eNeurologicalSci最新文献

{"title":"Antecedent sedative use is independently associated with stroke occurrence among west Africans: Evidence from the SIREN case-control study","authors":"Ezinne O. Uvere ,&nbsp;Joshua Akinyemi ,&nbsp;Fred S. Sarfo ,&nbsp;Adekunle Fakunle ,&nbsp;Akinkunmi Paul Okekunle ,&nbsp;Onoja Akpa ,&nbsp;Albert Akpalu ,&nbsp;Kolawole Wahab ,&nbsp;Reginald Obiako ,&nbsp;Morenikeji Komolafe ,&nbsp;Lukman Owolabi ,&nbsp;Godwin O. Osaigbovo ,&nbsp;Godwin Ogbole ,&nbsp;Hemant K. Tiwari ,&nbsp;Carolyn Jenkins ,&nbsp;Samuel Olowookere ,&nbsp;Oyedunni Arulogun ,&nbsp;Josephine Akpalu ,&nbsp;Osahon J. Asowata ,&nbsp;Philip Ibinaiye ,&nbsp;Mayowa Owolabi","doi":"10.1016/j.ensci.2025.100573","DOIUrl":"10.1016/j.ensci.2025.100573","url":null,"abstract":"<div><h3>Background</h3><div>Several factors have been independently associated with stroke occurrence globally. However, the association between sedative use and stroke risk is yet to be established in West Africa.</div></div><div><h3>Objective</h3><div>To assess the association between sedatives and stroke among West Africans.</div></div><div><h3>Methods</h3><div>Adults aged ≥18 years with confirmed stroke as well as age- and sex-matched controls were enrolled into the Stroke Investigative Research and Education Network (SIREN) study. Sedative use was determined by retrospective assessment on the use of any type of sedative in the preceding year while stroke was confirmed with brain scan and clinical features. Univariate and multivariate analyses, using logistic regressions, were performed to establish associations between sedative use and stroke while adjusting for other stroke risk factors.</div></div><div><h3>Results</h3><div>A total of 7104 subjects (3553 stroke cases and 3551 stroke-free controls participated in this study. The mean age was 60.9 ± 0.78 among cases and 59.8 ± 11.44 years among controls (<em>p</em> &lt; 0.029). History of sedative use was more common in cases (7.7 %) compared to controls (4.3 %; <em>p</em> &lt; 0.001)<strong>.</strong> After adjusting for age, income &gt;$100, history of hypertension, diabetes, dyslipidaemia, tobacco &amp; alcohol use, physical inactivity, green leafy vegetable and meat consumption, sedative use was independently associated with stroke risk (aOR: 1.41; 95 %CI: 1.01–1.96; <em>p</em> &lt; 0.041). Sedative use was associated with higher odds of stroke among adults aged ≥50 years (aOR: 1.53; 95 %CI: 1.28–2.04; <em>p</em> &lt; 0.019).</div></div><div><h3>Conclusion</h3><div>Sedative use was independently associated with stroke risk among adults in West Africa. Its use requires further exploration and prospective study to address the emerging association with stroke occurrence.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"Article 100573"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report: The cerebral metabolic rate of oxygen evaluated by 15O positron emission tomography may predict the recovery of cortical deafness due to bilateral cerebral hemorrhage.","authors":"Kosuke Sasaki, Yasuaki Kokubo, Shinji Sato, Kohei Igarashi, Hiroyuki Chiba, Tsukasa Ito, Yukihiko Sonoda","doi":"10.1016/j.ensci.2025.100582","DOIUrl":"10.1016/j.ensci.2025.100582","url":null,"abstract":"<p><p>Cortical deafness is a rare central auditory disorder resulting in severe hearing loss. It is caused by bilateral damage to the auditory cortex, auditory radiation, or medial geniculate body. We herein report a case of cortical deafness recovery caused by left thalamic hemorrhage following right putaminal hemorrhage. The evaluation of the cerebral metabolic rate of oxygen (CMRO2) using 15O positron emission tomography (15O-PET) at the onset helped predict the functional outcomes. A CMRO2 evaluation using 15O-PET was valuable for predicting the outcome of cortical deafness. We should remain aware of the possibility of cortical deafness in stroke patients with bilateral temporal lobe lesions, basal ganglia lesions near auditory tracts, or brainstem lesions, including those with preexisting lesions.