eNeurologicalSci最新文献_第3页

Internal jugular vein compression: A benign entity or an underappreciated phenomenon? 颈内静脉压迫：是良性的还是被忽视的现象？

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1016/j.ensci.2025.100577

Paul Francis Greene

引用次数: 0

Anna GALSTYAN the first Armenian female neurosurgeon Anna GALSTYAN亚美尼亚第一位女性神经外科医生

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-05-20 DOI: 10.1016/j.ensci.2025.100569

Keyvan Mostofi

引用次数: 0

Changes in conditioned pain modulation using anti-Parkinson drugs in patients with Parkinson's disease 帕金森病患者使用抗帕金森药物调节条件疼痛的变化

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI: 10.1016/j.ensci.2025.100574

Eiichirou Urasaki , Yasushi Miyagi , Junji Kishimoto

{"title":"Changes in conditioned pain modulation using anti-Parkinson drugs in patients with Parkinson's disease","authors":"Eiichirou Urasaki , Yasushi Miyagi , Junji Kishimoto","doi":"10.1016/j.ensci.2025.100574","DOIUrl":"10.1016/j.ensci.2025.100574","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with Parkinson's disease (PD) highly complain of pain, probably due to the lowered pain threshold caused by dopamine deficiency. Nonetheless, only a few studies have investigated the effects of anti-PD medications on “pain inhibits pain” ability. This study aimed to evaluate conditioned pain modulation (CPM) using the cutaneous silent period (CSP) and the numerical rating scale (NRS) and to investigate the effect of anti-PD medications on CPM.</div></div><div><h3>Materials and methods</h3><div>The CSP was recorded in 40 patients with PD under drug-on and drug-off conditions. Changes in the CSP elicited by electrical test stimulation and in the NRS when the patients experienced pain with cold pressure as a conditioned stimulus were assessed. A shortened CSP duration or reduced CSP score due to cold pressure were interpreted as objective CPM responses.</div></div><div><h3>Results</h3><div>The CSP latency was analyzed in 22 patients when the electromyographic contamination in the CSP waveform was low. The CSP duration shortening during cold pressure was significantly greater under the drug-on condition than under the drug-off condition. The change in CSP duration exhibited a significant correlation with the change in the NRS scores. CSP score analysis was performed on 18 patients in whom latency analysis was difficult owing to electromyographic contamination. In the drug-on state, conditioned cold-pressure pain significantly decreased the CSP score.</div></div><div><h3>Conclusions</h3><div>Dynamic changes in the CSP caused by cold pressure in patients with PD suggest that anti-PD medications may enhance CPM ability.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupil response as a window into cognitive processing in amyotrophic lateral sclerosis 瞳孔反应是肌萎缩性侧索硬化症认知过程的一个窗口

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI: 10.1016/j.ensci.2025.100575

Mohamad El Haj , Souheil Hallit , Claire Boutoleau-Bretonnière

{"title":"Pupil response as a window into cognitive processing in amyotrophic lateral sclerosis","authors":"Mohamad El Haj , Souheil Hallit , Claire Boutoleau-Bretonnière","doi":"10.1016/j.ensci.2025.100575","DOIUrl":"10.1016/j.ensci.2025.100575","url":null,"abstract":"<div><h3>Purpose</h3><div>This preliminary study aimed to investigate whether the pupil size reflects cognitive load in patients with amyotrophic lateral sclerosis (ALS).</div></div><div><h3>Methods</h3><div>Pupil activity was monitored in three patients with ALS and a group of healthy control participants (<em>n</em> = 16) while performing three tasks: a forward span task, a backward span task, and a control task involving counting aloud. These tasks were designed to impose increasing cognitive demands, with the backward span task being the most challenging.</div></div><div><h3>Results</h3><div>Analysis revealed no significant difference in pupil size between patients with ALS and controls for the forward or backward spans or the control condition. Both groups demonstrated a consistent pattern of increased pupil size during the backward span task compared to the forward span task, and during the forward span task compared to the control condition.</div></div><div><h3>Conclusion</h3><div>These findings suggest that pupil dilation reflects task-related cognitive load similarly in ALS patients and healthy controls. This supports the use of pupillometry as a non-invasive and sensitive marker of cognitive processing in ALS.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100575"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience with surgical evacuation of neonatal brain abscess: A patient series and review of literature 新生儿脑脓肿手术引流的经验：病人系列及文献回顾

