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引用次数: 0

摘要

背景新生儿脑脓肿是一种局灶性脑内感染,虽然在新生儿中罕见,但与高死亡率和长期并发症相关。在新生儿中,它主要作为新生儿败血症和脑膜炎的并发症发生。本病例系列报告了3例新生儿脑脓肿病例,患儿表现为发热和其他症状,接受了抗生素、手术疏散和预防性抗癫痫治疗。治疗后,所有婴儿均表现出明显的放射学改善和脓肿大小缩小。此外,脓液培养、血培养和脑脊液分析报告具有典型性。尽管病情严重,但这三个婴儿都恢复得很好,并达到了适当的发育里程碑。观察:新生儿出现败血症或脑膜炎、发热、营养不良、癫痫发作或虽经治疗仍健康状况恶化时,应怀疑存在新生儿脑脓肿。最常见的是由革兰氏阴性菌引起的。然而,在许多情况下,如我们的3例,无菌液体可以从脑脓肿中抽吸,这被认为是一个很好的预后因素。结论早期诊断临床疑点较高的新生儿脑脓肿,及时应用敏感抗生素及神经外科干预可改善预后,减少并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experience with surgical evacuation of neonatal brain abscess: A patient series and review of literature

Background

Neonatal brain abscess is a focal intracerebral infection that, although rare in neonates, is associated with high mortality rates and long-term complications. In neonates, it mainly occurs as a complication of neonatal sepsis and meningitis. This case series reports three cases of neonatal brain abscesses involving infants who presented with fever and other symptoms and were treated with antibiotics, surgical evacuation, and prophylactic anti-epileptic treatment. Following treatment, all infants showed marked radiological improvement and reduced abscess size. In addition, pus culture, blood culture, and CSF analysis reports were typical. Despite the severe nature of the condition, all three infants recovered well and achieved appropriate developmental milestones.

Observations

Neonatal brain abscess should be suspected in neonates with sepsis or meningitis developing fever, poor feeding, seizures, or general deterioration of health despite treatment. It is most commonly caused by gram-negative bacteria. However, in many instances, like in our 3 cases, sterile fluid may be aspirated from a brain abscess, which is considered a good prognostic factor.

Lessons

Early diagnosis of neonatal brain abscess with high clinical suspicion use of neuroradiological imaging and prompt treatment with sensitive antibiotics and neurosurgical interventions can improve the prognosis and reduce its complications.
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来源期刊
eNeurologicalSci
eNeurologicalSci Neuroscience-Neurology
CiteScore
3.50
自引率
0.00%
发文量
45
审稿时长
62 days
期刊介绍: eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.
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