</p>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"40 ","pages":"100582"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphorylated TDP-43 and tau deposition around the tip of deep brain stimulation leads","authors":"Goichi Beck ,&nbsp;Yuki Yonenobu ,&nbsp;Kenichiro Maeda ,&nbsp;Satoru Oshino ,&nbsp;Haruhiko Kishima ,&nbsp;Masanori P. Takahashi ,&nbsp;Hideki Mochizuki ,&nbsp;Shigeo Murayama","doi":"10.1016/j.ensci.2025.100568","DOIUrl":"10.1016/j.ensci.2025.100568","url":null,"abstract":"<div><div>Deep brain stimulation (DBS) is an established and effective surgical treatment for movement disorders, including Parkinson's disease (PD). However, postmortem studies of patients with PD have revealed the presence of gliosis and inflammatory responses around the tracts of DBS electrodes. The objective of this study was to investigate the deposition of abnormal proteins, including phosphorylated tau (p-tau) and transactivation response DNA-binding protein 43 kDa (p-TDP-43), around the tips of DBS electrodes. Neuropathological examination was performed in two Japanese patients with PD: Case 1 describes a patient who underwent DBS lead placement into the left ventral intermediate nucleus of the thalamus at 79 years of age, and died at 88 years of age; Case 2 describes a patient who underwent DBS lead placement into the bilateral subthalamic nuclei at 70 years of age, and died 14 years after surgery. Postmortem neuropathological examination revealed fibrous gliosis, mild infiltration of lymphocytes, and hemosiderin deposition around the DBS lead tip-associated defects. Moreover, p-TDP-43 and p-tau deposits were visible around the electrode termination sites in both cases. These findings suggest that p-TDP-43 and p-tau accumulated around the DBS lead tip in response to chronic DBS. This is the first study to report the deposition of p-TDP-43 around the tip of a DBS electrode.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100568"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area postrema syndrome as the only sign of medullary infarction adjacent to area postrema","authors":"Patrick Stancu ,&nbsp;Nicolae Sanda ,&nbsp;Karl-Olof Lovblad ,&nbsp;Nils Guinand ,&nbsp;Andreas Kleinschmidt ,&nbsp;José Bernardo Escribano Paredes","doi":"10.1016/j.ensci.2025.100563","DOIUrl":"10.1016/j.ensci.2025.100563","url":null,"abstract":"<div><div>Area postrema syndrome (APS) is characterized by acute or subacute intractable nausea, vomiting, and/or hiccups lasting for at least 48 h. These symptoms can occur individually or in combination and are typically linked to periventricular brainstem lesions, particularly involving the area postrema (AP). The AP, a highly vascularized circumventricular organ located in the dorsal medulla oblongata, is supplied by the anterior spinal artery and perforating branches of the posterior inferior cerebellar artery (PICA), making it susceptible to pathological processes that can lead to APS. APS rarely occurs in stroke patients, but has been seen with ischemic lesions in the medial brachium pontis. The underlying pathophysiology of APS remains unclear, but remote lesions from the AP suggest involvement of an autonomic network of neuronal structures. This article reports a rare case of APS caused by ischemic stroke near the area postrema, without accompanying neurological impairments. The case highlights the importance of vascular investigation in intractable APS cases, even without focal neurological symptoms, and supports the role of neuronal structures connected to the AP in APS development.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Cerebral syphilitic gumma mimicking a brain tumor that enlarged temporarily after commencing antibiotic treatment” [eNeurologicalSci 29 (2022) 100436]","authors":"Yoshiaki Takahashi ,&nbsp;Nobutoshi Morimoto ,&nbsp;Mizuki Morimoto ,&nbsp;Shunsuke Mori ,&nbsp;Yu Takahashi ,&nbsp;Tomotsugu Ichikawa ,&nbsp;Kyoko Yokota ,&nbsp;Toru Yamashita","doi":"10.1016/j.ensci.2025.100564","DOIUrl":"10.1016/j.ensci.2025.100564","url":null,"abstract":"","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100564"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An invisible enemy. Echoacousis and aphasia as a rare presentation of a non convulsive status epilepticus. Clinical case","authors":"Yuliia Solodovnikova ,&nbsp;Anatoliy Son ,&nbsp;Tetiana Marusich ,&nbsp;Asel