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-06-03 DOI: 10.1016/j.ensci.2025.100572

Sunil Kumar , Pradeep Kumar , Vivek Sanker , Savvy Aujla , Kanika Handu , Riya Mary Richard , S. Gayathri , Tirth Dave

{"title":"Experience with surgical evacuation of neonatal brain abscess: A patient series and review of literature","authors":"Sunil Kumar , Pradeep Kumar , Vivek Sanker , Savvy Aujla , Kanika Handu , Riya Mary Richard , S. Gayathri , Tirth Dave","doi":"10.1016/j.ensci.2025.100572","DOIUrl":"10.1016/j.ensci.2025.100572","url":null,"abstract":"<div><h3>Background</h3><div>Neonatal brain abscess is a focal intracerebral infection that, although rare in neonates, is associated with high mortality rates and long-term complications. In neonates, it mainly occurs as a complication of neonatal sepsis and meningitis. This case series reports three cases of neonatal brain abscesses involving infants who presented with fever and other symptoms and were treated with antibiotics, surgical evacuation, and prophylactic anti-epileptic treatment. Following treatment, all infants showed marked radiological improvement and reduced abscess size. In addition, pus culture, blood culture, and CSF analysis reports were typical. Despite the severe nature of the condition, all three infants recovered well and achieved appropriate developmental milestones.</div></div><div><h3>Observations</h3><div>Neonatal brain abscess should be suspected in neonates with sepsis or meningitis developing fever, poor feeding, seizures, or general deterioration of health despite treatment. It is most commonly caused by gram-negative bacteria. However, in many instances, like in our 3 cases, sterile fluid may be aspirated from a brain abscess, which is considered a good prognostic factor.</div></div><div><h3>Lessons</h3><div>Early diagnosis of neonatal brain abscess with high clinical suspicion use of neuroradiological imaging and prompt treatment with sensitive antibiotics and neurosurgical interventions can improve the prognosis and reduce its complications.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100572"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FXTAS presenting with cervical dystonia as the initial symptom: Considering FXTAS in the clinical evaluation of cervical dystonia FXTAS以宫颈张力障碍为首发症状：考虑FXTAS在宫颈张力障碍临床评价中的作用

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1016/j.ensci.2025.100578

Homare Funasaka, Serika Kanazawa, Sachiko Kamada

{"title":"FXTAS presenting with cervical dystonia as the initial symptom: Considering FXTAS in the clinical evaluation of cervical dystonia","authors":"Homare Funasaka, Serika Kanazawa, Sachiko Kamada","doi":"10.1016/j.ensci.2025.100578","DOIUrl":"10.1016/j.ensci.2025.100578","url":null,"abstract":"<div><div>FXTAS (Fragile X-associated tremor/ataxia syndrome) is characterized by typical clinical features, including tremor, cerebellar ataxia, parkinsonism, and the middle cerebellar peduncle (MCP) sign, which appears as T2 hyperintensity in the MCP on MRI. FXTAS is almost never considered in the context of cervical dystonia. However, this case demonstrates that FXTAS can initially present with cervical dystonia.</div><div>A 59-year-old man presented with cervical dystonia, characterized by right lateral flexion, and sensory trick. His initial symptom was cervical tilt at age 54. At age 55, the patient developed an unsteady gait. The patient was unable to perform a tandem gait and stand up from a crouch, suggesting trunk ataxia, and exhibited lateral gaze nystagmus, which was indicative of a cerebellar disorder. MRI revealed MCP sign. Genetic testing confirmed FXTAS, revealing 90 CGG repeats in the <em>FMR 1</em> (Fragile X Mental Retardation 1) gene.</div><div>Notably, a pre-symptomatic MRI, incidentally acquired at the age of 52, retrospectively revealed the presence of the MCP sign. This suggests that, even when FXTAS initially presents as cervical dystonia, the MCP sign can remain a reliable diagnostic feature for early detection.</div><div>This case highlights that early FXTAS may mimic idiopathic cervical dystonia and that considering FXTAS during the clinical evaluation of cervical dystonia can enable early diagnosis.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100578"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neuroinfectious diseases profile in a specialist neurology centre in South Africa 南非某神经病学专科中心的神经传染病概况

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.ensci.2025.100581

Katryn Oosthuizen , Suzaan Marais

{"title":"The Neuroinfectious diseases profile in a specialist neurology centre in South Africa","authors":"Katryn Oosthuizen , Suzaan Marais","doi":"10.1016/j.ensci.2025.100581","DOIUrl":"10.1016/j.ensci.2025.100581","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the burden of neuroinfectious diseases and describe the causes and presentation of neurological infections to a tertiary level hospital neurology service in South Africa.</div></div><div><h3>Methods</h3><div>A retrospective electronic search of medical discharge records was conducted for adult patients admitted to the neurology ward over a two-year period, and patients with neuroinfectious diseases were identified. Diagnostic criteria were applied to classify patients according to the certainty of their neuroinfectious disease diagnosis.</div></div><div><h3>Results</h3><div>Neuroinfectious diseases accounted for 15 % of the 802 admissions to the neurology ward. The most common infectious aetiologies were tuberculosis (27 %), syphilis (21 %), neurological diseases related to human immunodeficiency virus (HIV) itself (19 %), and HIV-associated opportunistic infections (10 %). Diagnostic challenges were observed, with only 17 % of cases having a definite diagnosis. The majority of patients with neuroinfectious diseases were young, with a median age of 38 years (IQR: 32–46), and 56 % were HIV-positive. Morbidity was high, with prolonged hospitalisation (>2 weeks) and limited full recovery at discharge in 56 % and 98 % of patients, respectively.</div></div><div><h3>Conclusions</h3><div>This study provides important insights into the burden and characteristics of neuroinfectious diseases encountered at an inpatient South African neurology service. The findings highlight the need for increased investment in primary care prevention and treatment of HIV, TB and syphilis − before patients require hospital admission or develop neurological pathology.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100581"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CANOMAD mimicking anti-MAG/SGPG neuropathy: A case highlighting the diagnostic specificity of ophthalmoplegia and cold agglutination CANOMAD模拟抗mag /SGPG神经病变：1例突出眼麻痹和冷凝集的诊断特异性

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1016/j.ensci.2025.100580

Homare Funasaka , Akira Hanazono , Koh Abe , Takaya Yamashita , Hinako Shimada , Keita Yasuda , Yoshiko Takahashi , Yui Sanpei , Masashiro Sugawara