Jusupova","doi":"10.1016/j.ensci.2025.100565","DOIUrl":"10.1016/j.ensci.2025.100565","url":null,"abstract":"<div><div>Status epilepticus is not always an easily recognised condition, which can become a cause of serious consequences, and even death. It can present in two clinical forms: convulsive and nonconvulsive. The clinical symptoms representing nonconvulsive status epilepticus (NCSE) can vary a lot and sometimes be very misleading. We present here a case of a woman, who is a carrier of 6 platinum spirals as a result of endovascular aneurysm embolisation and has undergone a surgery for the removal of the left temporal lobe meningioma. The patient showed the signs of sensorimotor aphasia and echoacusis in the early postoperative period. Taking into account the past history of a tonic-clonic seizure and inability to perform EEG during the clinical manifestations, the diagnosis of NCSE was done clinically, and the treatment started immediately with the IV diazepam and valproic acid administration, leading to complete resolution of aphasia and echoacusis.</div><div>Negative neurological clinical symptoms are rare in the presentation of epilepsy, and echolalia is not yet described as a symptom of a NCSE. In our case the patient presents with the combination of these two symptoms, which can make the diagnosing even more challenging. This case report aims to highlight the variety of clinical symptoms which can represent NCSE and prompt early diagnosis and treatment, avoiding life threatening consequences.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100565"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutting-edge stroke prevention strategies","authors":"Lisa Kaindl ,&nbsp;Julian Frederic Hotz ,&nbsp;Julia Ferrari","doi":"10.1016/j.ensci.2025.100561","DOIUrl":"10.1016/j.ensci.2025.100561","url":null,"abstract":"<div><div>Stroke represents a major public health problem, ranking as a leading cause of death and long-term disability worldwide (1–3). The goal of prevention strategies is to avoid the occurrence of stroke by educating both healthcare professionals and patients about the reduction of risk factors. Despite increasing improvements in acute revascularization therapies, preventive measures remain more effective in decreasing the burden of stroke, as evidenced by the fact that over 75 % of strokes are first events (2). This paper attempts to provide a comprehensive approach by outlining risk factors and new therapeutic approaches. Understanding these is essential for healthcare providers and the general public to develop effective prevention strategies and ultimately reduce the overall incidence of stroke.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100561"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophobia among students and interns at the Abidjan Faculty of Medicine (Côte d'Ivoire)","authors":"Kadjo Claude Valery Cedric Aka ,&nbsp;Essoin-de Souza Tamia Nancy ,&nbsp;Amon-tanoh Muriel ,&nbsp;Agbo-Panzo Cedric ,&nbsp;Offoumou Fiacre Delors ,&nbsp;Aka Arlette Desirée ,&nbsp;Baugnan Davide ,&nbsp;Toa Bi Axel ,&nbsp;Yapo-Ehounoud Constance ,&nbsp;Tanoh Christian ,&nbsp;Aka-Diarra Evelyne ,&nbsp;Assi Berthe","doi":"10.1016/j.ensci.2025.100566","DOIUrl":"10.1016/j.ensci.2025.100566","url":null,"abstract":"<div><h3>Introduction</h3><div>As defined by Jozefowicz in 1994, neurophobia is the fear of neuroscience and clinical neurology. We carried out this study, the first on neurophobia in the Ivory Coast, in order to assess its prevalence among medical students and interns in the Ivorian environment, to identify the factors involved and to propose solutions.</div></div><div><h3>Methodology</h3><div>This was a prospective cross-sectional study carried out during the 2022–2023 academic year at the Abidjan UFR of Medical Sciences. The study population consisted of all students in years 3^ème to 6^ème and hospital interns. The Schon questionnaire, transcribed using google form software, was sent to students using the “wathsapp” social network.