{"title":"CANOMAD mimicking anti-MAG/SGPG neuropathy: A case highlighting the diagnostic specificity of ophthalmoplegia and cold agglutination","authors":"Homare Funasaka , Akira Hanazono , Koh Abe , Takaya Yamashita , Hinako Shimada , Keita Yasuda , Yoshiko Takahashi , Yui Sanpei , Masashiro Sugawara","doi":"10.1016/j.ensci.2025.100580","DOIUrl":"10.1016/j.ensci.2025.100580","url":null,"abstract":"<div><div>Anti-myelin-associated glycoprotein/sulfated glucuronyl paragloboside (MAG/SGPG) neuropathy is a major differential diagnosis for sensory ataxic neuropathy with IgM κ type M proteinemia. Alternatively and less commonly, an important differential diagnosis for chronic sensory ataxic neuropathy with IgM κ type M proteinemia is chronic ataxic neuropathy with ophthalmoplegia, M proteinemia, cold agglutinins, and disialosyl antibodies (CANOMAD), which has been reported to respond to therapies such as intravenous immunoglobulin (IVIg). Confusingly, this case tested positive for anti-SGPG antibodies despite CANOMAD.</div><div>A 68-year-old man had sensory ataxia, IgM κ type M protein, prolongation of distal latency without conduction block, and was positive for anti-SGPG IgM antibodies, which could be the misdiagnosis of anti-MAG/SGPG neuropathy. However, the patient had ptosis, binocular diplopia, cold agglutination, and anti-GQ1b IgM antibodies, fulfilling all the key features of CANOMAD. Consistently, IVIg therapy improved both clinical symptoms and electrophysiological findings. After that, anti-MAG antibody testing returned negative results.</div><div>Here, we report a case of CANOMAD with the presence of misleading anti-SGPG antibodies, revealing the risk of misdiagnosis because of reliance on anti-SGPG antibodies in the diagnosis of sensory ataxic neuropathy. The present case also emphasized that ocular symptoms (ptosis, binocular diplopia), and cold agglutination were more specific keys to the initial diagnosis of CANOMAD. The accurate diagnosis of CANOMAD may benefit patients by enabling appropriate treatment selection.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100580"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elizabethkingia meningoseptica infection in a geriatric patient with other recurrent bacterial infections 老年患者伊莉莎白氏脑膜炎败血症感染伴其他复发性细菌感染

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI: 10.1016/j.ensci.2025.100576

Luis Castañeda Pelaez , Jesús Eduardo Rojas Jaimes , Elsa Nuñez Infanzón , Delza Tárraga Gonzales , Sergio Ronceros Medrano

引用次数: 0

A case of fragile X-associated tremor/ataxia syndrome with superior cerebellar peduncle lesions 脆性x相关震颤/共济失调综合征伴小脑上足部病变1例

eNeurologicalSci Pub Date : 2025-09-01 Epub Date: 2025-05-25 DOI: 10.1016/j.ensci.2025.100571

Kunihiko Ishizawa , Kentaro Hashimoto , Hironori Oka , Takashi Sugawara , Masakuni Amari , Takeshi Kawarabayashi , Koichi Okamoto , Chisato Tamai , Jun Sone , Yoshio Ikeda , Masamitsu Takatama , Mikio Shoji

{"title":"A case of fragile X-associated tremor/ataxia syndrome with superior cerebellar peduncle lesions","authors":"Kunihiko Ishizawa , Kentaro Hashimoto , Hironori Oka , Takashi Sugawara , Masakuni Amari , Takeshi Kawarabayashi , Koichi Okamoto , Chisato Tamai , Jun Sone , Yoshio Ikeda , Masamitsu Takatama , Mikio Shoji","doi":"10.1016/j.ensci.2025.100571","DOIUrl":"10.1016/j.ensci.2025.100571","url":null,"abstract":"<div><div>Fragile X-associated tremor/ataxia syndrome is a neurodegenerative disorder affecting carriers of a premutation in the <em>FMR1</em> gene involving expansion of CGG repeats. We present the case of a 66-year-old man with fragile X-associated tremor/ataxia syndrome caused by a premutation of the <em>FMR1</em> gene with approximately 80–110 CGG repeats. He demonstrated progressive cognitive decline, dysarthria, truncal ataxia, and incoordination. Magnetic resonance imaging revealed prominent middle cerebellar peduncle and corpus callosum splenium signs, while skin biopsy showed p62-positive nuclear inclusion bodies. Genetic analysis showed no expansion of the <em>NOTCH2NLC</em> gene. The diagnosis of fragile X-associated tremor/ataxia syndrome was confirmed by the CGG repeats in the <em>FMR1</em> gene. We discovered new superior cerebellar peduncle and superior cerebellar peduncle decussation lesions in our case, suggesting the possibility of prominent and early magnetic resonance imaging lesions in fragile X-associated tremor/ataxia syndrome.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100571"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0