</div></div><div><h3>Result</h3><div>We obtained 284 responses, i.e. 23 % of all respondents (<em>n</em> = 1228). The sex ratio was 1.65 in favour of men. The subjects considered that they had a level of competence in neurology higher than 6 of the nine specialities selected. These were nephrology, cardiology, rheumatology, endocrinology, psychiatry and geriatrics. Neurology was considered more difficult than cardiology, endocrinology, psychiatry and geriatrics. Subjects' level of knowledge in neurology was rated higher than in nephrology, cardiology, rheumatology, endocrinology, psychiatry and geriatrics. The subjects' level of interest in neurology was higher than in the other specialities. 27.46 % of subjects surveyed were neurophobic.</div></div><div><h3>Conclusion</h3><div>The impact of neurophobia remains harmful to public health, as it is a factor in the sub-optimal management of patients with neurological disorders.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100566"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of immunotherapy on isolated optic neuritis associated with ozoralizumab, a novel anti-tumor necrosis factor α NANOBODY® compound: A case report","authors":"Masato Okitsu ,&nbsp;Keizo Sugaya ,&nbsp;Yuya Shiotani ,&nbsp;Kazushi Takahashi","doi":"10.1016/j.ensci.2025.100567","DOIUrl":"10.1016/j.ensci.2025.100567","url":null,"abstract":"<div><div>Tumor necrosis factor (TNF)-α inhibitors rarely cause optic neuritis as a side effect although the disease associated with ozoralizumab, a novel anti-TNF-α NANOBODY® compound, has not been reported. A 76-year-old female with rheumatoid arthritis, medicated with ozoralizumab, was hospitalized with a two-day history of extending partial visual field loss in the left eye. Campimetry revealed top horizontal hemianopia in the left eye. Swelling and abnormally high intensity of the left optic nerve were observed in magnetic resonance imaging. Visual evoked potential tests revealed delayed latency and reduced amplitude on the left side. She was diagnosed with ozoralizumab-associated isolated optic neuritis and cured with two courses of high-dose intravenous methylprednisolone, followed by oral prednisolone. Ozoralizumab may be associated with optic neuritis although early diagnosis and immunotherapy possibly achieve a good outcome.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100567"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia and outcome of patients with ischemic stroke in a referral hospital in Cameroon","authors":"Yacouba Njankouo Mapoure ,&nbsp;Elodie Dorothée Ebogo Fouda ,&nbsp;Daniel Gams Massi ,&nbsp;Caroline Kenmegne ,&nbsp;Bertrand Hugo Ngahane Mbatchou","doi":"10.1016/j.ensci.2025.100560","DOIUrl":"10.1016/j.ensci.2025.100560","url":null,"abstract":"<div><h3>Background</h3><div>Stroke and anemia are major public health concerns in Sub-Saharan Africa. However, few data are available on anemia and acute ischemic stroke in our setting.</div></div><div><h3>Purpose</h3><div>To assess the impact of anemia on the outcome of patients with ischemic stroke.</div></div><div><h3>Methods</h3><div>We collected retrospectively data of patients &gt;15 years hospitalized for ischemic stroke at the Douala General Hospital over a period of 9 years, in whom full blood count was done. Anemia was classified as mild, moderate and severe. Multivariate analysis was used to determine predictive factors of poor outcome at 3 months (mortality and poor functional recovery) in ischemic stroke patients with anemia.</div></div><div><h3>Results</h3><div>A total of 691 patients (male, 53.3 %) male were included. Anemia was found in 44.4 % of cases (severe anemia, 10.4 %). Severe anemia was significantly associated with poor functional recovery at 3 months (OR:4.43, 95 %CI:1.02–12.24, <em>p</em> = 0.04). We found no difference in mortality at 3 months between patients with (4.6 %, <em>n</em> = 14) and without (3.9 %, <em>n</em> = 15) anemia (OR:1.48, 95 %CI:0.69–3.14, <em>p</em> = 0.330). Age &gt; 60 years, diastolic blood pressure &gt; 90 mmHg, NIHSS score ≥ 15, and INR &gt; 1.2 were predictive factors of mortality at 3 months in ischemic stroke patients with anemia.</div></div><div><h3>Conclusion</h3><div>Anemia is common in ischemic stroke cases and must be systematically screened.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"39 ","pages":"Article 100560"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}